HUP0203746A2 - Új kompozíció és eljárás stabilizálására - Google Patents
Új kompozíció és eljárás stabilizálásáraInfo
- Publication number
- HUP0203746A2 HUP0203746A2 HU0203746A HUP0203746A HUP0203746A2 HU P0203746 A2 HUP0203746 A2 HU P0203746A2 HU 0203746 A HU0203746 A HU 0203746A HU P0203746 A HUP0203746 A HU P0203746A HU P0203746 A2 HUP0203746 A2 HU P0203746A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- carbon
- atom
- represent
- lower alkyl
- Prior art date
Links
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- -1 bicyclic compound Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005456 glyceride group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Abstract
A találmány olyan új kompozícióra vonatkozik, amely egy új biciklusosvegyületet és egy gliceridet tartalmaz. A találmány tárgya továbbáeljárás a biciklusos vegyület stabilizálására, amelynek lényege az,hogy a biciklusos vegyületet egy gliceriddel keverik össze. Atalálmány továbbá az új biciklusos vegyületekre vonatkozik, amelyek(I) általános képletében A jelentése -CH2OH, -COCH2OH vagy -COOHcsoport vagy ezek valamelyikének funkcionális származéka; X1 és X2hidrogénatomot, halogénatomot vagy rövid szénláncú alkilcsoportotjelentenek; V1 és V2 szénatomot vagy oxigénatomot jelentenek; továbbáW1 és W2 (III), (IV) vagy (V) képletű csoportot jelentenek, és az elsőkettőben R4 és R5 egymástól függetlenül hidrogénatomot, halogénatomot,hidroxilcsoportot, rövid szénláncú alkilcsoportot, rövid szénláncúalkoxicsoportot vagy hidroxi(rövid szénláncú)alkilcsoportot jelent,azzal a megkötéssel, hogy R4 és R5 egyidejű jelentésehidroxilcsoporttól vagy rövid szénláncú alkoxicsoporttól eltérő; Zjelentése szén-, oxigén-, kén- vagy nitrogénatom; R1 jelentésetelített vagy telítetlen, kétértékű rövid vagy közepes szénláncúalifás szénhidrogén-maradék, amely adott esetben szubsztituálva van;R2 jelentése telített vagy telítetlen, rövid vagy közepes szénláncúalifás szénhidrogén-maradék, amely adott esetben szubsztituálva van;vagy továbbá R2 jelentése rövid szénláncú cikloalkilcsoport, rövidszénláncú cikloalkoxicsoport, arilcsoport, ariloxicsoport,heterociklusos csoport vagy heterociklusos oxicsoport; és R3 jelentésehidrogénatom, rövid szénláncú alkilcsoport, rövid szénláncúcikloalkilcsoport, arilcsoport vagy heterociklusos csoport. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15954999P | 1999-10-15 | 1999-10-15 | |
PCT/JP2000/007109 WO2001027099A2 (en) | 1999-10-15 | 2000-10-13 | Bicyclic compounds composition and method for stabilizing the same |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0203746A2 true HUP0203746A2 (hu) | 2003-03-28 |
HUP0203746A3 HUP0203746A3 (en) | 2005-02-28 |
HU229547B1 HU229547B1 (en) | 2014-01-28 |
Family
ID=22573018
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203746A HU229547B1 (en) | 1999-10-15 | 2000-10-13 | Novel composition and method for stabilizing the same |
HU1300369A HU230484B1 (hu) | 1999-10-15 | 2000-10-13 | Egy biciklusos vegyületet és egy gliceridet tartalmazó új kompozíció |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU1300369A HU230484B1 (hu) | 1999-10-15 | 2000-10-13 | Egy biciklusos vegyületet és egy gliceridet tartalmazó új kompozíció |
Country Status (26)
Country | Link |
---|---|
US (5) | US6583174B1 (hu) |
EP (2) | EP1426361B2 (hu) |
JP (2) | JP4332316B2 (hu) |
KR (1) | KR100830061B1 (hu) |
CN (1) | CN1268623C (hu) |
AR (3) | AR026046A1 (hu) |
AT (2) | ATE267189T1 (hu) |
AU (2) | AU780342B2 (hu) |
BR (1) | BRPI0014869B8 (hu) |
CA (1) | CA2385732C (hu) |
CZ (1) | CZ303625B6 (hu) |
