ES2196528T3 - Derivados de gemcitabina. - Google Patents

Derivados de gemcitabina.

Info

Publication number
ES2196528T3
ES2196528T3 ES98901592T ES98901592T ES2196528T3 ES 2196528 T3 ES2196528 T3 ES 2196528T3 ES 98901592 T ES98901592 T ES 98901592T ES 98901592 T ES98901592 T ES 98901592T ES 2196528 T3 ES2196528 T3 ES 2196528T3
Authority
ES
Spain
Prior art keywords
gemcitabine
eicosenoyl
amides
sub
gemcitabine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98901592T
Other languages
English (en)
Inventor
Finn Myhren
Bernt Borretzen
Are Dalen
Marit Liland Sandvold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Conpharma AS
Original Assignee
Conpharma AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conpharma AS filed Critical Conpharma AS
Application granted granted Critical
Publication of ES2196528T3 publication Critical patent/ES2196528T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a ésteres o amidas de gemcitabina, en los que el grupo 3''-y/o 5''-OH y/o el grupo N{sup,4}-amino se deriva mediante un grupo acilo C{sub,18} y/o C{sub,20} saturado o monosaturado, preferentemente un grupo acilo elegido entre oleoilo, elaidoilo, cis-eicosenoilo y trans-eicosenoilo. Los ésteres y amidas de gemcitabina son útiles como agentes anticancerosos y antivirales.
ES98901592T 1997-01-24 1998-01-23 Derivados de gemcitabina. Expired - Lifetime ES2196528T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9701427A GB2321454A (en) 1997-01-24 1997-01-24 Gemcitabine esters and amides

Publications (1)

Publication Number Publication Date
ES2196528T3 true ES2196528T3 (es) 2003-12-16

Family

ID=10806509

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98901592T Expired - Lifetime ES2196528T3 (es) 1997-01-24 1998-01-23 Derivados de gemcitabina.

Country Status (7)

Country Link
CZ (1) CZ293245B6 (es)
ES (1) ES2196528T3 (es)
GB (1) GB2321454A (es)
IL (1) IL130971A0 (es)
RU (1) RU2194711C2 (es)
TW (1) TW458981B (es)
ZA (1) ZA98576B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
JP5022911B2 (ja) * 2004-12-17 2012-09-12 イーライ リリー アンド カンパニー ゲムシタビンのアミドプロドラック、組成物、及びそれらの使用
CN102056607B (zh) * 2008-04-17 2014-07-30 约翰·霍普金斯大学 On01910.na促进在抗药性肿瘤中化学治疗剂的活性
CN104968353B (zh) 2012-11-13 2017-12-22 博研医药开发股份有限公司 吉西他滨前药及其用途
CN110713502A (zh) * 2019-11-29 2020-01-21 南京科技职业学院 一种吉西他滨杂质的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA891076B (en) * 1988-02-16 1990-10-31 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi

Also Published As

Publication number Publication date
GB2321454A (en) 1998-07-29
IL130971A0 (en) 2001-01-28
CZ247999A3 (cs) 1999-12-15
TW458981B (en) 2001-10-11
RU2194711C2 (ru) 2002-12-20
ZA98576B (en) 1998-07-23
CZ293245B6 (cs) 2004-03-17
GB9701427D0 (en) 1997-03-12

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