FI964727A - Nukleosidimonofosfaattien uudet lipidiesterit ja niiden käyttö immuunivastetta heikentävinä lääkkeinä - Google Patents

Nukleosidimonofosfaattien uudet lipidiesterit ja niiden käyttö immuunivastetta heikentävinä lääkkeinä Download PDF

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Publication number
FI964727A
FI964727A FI964727A FI964727A FI964727A FI 964727 A FI964727 A FI 964727A FI 964727 A FI964727 A FI 964727A FI 964727 A FI964727 A FI 964727A FI 964727 A FI964727 A FI 964727A
Authority
FI
Finland
Prior art keywords
desoxy
chain
immunosuppressive drugs
branched
saturated
Prior art date
Application number
FI964727A
Other languages
English (en)
Swedish (sv)
Other versions
FI964727A0 (fi
FI117673B (fi
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI964727A0 publication Critical patent/FI964727A0/fi
Publication of FI964727A publication Critical patent/FI964727A/fi
Application granted granted Critical
Publication of FI117673B publication Critical patent/FI117673B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI964727A 1994-05-28 1996-11-27 Nukleosidimonofosfaattijohdannaiset, niiden valmistus ja käyttö immuunivastetta heikentävien lääkkeiden valmistukseen FI117673B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
DE4418690 1994-05-28
PCT/EP1995/001951 WO1995032984A1 (en) 1994-05-28 1995-05-23 New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs
EP9501951 1995-05-23

Publications (3)

Publication Number Publication Date
FI964727A0 FI964727A0 (fi) 1996-11-27
FI964727A true FI964727A (fi) 1996-11-27
FI117673B FI117673B (fi) 2007-01-15

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964727A FI117673B (fi) 1994-05-28 1996-11-27 Nukleosidimonofosfaattijohdannaiset, niiden valmistus ja käyttö immuunivastetta heikentävien lääkkeiden valmistukseen

Country Status (27)

Country Link
US (1) US6025343A (fi)
EP (2) EP0763049B1 (fi)
JP (1) JP3802057B2 (fi)
KR (1) KR100279087B1 (fi)
CN (1) CN1168735C (fi)
AT (2) ATE236189T1 (fi)
AU (1) AU688516B2 (fi)
BR (1) BR9507785A (fi)
CA (1) CA2190983C (fi)
CZ (1) CZ291846B6 (fi)
DE (3) DE4418690A1 (fi)
DK (2) DK1229040T3 (fi)
ES (2) ES2199250T3 (fi)
FI (1) FI117673B (fi)
HU (1) HU220336B (fi)
IL (1) IL113865A (fi)
MX (1) MX9605809A (fi)
NO (1) NO308998B1 (fi)
NZ (1) NZ287434A (fi)
PL (1) PL185290B1 (fi)
PT (2) PT763049E (fi)
RU (1) RU2165429C2 (fi)
SK (1) SK284207B6 (fi)
TW (1) TW420686B (fi)
UA (1) UA45339C2 (fi)
WO (1) WO1995032984A1 (fi)
ZA (1) ZA954374B (fi)

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US6881831B2 (en) 2001-05-16 2005-04-19 Migenix Inc. Nucleic acid-based compounds and methods of use thereof
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AU2005321239B2 (en) 2004-12-30 2009-02-12 Medivir Ab Compounds useful in the treatment of HIV
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PT2004654E (pt) 2006-04-04 2013-08-27 Univ California Derivados de pirazolopirimidina para utilização como antagonistas da quinase
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy
US7378401B2 (en) 2006-07-14 2008-05-27 Heidelberg Pharma Gmbh Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
WO2009009625A2 (en) 2007-07-09 2009-01-15 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
AU2009204483B2 (en) 2008-01-04 2014-03-13 Intellikine, Llc Certain chemical entities, compositions and methods
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JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン， エルエルシー キナーゼ阻害剤および使用方法
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US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
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EP2346508B1 (en) 2008-09-26 2016-08-24 Intellikine, LLC Heterocyclic kinase inhibitors
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Also Published As

Publication number Publication date
ES2199250T3 (es) 2004-02-16
ZA954374B (en) 1996-11-29
AU688516B2 (en) 1998-03-12
BR9507785A (pt) 1997-09-23
WO1995032984A1 (en) 1995-12-07
HU9603269D0 (en) 1997-01-28
DE69531749D1 (de) 2003-10-16
NO308998B1 (no) 2000-11-27
DK1229040T3 (da) 2003-12-22
CN1168735C (zh) 2004-09-29
DK0763049T3 (da) 2003-07-28
JP3802057B2 (ja) 2006-07-26
CA2190983C (en) 2006-08-15
ATE236189T1 (de) 2003-04-15
IL113865A0 (en) 1995-08-31
EP1229040A2 (en) 2002-08-07
EP1229040A3 (en) 2002-08-21
CZ347796A3 (en) 1997-04-16
EP1229040B8 (en) 2003-11-05
ES2206429T3 (es) 2004-05-16
NO965054D0 (no) 1996-11-27
SK151896A3 (en) 1997-06-04
FI964727A0 (fi) 1996-11-27
IL113865A (en) 2008-12-29
UA45339C2 (uk) 2002-04-15
EP0763049B1 (en) 2003-04-02
KR970703354A (ko) 1997-07-03
TW420686B (en) 2001-02-01
KR100279087B1 (ko) 2001-01-15
ATE249472T1 (de) 2003-09-15
DE4418690A1 (de) 1996-01-11
CZ291846B6 (cs) 2003-06-18
JPH10500964A (ja) 1998-01-27
HU220336B (hu) 2001-12-28
DE69530197D1 (de) 2003-05-08
SK284207B6 (en) 2004-11-03
CA2190983A1 (en) 1995-12-07
PT763049E (pt) 2003-08-29
NZ287434A (en) 1998-01-26
HUT75340A (en) 1997-05-28
NO965054L (no) 1997-01-28
EP1229040B1 (en) 2003-09-10
WO1995032984A8 (en) 2003-01-16
PT1229040E (pt) 2003-12-31
AU2615495A (en) 1995-12-21
DE69530197T2 (de) 2004-01-29
EP0763049A1 (en) 1997-03-19
PL317380A1 (en) 1997-04-01
FI117673B (fi) 2007-01-15
MX9605809A (es) 1997-12-31
US6025343A (en) 2000-02-15
RU2165429C2 (ru) 2001-04-20
PL185290B1 (pl) 2003-04-30
DE69531749T2 (de) 2004-07-29
CN1154111A (zh) 1997-07-09

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