ATE154359T1 - 2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellung - Google Patents
2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellungInfo
- Publication number
- ATE154359T1 ATE154359T1 AT93109165T AT93109165T ATE154359T1 AT E154359 T1 ATE154359 T1 AT E154359T1 AT 93109165 T AT93109165 T AT 93109165T AT 93109165 T AT93109165 T AT 93109165T AT E154359 T1 ATE154359 T1 AT E154359T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- stands
- production
- nucleoside compounds
- methylidenepyrimidine
- Prior art date
Links
- -1 NUCLEOSIDE COMPOUNDS Chemical class 0.000 title abstract 2
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21206188 | 1988-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE154359T1 true ATE154359T1 (de) | 1997-06-15 |
Family
ID=16616219
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89115516T ATE109154T1 (de) | 1988-08-25 | 1989-08-23 | 2'-methylidenpyrimidin-nukleoside, ihre verwendung und verfahren zu ihrer herstellung. |
| AT93109165T ATE154359T1 (de) | 1988-08-25 | 1989-08-23 | 2'-methylidenpyrimidinnukleosidverbindungen, ihre verwendung und verfahren zu ihrer herstellung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89115516T ATE109154T1 (de) | 1988-08-25 | 1989-08-23 | 2'-methylidenpyrimidin-nukleoside, ihre verwendung und verfahren zu ihrer herstellung. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5705630A (de) |
| EP (2) | EP0566162B1 (de) |
| KR (1) | KR0136869B1 (de) |
| AT (2) | ATE109154T1 (de) |
| CA (1) | CA1319685C (de) |
| DE (2) | DE68928127T2 (de) |
| ES (1) | ES2057031T3 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9020930D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Pharmaceutical combinations |
| US5340816A (en) * | 1990-10-18 | 1994-08-23 | E. R. Squibb & Sons, Inc. | Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines |
| US5206244A (en) * | 1990-10-18 | 1993-04-27 | E. R. Squibb & Sons, Inc. | Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines |
| US5665711A (en) * | 1995-12-12 | 1997-09-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Antitumor composition for oral administration |
| EP1270008B1 (de) * | 2001-05-31 | 2006-07-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Kondensierte trizyklische Derivate des Guanosins zur Behandlung von Tumoren |
| KR100481356B1 (ko) * | 2002-10-17 | 2005-04-07 | 이수화학 주식회사 | 2'-ｏ-치환된 뉴클레오시드의 제조 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007049A1 (fr) * | 1987-03-19 | 1988-09-22 | Yamasa Shoyu Kabushiki Kaisha | Derives de nucleosides de 2'-alkylidene pyrimidine, procede de preparation et utilisation de ces composes |
-
1989
- 1989-08-23 EP EP93109165A patent/EP0566162B1/de not_active Expired - Lifetime
- 1989-08-23 ES ES89115516T patent/ES2057031T3/es not_active Expired - Lifetime
- 1989-08-23 EP EP89115516A patent/EP0360018B1/de not_active Expired - Lifetime
- 1989-08-23 DE DE68928127T patent/DE68928127T2/de not_active Expired - Fee Related
- 1989-08-23 DE DE68917060T patent/DE68917060T2/de not_active Expired - Fee Related
- 1989-08-23 AT AT89115516T patent/ATE109154T1/de not_active IP Right Cessation
- 1989-08-23 AT AT93109165T patent/ATE154359T1/de not_active IP Right Cessation
- 1989-08-24 CA CA000609209A patent/CA1319685C/en not_active Expired - Fee Related
- 1989-08-25 KR KR1019890012101A patent/KR0136869B1/ko not_active Expired - Fee Related
-
1992
- 1992-01-07 US US07/818,656 patent/US5705630A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2057031T3 (es) | 1994-10-16 |
| EP0360018B1 (de) | 1994-07-27 |
| DE68917060D1 (de) | 1994-09-01 |
| DE68928127T2 (de) | 1997-09-25 |
| US5705630A (en) | 1998-01-06 |
| EP0566162B1 (de) | 1997-06-11 |
| DE68917060T2 (de) | 1994-12-08 |
| CA1319685C (en) | 1993-06-29 |
| ATE109154T1 (de) | 1994-08-15 |
| KR0136869B1 (ko) | 1998-04-25 |
| EP0566162A1 (de) | 1993-10-20 |
| EP0360018A1 (de) | 1990-03-28 |
| KR900003195A (ko) | 1990-03-26 |
| DE68928127D1 (de) | 1997-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |