RS50629B - Amidni prolek gemcitabina, kompozicije i njihova primena - Google Patents

Amidni prolek gemcitabina, kompozicije i njihova primena

Info

Publication number
RS50629B
RS50629B RSP-2008/0502A RSP20080502A RS50629B RS 50629 B RS50629 B RS 50629B RS P20080502 A RSP20080502 A RS P20080502A RS 50629 B RS50629 B RS 50629B
Authority
RS
Serbia
Prior art keywords
gemcitabine
compositions
amide prodrug
prodrug
amide
Prior art date
Application number
RSP-2008/0502A
Other languages
English (en)
Inventor
David Michael Bender
David Michael Remick
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RS50629B publication Critical patent/RS50629B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Jedinjenje formulePrijava sadrži još 10 patentnih zahteva.
RSP-2008/0502A 2004-12-17 2005-11-30 Amidni prolek gemcitabina, kompozicije i njihova primena RS50629B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63742204P 2004-12-17 2004-12-17
PCT/US2005/043125 WO2006065525A1 (en) 2004-12-17 2005-11-30 Amide prodrug of gemcitabine, compositions and use thereof

Publications (1)

Publication Number Publication Date
RS50629B true RS50629B (sr) 2010-06-30

Family

ID=36168678

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2008/0502A RS50629B (sr) 2004-12-17 2005-11-30 Amidni prolek gemcitabina, kompozicije i njihova primena

Country Status (32)

Country Link
US (1) US7691827B2 (sr)
EP (1) EP1831237B1 (sr)
JP (1) JP5022911B2 (sr)
KR (1) KR100874052B1 (sr)
CN (1) CN101080417B (sr)
AR (1) AR055009A1 (sr)
AT (1) ATE405573T1 (sr)
AU (1) AU2005316922B2 (sr)
BR (1) BRPI0519117A2 (sr)
CA (1) CA2589850C (sr)
CY (1) CY1108447T1 (sr)
DE (1) DE602005009255D1 (sr)
DK (1) DK1831237T3 (sr)
EA (1) EA011868B1 (sr)
ES (1) ES2310860T3 (sr)
HK (1) HK1109903A1 (sr)
HR (1) HRP20080529T3 (sr)
IL (1) IL183666A (sr)
MA (1) MA29154B1 (sr)
MX (1) MX2007007228A (sr)
MY (1) MY143677A (sr)
NO (1) NO20073368L (sr)
NZ (1) NZ554732A (sr)
PE (1) PE20060771A1 (sr)
PL (1) PL1831237T3 (sr)
PT (1) PT1831237E (sr)
RS (1) RS50629B (sr)
SI (1) SI1831237T1 (sr)
TW (1) TWI326687B (sr)
UA (1) UA86119C2 (sr)
WO (1) WO2006065525A1 (sr)
ZA (1) ZA200705019B (sr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA014909B1 (ru) * 2006-06-21 2011-02-28 Эли Лилли Энд Компани Кристаллические формы пролекарства на основе амида гемцитабина, композиции на их основе и их применение
TWI436775B (zh) 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
CN101525361B (zh) 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
US9447137B2 (en) 2012-11-07 2016-09-20 Nucorion Pharmaceuticals, Inc. Substituted gemcitabine aryl amide analogs
WO2014078295A1 (en) 2012-11-13 2014-05-22 BoYen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof
CN106459130A (zh) * 2014-03-03 2017-02-22 纽科利制药公司 吉西他滨类似物
WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
EP3784681A4 (en) * 2018-04-26 2022-10-26 NanoMed Holdings Pty Ltd GEMCITABIN AMPHIPHIL PRODRUGS
CN108864250A (zh) * 2018-05-29 2018-11-23 北京大学 一种FAPα酶敏感的吉西他滨前体药物及其制备方法和应用
JP2021534085A (ja) * 2018-08-03 2021-12-09 セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited 癌治療のための組成物及び方法
JP2023523415A (ja) 2020-04-21 2023-06-05 リガンド・ファーマシューティカルズ・インコーポレイテッド ヌクレオチドプロドラッグ化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
JP4352115B2 (ja) * 1997-01-24 2009-10-28 クラヴィス・ファルマ・アーエスアー ゲムシタビン誘導体
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
EP1567169A4 (en) * 2002-11-04 2009-10-21 Xenoport Inc GEMCITABINE PROMOTERS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds

Also Published As

Publication number Publication date
KR20070086308A (ko) 2007-08-27
BRPI0519117A2 (pt) 2008-12-23
TWI326687B (en) 2010-07-01
CN101080417A (zh) 2007-11-28
MY143677A (en) 2011-06-30
DE602005009255D1 (de) 2008-10-02
NZ554732A (en) 2010-09-30
CA2589850C (en) 2012-05-01
WO2006065525A1 (en) 2006-06-22
CA2589850A1 (en) 2006-06-22
CY1108447T1 (el) 2014-04-09
EP1831237A1 (en) 2007-09-12
IL183666A (en) 2011-09-27
PL1831237T3 (pl) 2009-01-30
HK1109903A1 (en) 2008-06-27
JP5022911B2 (ja) 2012-09-12
HRP20080529T3 (en) 2008-12-31
SI1831237T1 (sl) 2009-02-28
EA200701300A1 (ru) 2007-10-26
NO20073368L (no) 2007-07-16
ES2310860T3 (es) 2009-01-16
US7691827B2 (en) 2010-04-06
PT1831237E (pt) 2008-09-22
AR055009A1 (es) 2007-08-01
CN101080417B (zh) 2011-01-19
EP1831237B1 (en) 2008-08-20
MA29154B1 (fr) 2008-01-02
IL183666A0 (en) 2007-09-20
AU2005316922B2 (en) 2011-08-25
KR100874052B1 (ko) 2008-12-12
ATE405573T1 (de) 2008-09-15
EA011868B1 (ru) 2009-06-30
DK1831237T3 (da) 2008-10-27
JP2008524218A (ja) 2008-07-10
US20090156547A1 (en) 2009-06-18
TW200634023A (en) 2006-10-01
UA86119C2 (ru) 2009-03-25
AU2005316922A1 (en) 2006-06-22
ZA200705019B (en) 2008-10-29
PE20060771A1 (es) 2006-09-23
MX2007007228A (es) 2007-08-14

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