MX9706014A - Derivados de xanteno y acridina y su empleo. - Google Patents

Derivados de xanteno y acridina y su empleo.

Info

Publication number
MX9706014A
MX9706014A MX9706014A MX9706014A MX9706014A MX 9706014 A MX9706014 A MX 9706014A MX 9706014 A MX9706014 A MX 9706014A MX 9706014 A MX9706014 A MX 9706014A MX 9706014 A MX9706014 A MX 9706014A
Authority
MX
Mexico
Prior art keywords
lower alkyl
halo
het
nitro
substituents
Prior art date
Application number
MX9706014A
Other languages
English (en)
Other versions
MXPA97006014A (es
Inventor
Joseph Armstrong Martin
Bradley Stuart Sherborne
Gareth Mark Taylor
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9616565.9A external-priority patent/GB9616565D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA97006014A publication Critical patent/MXPA97006014A/es
Publication of MX9706014A publication Critical patent/MX9706014A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se refiere a nuevos y conocidos derivados de diona tricíclicos, de formula general (I), en donde W representa hidrogeno o alquilo inferior; X representa alquilo inferior; Y representa un átomo de oxígeno o NR1; R1 representa hidrogeno, alquilo inferior, alcoxicarbonilo inferior o alcoxicarbonilo inferior-alquilo inferior; Z representa arilo o heteroarilo opcionalmente substituido con uno o más substituyentes halogeno, ciano, nitro, alquilo inferior, halogeno-alquilo inferior, alcoxilo inferior, halogeno-alcoxilo inferior, COR2, OCOR2, CO2R2, OR2, S(O)nR2, NR2R3, N(R4)COR5, Ar, Ar-alquilo inferior, Het o Het-alquilo inferior y/o en los átomos de carbono adyacentes con alquilendioxilo inferior; R2, R3, R4 y R5 representan cada uno individualmente substituyentes hidrogeno, alquilo inferior, Ar, Ar-alquilo inferior, Het o Het-alquilo inferior, o R2 y R3 juntos representan el grupo -CH=CH-CH=CH- o -CH=N-CH=CH-; Ar representa arilo opcionalmente substituido con uno o más substituyentes halogeno, alquilo inferior, alcoxilo inferior o nitro; Het representa heteroarilo opcionalmente substituido con uno o más substituyentes halogeno, alquilo inferior, alcoxilo inferior o nitro; y representa 0, 1 o 2 y a sus sales, que son inhibidores de la timidina quinasa del virus del herpes simplex, en el tratamiento y profilaxis de infecciones causadas por el virus del herpes simplex.
MX9706014A 1996-08-07 1997-08-06 Derivados de xanteno y acridina y su empleo. MX9706014A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9616565.9A GB9616565D0 (en) 1996-08-07 1996-08-07 Tricyclic dione derivatives
GB9616565.9 1997-04-18
GB9707695.4 1997-04-18
GBGB9707695.4A GB9707695D0 (en) 1996-08-07 1997-04-18 Tricyclic dione derivatives

Publications (2)

Publication Number Publication Date
MXPA97006014A MXPA97006014A (es) 1998-02-01
MX9706014A true MX9706014A (es) 1998-02-28

Family

ID=26309831

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706014A MX9706014A (es) 1996-08-07 1997-08-06 Derivados de xanteno y acridina y su empleo.

Country Status (10)

