ES2156293T3 - Metodo para producir vasodilatacion con derivados de (1,5-inter)arilprostaglandina. - Google Patents
Metodo para producir vasodilatacion con derivados de (1,5-inter)arilprostaglandina.Info
- Publication number
- ES2156293T3 ES2156293T3 ES96931432T ES96931432T ES2156293T3 ES 2156293 T3 ES2156293 T3 ES 2156293T3 ES 96931432 T ES96931432 T ES 96931432T ES 96931432 T ES96931432 T ES 96931432T ES 2156293 T3 ES2156293 T3 ES 2156293T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- presents
- carbon atoms
- formula
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010047141 Vasodilatation Diseases 0.000 title abstract 2
- 230000024883 vasodilation Effects 0.000 title abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION DESCRIBE UN PROCEDIMIENTO PARA LLEVAR A CABO LA VASODILATACION, QUE INCLUYE: ADMINISTRAR A UN ANIMAL DE SANGRE CALIENTE QUE NECESITE TAL TRATAMIENTO UNA CANTIDAD EFICAZ DE UN DERIVADO DE (1,5 PRESENTADO POR LA FORMULA (I), EN LA CUAL N ES 0 O UN NUMERO ENTERO DE 1 A 6, R SE SELECCIONA ENTRE EL GRUPO DE RADICALES REPRESENTADOS POR LAS FORMULAS: CO SUB,2}R , CONR SUB,2}, CH SUB,2}OR Y SO SUB,2}NR SUB,2}, EN LAS CUALES R ES HIDROGENO O UN RADICAL ALQUILO INFERIOR QUE PRESENTA DE UNO A SEIS ATOMOS DE CARBONO; R ES HIDROGENO O UN RADICAL ACILO QUE PRESENTA LA FORMULA: (CO)R , EN LA CUAL R ES UN RADICAL HIDROCARBURO ACICLICO SATURADO O INSATURADO QUE PRESENTA DE 1 A APROXIMADAMENTE 10 ATOMOS DE CARBONO, O O UN NUMERO ENTERO DE 1 A 6, Y R ES UN ANILLO ALIFATICO QUE PRESENTA DE 3 A 7 ATOMOS DE CARBONO O UN GRUPO ARILO, POR EJEMPLO FENILO, O UN GRUPO HETEROARILO, POR EJEMPLO TIENILO, FURANILO O PIRIDILO, Y PREFERIBLEMENTE R ES UN GRUPO ALQUILO INFERIOR QUE PRESENTA DE 1 A 6 ATOMOS DE CARBONO; LOS SEGMENTOS TRIANGULARES SOMBREADOS REPRESENTAN ENLACES CON ORIENTACION ALFA, LOS SEGMENTOS TRIANGULARES NEGROS REPRESENTAN ENLACES CON ORIENTACION BETA Y LOS SEGMENTOS ONDULADOS REPRESENTAN ENLACES QUE PUEDEN PRESENTAR UNA ORIENTACION CIS O TRANS. MAS PREFERIBLEMENTE, DICHO DERIVADO DE (1,5 ESTO REPRESENTADO POR LA FORMULA (II). LO MAS PREFERIBLE ES QUE DICHO DERIVADO DE (1,5 ESTO DE FORMULA (II) EN LA CUAL R ES CO SUB,2}R , R ES HIDROGENO Y N ES 0.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/522,775 US5661178A (en) | 1995-09-01 | 1995-09-01 | Method for effecting vasodilation with (1,5-inter)aryl prostaglandin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2156293T3 true ES2156293T3 (es) | 2001-06-16 |
Family
ID=24082299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96931432T Expired - Lifetime ES2156293T3 (es) | 1995-09-01 | 1996-08-28 | Metodo para producir vasodilatacion con derivados de (1,5-inter)arilprostaglandina. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5661178A (es) |
EP (1) | EP0847276B1 (es) |
JP (1) | JP2000512262A (es) |
AU (1) | AU701835B2 (es) |
CA (1) | CA2230687A1 (es) |
DE (1) | DE69612006T2 (es) |
ES (1) | ES2156293T3 (es) |
