MX2010006111A - Derivados de 5-aminociclilmetil-oxazolidin-2-ona y su uso como antibacteriales. - Google Patents

Derivados de 5-aminociclilmetil-oxazolidin-2-ona y su uso como antibacteriales.

Info

Publication number
MX2010006111A
MX2010006111A MX2010006111A MX2010006111A MX2010006111A MX 2010006111 A MX2010006111 A MX 2010006111A MX 2010006111 A MX2010006111 A MX 2010006111A MX 2010006111 A MX2010006111 A MX 2010006111A MX 2010006111 A MX2010006111 A MX 2010006111A
Authority
MX
Mexico
Prior art keywords
represent
aminocyclylmethyl
oxazolidin
derivatives
och2
Prior art date
Application number
MX2010006111A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Cornelia Zumbrunn Acklin
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40471513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010006111(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2010006111A publication Critical patent/MX2010006111A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se relaciona con compuestos antibacteriales de la fórmula I en la cual uno o dos de U, V, W, y X representan N, el resto representan CH o, en el caso de X, puede también representar CRa en donde Ra es flúor; R1 representa alcoxi, halógeno o ciano; R2 representa H, CH2OH, CH2N3, CH2NH2, alquilcarbonilaminometilo o triazol-1-ilmetil; R3 representa H, o, cuando n es 1, R3 puede también representar OH, NH2, NHCOR6 o triazol-1-il; A representa CR4; K representa O, NH, OCH2, NHCO, NHCH2, CH2NH, CH2CH2, CH=CH, CHOHCHOH o CHR5; R4 representa H o en conjunto con R5 forma un enlace, o también R4 puede representar OH cuando K no es O, NH, OCH2 o NHCO; R5 representa OH o en conjunto con R4 forma un enlace; R6 representa alquilo; m es 0 ó 1 y n es 0 ó 1; y G es tal como se define en la descripción; y con sales tales compuestos.
MX2010006111A 2007-12-18 2008-12-17 Derivados de 5-aminociclilmetil-oxazolidin-2-ona y su uso como antibacteriales. MX2010006111A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2007055194 2007-12-18
IB2008054170 2008-10-10
PCT/IB2008/055374 WO2009077989A1 (en) 2007-12-18 2008-12-17 5-aminocyclylmethyl-oxazolidin-2-one derivatives

Publications (1)

Publication Number Publication Date
MX2010006111A true MX2010006111A (es) 2010-06-25

Family

ID=40471513

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006111A MX2010006111A (es) 2007-12-18 2008-12-17 Derivados de 5-aminociclilmetil-oxazolidin-2-ona y su uso como antibacteriales.

Country Status (16)

Country Link
US (1) US9505750B2 (es)
EP (1) EP2245028B1 (es)
JP (1) JP5323088B2 (es)
KR (1) KR101578234B1 (es)
CN (1) CN101903380B (es)
AR (1) AR069800A1 (es)
AT (1) ATE546446T1 (es)
AU (1) AU2008337096B2 (es)
BR (1) BRPI0820985A2 (es)
CA (1) CA2706837C (es)
ES (1) ES2380398T3 (es)
MX (1) MX2010006111A (es)
PL (1) PL2245028T3 (es)
RU (1) RU2492169C2 (es)
TW (1) TWI441636B (es)
WO (1) WO2009077989A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200940551A (en) 2008-02-20 2009-10-01 Actelion Pharmaceuticals Ltd Azatricyclic antibiotic compounds
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
CN102164919B (zh) * 2008-10-10 2014-04-09 埃科特莱茵药品有限公司 噁唑烷基抗生素
ES2395491T3 (es) * 2008-10-10 2013-02-13 Actelion Pharmaceuticals Ltd. 2-Benzotiofenil y 2-naftil-oxazolidinonas y sus análogos azaisósteros como agentes antibacterianos
US8952010B2 (en) 2011-02-07 2015-02-10 Daiichi Sankyo Company, Limited Amino group-containing pyrrolidinone derivative
CA2854264A1 (en) * 2011-11-08 2013-05-16 Actelion Pharmaceuticals Ltd 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
IT1297874B1 (it) 1997-06-19 1999-12-20 Ezio Pellegrinotti Cerniera elastica per occhiali.
DE60011570T2 (de) 1999-01-07 2004-11-25 Wyeth Arylpiperazinyl-cyclohexyl indolderivate zur behandlung von depressionen
MY145722A (en) 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0112836D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
CA2447475A1 (en) 2001-05-25 2002-12-05 Chu-Biao Xue Hydantion derivatives as inhibitors of matrix metalloproteinases
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
AU2003275480A1 (en) 2002-10-07 2004-05-04 Smithkline Beecham Corporation Compounds
US7491714B2 (en) 2002-12-04 2009-02-17 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
EP1771456A2 (fr) * 2004-07-30 2007-04-11 Palumed SA Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
DE102004041163A1 (de) 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
WO2006032466A2 (en) 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
WO2007012210A2 (de) 2005-07-23 2007-02-01 Schlittler & Co. Ag Reiniger mit einweg-wischtasche
CA2643962A1 (en) 2006-03-10 2007-09-20 Actelion Pharmaceuticals Ltd Antibiotic compounds
US7888359B2 (en) 2006-03-23 2011-02-15 Actelion Pharmaceutical Ltd. Cyclohexyl or piperidinyl carboxamide antibiotic derivatives
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CL2008001002A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.

Also Published As

Publication number Publication date
ATE546446T1 (de) 2012-03-15
CA2706837C (en) 2016-05-03
AU2008337096A1 (en) 2009-06-25
EP2245028B1 (en) 2012-02-22
ES2380398T3 (es) 2012-05-11
BRPI0820985A2 (pt) 2015-06-16
KR101578234B1 (ko) 2015-12-16
CN101903380B (zh) 2013-04-17
WO2009077989A1 (en) 2009-06-25
JP5323088B2 (ja) 2013-10-23
TWI441636B (zh) 2014-06-21
AU2008337096B2 (en) 2013-10-17
PL2245028T3 (pl) 2012-07-31
RU2492169C2 (ru) 2013-09-10
AR069800A1 (es) 2010-02-17
CA2706837A1 (en) 2009-06-25
US20110003789A1 (en) 2011-01-06
TW200932230A (en) 2009-08-01
KR20100092965A (ko) 2010-08-23
JP2011506593A (ja) 2011-03-03
RU2010129113A (ru) 2012-01-27
CN101903380A (zh) 2010-12-01
US9505750B2 (en) 2016-11-29
EP2245028A1 (en) 2010-11-03

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