DE (2) | DE60010913T2 (hu) |
DK (2) | DK1426361T4 (hu) |
ES (2) | ES2221859T3 (hu) |
HK (2) | HK1066792A1 (hu) |
HU (2) | HU229547B1 (hu) |
IL (2) | IL148803A0 (hu) |
MX (1) | MXPA02003756A (hu) |
NO (1) | NO330258B1 (hu) |
NZ (1) | NZ518020A (hu) |
PT (2) | PT1220849E (hu) |
RU (1) | RU2695274C3 (hu) |
TR (1) | TR200201032T2 (hu) |
TW (1) | TWI281918B (hu) |
WO (1) | WO2001027099A2 (hu) |
ZA (1) | ZA200202312B (hu) |
Families Citing this family (30)
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ES2221859T3 (es) * | 1999-10-15 | 2005-01-16 | Sucampo Ag | Composicion de compuestos biciclicos y procedimiento para su estabilizacion. |
US6414016B1 (en) * | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
TWI331920B (en) | 2001-11-14 | 2010-10-21 | Sucampo Ag | Unit dosage form for relieving or treating constipation in human patients |
FR2842810B1 (fr) * | 2002-07-25 | 2006-01-27 | Inst Nat Sciences Appliq | Nouveaux composes gem difluores, leur procedes de preparation et leurs applications. |
EP1562604B1 (en) * | 2002-10-23 | 2012-01-04 | Sucampo AG | Prostaglandin compounds for the treatment of obesity |
EP2281564A3 (en) * | 2002-12-27 | 2012-09-05 | Sucampo AG | Derivatives of prostaglandins for treating abdominal discomfort |
JP5294559B2 (ja) * | 2003-07-03 | 2013-09-18 | スキャンポ・アーゲー | クロライドチャンネルオープナーとしてプロスタグランジンアナログを含む腸溶性組成物 |
TWI348386B (en) * | 2003-08-12 | 2011-09-11 | R Tech Ueno Ltd | Composition and method for promoting hair growth |
TWI387454B (zh) | 2004-09-02 | 2013-03-01 | Sucampo Ag | 治療胃腸道疾病之方法及組成物 |
CN101198334B (zh) * | 2005-04-12 | 2013-02-06 | 苏坎波公司 | 前列腺素化合物和质子泵抑制剂用于治疗肠胃病的联合应用 |
CN101466407B (zh) | 2006-01-24 | 2013-05-15 | 株式会社·R-技术上野 | 包含双环化合物的药物组合物和使所述双环化合物稳定的方法 |
AU2007208632B2 (en) * | 2006-01-24 | 2012-01-19 | R-Tech Ueno, Ltd. | Soft-gelatin capsule formulation |
CN103804338A (zh) * | 2006-02-07 | 2014-05-21 | 株式会社·R-技术上野 | 用于制备前列腺素衍生物的方法 |
US20090012165A1 (en) | 2007-07-03 | 2009-01-08 | Sucampo Ag | Pharmaceutical combination of nsaid and prostaglandin compound |
US20090030072A1 (en) | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
JP5390519B2 (ja) * | 2007-07-19 | 2014-01-15 | 株式会社アールテック・ウエノ | 11−デオキシ−プロスタグランジン化合物を含む医薬組成物およびその安定化方法 |
US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
CN101318948B (zh) | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
US8569279B2 (en) * | 2009-05-27 | 2013-10-29 | Sucampo Ag | Method for modulating claudin mediated functions |
US20110034424A1 (en) * | 2009-06-30 | 2011-02-10 | Sucampo Ag | Method for the long term nsaid use |
EP2460801B1 (en) | 2009-07-28 | 2014-06-25 | ONO Pharmaceutical Co., Ltd. | Bicyclic compound and use thereof for medical purposes |
CN104958298A (zh) * | 2009-09-18 | 2015-10-07 | 阿得罗公司 | 阿片样受体拮抗剂用于胃肠道疾病的用途 |
CA2779736A1 (en) * | 2009-11-03 | 2011-05-12 | Bernard Charles Sherman | Stable pharmaceutical formulations comprising lubiprostone |
JP5907077B2 (ja) | 2011-01-27 | 2016-04-20 | 小野薬品工業株式会社 | 二環式化合物およびその医薬用途 |
EP2669279B1 (en) | 2011-01-27 | 2017-01-11 | ONO Pharmaceutical Co., Ltd. | Bicyclic compound and use thereof for medical purposes |
WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
EP3277274A4 (en) | 2015-04-01 | 2018-12-05 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
ES2890989T3 (es) | 2016-06-30 | 2022-01-25 | Ono Pharmaceutical Co | Método para producir un compuesto bicíclico |
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2000
- 2000-10-13 ES ES00966462T patent/ES2221859T3/es not_active Expired - Lifetime
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