DE69530197D1 - Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel - Google Patents

Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel

Info

Publication number
DE69530197D1
DE69530197D1 DE69530197T DE69530197T DE69530197D1 DE 69530197 D1 DE69530197 D1 DE 69530197D1 DE 69530197 T DE69530197 T DE 69530197T DE 69530197 T DE69530197 T DE 69530197T DE 69530197 D1 DE69530197 D1 DE 69530197D1
Authority
DE
Germany
Prior art keywords
desoxy
chain
nucleoside monophosphate
immunsuppresive
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530197T
Other languages
English (en)
Other versions
DE69530197T2 (de
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heidelberg Pharma Holding GmbH
Original Assignee
Heidelberg Pharma Holding GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Holding GmbH filed Critical Heidelberg Pharma Holding GmbH
Priority to DE69530197T priority Critical patent/DE69530197T2/de
Application granted granted Critical
Publication of DE69530197D1 publication Critical patent/DE69530197D1/de
Publication of DE69530197T2 publication Critical patent/DE69530197T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69530197T 1994-05-28 1995-05-23 Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel Expired - Fee Related DE69530197T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69530197T DE69530197T2 (de) 1994-05-28 1995-05-23 Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
PCT/EP1995/001951 WO1995032984A1 (en) 1994-05-28 1995-05-23 New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs
DE69530197T DE69530197T2 (de) 1994-05-28 1995-05-23 Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel

Publications (2)

Publication Number Publication Date
DE69530197D1 true DE69530197D1 (de) 2003-05-08
DE69530197T2 DE69530197T2 (de) 2004-01-29

Family

ID=6519215

Family Applications (3)

Application Number Title Priority Date Filing Date
DE4418690A Withdrawn DE4418690A1 (de) 1994-05-26 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
DE69531749T Expired - Fee Related DE69531749T2 (de) 1994-05-28 1995-05-23 Nukleosid-Monophosphatderivate, Verfahren zu deren Herstellung sowie deren Verwendung als Immunsuppressive Arzneimittel
DE69530197T Expired - Fee Related DE69530197T2 (de) 1994-05-28 1995-05-23 Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE4418690A Withdrawn DE4418690A1 (de) 1994-05-26 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
DE69531749T Expired - Fee Related DE69531749T2 (de) 1994-05-28 1995-05-23 Nukleosid-Monophosphatderivate, Verfahren zu deren Herstellung sowie deren Verwendung als Immunsuppressive Arzneimittel

Country Status (27)

