ATE236189T1 - Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel - Google Patents
Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittelInfo
- Publication number
- ATE236189T1 ATE236189T1 AT95920864T AT95920864T ATE236189T1 AT E236189 T1 ATE236189 T1 AT E236189T1 AT 95920864 T AT95920864 T AT 95920864T AT 95920864 T AT95920864 T AT 95920864T AT E236189 T1 ATE236189 T1 AT E236189T1
- Authority
- AT
- Austria
- Prior art keywords
- desoxy
- chain
- nucleoside monophosphate
- production
- monophosphate derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4418690A DE4418690A1 (de) | 1994-05-28 | 1994-05-28 | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
PCT/EP1995/001951 WO1995032984A1 (en) | 1994-05-28 | 1995-05-23 | New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE236189T1 true ATE236189T1 (de) | 2003-04-15 |
Family
ID=6519215
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02008360T ATE249472T1 (de) | 1994-05-28 | 1995-05-23 | Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppressive arzneimittel |
AT95920864T ATE236189T1 (de) | 1994-05-28 | 1995-05-23 | Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02008360T ATE249472T1 (de) | 1994-05-28 | 1995-05-23 | Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppressive arzneimittel |
Country Status (27)
Country | Link |
---|---|
US (1) | US6025343A (de) |
EP (2) | EP1229040B8 (de) |
JP (1) | JP3802057B2 (de) |
KR (1) | KR100279087B1 (de) |
CN (1) | CN1168735C (de) |
AT (2) | ATE249472T1 (de) |
AU (1) | AU688516B2 (de) |
BR (1) | BR9507785A (de) |
CA (1) | CA2190983C (de) |
CZ (1) | CZ291846B6 (de) |
DE (3) | DE4418690A1 (de) |
DK (2) | DK1229040T3 (de) |
ES (2) | ES2199250T3 (de) |
FI (1) | FI117673B (de) |
HU (1) | HU220336B (de) |
IL (1) | IL113865A (de) |
MX (1) | MX9605809A (de) |
NO (1) | NO308998B1 (de) |
NZ (1) | NZ287434A (de) |
PL (1) | PL185290B1 (de) |
PT (2) | PT1229040E (de) |
RU (1) | RU2165429C2 (de) |
SK (1) | SK284207B6 (de) |
TW (1) | TW420686B (de) |
UA (1) | UA45339C2 (de) |
WO (1) | WO1995032984A1 (de) |
ZA (1) | ZA954374B (de) |
Families Citing this family (61)
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US6458772B1 (en) | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
JP3839857B2 (ja) * | 1994-09-20 | 2006-11-01 | 塩野義製薬株式会社 | エーテル型チオリン脂質化合物の製造方法 |
RU2130029C1 (ru) * | 1994-12-13 | 1999-05-10 | Тайхо Фармасьютикал Ко., Лтд. | 3'-замещенные производные нуклеозида, способ их получения (варианты), лекарственное средство, способ лечения и профилактики |
WO1999051613A1 (en) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
US6407077B1 (en) | 1998-11-05 | 2002-06-18 | Emory University | β-L nucleosides for the treatment of HIV infection |
KR100618028B1 (ko) | 1998-11-05 | 2006-08-30 | 쌍트르 나쉬오날 드 라 르쉐르스 쉬앙티피끄 | 항-b형 간염 활성을 가진 뉴클레오시드 |
DE19855963A1 (de) * | 1998-12-04 | 2000-06-08 | Herbert Schott | Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung |
US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
EP1230253A1 (de) | 1999-11-08 | 2002-08-14 | Migenix Inc. | Synthese von kombinationsbibliotheken und dadurch hergestellte pharmazeutisch aktive verbindungen |
US6787526B1 (en) | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
WO2002057498A1 (en) * | 2001-01-22 | 2002-07-25 | Emergen, Inc. | Isotopically enriched nucleic acids and associated methods for the production and purification thereof |
CN101113160A (zh) | 2001-05-16 | 2008-01-30 | 米珍尼克斯公司 | 基于核酸的化合物及其使用方法 |
AU2002356672A1 (en) * | 2001-11-21 | 2003-06-10 | Ganymed 256 Vermogensverwaltungs Gmbh | Phospholipid derivitives of nucleosides as antitumoral medicaments |
WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
ES2401285T3 (es) * | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
AU2005321239B2 (en) | 2004-12-30 | 2009-02-12 | Medivir Ab | Compounds useful in the treatment of HIV |
GB0505781D0 (en) | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
EP1907407A1 (de) * | 2005-07-22 | 2008-04-09 | Giuliani International Limited | Verbesserungen bei 6-thioguanosintriphosphat-analoga, deren verwendung auf dem medizinischen gebiet und verfahren zu deren herstellung |
ITRM20050391A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti analoghi della 6-tioguanosina trifosfato, loro uso in campo medico e procedimento per la loro preparazione. |
US7585868B2 (en) | 2006-04-04 | 2009-09-08 | The Regents Of The University Of California | Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists |
GB0608876D0 (en) | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
US7378401B2 (en) * | 2006-07-14 | 2008-05-27 | Heidelberg Pharma Gmbh | Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases |
BRPI0813709A2 (pt) | 2007-07-09 | 2015-01-06 | Eastern Virginia Med School | Derivados de nucleosídeo substituído com propriedades antiviral e antimicrobiana |
US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
WO2009088990A1 (en) | 2008-01-04 | 2009-07-16 | Intellikine, Inc. | Certain chemical entities, compositions and methods |
US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
WO2009114874A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
WO2010006072A2 (en) | 2008-07-08 | 2010-01-14 | The Regents Of The University Of California | Mtor modulators and uses thereof |
CN102124009B (zh) | 2008-07-08 | 2014-07-23 | 因特利凯公司 | 激酶抑制剂及其使用方法 |
WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
DK2358720T3 (en) | 2008-10-16 | 2016-06-06 | Univ California | Heteroarylkinaseinhibitorer fused-ring |
US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
WO2010129816A2 (en) | 2009-05-07 | 2010-11-11 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
EP2637669A4 (de) | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Heterocyclische verbindungen und ihre verwendung |
NZ612909A (en) | 2011-01-10 | 2015-09-25 | Infinity Pharmaceuticals Inc | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
AR085397A1 (es) | 2011-02-23 | 2013-09-25 | Intellikine Inc | Combinacion de inhibidores de quinasa y sus usos |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
TWI565709B (zh) | 2011-07-19 | 2017-01-11 | 英菲尼提製藥股份有限公司 | 雜環化合物及其用途 |
AR091790A1 (es) | 2011-08-29 | 2015-03-04 | Infinity Pharmaceuticals Inc | Derivados de isoquinolin-1-ona y sus usos |
JP6342805B2 (ja) | 2011-09-02 | 2018-06-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 置換ピラゾロ[3,4−d]ピリミジンおよびその用途 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
SG11201502331RA (en) | 2012-09-26 | 2015-04-29 | Univ California | Modulation of ire1 |
JP6462659B2 (ja) | 2013-03-15 | 2019-01-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 非環式ヌクレオシドホスホン酸ジエステル |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
EA201690713A1 (ru) | 2013-10-04 | 2016-08-31 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2943075C (en) | 2014-03-19 | 2023-02-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
DE102014112055A1 (de) * | 2014-08-22 | 2016-02-25 | Universität Hamburg | Di- und Triphosphat-Propharmaka |
ES2915381T3 (es) | 2014-09-15 | 2022-06-22 | Univ California | Análogos de nucleótidos |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
NZ740616A (en) | 2015-09-14 | 2023-05-26 | Infinity Pharmaceuticals Inc | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
EP3350191B9 (de) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nukleotidanaloga |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
Family Cites Families (12)
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---|---|---|---|---|
DE2930904A1 (de) * | 1979-07-30 | 1981-02-19 | Kailash Kumar Dr Gauri | Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs |
EP0122151B1 (de) * | 1983-04-11 | 1989-02-15 | Meito Sangyo Kabushiki Kaisha | Herstellung von primären oder sekundären Phospholipid-Alkohol-Derivaten durch enzymatische Technik |
US4797479A (en) * | 1985-04-15 | 1989-01-10 | Toyo Jozo Kabushiki Kaisha | Nucleoside-phospholipid conjugate |
EP0262876B1 (de) * | 1986-09-27 | 1992-04-29 | Toyo Jozo Kabushiki Kaisha | Nukleosid-Phospholipid-Konjugat |
JP2796089B2 (ja) * | 1986-10-06 | 1998-09-10 | 旭化成工業株式会社 | リン脂質誘導体の製造法 |
DE3730542A1 (de) * | 1987-09-11 | 1989-04-06 | Hoechst Ag | Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung |
US5463092A (en) * | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
US5563257A (en) * | 1990-08-20 | 1996-10-08 | Boehringer Mannheim Gmbh | Phospholipid derivatives of nucleosides |
DE4026265A1 (de) * | 1990-08-20 | 1992-02-27 | Boehringer Mannheim Gmbh | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
DE4111730A1 (de) * | 1991-04-10 | 1992-10-15 | Knoll Ag | Neue cytarabin-derivate, ihre herstellung und verwendung |
DE4204032A1 (de) * | 1992-02-12 | 1993-08-19 | Boehringer Mannheim Gmbh | Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel |
US5512671A (en) * | 1993-02-16 | 1996-04-30 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
-
1994
- 1994-05-28 DE DE4418690A patent/DE4418690A1/de not_active Withdrawn
-
1995
- 1995-05-23 PT PT02008360T patent/PT1229040E/pt unknown
- 1995-05-23 NZ NZ287434A patent/NZ287434A/en not_active IP Right Cessation
- 1995-05-23 HU HU9603269A patent/HU220336B/hu not_active IP Right Cessation
- 1995-05-23 DK DK02008360T patent/DK1229040T3/da active
- 1995-05-23 MX MX9605809A patent/MX9605809A/es not_active IP Right Cessation
- 1995-05-23 PT PT95920864T patent/PT763049E/pt unknown
- 1995-05-23 AT AT02008360T patent/ATE249472T1/de not_active IP Right Cessation
- 1995-05-23 WO PCT/EP1995/001951 patent/WO1995032984A1/en active IP Right Grant
- 1995-05-23 ES ES95920864T patent/ES2199250T3/es not_active Expired - Lifetime
- 1995-05-23 CN CNB951943715A patent/CN1168735C/zh not_active Expired - Fee Related
- 1995-05-23 KR KR1019960706690A patent/KR100279087B1/ko not_active IP Right Cessation
- 1995-05-23 AU AU26154/95A patent/AU688516B2/en not_active Ceased
- 1995-05-23 RU RU96124383/04A patent/RU2165429C2/ru active
- 1995-05-23 ES ES02008360T patent/ES2206429T3/es not_active Expired - Lifetime
- 1995-05-23 UA UA96114469A patent/UA45339C2/uk unknown
- 1995-05-23 EP EP02008360A patent/EP1229040B8/de not_active Expired - Lifetime
- 1995-05-23 DE DE69530197T patent/DE69530197T2/de not_active Expired - Fee Related
- 1995-05-23 AT AT95920864T patent/ATE236189T1/de not_active IP Right Cessation
- 1995-05-23 DE DE69531749T patent/DE69531749T2/de not_active Expired - Fee Related
- 1995-05-23 CZ CZ19963477A patent/CZ291846B6/cs not_active IP Right Cessation
- 1995-05-23 EP EP95920864A patent/EP0763049B1/de not_active Expired - Lifetime
- 1995-05-23 BR BR9507785A patent/BR9507785A/pt not_active Application Discontinuation
- 1995-05-23 JP JP50026296A patent/JP3802057B2/ja not_active Expired - Fee Related
- 1995-05-23 CA CA002190983A patent/CA2190983C/en not_active Expired - Fee Related
- 1995-05-23 SK SK1518-96A patent/SK284207B6/sk not_active IP Right Cessation
- 1995-05-23 DK DK95920864T patent/DK0763049T3/da active
- 1995-05-24 TW TW084105233A patent/TW420686B/zh active
- 1995-05-25 IL IL113865A patent/IL113865A/en not_active IP Right Cessation
- 1995-05-29 ZA ZA954374A patent/ZA954374B/xx unknown
-
1996
- 1996-11-21 PL PL95317380A patent/PL185290B1/pl not_active IP Right Cessation
- 1996-11-27 FI FI964727A patent/FI117673B/fi active IP Right Grant
- 1996-11-27 US US08/753,633 patent/US6025343A/en not_active Expired - Fee Related
- 1996-11-27 NO NO965054A patent/NO308998B1/no not_active IP Right Cessation
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