WO (1) | WO1997009049A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070191320A1 (en) * | 1998-12-10 | 2007-08-16 | Nexmed Holdings, Inc. | Methods of treatment for female sexual arousal disorder |
US6825234B2 (en) | 1998-12-10 | 2004-11-30 | Nexmed (Holdings) , Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
US6486207B2 (en) | 1998-12-10 | 2002-11-26 | Nexmed (Holdings), Inc. | Compositions and methods for amelioration of human female sexual dysfunction |
AU3713600A (en) | 1999-03-01 | 2000-09-21 | Nitromed, Inc. | Nitrosated and nitrosylated prostaglandins, compositions and metods of use |
WO2000051980A1 (en) | 1999-03-05 | 2000-09-08 | The Procter & Gamble Company | C16 unsaturated fp-selective prostaglandins analogs |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US7511168B2 (en) * | 2006-01-18 | 2009-03-31 | Shih-Yi Wei | Processes and intermediates for the preparations of prostaglandins |
EP1810967B1 (en) * | 2006-01-18 | 2014-07-30 | Chirogate International Inc. | Processes and intermediates for the preparations of prostaglandins |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3944595A (en) * | 1972-10-30 | 1976-03-16 | The Upjohn Company | PGF1.sub.α -oxaphenylene compounds |
US4048058A (en) * | 1975-08-13 | 1977-09-13 | Standard Oil Company (Indiana) | Methods to be used in reforming processes employing multi-metallic catalysts |
US4312810A (en) * | 1978-11-22 | 1982-01-26 | The Upjohn Company | 2,5-Inter-o-phenylene-3,4-dinor-5,9α-epoxy-9-deoxy-PGF1 compounds |
AU541825B2 (en) * | 1978-11-22 | 1985-01-24 | Upjohn Company, The | Prostacyclin intermediate |
IL65387A0 (en) * | 1981-04-14 | 1982-05-31 | Chinoin Gyogyszer Es Vegyeszet | 2,3,4-trinor-m-inter-phenylene-prostaglandin derivatives and a process for the preparation thereof |
US5306729A (en) * | 1992-02-25 | 1994-04-26 | Joslin Diabetes Center | Method for effecting vasodilation with monoglycerides |
-
1995
- 1995-09-01 US US08/522,775 patent/US5661178A/en not_active Expired - Fee Related
-
1996
- 1996-08-28 CA CA002230687A patent/CA2230687A1/en not_active Abandoned
- 1996-08-28 WO PCT/US1996/013889 patent/WO1997009049A2/en active IP Right Grant
- 1996-08-28 JP JP09511279A patent/JP2000512262A/ja active Pending
- 1996-08-28 AU AU70113/96A patent/AU701835B2/en not_active Ceased
- 1996-08-28 DE DE69612006T patent/DE69612006T2/de not_active Expired - Fee Related
- 1996-08-28 EP EP96931432A patent/EP0847276B1/en not_active Expired - Lifetime
- 1996-08-28 ES ES96931432T patent/ES2156293T3/es not_active Expired - Lifetime
-
1997
- 1997-02-18 US US08/801,445 patent/US5750784A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0847276B1 (en) | 2001-03-07 |
US5750784A (en) | 1998-05-12 |
WO1997009049A3 (en) | 1997-07-10 |
JP2000512262A (ja) | 2000-09-19 |
EP0847276A2 (en) | 1998-06-17 |
US5661178A (en) | 1997-08-26 |
DE69612006D1 (de) | 2001-04-12 |
CA2230687A1 (en) | 1997-03-13 |
AU701835B2 (en) | 1999-02-04 |
AU7011396A (en) | 1997-03-27 |
DE69612006T2 (de) | 2001-08-23 |
WO1997009049A2 (en) | 1997-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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