EP1085863A4 - Cross-reference to related applications - Google Patents
Cross-reference to related applicationsInfo
- Publication number
- EP1085863A4 EP1085863A4 EP99928427A EP99928427A EP1085863A4 EP 1085863 A4 EP1085863 A4 EP 1085863A4 EP 99928427 A EP99928427 A EP 99928427A EP 99928427 A EP99928427 A EP 99928427A EP 1085863 A4 EP1085863 A4 EP 1085863A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cross
- related applications
- applications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8846598P | 1998-06-08 | 1998-06-08 | |
US88465P | 1998-06-08 | ||
US9306898P | 1998-07-16 | 1998-07-16 | |
US93068P | 1998-07-16 | ||
US10386698P | 1998-10-12 | 1998-10-12 | |
US103866P | 1998-10-12 | ||
PCT/US1999/012672 WO1999063992A1 (en) | 1998-06-08 | 1999-06-07 | Novel calcium channel drugs and uses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1085863A1 EP1085863A1 (en) | 2001-03-28 |
EP1085863A4 true EP1085863A4 (en) | 2001-03-28 |
Family
ID=27375969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99928427A Withdrawn EP1085863A4 (en) | 1998-06-08 | 1999-06-07 | Cross-reference to related applications |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1085863A4 (en) |
JP (1) | JP2002517440A (en) |
AR (1) | AR020876A1 (en) |
AU (1) | AU4549399A (en) |
CA (1) | CA2318901A1 (en) |
SG (1) | SG80038A1 (en) |
WO (1) | WO1999063992A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7101909B2 (en) | 1998-10-12 | 2006-09-05 | Theravance, Inc. | Calcium channel drugs and uses |
WO2004110354A2 (en) | 2003-05-15 | 2004-12-23 | Roskamp Research, Llc | Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis |
ES2449594T3 (en) | 2007-10-05 | 2014-03-20 | Alzheimer's Institute Of America, Inc. | Method to reduce amyloid deposition, amyloid neurotoxicity and microgliosis with enantiomer (-) - nilvadipine |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052300A1 (en) * | 1980-11-13 | 1982-05-26 | Bayer Ag | C-3-linked 1,4-dihydropyridines, their use in pharmaceutical preparations and processes for their preparation |
US4532248A (en) * | 1981-07-30 | 1985-07-30 | Bayer Aktiengesellschaft | Method of combatting coronary and vascular diseases |
WO1996033972A1 (en) * | 1995-04-28 | 1996-10-31 | Glaxo Group Limited | Methods for synthesizing diverse collections of pyridines, pyrimidines, 1,4-dihydro derivatives thereof, and piperidine derivatives |
US5723618A (en) * | 1995-11-01 | 1998-03-03 | Apotex, Inc. | 1,4-dihydropyridines, N-substituted bicyclic 4-hydropyridines, and bicyclic N-substituted 4,5-dihydropyridines |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
WO1992005802A1 (en) * | 1990-09-28 | 1992-04-16 | Neorx Corporation | Polymeric carriers for release of covalently linked agents |
KR100517210B1 (en) * | 1994-12-12 | 2006-06-07 | 오메로스 코포레이션 | Infusion solution for pain, inflammation and spasm |
US5965532A (en) * | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
US6403305B1 (en) * | 1997-02-06 | 2002-06-11 | Cornell Research Foundation, Inc. | Methods of identifying peptide agonists or negative antagonists of a G protein coupled receptor |
-
1999
- 1999-06-07 AU AU45493/99A patent/AU4549399A/en not_active Abandoned
- 1999-06-07 WO PCT/US1999/012672 patent/WO1999063992A1/en not_active Application Discontinuation
- 1999-06-07 JP JP2000553061A patent/JP2002517440A/en not_active Withdrawn
- 1999-06-07 CA CA002318901A patent/CA2318901A1/en not_active Abandoned
- 1999-06-07 EP EP99928427A patent/EP1085863A4/en not_active Withdrawn
- 1999-06-08 AR ARP990102696A patent/AR020876A1/en unknown
- 1999-06-08 SG SG9902716A patent/SG80038A1/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052300A1 (en) * | 1980-11-13 | 1982-05-26 | Bayer Ag | C-3-linked 1,4-dihydropyridines, their use in pharmaceutical preparations and processes for their preparation |
US4532248A (en) * | 1981-07-30 | 1985-07-30 | Bayer Aktiengesellschaft | Method of combatting coronary and vascular diseases |
WO1996033972A1 (en) * | 1995-04-28 | 1996-10-31 | Glaxo Group Limited | Methods for synthesizing diverse collections of pyridines, pyrimidines, 1,4-dihydro derivatives thereof, and piperidine derivatives |
US5723618A (en) * | 1995-11-01 | 1998-03-03 | Apotex, Inc. | 1,4-dihydropyridines, N-substituted bicyclic 4-hydropyridines, and bicyclic N-substituted 4,5-dihydropyridines |
Non-Patent Citations (2)
Title |
---|
JOSLYN, ALAN F. ET AL: "Dimeric 1,4-dihydropyridines as calcium channel antagonists", J. MED. CHEM. (1988), 31(8), 1489-92, XP002143667 * |
See also references of WO9963992A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999063992A9 (en) | 2002-08-22 |
EP1085863A1 (en) | 2001-03-28 |
CA2318901A1 (en) | 1999-12-16 |
SG80038A1 (en) | 2001-04-17 |
WO1999063992A8 (en) | 2001-02-22 |
WO1999063992A1 (en) | 1999-12-16 |
AR020876A1 (en) | 2002-06-05 |
JP2002517440A (en) | 2002-06-18 |
AU4549399A (en) | 1999-12-30 |
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EP1085863A4 (en) | Cross-reference to related applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000616 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20001128 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THERAVANCE, INC. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Withdrawal date: 20020905 |