GB2321454A - Gemcitabine esters and amides - Google Patents

Gemcitabine esters and amides Download PDF

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Publication number
GB2321454A
GB2321454A GB9701427A GB9701427A GB2321454A GB 2321454 A GB2321454 A GB 2321454A GB 9701427 A GB9701427 A GB 9701427A GB 9701427 A GB9701427 A GB 9701427A GB 2321454 A GB2321454 A GB 2321454A
Authority
GB
United Kingdom
Prior art keywords
gemcitabine
ester
amide
acyl
amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9701427A
Other languages
English (en)
Other versions
GB9701427D0 (en
Inventor
Finn Myhren
Bernt Borretzen
Marit Liland Sandvold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norsk Hydro ASA
Original Assignee
Norsk Hydro ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro ASA filed Critical Norsk Hydro ASA
Priority to GB9701427A priority Critical patent/GB2321454A/en
Publication of GB9701427D0 publication Critical patent/GB9701427D0/en
Priority to CA002278056A priority patent/CA2278056C/en
Priority to NZ336676A priority patent/NZ336676A/xx
Priority to UA99084763A priority patent/UA67736C2/uk
Priority to RU99118222/04A priority patent/RU2194711C2/ru
Priority to AT98901592T priority patent/ATE236188T1/de
Priority to SK1029-99A priority patent/SK283879B6/sk
Priority to KR10-1999-7006584A priority patent/KR100483256B1/ko
Priority to HU0000721A priority patent/HU224918B1/hu
Priority to IL13097198A priority patent/IL130971A0/xx
Priority to US09/355,112 priority patent/US6384019B1/en
Priority to DE69812934T priority patent/DE69812934T2/de
Priority to DK98901592T priority patent/DK0986570T3/da
Priority to ES98901592T priority patent/ES2196528T3/es
Priority to EP98901592A priority patent/EP0986570B9/en
Priority to PL98334856A priority patent/PL186888B1/pl
Priority to ZA98576A priority patent/ZA98576B/xx
Priority to PCT/NO1998/000020 priority patent/WO1998032762A1/en
Priority to AU57827/98A priority patent/AU720451B2/en
Priority to CZ19992479A priority patent/CZ293245B6/cs
Priority to JP53186298A priority patent/JP4352115B2/ja
Priority to TW087103708A priority patent/TW458981B/zh
Publication of GB2321454A publication Critical patent/GB2321454A/en
Priority to NO19993562A priority patent/NO318934B1/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB9701427A 1997-01-24 1997-01-24 Gemcitabine esters and amides Withdrawn GB2321454A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
GB9701427A GB2321454A (en) 1997-01-24 1997-01-24 Gemcitabine esters and amides
JP53186298A JP4352115B2 (ja) 1997-01-24 1998-01-23 ゲムシタビン誘導体
US09/355,112 US6384019B1 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives
DK98901592T DK0986570T3 (da) 1997-01-24 1998-01-23 Gemcitabinderivat
UA99084763A UA67736C2 (uk) 1997-01-24 1998-01-23 Похідні гемцитабіну, спосіб їх одержання та фармацевтична композиція на їх основі
RU99118222/04A RU2194711C2 (ru) 1997-01-24 1998-01-23 Производные гемцитабина
AT98901592T ATE236188T1 (de) 1997-01-24 1998-01-23 Gemcitabin-derivate
SK1029-99A SK283879B6 (sk) 1997-01-24 1998-01-23 Deriváty gemcitabínu, spôsob ich prípravy, ich použitie a farmaceutický prostriedok s ich obsahom
KR10-1999-7006584A KR100483256B1 (ko) 1997-01-24 1998-01-23 젬시타빈 유도체
HU0000721A HU224918B1 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives, process for their preparation and pharmaceutical compositions containing them
IL13097198A IL130971A0 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives
CA002278056A CA2278056C (en) 1997-01-24 1998-01-23 Gemcitabine derivatives
DE69812934T DE69812934T2 (de) 1997-01-24 1998-01-23 Gemcitabin-derivate
NZ336676A NZ336676A (en) 1997-01-24 1998-01-23 Gemcitabine esters or amides useful as anti-cancer and anti-viral agents
ES98901592T ES2196528T3 (es) 1997-01-24 1998-01-23 Derivados de gemcitabina.
EP98901592A EP0986570B9 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives
PL98334856A PL186888B1 (pl) 1997-01-24 1998-01-23 Pochodne gemcytabiny
ZA98576A ZA98576B (en) 1997-01-24 1998-01-23 Gemcitabine derivatives
PCT/NO1998/000020 WO1998032762A1 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives
AU57827/98A AU720451B2 (en) 1997-01-24 1998-01-23 Gemcitabine derivatives
CZ19992479A CZ293245B6 (cs) 1997-01-24 1998-01-23 Deriváty gemcitabinu
TW087103708A TW458981B (en) 1997-01-24 1998-03-13 Gemcitabine derivatives
NO19993562A NO318934B1 (no) 1997-01-24 1999-07-21 Gemcitabinderivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9701427A GB2321454A (en) 1997-01-24 1997-01-24 Gemcitabine esters and amides

Publications (2)

Publication Number Publication Date
GB9701427D0 GB9701427D0 (en) 1997-03-12
GB2321454A true GB2321454A (en) 1998-07-29

Family

ID=10806509

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9701427A Withdrawn GB2321454A (en) 1997-01-24 1997-01-24 Gemcitabine esters and amides

Country Status (7)

Country Link
CZ (1) CZ293245B6 (es)
ES (1) ES2196528T3 (es)
GB (1) GB2321454A (es)
IL (1) IL130971A0 (es)
RU (1) RU2194711C2 (es)
TW (1) TW458981B (es)
ZA (1) ZA98576B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110713502A (zh) * 2019-11-29 2020-01-21 南京科技职业学院 一种吉西他滨杂质的合成方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
ATE405573T1 (de) * 2004-12-17 2008-09-15 Lilly Co Eli Amid-prodrug von gemcitabin, zusammensetzungen und verwendung damit
WO2009128805A1 (en) * 2008-04-17 2009-10-22 The Johns Hopkins University On01910. na enhances chemotherapeutic agent activity in drug-resistant tumors
EP2919790B1 (en) 2012-11-13 2018-04-04 Boyen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329348A2 (en) * 1988-02-16 1989-08-23 Eli Lilly And Company 2',3'-Dideoxy-2',2'-difluoronucleosides
EP0576230A1 (en) * 1992-06-22 1993-12-29 Eli Lilly And Company 2'-deoxy-2', 2'-difluoro(4-substituted pyrimidine) nucleosides having antiviral and anti-cancer activity and intermediates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329348A2 (en) * 1988-02-16 1989-08-23 Eli Lilly And Company 2',3'-Dideoxy-2',2'-difluoronucleosides
EP0576230A1 (en) * 1992-06-22 1993-12-29 Eli Lilly And Company 2'-deoxy-2', 2'-difluoro(4-substituted pyrimidine) nucleosides having antiviral and anti-cancer activity and intermediates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110713502A (zh) * 2019-11-29 2020-01-21 南京科技职业学院 一种吉西他滨杂质的合成方法

Also Published As

Publication number Publication date
CZ247999A3 (cs) 1999-12-15
CZ293245B6 (cs) 2004-03-17
TW458981B (en) 2001-10-11
ZA98576B (en) 1998-07-23
ES2196528T3 (es) 2003-12-16
GB9701427D0 (en) 1997-03-12
RU2194711C2 (ru) 2002-12-20
IL130971A0 (en) 2001-01-28

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)