DK0986570T3 - Gemcitabinderivat - Google Patents

Gemcitabinderivat

Info

Publication number
DK0986570T3
DK0986570T3 DK98901592T DK98901592T DK0986570T3 DK 0986570 T3 DK0986570 T3 DK 0986570T3 DK 98901592 T DK98901592 T DK 98901592T DK 98901592 T DK98901592 T DK 98901592T DK 0986570 T3 DK0986570 T3 DK 0986570T3
Authority
DK
Denmark
Prior art keywords
gemcita
eicosenoyl
amides
binder
derivative
Prior art date
Application number
DK98901592T
Other languages
English (en)
Inventor
Finn Myhren
Are Dalen
Marit Liland Sandvold
Bernt Borretzen
Original Assignee
Conpharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9701427A external-priority patent/GB2321454A/en
Application filed by Conpharma As filed Critical Conpharma As
Application granted granted Critical
Publication of DK0986570T3 publication Critical patent/DK0986570T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK98901592T 1997-01-24 1998-01-23 Gemcitabinderivat DK0986570T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9701427A GB2321454A (en) 1997-01-24 1997-01-24 Gemcitabine esters and amides
PCT/NO1998/000020 WO1998032762A1 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives

Publications (1)

Publication Number Publication Date
DK0986570T3 true DK0986570T3 (da) 2003-07-28

Family

ID=26310850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98901592T DK0986570T3 (da) 1997-01-24 1998-01-23 Gemcitabinderivat

Country Status (15)

Country Link
US (1) US6384019B1 (da)
EP (1) EP0986570B9 (da)
JP (1) JP4352115B2 (da)
KR (1) KR100483256B1 (da)
AT (1) ATE236188T1 (da)
AU (1) AU720451B2 (da)
CA (1) CA2278056C (da)
DE (1) DE69812934T2 (da)
DK (1) DK0986570T3 (da)
HU (1) HU224918B1 (da)
NZ (1) NZ336676A (da)
PL (1) PL186888B1 (da)
SK (1) SK283879B6 (da)
UA (1) UA67736C2 (da)
WO (1) WO1998032762A1 (da)

Families Citing this family (79)

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WO2002076402A2 (en) * 2001-03-23 2002-10-03 Protarga, Inc. Fatty amine drug conjugates
SI1385551T1 (sl) * 2001-04-06 2008-12-31 Wyeth Five Giralda Farms Antineoplastiäśne kombinacije, ki vsebujejo cci-779 (derivat rapamicina) skupaj z gemcitabinom ali fluorouracilom
EP1465615B1 (en) 2002-01-15 2012-08-01 Trustees of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US7265096B2 (en) 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
WO2005094358A2 (en) * 2004-03-29 2005-10-13 Roswell Park Cancer Institute Method of treating solid tumors and leukemias using combination therapy of vitamin d and anti-metabolic nucleoside analogs
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WO2006029081A2 (en) * 2004-09-02 2006-03-16 Neopharm, Inc. Nucleoside-lipid conjugates, their method of preparation and uses thereof
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SI1831237T1 (sl) * 2004-12-17 2009-02-28 Lilly Co Eli Amidno predzdravilo gemcitabina, zmesi in njihovauporaba
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JP5225271B2 (ja) 2006-06-21 2013-07-03 イーライ リリー アンド カンパニー ゲムシタビンアミドプロドラッグの結晶形、その組成物および使用
JP2010510243A (ja) 2006-11-17 2010-04-02 トラスティーズ オブ ダートマス カレッジ 三環系−ビス−エノン（ｔｂｅ）の合成および生物学的活性
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
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GB9515279D0 (en) * 1995-07-25 1995-09-20 Norsk Hydro As Improved therapeutic agents

Also Published As

Publication number Publication date
NZ336676A (en) 2000-01-28
US20020042391A1 (en) 2002-04-11
AU5782798A (en) 1998-08-18
JP2001509160A (ja) 2001-07-10
SK102999A3 (en) 2000-05-16
KR100483256B1 (ko) 2005-04-15
EP0986570B1 (en) 2003-04-02
DE69812934D1 (de) 2003-05-08
AU720451B2 (en) 2000-06-01
ATE236188T1 (de) 2003-04-15
UA67736C2 (uk) 2004-07-15
EP0986570B9 (en) 2004-01-02
HU224918B1 (en) 2006-04-28
WO1998032762A1 (en) 1998-07-30
PL334856A1 (en) 2000-03-27
CA2278056C (en) 2006-12-12
KR20000070351A (ko) 2000-11-25
SK283879B6 (sk) 2004-04-06
JP4352115B2 (ja) 2009-10-28
CA2278056A1 (en) 1998-07-30
DE69812934T2 (de) 2004-01-29
EP0986570A1 (en) 2000-03-22
PL186888B1 (pl) 2004-03-31
HUP0000721A3 (en) 2002-12-28
HUP0000721A2 (hu) 2001-05-28
US6384019B1 (en) 2002-05-07

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