ES2174716B1 - NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE. - Google Patents

NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE.

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Publication number
ES2174716B1
ES2174716B1 ES200001920A ES200001920A ES2174716B1 ES 2174716 B1 ES2174716 B1 ES 2174716B1 ES 200001920 A ES200001920 A ES 200001920A ES 200001920 A ES200001920 A ES 200001920A ES 2174716 B1 ES2174716 B1 ES 2174716B1
Authority
ES
Spain
Prior art keywords
affinity
arachidonic acid
anandamide
transporter
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200001920A
Other languages
Spanish (es)
Other versions
ES2174716A1 (en
Inventor
Maria Luz Lopez Rodriguez
Alma Viso Beronda
Silvia Ortega Gutierrez
Isabel Lastres Becker
Jose Antonio Ramos Atance
Javier J. Fernandez Ruiz
Sara Gonzalez Rodriguez De Castro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Complutense de Madrid
Original Assignee
Universidad Complutense de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Complutense de Madrid filed Critical Universidad Complutense de Madrid
Priority to ES200001920A priority Critical patent/ES2174716B1/en
Priority to AU2001284061A priority patent/AU2001284061A1/en
Priority to PCT/ES2001/000305 priority patent/WO2002012167A1/en
Publication of ES2174716A1 publication Critical patent/ES2174716A1/en
Application granted granted Critical
Publication of ES2174716B1 publication Critical patent/ES2174716B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Nuevos derivados de ácido araquidónico con afinidad por el transportador de anandamida. La presente invención se refiere a los compuestos representados en la fórmula I: **FIGURA** sus enantiómeros, así como sus sales aceptables farmacéuticamente, en la que: X está representado por un átomo de oxígeno o un átomo de azufre; Y es CH{sub,2}, O, S, NH, NR (R es alquilo, alquilarilo o arilo); n es 0-4; la subunidad cíclica está representada por un anillo aromático de cinco eslabones uno de los cuales es un heteroátomo (O, N ó S), o por sus derivados benzofusionados, o por un anillo alifático de 3-8 eslabones que contiene opcionalmente un heteroátomo, o por un anillo bicíclico, o por un monosacárido. Se incluyen también los métodos de preparación, la caracterización farmacológica y las aplicaciones terapéuticas.New derivatives of arachidonic acid with affinity for the anandamide transporter. The present invention relates to the compounds represented in formula I: ** FIGURE ** their enantiomers, as well as their pharmaceutically acceptable salts, in which: X is represented by an oxygen atom or a sulfur atom; Y is CH {sub, 2}, O, S, NH, NR (R is alkyl, alkylaryl or aryl); n is 0-4; The cyclic subunit is represented by a five-link aromatic ring, one of which is a heteroatom (O, N or S), or by its benzofused derivatives, or by an 3-8-link aliphatic ring that optionally contains a heteroatom, or by a bicyclic ring, or by a monosaccharide. Preparation methods, pharmacological characterization and therapeutic applications are also included.

ES200001920A 2000-07-28 2000-07-28 NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE. Expired - Fee Related ES2174716B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200001920A ES2174716B1 (en) 2000-07-28 2000-07-28 NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE.
AU2001284061A AU2001284061A1 (en) 2000-07-28 2001-07-27 Novel araquidonic acid derivatives with affinity toward the anandamide transporter
PCT/ES2001/000305 WO2002012167A1 (en) 2000-07-28 2001-07-27 Novel araquidonic acid derivatives with affinity toward the anandamide transporter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200001920A ES2174716B1 (en) 2000-07-28 2000-07-28 NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE.

Publications (2)

Publication Number Publication Date
ES2174716A1 ES2174716A1 (en) 2002-11-01
ES2174716B1 true ES2174716B1 (en) 2004-08-01

Family

ID=8494498

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200001920A Expired - Fee Related ES2174716B1 (en) 2000-07-28 2000-07-28 NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE.

Country Status (1)

Country Link
ES (1) ES2174716B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688825A (en) * 1996-05-31 1997-11-18 University Of Connecticut Anandamide amidase inhibitors as analgesic agents
WO1999064389A1 (en) * 1998-06-09 1999-12-16 Alexandros Makriyannis Inhibitors of the anandamide transporter as analgesic agents
IT1302264B1 (en) * 1998-09-24 2000-09-05 Innovet Italia Srl DERIVATIVES WITH N-ACYL VANILLYAMIDE STRUCTURE ABLE TO ACTIVATE PERIPHERAL IRECEPTORS OF CANNABINOIDS
AU1833600A (en) * 1998-11-24 2000-06-19 Andreas Goutopoulos Cannabimimetic lipid amides as useful medications

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BASE DE DATOS CAPLUS en STN, AN 1999:314488 & Proc. Nat. Acad. Sci. USA, 1999, Vol. 96, páginas 5802-5807. D. PIOMELLI et al. "Structural determinants for recognition and translocation by the anandamide transporter". Resumen. *
WO0032200 A (A. MAKRIYANNIS et al.) 08.06.2000, reivindicaciones; tabla 1. *

Also Published As

Publication number Publication date
ES2174716A1 (en) 2002-11-01

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