Country Link
US (2) US5969139A (es)
EP (1) EP0823426A1 (es)
JP (1) JPH1067749A (es)
CN (1) CN1100759C (es)
AR (1) AR008826A1 (es)
BR (1) BR9704271A (es)
CA (1) CA2210415A1 (es)
GB (1) GB9707695D0 (es)
MX (1) MX9706014A (es)
TR (1) TR199700761A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055517A1 (en) * 2000-09-15 2002-05-09 3M Innovative Properties Company Methods for delaying recurrence of herpes virus symptoms
WO2006002142A2 (en) * 2004-06-18 2006-01-05 The Johns Hopkins University Imaging infection with compounds that bind to thymidine kinase
FR2962436B1 (fr) * 2010-07-09 2012-12-14 Fabre Pierre Dermo Cosmetique Derives de xanthedediones pour le traitement des troubles de la pigmentation et du vieillissement cutane
TW201444827A (zh) 2013-03-12 2014-12-01 Daiichi Sankyo Co Ltd 苯基□衍生物
CN103396362B (zh) * 2013-08-21 2015-11-04 郑州西格玛化工有限公司 一种制备吖啶酮乙酸的方法
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
AU2018236188B2 (en) * 2017-03-13 2022-01-27 Assembly Biosciences, Inc. Process for making hepatitis B core protein modulators
US11976041B1 (en) 2023-10-23 2024-05-07 King Faisal University 9-(5-bromo-2-hydroxyphenyl)-10-[3-(dimethylamino)propyl]-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione as an antimicrobial compound
US11952385B1 (en) 2023-10-31 2024-04-09 King Faisal University 12-bromo-2,16-dioxa-9,9,18,18-tetramethylpentacyclo[7.7.5.0 1, 21.0 3,8.0 10,15]henicosa3(8),10,12,14-tetraene-7,20-dione as an antimicrobial compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3414587A (en) * 1965-11-09 1968-12-03 Hoffmann La Roche 4-(1, 2, 3, 4, 5, 6, 7, 8-octahydro-1, 8-dioxo-9-xanthenyl)-benzene-sulfonamide and derivatives
US3454577A (en) * 1965-11-09 1969-07-08 Hoffmann La Roche 4-(1,2,3,4,5,6,7,8 - octahydro - 1,8 - dioxo-9-acridanyl) - benzenesulfonamide and derivatives
US3539590A (en) * 1968-05-20 1970-11-10 Monsanto Co Substituted 3,3,6,6 - tetramethyl-1,8 - diketo - 9 - (2 - hydroxyphenyl) octahydroxanthenes
DE2003148A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
GB9113624D0 (en) * 1991-06-25 1991-08-14 Wellcome Found Pesticides
ATE161531T1 (de) * 1991-10-21 1998-01-15 Zeneca Ltd Acridine-1,8-dionderivate als therapeutisches mittel
GB9220570D0 (en) * 1991-10-21 1992-11-11 Ici Plc Therapeutic agent
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
CA2119315A1 (en) * 1993-03-18 1994-09-19 Tsujiaki Hata Nucleoside derivatives and anti-herpes composition

Also Published As

Publication number Publication date
CA2210415A1 (en) 1998-02-07
GB9707695D0 (en) 1997-06-04
US6162918A (en) 2000-12-19
CN1100759C (zh) 2003-02-05
US5969139A (en) 1999-10-19
CN1178789A (zh) 1998-04-15
AR008826A1 (es) 2000-02-23
BR9704271A (pt) 1998-11-03
TR199700761A2 (xx) 1998-02-21
JPH1067749A (ja) 1998-03-10
EP0823426A1 (en) 1998-02-11

Similar Documents

Publication Publication Date Title
MY105438A (en) 3-aminopiperidine derivatives and related nitrogen containing heterocycles.
SI1070056T1 (en) Phthalazinone pde iii/iv inhibitors
TW369526B (en) Diazabicyclic neurokinin antagonists
MY119800A (en) Pyridine derivatives
RU95108387A (ru) Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина
AP1246A (en) Substituted pyrazoles as p38 Kinase inhibitors.
MY118904A (en) 4-oxo-1, 4-dihydro-3-quinolinecarboxamides as antiviral agents
IL148498A0 (en) Quinazoline derivatives
TR199900920T2 (xx) Nafthiridin t�revleri.
FI934626A (fi) Substituerade bensylaminokinuklidiner
CY2509B1 (en) New thiazole derivatives with phosphodiesterase-inhibitting effect
IL110091A (en) POLYSUBSTITUTED IMIDAZO £4, 5-c| PYRIDIN-4-AMINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GEP20063915B (en) PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND USE THEREOF FOR TREATING p38 KINASE-ASSOCIATED CONDITIONS
HUP9903707A2 (hu) 17Béta-karboxi-,-tio-karboxi-vagy -amido-androsztánszármazékok laktonszármazékai, előállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
UA41290C2 (uk) Гетероариламіни, фармацевтична композиція, спосіб інгібування холінестерази у ссавців, спосіб покращення пам'яті
CA2203237A1 (en) Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
MX9706014A (es) Derivados de xanteno y acridina y su empleo.
HUP0203422A2 (hu) Foszfodiészteráz VII inhibitor hatású imidazolszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
NZ512981A (en) Use of pyridazino[4,5-b]indole-1-acetamide derivatives for treating diseases related to the dysfunction of peripheral benzodiazepine receptors
HK1048303A1 (en) Aminobenzophenoses as inhibitors of il-1b and tnf -a.
MY118004A (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
ES2184318T3 (es) 6-alquilfenantridinas sustituidas.
DK0632805T3 (da) Melaminderivater til anvendelse i behandlingen af cancer
ATE247660T1 (de) Furopyridinderivate und ihre therapeutische verwendung
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means