EP1049474A4 - Cannabimimetic lipid amides as useful medications - Google Patents

Cannabimimetic lipid amides as useful medications

Info

Publication number
EP1049474A4
EP1049474A4 EP99961838A EP99961838A EP1049474A4 EP 1049474 A4 EP1049474 A4 EP 1049474A4 EP 99961838 A EP99961838 A EP 99961838A EP 99961838 A EP99961838 A EP 99961838A EP 1049474 A4 EP1049474 A4 EP 1049474A4
Authority
EP
European Patent Office
Prior art keywords
useful medications
cannabimimetic
lipid amides
cannabimimetic lipid
amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99961838A
Other languages
German (de)
French (fr)
Other versions
EP1049474A1 (en
Inventor
Alexandros Stearns Makriyannis
Atmaram Khanolkar
Andreas Goutopoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Original Assignee
University of Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Publication of EP1049474A1 publication Critical patent/EP1049474A1/en
Publication of EP1049474A4 publication Critical patent/EP1049474A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP99961838A 1998-11-24 1999-11-24 Cannabimimetic lipid amides as useful medications Withdrawn EP1049474A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10961598P 1998-11-24 1998-11-24
US109615P 1998-11-24
PCT/US1999/028136 WO2000032200A1 (en) 1998-11-24 1999-11-24 Cannabimimetic lipid amides as useful medications

Publications (2)

Publication Number Publication Date
EP1049474A1 EP1049474A1 (en) 2000-11-08
EP1049474A4 true EP1049474A4 (en) 2004-12-29

Family

ID=22328628

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99961838A Withdrawn EP1049474A4 (en) 1998-11-24 1999-11-24 Cannabimimetic lipid amides as useful medications

Country Status (3)

Country Link
EP (1) EP1049474A4 (en)
AU (1) AU1833600A (en)
WO (1) WO2000032200A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69910373T2 (en) 1998-05-04 2004-04-01 The University Of Connecticut, Farmington ANALGETIC AND IMMUNOMODULATING CANNABINOIDS
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
DE60033834T2 (en) 1999-10-18 2007-11-15 The University Of Connecticut, Farmington FOR PERIPHERAL CANNABINOID RECEPTORS SELECTIVE LIGANDS
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
ES2174716B1 (en) * 2000-07-28 2004-08-01 Universidad Complutense De Madrid NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE.
AU2001284061A1 (en) * 2000-07-28 2002-02-18 Universidad Complutense De Madrid Novel araquidonic acid derivatives with affinity toward the anandamide transporter
ES2181601B2 (en) * 2001-07-27 2004-04-01 Univ Madrid Complutense ARAQUIDONIC ACID DERIVATIVES AFFINED BY THE ANANDAMIDE CARRIER
US8449908B2 (en) 2000-12-22 2013-05-28 Alltranz, Llc Transdermal delivery of cannabidiol
DE60237431D1 (en) 2001-01-29 2010-10-07 Univ Connecticut RECEPTOR-SELECTIVE CANNABIMIMETIC AMINO ALKYLINDOLE
JP4312594B2 (en) 2001-07-13 2009-08-12 ユニバーシティ オブ コネチカット Novel bicyclic and tricyclic cannabinoids
US7351729B2 (en) 2002-03-08 2008-04-01 Signal Pharmaceuticals, Llc JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers
CN1678303A (en) 2002-08-23 2005-10-05 康涅狄格大学 Keto cannabinoids with therapeutic indications
GB0403629D0 (en) * 2004-02-19 2004-03-24 Imp College Innovations Ltd Methods
DK2176208T3 (en) 2007-07-30 2015-04-27 Zynerba Pharmaceuticals Inc Prodrugs of cannabidiol, compositions containing prodrugs of cannabidiol and methods of use thereof
CN102725261B (en) * 2009-11-25 2014-07-30 赛托麦蒂克斯有限公司 Arachidonic acid analogs and methods for analgesic treatment using same
US20130089884A1 (en) * 2009-12-23 2013-04-11 Life Technologies Corporation Protein Modification from the Oxidation of Clickable Polyunsaturated Fatty Acid Analogs
AU2013288738A1 (en) * 2012-07-10 2015-01-29 Baseclick Gmbh Anandamide-modified nucleic acid molecules
WO2017185038A1 (en) 2016-04-22 2017-10-26 Receptor Life Sciences Fast-acting plant-based medicinal compounds and nutritional supplements
EA201892396A1 (en) 2016-12-02 2019-04-30 Ресептор Лайф Сайенсиз, Инк. QUICKLY PRODUCTIVE PLANT MEDICINES AND BIOLOGICALLY ACTIVE ADDITIVES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012466A1 (en) * 1992-11-30 1994-06-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Fatty acid derivatives and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012466A1 (en) * 1992-11-30 1994-06-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Fatty acid derivatives and pharmaceutical compositions containing them

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HANUS L. ET AL.: "Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor", JOURNAL OF MEDICINAL CHEMISTRY., vol. 36, no. 20, 1993, USAMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 3032 - 3034, XP002303407 *
LIN S. ET AL.: "Novel analogues of arachidonylethanolamide (Anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability", JOURNAL OF MEDICINAL CHEMISTRY., vol. 41, no. 27, 31 December 1998 (1998-12-31), USAMERICAN CHEMICAL SOCIETY. WASHINGTON., pages 5353 - 5361, XP002303408 *
MECHOULAM R ET AL: "TOWARDS CANNABINOID DRUGS - REVISITED", PROGRESS IN MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 35, 3 July 1998 (1998-07-03), pages 199 - 243, XP009024019, ISSN: 0079-6468 *
See also references of WO0032200A1 *

Also Published As

Publication number Publication date
WO2000032200A1 (en) 2000-06-08
EP1049474A1 (en) 2000-11-08
AU1833600A (en) 2000-06-19

Similar Documents

Publication Publication Date Title
EP1049474A4 (en) Cannabimimetic lipid amides as useful medications
NO20001349D0 (en) product Unit
GB2346996B (en) Computer displays
HK1038972A1 (en) Internet advertising system
IL129302A (en) Display arrangements
DE69939363D1 (en) Amphipatic lipid dispersion
EP1033696A4 (en) Display
GB9906537D0 (en) Improvements relating to products displays
EP1085863A4 (en) Cross-reference to related applications
DE69826980D1 (en) Composite confectionery product
GB9908340D0 (en) Display arrangement
GB2335072B (en) Flag display structure
GB2343781B (en) External advertising arrangements
GB2321235B (en) Display packaging
IT1303670B1 (en) DIETARY SUPPLEMENT FOR ARTHROPODS
GB9820790D0 (en) Product display packaging
GB9828707D0 (en) Pharmaceutical uses
CA84006S (en) Computer stand
AU137530S (en) Advertising unit
AU137531S (en) Advertising unit
GB9826852D0 (en) Display arrangement
CA83279S (en) Display unit
CA83596S (en) Display unit
CA83280S (en) Display unit
PL108811U1 (en) Display advertisement

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000817

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE UNIVERSITY OF CONNECTICUT

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GOUTOPOULOS, ANDREAS

Inventor name: KHANOLKAR, ATMARAM

Inventor name: MAKRIYANNIS, ALEXANDROS 16 STEARNS ROAD,

A4 Supplementary search report drawn up and despatched

Effective date: 20041111

17Q First examination report despatched

Effective date: 20050803

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080918