ES2174716B1 - NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE. - Google Patents
NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE.Info
- Publication number
- ES2174716B1 ES2174716B1 ES200001920A ES200001920A ES2174716B1 ES 2174716 B1 ES2174716 B1 ES 2174716B1 ES 200001920 A ES200001920 A ES 200001920A ES 200001920 A ES200001920 A ES 200001920A ES 2174716 B1 ES2174716 B1 ES 2174716B1
- Authority
- ES
- Spain
- Prior art keywords
- affinity
- arachidonic acid
- anandamide
- transporter
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
Nuevos derivados de ácido araquidónico con afinidad por el transportador de anandamida. La presente invención se refiere a los compuestos representados en la fórmula I: **FIGURA** sus enantiómeros, así como sus sales aceptables farmacéuticamente, en la que: X está representado por un átomo de oxígeno o un átomo de azufre; Y es CH{sub,2}, O, S, NH, NR (R es alquilo, alquilarilo o arilo); n es 0-4; la subunidad cíclica está representada por un anillo aromático de cinco eslabones uno de los cuales es un heteroátomo (O, N ó S), o por sus derivados benzofusionados, o por un anillo alifático de 3-8 eslabones que contiene opcionalmente un heteroátomo, o por un anillo bicíclico, o por un monosacárido. Se incluyen también los métodos de preparación, la caracterización farmacológica y las aplicaciones terapéuticas.New derivatives of arachidonic acid with affinity for the anandamide transporter. The present invention relates to the compounds represented in formula I: ** FIGURE ** their enantiomers, as well as their pharmaceutically acceptable salts, in which: X is represented by an oxygen atom or a sulfur atom; Y is CH {sub, 2}, O, S, NH, NR (R is alkyl, alkylaryl or aryl); n is 0-4; The cyclic subunit is represented by a five-link aromatic ring, one of which is a heteroatom (O, N or S), or by its benzofused derivatives, or by an 3-8-link aliphatic ring that optionally contains a heteroatom, or by a bicyclic ring, or by a monosaccharide. Preparation methods, pharmacological characterization and therapeutic applications are also included.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001920A ES2174716B1 (en) | 2000-07-28 | 2000-07-28 | NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE. |
AU2001284061A AU2001284061A1 (en) | 2000-07-28 | 2001-07-27 | Novel araquidonic acid derivatives with affinity toward the anandamide transporter |
PCT/ES2001/000305 WO2002012167A1 (en) | 2000-07-28 | 2001-07-27 | Novel araquidonic acid derivatives with affinity toward the anandamide transporter |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001920A ES2174716B1 (en) | 2000-07-28 | 2000-07-28 | NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2174716A1 ES2174716A1 (en) | 2002-11-01 |
ES2174716B1 true ES2174716B1 (en) | 2004-08-01 |
Family
ID=8494498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200001920A Expired - Fee Related ES2174716B1 (en) | 2000-07-28 | 2000-07-28 | NEW DERIVATIVES OF ARACHIDONIC ACID WITH AFFINITY BY THE TRANSPORTER OF ANANDAMIDE. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2174716B1 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5688825A (en) * | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
WO1999064389A1 (en) * | 1998-06-09 | 1999-12-16 | Alexandros Makriyannis | Inhibitors of the anandamide transporter as analgesic agents |
IT1302264B1 (en) * | 1998-09-24 | 2000-09-05 | Innovet Italia Srl | DERIVATIVES WITH N-ACYL VANILLYAMIDE STRUCTURE ABLE TO ACTIVATE PERIPHERAL IRECEPTORS OF CANNABINOIDS |
AU1833600A (en) * | 1998-11-24 | 2000-06-19 | Andreas Goutopoulos | Cannabimimetic lipid amides as useful medications |
-
2000
- 2000-07-28 ES ES200001920A patent/ES2174716B1/en not_active Expired - Fee Related
Non-Patent Citations (2)
Title |
---|
BASE DE DATOS CAPLUS en STN, AN 1999:314488 & Proc. Nat. Acad. Sci. USA, 1999, Vol. 96, páginas 5802-5807. D. PIOMELLI et al. "Structural determinants for recognition and translocation by the anandamide transporter". Resumen. * |
WO0032200 A (A. MAKRIYANNIS et al.) 08.06.2000, reivindicaciones; tabla 1. * |
Also Published As
Publication number | Publication date |
---|---|
ES2174716A1 (en) | 2002-11-01 |
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Legal Events
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