MX9605809A - Nuevos esteres lipidicos de monofosfatos nucleosidos y su uso como medicamentos inmunosupresores. - Google Patents

Nuevos esteres lipidicos de monofosfatos nucleosidos y su uso como medicamentos inmunosupresores.

Info

Publication number
MX9605809A
MX9605809A MX9605809A MX9605809A MX9605809A MX 9605809 A MX9605809 A MX 9605809A MX 9605809 A MX9605809 A MX 9605809A MX 9605809 A MX9605809 A MX 9605809A MX 9605809 A MX9605809 A MX 9605809A
Authority
MX
Mexico
Prior art keywords
hydrogen
oxygen
optionally substituted
carbon atoms
substituted alkyl
Prior art date
Application number
MX9605809A
Other languages
English (en)
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of MX9605809A publication Critical patent/MX9605809A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invencion se dirige a nuevos derivados de monofosfato de nucleosido de residuos de éster lipídico de formula general (I) (Ver Formula) en la que R1 puede ser una cadena alquilo opcionalmente sustituida que tiene 1-20 átomos de carbono; R2 representa hidrogeno, una cadena alquilo opcionalmente sustituida que tiene 1-20 átomos de carbono, R3, R4 y R5 representan hidrogeno, hidroxi, azido, amino, ciano o halogeno; X representa una valencia, oxígeno, azufre, un grupo sulfinilo o sulfonilo; Y representa una valencia, un átomo de oxígeno o de azufre; B representa una base purínica y/o pirimidínica; con la condicion de que por lo menos uno de los residuos R4 o R5 es hidrogeno; con sus tautomeros y sus sales fisiologicamente aceptables de ácidos y/o bases inorgánicas y orgánicas, así como con procesos para su preparacion y con drogas o medicamentos que contienen tales compuestos.
MX9605809A 1994-05-28 1995-05-23 Nuevos esteres lipidicos de monofosfatos nucleosidos y su uso como medicamentos inmunosupresores. MX9605809A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
PCT/EP1995/001951 WO1995032984A1 (en) 1994-05-28 1995-05-23 New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs

Publications (1)

Publication Number Publication Date
MX9605809A true MX9605809A (es) 1997-12-31

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605809A MX9605809A (es) 1994-05-28 1995-05-23 Nuevos esteres lipidicos de monofosfatos nucleosidos y su uso como medicamentos inmunosupresores.

Country Status (27)

Country Link
US (1) US6025343A (es)
EP (2) EP1229040B8 (es)
JP (1) JP3802057B2 (es)
KR (1) KR100279087B1 (es)
CN (1) CN1168735C (es)
AT (2) ATE249472T1 (es)
AU (1) AU688516B2 (es)
BR (1) BR9507785A (es)
CA (1) CA2190983C (es)
CZ (1) CZ291846B6 (es)
DE (3) DE4418690A1 (es)
DK (2) DK0763049T3 (es)
ES (2) ES2199250T3 (es)
FI (1) FI117673B (es)
HU (1) HU220336B (es)
IL (1) IL113865A (es)
MX (1) MX9605809A (es)
NO (1) NO308998B1 (es)
NZ (1) NZ287434A (es)
PL (1) PL185290B1 (es)
PT (2) PT763049E (es)
RU (1) RU2165429C2 (es)
SK (1) SK284207B6 (es)
TW (1) TW420686B (es)
UA (1) UA45339C2 (es)
WO (1) WO1995032984A1 (es)
ZA (1) ZA954374B (es)

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Also Published As

Publication number Publication date
CZ347796A3 (en) 1997-04-16
EP1229040B8 (en) 2003-11-05
DK1229040T3 (da) 2003-12-22
ES2199250T3 (es) 2004-02-16
DK0763049T3 (da) 2003-07-28
IL113865A (en) 2008-12-29
SK284207B6 (en) 2004-11-03
EP1229040B1 (en) 2003-09-10
TW420686B (en) 2001-02-01
HU220336B (hu) 2001-12-28
UA45339C2 (uk) 2002-04-15
ATE236189T1 (de) 2003-04-15
FI964727A0 (fi) 1996-11-27
NO308998B1 (no) 2000-11-27
EP1229040A2 (en) 2002-08-07
SK151896A3 (en) 1997-06-04
CA2190983A1 (en) 1995-12-07
ZA954374B (en) 1996-11-29
RU2165429C2 (ru) 2001-04-20
DE69531749T2 (de) 2004-07-29
US6025343A (en) 2000-02-15
PL317380A1 (en) 1997-04-01
CZ291846B6 (cs) 2003-06-18
ATE249472T1 (de) 2003-09-15
PT763049E (pt) 2003-08-29
WO1995032984A1 (en) 1995-12-07
JP3802057B2 (ja) 2006-07-26
DE69530197D1 (de) 2003-05-08
CN1168735C (zh) 2004-09-29
BR9507785A (pt) 1997-09-23
KR970703354A (ko) 1997-07-03
PT1229040E (pt) 2003-12-31
AU688516B2 (en) 1998-03-12
NO965054D0 (no) 1996-11-27
JPH10500964A (ja) 1998-01-27
PL185290B1 (pl) 2003-04-30
CA2190983C (en) 2006-08-15
NO965054L (no) 1997-01-28
FI964727A (fi) 1996-11-27
HU9603269D0 (en) 1997-01-28
ES2206429T3 (es) 2004-05-16
DE69530197T2 (de) 2004-01-29
EP0763049A1 (en) 1997-03-19
EP0763049B1 (en) 2003-04-02
AU2615495A (en) 1995-12-21
WO1995032984A8 (en) 2003-01-16
IL113865A0 (en) 1995-08-31
DE4418690A1 (de) 1996-01-11
FI117673B (fi) 2007-01-15
NZ287434A (en) 1998-01-26
HUT75340A (en) 1997-05-28
CN1154111A (zh) 1997-07-09
EP1229040A3 (en) 2002-08-21
DE69531749D1 (de) 2003-10-16
KR100279087B1 (ko) 2001-01-15

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Owner name: HEIDELBERG PHARMA HOLDING GMBH

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