BR112014011064A8 - 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives - Google Patents
2-oxo-oxazolidin-3,5-diyl antibiotic derivativesInfo
- Publication number
- BR112014011064A8 BR112014011064A8 BR112014011064A BR112014011064A BR112014011064A8 BR 112014011064 A8 BR112014011064 A8 BR 112014011064A8 BR 112014011064 A BR112014011064 A BR 112014011064A BR 112014011064 A BR112014011064 A BR 112014011064A BR 112014011064 A8 BR112014011064 A8 BR 112014011064A8
- Authority
- BR
- Brazil
- Prior art keywords
- oxazolidin
- oxo
- diyl
- antibiotic derivatives
- alkyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADOS DE ANTIBIÓTICOS 2-OXO-OXAZOLIDIN-3,5-DIILA. A invenção refere-se aos compostos anti-bacterianos da fórmula I em que R1a representa H ou carboxi e R1b representa H, ou R1a e R1b representam em conjunto seja o grupo *-C (O) -NH-S-# ou o grupo *-C (OH) =N-S-# em que "*" representa o ponto de ligação de R1a e "#" representa o ponto de ligação de R1b; R2 representa H, alquila(C1-C3), hidroxi-alquila(C1-C3), benzila ou cicloalquila(C3-C5); R3 representa H ou halogênio; U representa N ou CR4; em que R4 é H ou alcoxi(C1-C3); A representa CH, B representa NH e m representa 1 ou 2 e n representa 1 ou 2; ou A representa N, B está ausente, m representa 2 e n representa 2; Y representa CH ou N; e Q representa O ou S; e os sais de tais compostos.ANTIBIOTIC DERIVATIVES 2-OXO-OXAZOLIDIN-3,5-DIYLA. The invention relates to antibacterial compounds of the formula I in which R1a represents H or carboxy and R1b represents H, or R1a and R1b together represent either the group *-C(O)-NH-S-# or the group *-C(OH)=N-S-# where "*" represents the attachment point of R1a and "#" represents the attachment point of R1b; R2 represents H, (C1-C3)alkyl, hydroxy(C1-C3)alkyl, benzyl or (C3-C5)cycloalkyl; R3 represents H or halogen; U represents N or CR4; wherein R4 is H or (C1-C3)alkoxy; A represents CH, B represents NH and m represents 1 or 2 and n represents 1 or 2; or A represents N, B is absent, m represents 2 and n represents 2; Y represents CH or N; and Q represents O or S; and the salts of such compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2011054968 | 2011-11-08 | ||
PCT/IB2012/056236 WO2013068948A1 (en) | 2011-11-08 | 2012-11-07 | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014011064A2 BR112014011064A2 (en) | 2017-06-13 |
BR112014011064A8 true BR112014011064A8 (en) | 2017-12-26 |
Family
ID=47258051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014011064A BR112014011064A8 (en) | 2011-11-08 | 2012-11-07 | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
Country Status (20)
Country | Link |
---|---|
US (1) | US9079922B2 (en) |
EP (1) | EP2776431B1 (en) |
JP (1) | JP6030146B2 (en) |
KR (1) | KR20140096337A (en) |
AR (1) | AR088691A1 (en) |
AU (1) | AU2012335207B2 (en) |
BR (1) | BR112014011064A8 (en) |
CA (1) | CA2854264A1 (en) |
CL (1) | CL2014001154A1 (en) |
ES (1) | ES2581056T3 (en) |
HK (1) | HK1202288A1 (en) |
IL (1) | IL232463A0 (en) |
IN (1) | IN2014CN04126A (en) |
MX (1) | MX344529B (en) |
PL (1) | PL2776431T3 (en) |
RU (1) | RU2616609C2 (en) |
SG (1) | SG11201401710PA (en) |
TW (1) | TWI594996B (en) |
WO (1) | WO2013068948A1 (en) |
ZA (1) | ZA201404176B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011003370A (en) | 2008-10-07 | 2011-04-28 | Actelion Pharmaceuticals Ltd | Tricyclic oxazolidinone antibiotic compounds. |
MA38588B1 (en) | 2013-04-16 | 2018-04-30 | Idorsia Pharmaceuticals Ltd | Bi-aromatic antibacterial derivatives |
AR096135A1 (en) | 2013-05-02 | 2015-12-09 | Actelion Pharmaceuticals Ltd | DERIVATIVES OF QUINOLONA |
AR102256A1 (en) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | ANTIBACTERIAL BASIC BIAROMATIC DERIVATIVES WITH REPLACEMENT OF AMINOALCOXI |
MA41168A (en) | 2014-12-17 | 2017-10-24 | Acraf | NEW ANTIBACTERIAL COMPOUNDS |
MA41169A (en) * | 2014-12-17 | 2017-10-24 | Acraf | WIDE-SPECTRUM ANTIBACTERIAL COMPOUNDS |
BR112018016208A2 (en) * | 2016-02-08 | 2018-12-18 | Redx Pharma Plc | heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their uses as antibacterial compounds |
GB201602235D0 (en) * | 2016-02-08 | 2016-03-23 | Redx Pharma Plc | Antibacterial compounds |
WO2017137743A1 (en) * | 2016-02-08 | 2017-08-17 | Redx Pharma Plc | Antibacterial compounds |
AU2017276626A1 (en) | 2016-06-08 | 2018-12-20 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | New antibacterial compounds |
TW201833120A (en) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | Aryloxazolidinone antibiotic compounds |
JP7148991B2 (en) * | 2017-06-08 | 2022-10-06 | バグワークス・リサーチ・インコーポレイテッド | Heterocyclic compound useful as an antibacterial agent and method for producing the same |
ES2952989T3 (en) * | 2017-11-29 | 2023-11-07 | Bugworks Res Inc | Antibacterial heterocyclic compounds and their synthesis |
Family Cites Families (26)
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US3149104A (en) | 1961-01-03 | 1964-09-15 | Sterling Drug Inc | 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters |
CA1006521A (en) | 1972-12-18 | 1977-03-08 | Minoru Sugita | Piperazine derivatives and process for preparing them |
GB1598915A (en) | 1977-09-20 | 1981-09-23 | Bellon Labor Sa Roger | 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them |
SE444566B (en) | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-DIALKYLAMINE-6-HALOGEN-4-OXO-1,4-DIHYDROQINOLINE-3-CARBOXYLIC ACID, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION OF THEREOF |
CS274601B2 (en) | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
JPS62205060A (en) | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | 8-substituted quinolonecarboxylic acid derivative |
AU618235B2 (en) | 1986-03-31 | 1991-12-19 | Sankyo Company Limited | Quinoline-3-carboxylic acid derivatives, their preparation and use |
JP2631854B2 (en) | 1987-12-23 | 1997-07-16 | 藤本製薬株式会社 | Novel 1,8-naphthyridine derivative |
DE4301246A1 (en) | 1993-01-19 | 1994-07-21 | Bayer Ag | Quinolone and naphthyridonecarboxylic acid derivatives |
WO2004002973A1 (en) | 2002-06-28 | 2004-01-08 | Kaneka Corporation | Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for the synthesis thereof and process for preparation of the intermediates |
EP1620098B1 (en) * | 2003-04-30 | 2008-06-11 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
CN1898238A (en) * | 2003-12-18 | 2007-01-17 | 莫弗凯姆联合化学股份公司 | Oxazolidinone-quinolone hybrid antibiotics |
WO2006024741A2 (en) | 2004-07-30 | 2006-03-09 | Palumed S.A. | Hybrid qa molecules wherein q is an aminoquinoline and a is an antibiotic residue, their synthesis and their uses as antibacterial agent |
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CL2007003232A1 (en) * | 2006-11-10 | 2008-06-27 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM 5-HYDROXIMETHYL OXAZOLIDIN-2-ONA; PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS; AND ITS USE TO TREAT AND PREVENT BACTERIAL INFECTIONS. |
CL2008001002A1 (en) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
CL2008001003A1 (en) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
