ZA891076B - 2',3'-dideoxy-2',2'-difluoronucleosides - Google Patents

2',3'-dideoxy-2',2'-difluoronucleosides

Info

Publication number
ZA891076B
ZA891076B ZA891076A ZA891076A ZA891076B ZA 891076 B ZA891076 B ZA 891076B ZA 891076 A ZA891076 A ZA 891076A ZA 891076 A ZA891076 A ZA 891076A ZA 891076 B ZA891076 B ZA 891076B
Authority
ZA
South Africa
Prior art keywords
difluoronucleosides
dideoxy
Prior art date
Application number
ZA891076A
Inventor
Larry Wayne Hertel
Wayne Hertel Larry
Cora Sue Grossman
Sue Grossman Cora
Julian Stanley Kroin
Stanley Kroin Julian
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA891076B publication Critical patent/ZA891076B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
ZA891076A 1988-02-16 1989-02-10 2',3'-dideoxy-2',2'-difluoronucleosides ZA891076B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15611688A 1988-02-16 1988-02-16

Publications (1)

Publication Number Publication Date
ZA891076B true ZA891076B (en) 1990-10-31

Family

ID=22558157

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA891076A ZA891076B (en) 1988-02-16 1989-02-10 2',3'-dideoxy-2',2'-difluoronucleosides

Country Status (16)

Country Link
EP (1) EP0329348B1 (en)
JP (1) JP3142128B2 (en)
KR (1) KR890013049A (en)
CN (1) CN1035117A (en)
AU (1) AU607840B2 (en)
CA (1) CA1312599C (en)
DE (1) DE68923387T2 (en)
DK (1) DK66389A (en)
ES (1) ES2075040T3 (en)
HU (1) HU203363B (en)
IL (1) IL89258A0 (en)
MX (1) MX14910A (en)
NZ (1) NZ227960A (en)
PH (1) PH25381A (en)
PT (1) PT89705B (en)
ZA (1) ZA891076B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
FI95384C (en) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Process for the preparation of 3'-deoxy-3'-substituted methyl nucleosides and intermediates used in the process
FI95269C (en) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co Antiviral, highly water-soluble, stable, crystalline salts of 2 ', 3'-dideoxyinosine monohydrate, 2', 3'-dideoxy-2 ', 3'-didehydrotymidine monohydrate and 2', 3'-dideoxy-2'-fluorinosine hemihydrate
AU629988B2 (en) * 1989-10-11 1992-10-15 Merrell Dow Pharmaceuticals Inc. Inosine/guanosine derivatives as antineoplastic agents
AU636678B2 (en) * 1989-11-06 1993-05-06 Nycomed Imaging As Nucleoside derivatives
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
HUT63170A (en) * 1990-01-11 1993-07-28 Isis Pharmaceuticals Inc Process and composition for detecting and modifying rna activity and gene expression
AU7558491A (en) * 1990-04-04 1991-10-30 Nycomed Imaging As Nucleoside derivatives
ZA914894B (en) * 1990-07-02 1992-04-29 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US6262241B1 (en) 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
AU4134793A (en) * 1992-06-22 1993-12-23 Eli Lilly And Company 2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
YU43193A (en) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-DEOXY-2 ', 2'-DIFLUORO (4-SUBSTITUTED) PYRIMIDINE NUCLEOSIDS OF ANTIVIRUS AND ANTICANCEROGENIC ACTIVITY AND INTERMEDIATES
US6013790A (en) * 1996-09-25 2000-01-11 Board Of Regents University Of Nebraska-Lincoln Heavily fluorinated sugar analogs
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
WO2003059339A1 (en) 2002-01-15 2003-07-24 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
EP2094651A1 (en) 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2009061894A1 (en) * 2007-11-06 2009-05-14 Pharmaessentia Corporation Novel synthesis of beta-nucleosides
TW200942231A (en) 2008-01-11 2009-10-16 Reata Pharmaceuticals Inc Synthetic triterpenoids and methods of use in the treatment of disease
CN103588678A (en) 2008-04-18 2014-02-19 里亚塔医药公司 Compound including an anti-inflammatory pharmacore and method of use
PT2276493T (en) 2008-04-18 2019-01-10 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
KR101713140B1 (en) 2008-04-18 2017-03-08 리타 파마슈티컬스 잉크. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
CN102066398B (en) 2008-04-18 2014-09-10 里亚塔医药公司 Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
SI2833905T1 (en) 2012-04-04 2018-08-31 Halozyme, Inc. Combination therapy with hyaluronidase and a tumor-targeted taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ATE92499T1 (en) * 1984-12-04 1993-08-15 Lilly Co Eli TUMOR TREATMENT IN MAMMALS.
RU1787160C (en) * 1986-12-24 1993-01-07 Эли Лилли Энд Компани Method of immunoglobulin conjugated preparation

Also Published As

Publication number Publication date
EP0329348A2 (en) 1989-08-23
PT89705B (en) 1994-04-29
HU203363B (en) 1991-07-29
NZ227960A (en) 1990-11-27
HUT49366A (en) 1989-09-28
DE68923387T2 (en) 1996-01-25
EP0329348B1 (en) 1995-07-12
CA1312599C (en) 1993-01-12
DE68923387D1 (en) 1995-08-17
IL89258A0 (en) 1989-09-10
ES2075040T3 (en) 1995-10-01
JPH01249797A (en) 1989-10-05
KR890013049A (en) 1989-09-21
DK66389A (en) 1989-08-17
PH25381A (en) 1991-06-03
EP0329348A3 (en) 1990-09-12
JP3142128B2 (en) 2001-03-07
DK66389D0 (en) 1989-02-13
MX14910A (en) 1993-11-01
CN1035117A (en) 1989-08-30
PT89705A (en) 1989-10-04
AU2992689A (en) 1989-08-17
AU607840B2 (en) 1991-03-14

Similar Documents

Publication Publication Date Title
IL89258A0 (en) 2',3'-dideoxy-2',2'-difluoro-nucleosides
EG18875A (en) Alpha-aryl-alpha-phenylethyl-1h-1,2,4-triazole-1-propanenitriles
AR244666A1 (en) 1,4-disubstituted-piperidinyl compounds
PH25045A (en) 1,2,3,6-tetrahydro-5-nitro-pyrimidine derivatives
ZA8784B (en) 1,6-anhydro-beta-hexopyranose derivatives
ZA874093B (en) Certain 2-phenylacetyl-1,3,5-cyclohexanetriones
ZA895454B (en) 2,2-dihalogenocy-clopropyl-hydroxy-ethyltriazoles
CS932686A1 (en) Zpusob pripravy 2,6 diaminomesitylen 4 sulfonove kyseliny
IE890468L (en) 2', 3' - dideoxy-2',2'-difluoronucleosides
ZA891059B (en) 1-aminomethyl-3-(2,4-difluoro-3-chlorophenyl)-4-cyano-pyrroles
IE880816L (en) 2',3'-dideoxynucleosides
CS650086A1 (en) Zpusob pripravy 2,6 dichlordifenylaminu
CS393386A1 (en) Sposob pripravy 2,2 dibenztiazolyldisulfidu
IE881104L (en) 2,3-bicyclopyrazolidinones
CS267188A1 (en) 1,2,2,6,6-pentamethyl-4-allyloxypiperidine
IE883873L (en) 1-aralkyl-1,2,-dihydropyrimidine-2-thiones
IE882166L (en) 11ß-PHENYL-4,9,15-ESTRATRIENES
IE881897L (en) 2, 2-dimethylchroman-3-ols
ZA899367B (en) 4,5,6,7-tetrahydrobenzimidazole derivatives
IE890176L (en) 1,4-disubstituted-piperidinyl compounds
ZA89387B (en) 1,4-disubstituted-piperidinyl compounds
ZA893348B (en) Prodrugs of 2',3'-dideoxy-2',3'-didehydronucleosides
IE883874L (en) 4-aralkyl-5-substituted-1,2,4-triazoles
GB8807523D0 (en) 1,2,4-trioxanes related to arteannuin
IE881100L (en) 1,3-Dioxanes