DE68917060T2 - 2'-Methylidenpyrimidin-Nukleoside, ihre Verwendung und Verfahren zu ihrer Herstellung. - Google Patents

2'-Methylidenpyrimidin-Nukleoside, ihre Verwendung und Verfahren zu ihrer Herstellung.

Info

Publication number
DE68917060T2
DE68917060T2 DE68917060T DE68917060T DE68917060T2 DE 68917060 T2 DE68917060 T2 DE 68917060T2 DE 68917060 T DE68917060 T DE 68917060T DE 68917060 T DE68917060 T DE 68917060T DE 68917060 T2 DE68917060 T2 DE 68917060T2
Authority
DE
Germany
Prior art keywords
stands
compounds
methylidene
preparation
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68917060T
Other languages
English (en)
Other versions
DE68917060D1 (de
Inventor
Tohru Ueda
Takuma Sasaki
Akira Minamishinkawa-K Matsuda
Keiji Yamagami
Akihiro Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Welfide Corp
Original Assignee
Yamasa Shoyu KK
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK, Welfide Corp filed Critical Yamasa Shoyu KK
Publication of DE68917060D1 publication Critical patent/DE68917060D1/de
Application granted granted Critical
Publication of DE68917060T2 publication Critical patent/DE68917060T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
DE68917060T 1988-08-25 1989-08-23 2'-Methylidenpyrimidin-Nukleoside, ihre Verwendung und Verfahren zu ihrer Herstellung. Expired - Fee Related DE68917060T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21206188 1988-08-25

Publications (2)

Publication Number Publication Date
DE68917060D1 DE68917060D1 (de) 1994-09-01
DE68917060T2 true DE68917060T2 (de) 1994-12-08

Family

ID=16616219

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68928127T Expired - Fee Related DE68928127T2 (de) 1988-08-25 1989-08-23 2'-Methylidenpyrimidinnukleosidverbindungen, ihre Verwendung und Verfahren zu ihrer Herstellung
DE68917060T Expired - Fee Related DE68917060T2 (de) 1988-08-25 1989-08-23 2'-Methylidenpyrimidin-Nukleoside, ihre Verwendung und Verfahren zu ihrer Herstellung.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68928127T Expired - Fee Related DE68928127T2 (de) 1988-08-25 1989-08-23 2'-Methylidenpyrimidinnukleosidverbindungen, ihre Verwendung und Verfahren zu ihrer Herstellung

Country Status (7)

Country Link
US (1) US5705630A (de)
EP (2) EP0566162B1 (de)
KR (1) KR0136869B1 (de)
AT (2) ATE154359T1 (de)
CA (1) CA1319685C (de)
DE (2) DE68928127T2 (de)
ES (1) ES2057031T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5665711A (en) * 1995-12-12 1997-09-09 Yoshitomi Pharmaceutical Industries, Ltd. Antitumor composition for oral administration
EP1270008B1 (de) * 2001-05-31 2006-07-12 Yung Shin Pharmaceutical Ind. Co., Ltd. Kondensierte trizyklische Derivate des Guanosins zur Behandlung von Tumoren
KR100481356B1 (ko) * 2002-10-17 2005-04-07 이수화학 주식회사 2'-ｏ-치환된 뉴클레오시드의 제조 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310673B1 (de) * 1987-03-19 1995-07-05 Yamasa Shoyu Kabushiki Kaisha 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung

Also Published As

Publication number Publication date
EP0566162A1 (de) 1993-10-20
KR0136869B1 (ko) 1998-04-25
ATE109154T1 (de) 1994-08-15
DE68917060D1 (de) 1994-09-01
CA1319685C (en) 1993-06-29
US5705630A (en) 1998-01-06
DE68928127D1 (de) 1997-07-17
EP0360018B1 (de) 1994-07-27
EP0360018A1 (de) 1990-03-28
KR900003195A (ko) 1990-03-26
ES2057031T3 (es) 1994-10-16
EP0566162B1 (de) 1997-06-11
DE68928127T2 (de) 1997-09-25
ATE154359T1 (de) 1997-06-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee