PE20210367A1 - Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina - Google Patents

Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina

Info

Publication number
PE20210367A1
PE20210367A1 PE2020001173A PE2020001173A PE20210367A1 PE 20210367 A1 PE20210367 A1 PE 20210367A1 PE 2020001173 A PE2020001173 A PE 2020001173A PE 2020001173 A PE2020001173 A PE 2020001173A PE 20210367 A1 PE20210367 A1 PE 20210367A1
Authority
PE
Peru
Prior art keywords
gemcitabin
monophosphate
small molecule
drug conjugates
molecule drug
Prior art date
Application number
PE2020001173A
Other languages
English (en)
Inventor
Steven Albert Verett
Craig Alan Coburn
Original Assignee
Maverix Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maverix Oncology Inc filed Critical Maverix Oncology Inc
Publication of PE20210367A1 publication Critical patent/PE20210367A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/24—Post-translational modifications [PTMs] in chemical analysis of biological material hydroxylation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE L, Y1, Y2, Y3, Y4, Y5, Z1, Z2, Z3, Z4, Z5 Y Z6 SON COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: ((2R,3R,5R)-5-(4-((((5,7-DIMETOXIBENZOFURAN-2-IL)METOXI)-CARBONIL)AMINO)-2-OXOPIRIMIDIN-1(2H)-IL)-4,4-DIFLUORO-3-HIDROXITETRAHIDROFURAN-2-IL)-METILFOSFATO DISODICO; ((2R,3R,5R)-5-(4-((((5,7-DIBROMOBENZOFURAN-2-IL)METOXI)CARBONIL)-AMINO)-2-OXOPIRIMIDIN-1(2H)-IL)-4,4-DIFLUORO-3-HIDROXITETRA-HIDROFURAN-2-IL)METILHIDROGENO-FOSFATO DE TRIETILAMONIO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON CONJUGADOS DE FARMACOS DE MOLECULA PEQUENA TAL COMO MONOFOSFATO DE GEMCITABINA SIENDO UTILES EN EL TRATAMIENTO DE CANCER.
PE2020001173A 2018-02-02 2019-02-04 Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina PE20210367A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862625820P 2018-02-02 2018-02-02
PCT/US2019/016557 WO2019152955A1 (en) 2018-02-02 2019-02-04 Small molecule drug conjugates of gemcitabine monophosphate

Publications (1)

Publication Number Publication Date
PE20210367A1 true PE20210367A1 (es) 2021-02-26

Family

ID=65494554

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020001173A PE20210367A1 (es) 2018-02-02 2019-02-04 Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina

Country Status (17)

Country Link
US (1) US11760773B2 (es)
EP (1) EP3746134A1 (es)
JP (2) JP2021512953A (es)
KR (1) KR20200118827A (es)
CN (1) CN112135634A (es)
AU (1) AU2019216531A1 (es)
BR (1) BR112020015745A2 (es)
CA (1) CA3091027A1 (es)
CL (1) CL2020002022A1 (es)
CO (1) CO2020010970A2 (es)
EA (1) EA202091856A1 (es)
IL (1) IL276436A (es)
MX (1) MX2020008188A (es)
PE (1) PE20210367A1 (es)
PH (1) PH12020551182A1 (es)
SG (1) SG11202007386RA (es)
WO (1) WO2019152955A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20210367A1 (es) * 2018-02-02 2021-02-26 Maverix Oncology Inc Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina

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Also Published As

Publication number Publication date
CO2020010970A2 (es) 2020-11-20
IL276436A (en) 2020-09-30
SG11202007386RA (en) 2020-08-28
US11760773B2 (en) 2023-09-19
JP2021512953A (ja) 2021-05-20
CN112135634A (zh) 2020-12-25
WO2019152955A1 (en) 2019-08-08
KR20200118827A (ko) 2020-10-16
US20210040136A1 (en) 2021-02-11
AU2019216531A1 (en) 2020-09-24
BR112020015745A2 (pt) 2020-12-08
CA3091027A1 (en) 2019-08-08
MX2020008188A (es) 2020-11-18
JP2024054873A (ja) 2024-04-17
EP3746134A1 (en) 2020-12-09
WO2019152955A9 (en) 2020-08-13
PH12020551182A1 (en) 2021-05-10
CL2020002022A1 (es) 2021-02-12
EA202091856A1 (ru) 2020-12-07

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