ES2058073T3 - Derivados de 5-fluorouracilo. - Google Patents

Derivados de 5-fluorouracilo.

Info

Publication number
ES2058073T3
ES2058073T3 ES87106264T ES87106264T ES2058073T3 ES 2058073 T3 ES2058073 T3 ES 2058073T3 ES 87106264 T ES87106264 T ES 87106264T ES 87106264 T ES87106264 T ES 87106264T ES 2058073 T3 ES2058073 T3 ES 2058073T3
Authority
ES
Spain
Prior art keywords
same
fluorouracilo
derivatives
hydrogen atom
against cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87106264T
Other languages
English (en)
Inventor
Setsuro Aig De Blanche Fujii
Mitsuru Hirohashi
Yoshihito Yamamoto
Yutaka Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2058073T3 publication Critical patent/ES2058073T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN DERIVADO DE 5-FLUOROURACILO REPRESENTADO POR LA FORMULA (I) EN LA QUE R1,R2,RX,RY,A,B Y N SON COMO SE HAN DEFINIDO EN LA MEMORIA Y EN LAS REIVINDICACIONES, CON LA CONDICION DE QUE CUANDO R1 ES UN ATOMO DE HIDROGENO O UN GRUPO ACILO, R2 NO SEA UN ATOMO DE HIDROGENO NI UN GRUPO ACILO; A UN PROCEDIMIENTO PARA PREPARAR EL MISMO; A UNA COMPOSICION CONTRA EL CANCER QUE COMPRENDE UNA CANTIDAD EFICAZ DEL MISMO; Y AL USO DEL MISMO PARA LA PREPARACION DE UNA COMPOSICION CONTRA EL CANCER.
ES87106264T 1986-04-30 1987-04-29 Derivados de 5-fluorouracilo. Expired - Lifetime ES2058073T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10128586 1986-04-30
JP4575487 1987-02-27

Publications (1)

Publication Number Publication Date
ES2058073T3 true ES2058073T3 (es) 1994-11-01

Family

ID=26385819

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87106264T Expired - Lifetime ES2058073T3 (es) 1986-04-30 1987-04-29 Derivados de 5-fluorouracilo.

Country Status (9)

Country Link
US (1) US5047521A (es)
EP (1) EP0247381B1 (es)
JP (1) JPH07103112B1 (es)
KR (1) KR950002161B1 (es)
DE (1) DE3786834T2 (es)
DK (1) DK166088C (es)
ES (1) ES2058073T3 (es)
GB (1) GB2200352B (es)
WO (1) WO1987006582A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
JP2006523184A (ja) * 2003-02-22 2006-10-12 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 液晶としてのシアノピリドン誘導体
EP1631301A4 (en) * 2003-05-20 2006-06-07 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH 5-FLUOROURACIL OR A DERIVATIVE AND A LIPOSOMAL PLATIN COMPLEX
JP2007077109A (ja) * 2005-09-16 2007-03-29 Tokyo Institute Of Technology ヌクレオシド誘導体及びその製造方法
US7561776B2 (en) * 2005-11-29 2009-07-14 Petrospec Engineering Ltd. Method of preventing hydrogen darkening of optic fibre
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
HUE033401T2 (en) * 2009-10-27 2017-11-28 Delta-Fly Pharma Inc New 5-fluorouracil derivative
EP3746134A1 (en) 2018-02-02 2020-12-09 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124765A (en) * 1975-05-13 1978-11-07 Ono Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
JPS6011704B2 (ja) * 1976-07-30 1985-03-27 大鵬薬品工業株式会社 ５−フルオルウラシル誘導体の製造法
DE2658672A1 (de) * 1976-12-23 1978-06-29 Robugen Gmbh Neue nucleosid-verbindungen und verfahren zu ihrer herstellung
JPS5379879A (en) * 1976-12-23 1978-07-14 Mitsui Toatsu Chem Inc 1,3-substituted-5-fluorouracils and process for their preparation
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
DE3105111A1 (de) * 1980-02-15 1981-12-24 Funai Yakuhin Kogyo K.K., Osaka "2 -desoxy-3',5-di-o-alkylcarbonyl-5-fluoruridin-derivate, verfahren zu ihrer herstellung, ihre verwendung zur behandlung von tumoren und antitumormittel"
JPS5929699A (ja) * 1982-08-11 1984-02-16 Funai Corp ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤
JPS58185522A (ja) * 1983-02-28 1983-10-29 Toyama Chem Co Ltd 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体
JPS6061593A (ja) * 1983-09-14 1985-04-09 Taiho Yakuhin Kogyo Kk ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤
AU548712B2 (en) * 1983-05-23 1986-01-02 Taiho Pharmaceutical Co., Ltd. 2:-deoxy-5-substituted uridine derivatives
WO1985000608A1 (en) * 1983-07-20 1985-02-14 Teijin Limited Antineoplastic agent
US4515618A (en) * 1983-12-07 1985-05-07 Chevron Research Company 5-Deoxy-3-O-thienylmethyl or furylmethyl-1,2-O-alkylidene-alpha-D-xylofuranose herbicide derivatives
EP0180188B1 (en) * 1984-10-30 1992-04-15 Otsuka Pharmaceutical Co., Ltd. A composition for increasing the anti-cancer activity of an anti-cancer compound
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
JPH02187484A (ja) * 1989-01-13 1990-07-23 Okitsumo Kk 紙用瞬間接着剤

Also Published As

Publication number Publication date
KR880701232A (ko) 1988-07-26
DK691287D0 (da) 1987-12-29
DE3786834T2 (de) 1994-03-03
DK166088C (da) 1993-08-23
EP0247381A3 (en) 1988-11-23
WO1987006582A1 (en) 1987-11-05
DK691287A (da) 1988-02-19
US5047521A (en) 1991-09-10
EP0247381B1 (en) 1993-08-04
DE3786834D1 (de) 1993-09-09
GB2200352A (en) 1988-08-03
GB8730031D0 (en) 1988-02-03
EP0247381A2 (en) 1987-12-02
KR950002161B1 (ko) 1995-03-14
GB2200352B (en) 1990-07-25
JPH07103112B1 (es) 1995-11-08
DK166088B (da) 1993-03-08

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