ES2380398T3 (en) * | 2007-12-18 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | 5-Aminocyclylmethyl-oxazolidin-2-one derivatives |
EP2254887B9 (en) * | 2008-02-22 | 2013-05-29 | Actelion Pharmaceuticals Ltd. | Oxazolidinone derivatives |
MX2011003370A (en) | 2008-10-07 | 2011-04-28 | Actelion Pharmaceuticals Ltd | Tricyclic oxazolidinone antibiotic compounds. |
TWI436999B (en) * | 2008-10-10 | 2014-05-11 | Actelion Pharmaceuticals Ltd | Oxazolidinyl antibiotics |
WO2010041219A1 (en) * | 2008-10-10 | 2010-04-15 | Actelion Pharmaceuticals Ltd | 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents |
TW201121965A (en) | 2009-09-28 | 2011-07-01 | Lg Life Sciences Ltd | Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis |
CN101792443A (en) | 2010-03-09 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Fluoro-carbostyril derivative as well as preparation method and application thereof |
-
2012
- 2012-11-07 EP EP12791863.9A patent/EP2776431B1/en not_active Not-in-force
- 2012-11-07 US US14/356,896 patent/US9079922B2/en not_active Expired - Fee Related
- 2012-11-07 AU AU2012335207A patent/AU2012335207B2/en not_active Ceased
- 2012-11-07 SG SG11201401710PA patent/SG11201401710PA/en unknown
- 2012-11-07 MX MX2014005637A patent/MX344529B/en active IP Right Grant
- 2012-11-07 RU RU2014123109A patent/RU2616609C2/en not_active IP Right Cessation
- 2012-11-07 ES ES12791863.9T patent/ES2581056T3/en active Active
- 2012-11-07 TW TW101141423A patent/TWI594996B/en not_active IP Right Cessation
- 2012-11-07 BR BR112014011064A patent/BR112014011064A8/en not_active Application Discontinuation
- 2012-11-07 WO PCT/IB2012/056236 patent/WO2013068948A1/en active Application Filing
- 2012-11-07 KR KR1020147014957A patent/KR20140096337A/en active IP Right Grant
- 2012-11-07 IN IN4126CHN2014 patent/IN2014CN04126A/en unknown
- 2012-11-07 AR ARP120104192A patent/AR088691A1/en unknown
- 2012-11-07 PL PL12791863.9T patent/PL2776431T3/en unknown
- 2012-11-07 JP JP2014540612A patent/JP6030146B2/en not_active Expired - Fee Related
- 2012-11-07 CA CA2854264A patent/CA2854264A1/en not_active Abandoned
-
2014
- 2014-04-30 CL CL2014001154A patent/CL2014001154A1/en unknown
- 2014-05-05 IL IL232463A patent/IL232463A0/en unknown
- 2014-06-06 ZA ZA2014/04176A patent/ZA201404176B/en unknown
-
2015
- 2015-03-16 HK HK15102622.5A patent/HK1202288A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW201326166A (en) | 2013-07-01 |
TWI594996B (en) | 2017-08-11 |
SG11201401710PA (en) | 2014-09-26 |
JP6030146B2 (en) | 2016-11-24 |
RU2014123109A (en) | 2015-12-20 |
JP2014532754A (en) | 2014-12-08 |
EP2776431B1 (en) | 2016-05-04 |
CA2854264A1 (en) | 2013-05-16 |
AU2012335207B2 (en) | 2017-05-25 |
CL2014001154A1 (en) | 2014-09-12 |
KR20140096337A (en) | 2014-08-05 |
ZA201404176B (en) | 2016-05-25 |
HK1202288A1 (en) | 2015-09-25 |
AR088691A1 (en) | 2014-06-25 |
IL232463A0 (en) | 2014-06-30 |
AU2012335207A1 (en) | 2014-07-03 |
RU2616609C2 (en) | 2017-04-18 |
PL2776431T3 (en) | 2016-11-30 |
BR112014011064A2 (en) | 2017-06-13 |
MX344529B (en) | 2016-12-19 |
CN103917539A (en) | 2014-07-09 |
WO2013068948A1 (en) | 2013-05-16 |
US9079922B2 (en) | 2015-07-14 |
US20150051188A1 (en) | 2015-02-19 |
MX2014005637A (en) | 2014-06-23 |
ES2581056T3 (en) | 2016-08-31 |
EP2776431A1 (en) | 2014-09-17 |
IN2014CN04126A (en) | 2015-07-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
B25C | Requirement related to requested transfer of rights |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |