MX2010001938A - Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina. - Google Patents

Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina.

Info

Publication number
MX2010001938A
MX2010001938A MX2010001938A MX2010001938A MX2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A MX 2010001938 A MX2010001938 A MX 2010001938A
Authority
MX
Mexico
Prior art keywords
preparing
methods
yrimidine
phenylethoxy
trifluoro
Prior art date
Application number
MX2010001938A
Other languages
English (en)
Inventor
Wenxue Wu
Ramanaiah C Kanamarlapudi
Jie Yan
Haiming Zhang
Shinya Iimura
Qiuling Song
Mark Stephen Bednarz
Hugh Alfred Burgoon Jr
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of MX2010001938A publication Critical patent/MX2010001938A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

Se describen métodos útiles para preparar compuestos de la fórmula l: (ver fórmula I) y sus sales. También se describen intermediarios útiles en la preparación de estos compuestos.
MX2010001938A 2007-08-24 2008-08-22 Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina. MX2010001938A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95774407P 2007-08-24 2007-08-24
PCT/US2008/073950 WO2009029499A1 (en) 2007-08-24 2008-08-22 Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds

Publications (1)

Publication Number Publication Date
MX2010001938A true MX2010001938A (es) 2010-03-11

Family

ID=40040082

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001938A MX2010001938A (es) 2007-08-24 2008-08-22 Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina.

Country Status (16)

Country Link
US (3) US20090062540A1 (es)
EP (3) EP2529740A1 (es)
JP (1) JP5553752B2 (es)
KR (1) KR101582697B1 (es)
CN (1) CN101801384B (es)
AU (1) AU2008293679B2 (es)
BR (1) BRPI0815754B1 (es)
CA (1) CA2697368C (es)
ES (2) ES2848152T3 (es)
HK (1) HK1143749A1 (es)
IL (2) IL203669A (es)
MX (1) MX2010001938A (es)
NZ (1) NZ583017A (es)
RU (1) RU2493156C2 (es)
WO (1) WO2009029499A1 (es)
ZA (1) ZA201000785B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
TWI439457B (zh) 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
AU2009231892A1 (en) * 2008-03-31 2009-10-08 The Trustees Of Columbia University In The City Of New York Methods of diagnosing, preventing and treating bone mass diseases
US8815883B2 (en) 2009-11-02 2014-08-26 The Trustees Of Columbia Unviersity In The City Of New York Compounds and methods for inhibiting serotonin synthesis
TW201245183A (en) 2010-11-05 2012-11-16 Lexicon Pharmaceuticals Inc Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
EP2812300B1 (en) * 2012-02-09 2017-04-12 Boehringer Ingelheim International GmbH Process for preparing carboxamidine compounds
TW201818964A (zh) 2016-09-30 2018-06-01 瑞士商諾伊曼特醫療公司 使用色胺酸羥化酶抑制劑之方法

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US4866181A (en) * 1986-08-29 1989-09-12 Aldrich-Boranes, Inc. Process for producing optically active alcohols
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
EP0504541B1 (en) * 1991-03-21 1998-07-22 Solutia Europe N.V./S.A. Improved catalytic process for selective alkylation of aromatic hydrocarbons
DE4131924A1 (de) * 1991-09-25 1993-07-08 Hoechst Ag Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
EP0929533B1 (en) * 1996-10-02 2003-09-03 Bristol-Myers Squibb Pharma Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
US6388084B1 (en) * 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
FR2804427B1 (fr) * 2000-01-27 2002-09-06 Rhodia Chimie Sa Procede de preparation de cetones alpha-halogenees
MY129000A (en) * 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
GB0213122D0 (en) 2002-06-07 2002-07-17 Glaxo Group Ltd Compounds
AR040441A1 (es) 2002-06-07 2005-04-06 Glaxo Group Ltd Compuesto de tiol, composicion farmaceutica que lo comprende, su uso para la fabricacion de un medicamento, procedimiento para prepararlo y compuesto intermediario de utilidad en dicho procedimiento
CA2507893A1 (en) * 2003-04-21 2004-11-04 Ustav Organicke Chemie A Biochemie Akademie Ved Ceske Republiky (purin-6-yl) amino acid and production method thereof
EP1638964B1 (en) * 2003-06-20 2011-07-27 Galderma Research & Development Novel compounds that modulate ppar-gamma type receptors, and use thereof in cosmetic or pharmaceutical compositions
BRPI0416238A (pt) * 2003-11-05 2007-01-02 Hoffmann La Roche compostos, processo para a sua preparação, composição farmacêutica que compreende os mesmos, uso dos compostos e métodos para o tratamento e/ou a prevenção de doenças que são moduladas por ppar(delta) e/ou agonistas ppar(alfa)
CN101351451B (zh) * 2005-12-29 2013-02-20 莱西肯医药有限公司 多环氨基酸衍生物及其使用方法
US7855291B2 (en) * 2005-12-29 2010-12-21 Lexicon Pharmaceuticals, Inc. Process for the preparation of substituted phenylalanines
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
WO2009014972A1 (en) * 2007-07-26 2009-01-29 Lexicon Pharmaceuticals, Inc. Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein
TWI439457B (zh) * 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法

Also Published As

Publication number Publication date
KR20100046026A (ko) 2010-05-04
BRPI0815754B1 (pt) 2022-03-22
HK1143749A1 (en) 2011-01-14
CA2697368C (en) 2016-06-21
EP3318260B1 (en) 2020-09-23
EP2187887B1 (en) 2017-11-15
RU2010111125A (ru) 2011-09-27
US20110301349A1 (en) 2011-12-08
WO2009029499A1 (en) 2009-03-05
CN101801384B (zh) 2012-03-21
CA2697368A1 (en) 2009-03-05
US7968729B2 (en) 2011-06-28
US20090062540A1 (en) 2009-03-05
JP5553752B2 (ja) 2014-07-16
IL226441A0 (en) 2013-06-27
US20100240906A1 (en) 2010-09-23
JP2010536879A (ja) 2010-12-02
IL203669A (en) 2015-07-30
NZ583017A (en) 2012-02-24
US8575362B2 (en) 2013-11-05
ES2656798T3 (es) 2018-02-28
AU2008293679B2 (en) 2013-09-12
ES2848152T3 (es) 2021-08-05
EP3318260A1 (en) 2018-05-09
RU2493156C2 (ru) 2013-09-20
IL226441A (en) 2014-06-30
EP2187887A1 (en) 2010-05-26
EP2529740A1 (en) 2012-12-05
KR101582697B1 (ko) 2016-01-05
ZA201000785B (en) 2011-04-28
CN101801384A (zh) 2010-08-11
BRPI0815754A2 (pt) 2017-05-30
AU2008293679A1 (en) 2009-03-05

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