ATE405573T1 - Amid-prodrug von gemcitabin, zusammensetzungen und verwendung damit - Google Patents

Amid-prodrug von gemcitabin, zusammensetzungen und verwendung damit

Info

Publication number
ATE405573T1
ATE405573T1 AT05852411T AT05852411T ATE405573T1 AT E405573 T1 ATE405573 T1 AT E405573T1 AT 05852411 T AT05852411 T AT 05852411T AT 05852411 T AT05852411 T AT 05852411T AT E405573 T1 ATE405573 T1 AT E405573T1
Authority
AT
Austria
Prior art keywords
gemcitabine
compositions
amide prodrug
prodrug
amide
Prior art date
Application number
AT05852411T
Other languages
English (en)
Inventor
David Bender
David Remick
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE405573T1 publication Critical patent/ATE405573T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT05852411T 2004-12-17 2005-11-30 Amid-prodrug von gemcitabin, zusammensetzungen und verwendung damit ATE405573T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63742204P 2004-12-17 2004-12-17

Publications (1)

Publication Number Publication Date
ATE405573T1 true ATE405573T1 (de) 2008-09-15

Family

ID=36168678

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05852411T ATE405573T1 (de) 2004-12-17 2005-11-30 Amid-prodrug von gemcitabin, zusammensetzungen und verwendung damit

Country Status (32)

Country Link
US (1) US7691827B2 (de)
EP (1) EP1831237B1 (de)
JP (1) JP5022911B2 (de)
KR (1) KR100874052B1 (de)
CN (1) CN101080417B (de)
AR (1) AR055009A1 (de)
AT (1) ATE405573T1 (de)
AU (1) AU2005316922B2 (de)
BR (1) BRPI0519117A2 (de)
CA (1) CA2589850C (de)
CY (1) CY1108447T1 (de)
DE (1) DE602005009255D1 (de)
DK (1) DK1831237T3 (de)
EA (1) EA011868B1 (de)
ES (1) ES2310860T3 (de)
HK (1) HK1109903A1 (de)
HR (1) HRP20080529T3 (de)
IL (1) IL183666A (de)
MA (1) MA29154B1 (de)
MX (1) MX2007007228A (de)
MY (1) MY143677A (de)
NO (1) NO20073368L (de)
NZ (1) NZ554732A (de)
PE (1) PE20060771A1 (de)
PL (1) PL1831237T3 (de)
PT (1) PT1831237E (de)
RS (1) RS50629B (de)
SI (1) SI1831237T1 (de)
TW (1) TWI326687B (de)
UA (1) UA86119C2 (de)
WO (1) WO2006065525A1 (de)
ZA (1) ZA200705019B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101448504B (zh) * 2006-06-21 2012-04-11 伊莱利利公司 吉西他滨酰胺前体药物的结晶形式、其组合物以及用途
TWI436775B (zh) 2007-08-24 2014-05-11 Oncotherapy Science Inc 以抗原胜肽合併化療藥劑治療胰臟癌
CN101525361B (zh) * 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN104955458A (zh) 2012-11-07 2015-09-30 Z·索 取代的吉西他滨芳基酰胺类似物和使用所述类似物的治疗方法
JP6420247B2 (ja) 2012-11-13 2018-11-07 ボーイエン セラピューティクス，インコーポレイティド ゲムシタビンプロドラッグ及びその使用
US10059733B2 (en) 2014-03-03 2018-08-28 Nucorion Pharmaceuticals, Inc. Gemcitabine analogs
WO2016078160A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
CA3091027A1 (en) 2018-02-02 2019-08-08 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
AU2019258590B2 (en) * 2018-04-26 2022-09-08 NanoMed Holdings Pty Ltd Gemcitabine amphiphile prodrugs
CN108864250A (zh) * 2018-05-29 2018-11-23 北京大学 一种FAPα酶敏感的吉西他滨前体药物及其制备方法和应用
CA3108362A1 (en) * 2018-08-03 2020-02-06 Cellix Bio Private Limited Compositions and methods for the treatment of cancer
EP4143199A1 (de) 2020-04-21 2023-03-08 Ligand Pharmaceuticals, Inc. Nukleotid-prodrug-verbindungen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
AU720451B2 (en) * 1997-01-24 2000-06-01 Conpharma As Gemcitabine derivatives
GB2321454A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Gemcitabine esters and amides
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6376470B1 (en) * 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
EP1567169A4 (de) * 2002-11-04 2009-10-21 Xenoport Inc Gemcitabin-prodrugs, phramazeutische zusammensetzungen und verwendungen davon
US7846436B2 (en) * 2003-11-28 2010-12-07 Chemgenes Corporation Oligonucleotides and related compounds

Also Published As

Publication number Publication date
JP5022911B2 (ja) 2012-09-12
EA011868B1 (ru) 2009-06-30
DE602005009255D1 (de) 2008-10-02
MY143677A (en) 2011-06-30
TW200634023A (en) 2006-10-01
US20090156547A1 (en) 2009-06-18
SI1831237T1 (sl) 2009-02-28
PE20060771A1 (es) 2006-09-23
KR100874052B1 (ko) 2008-12-12
EP1831237B1 (de) 2008-08-20
KR20070086308A (ko) 2007-08-27
EP1831237A1 (de) 2007-09-12
BRPI0519117A2 (pt) 2008-12-23
CY1108447T1 (el) 2014-04-09
RS50629B (sr) 2010-06-30
MX2007007228A (es) 2007-08-14
AU2005316922A1 (en) 2006-06-22
US7691827B2 (en) 2010-04-06
CA2589850A1 (en) 2006-06-22
ZA200705019B (en) 2008-10-29
IL183666A (en) 2011-09-27
JP2008524218A (ja) 2008-07-10
EA200701300A1 (ru) 2007-10-26
AR055009A1 (es) 2007-08-01
AU2005316922B2 (en) 2011-08-25
NZ554732A (en) 2010-09-30
UA86119C2 (ru) 2009-03-25
NO20073368L (no) 2007-07-16
CA2589850C (en) 2012-05-01
MA29154B1 (fr) 2008-01-02
IL183666A0 (en) 2007-09-20
PL1831237T3 (pl) 2009-01-30
HK1109903A1 (en) 2008-06-27
CN101080417B (zh) 2011-01-19
PT1831237E (pt) 2008-09-22
CN101080417A (zh) 2007-11-28
ES2310860T3 (es) 2009-01-16
DK1831237T3 (da) 2008-10-27
WO2006065525A1 (en) 2006-06-22
TWI326687B (en) 2010-07-01
HRP20080529T3 (en) 2008-12-31

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