Country Link
US (1) US6025343A (de)
EP (2) EP1229040B8 (de)
JP (1) JP3802057B2 (de)
KR (1) KR100279087B1 (de)
CN (1) CN1168735C (de)
AT (2) ATE249472T1 (de)
AU (1) AU688516B2 (de)
BR (1) BR9507785A (de)
CA (1) CA2190983C (de)
CZ (1) CZ291846B6 (de)
DE (3) DE4418690A1 (de)
DK (2) DK1229040T3 (de)
ES (2) ES2206429T3 (de)
FI (1) FI117673B (de)
HU (1) HU220336B (de)
IL (1) IL113865A (de)
MX (1) MX9605809A (de)
NO (1) NO308998B1 (de)
NZ (1) NZ287434A (de)
PL (1) PL185290B1 (de)
PT (2) PT763049E (de)
RU (1) RU2165429C2 (de)
SK (1) SK284207B6 (de)
TW (1) TW420686B (de)
UA (1) UA45339C2 (de)
WO (1) WO1995032984A1 (de)
ZA (1) ZA954374B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
JP3839857B2 (ja) * 1994-09-20 2006-11-01 塩野義製薬株式会社 エーテル型チオリン脂質化合物の製造方法
CN1195768C (zh) * 1994-12-13 2005-04-06 松田彰 3’－取代的核苷衍生物
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
KR100618028B1 (ko) 1998-11-05 2006-08-30 쌍트르 나쉬오날 드 라 르쉐르스 쉬앙티피끄 항-ｂ형 간염 활성을 가진 뉴클레오시드
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
DE19855963A1 (de) * 1998-12-04 2000-06-08 Herbert Schott Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
CA2390441A1 (en) 1999-11-08 2001-05-17 Origenix Technologies, Inc. Combinatorial library synthesis and pharmaceutically active compounds produced thereby
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
US6734294B2 (en) * 2001-01-22 2004-05-11 Chad C. Nelson Isotopically enriched nucleic acids and associated methods for the production and purification thereof
WO2002092006A2 (en) 2001-05-16 2002-11-21 Micrologix Biotech, Inc. Nucleic acid-based compounds and methods of use thereof
US20050090659A1 (en) * 2001-11-21 2005-04-28 Dieter Herrmann Phospholepid derivatives of nucleosides as antitumaorl medicaments
JP2008520744A (ja) 2004-11-19 2008-06-19 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗炎症性ピラゾロピリミジン
ES2401285T3 (es) * 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
ATE427110T1 (de) 2004-12-30 2009-04-15 Medivir Ab Verbindungen zur behandlung von hiv
GB0505781D0 (en) 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
CA2615980A1 (en) * 2005-07-22 2007-01-25 Giuliani International Limited Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation
ITRM20050391A1 (it) * 2005-07-22 2007-01-23 Giuliani Spa Composti analoghi della 6-tioguanosina trifosfato, loro uso in campo medico e procedimento per la loro preparazione.
EA019961B1 (ru) 2006-04-04 2014-07-30 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Антагонисты киназы
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy
US7378401B2 (en) * 2006-07-14 2008-05-27 Heidelberg Pharma Gmbh Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
EP2175863B1 (de) 2007-07-09 2018-03-21 Eastern Virginia Medical School Substituierte nukleosidderivate mit antiviralen und antimikrobiellen eigenschaften
US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
JP5869222B2 (ja) 2008-01-04 2016-02-24 インテリカイン， エルエルシー 特定の化学的実体、組成物および方法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2252293B1 (de) 2008-03-14 2018-06-27 Intellikine, LLC Kinasehemmer und verwendungsverfahren
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US9096611B2 (en) 2008-07-08 2015-08-04 Intellikine Llc Kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
JP5731978B2 (ja) 2008-09-26 2015-06-10 インテリカイン， エルエルシー 複素環キナーゼ阻害剤
ES2570429T3 (es) 2008-10-16 2016-05-18 Univ California Inhibidores de heteroaril quinasa de anillo condensado
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
EP2427195B1 (de) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclische verbindungen und ihre verwendung
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
US8604032B2 (en) 2010-05-21 2013-12-10 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
AU2011326427B2 (en) 2010-11-10 2016-01-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
UA115767C2 (uk) 2011-01-10 2017-12-26 Інфініті Фармасьютікалз, Інк. Способи отримання ізохінолінонів і тверді форми ізохінолінонів
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
AU2012284088B2 (en) 2011-07-19 2015-10-08 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
CA2846431A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
AU2012341028C1 (en) 2011-09-02 2017-10-19 Mount Sinai School Of Medicine Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
MX2015003874A (es) 2012-09-26 2015-12-16 Univ California Modulacion de ire1.
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
PL2970346T3 (pl) 2013-03-15 2019-02-28 The Regents Of The University Of California Acykliczne diestry fosfonianowe nukleozydów
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN105793255B (zh) 2013-10-04 2018-11-16 无限药品股份有限公司 杂环化合物及其用途
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
DE102014112055A1 (de) * 2014-08-22 2016-02-25 Universität Hamburg Di- und Triphosphat-Propharmaka
PT3194411T (pt) 2014-09-15 2022-06-06 Univ California Análogos de nucleótidos
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20180058741A (ko) 2015-09-14 2018-06-01 인피니티 파마슈티칼스, 인코포레이티드 이소퀴놀리논의 고체형, 그의 제조 방법, 이를 포함하는 조성물 및 이를 사용하는 방법
EP3350191B9 (de) 2015-09-15 2021-12-22 The Regents of the University of California Nukleotidanaloga
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20190033526A (ko) 2016-06-24 2019-03-29 인피니티 파마슈티칼스, 인코포레이티드 병용 요법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2930904A1 (de) * 1979-07-30 1981-02-19 Kailash Kumar Dr Gauri Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs
US4783402A (en) * 1983-04-11 1988-11-08 Meito Sangyo Kabushiki Kaisha Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
US4797479A (en) * 1985-04-15 1989-01-10 Toyo Jozo Kabushiki Kaisha Nucleoside-phospholipid conjugate
EP0262876B1 (de) * 1986-09-27 1992-04-29 Toyo Jozo Kabushiki Kaisha Nukleosid-Phospholipid-Konjugat
JP2796089B2 (ja) * 1986-10-06 1998-09-10 旭化成工業株式会社 リン脂質誘導体の製造法
DE3730542A1 (de) * 1987-09-11 1989-04-06 Hoechst Ag Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung
US5463092A (en) * 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
DE4026265A1 (de) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
US5563257A (en) * 1990-08-20 1996-10-08 Boehringer Mannheim Gmbh Phospholipid derivatives of nucleosides
DE4111730A1 (de) * 1991-04-10 1992-10-15 Knoll Ag Neue cytarabin-derivate, ihre herstellung und verwendung
DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
US5512671A (en) * 1993-02-16 1996-04-30 Wake Forest University Ether lipid-nucleoside covalent conjugates

Also Published As

Publication number Publication date
IL113865A0 (en) 1995-08-31
RU2165429C2 (ru) 2001-04-20
JPH10500964A (ja) 1998-01-27
NO965054L (no) 1997-01-28
TW420686B (en) 2001-02-01
CZ347796A3 (en) 1997-04-16
NO308998B1 (no) 2000-11-27
BR9507785A (pt) 1997-09-23
AU688516B2 (en) 1998-03-12
DE69531749T2 (de) 2004-07-29
CN1154111A (zh) 1997-07-09
ZA954374B (en) 1996-11-29
FI964727A (fi) 1996-11-27
FI964727A0 (fi) 1996-11-27
HU220336B (hu) 2001-12-28
HU9603269D0 (en) 1997-01-28
ATE236189T1 (de) 2003-04-15
CZ291846B6 (cs) 2003-06-18
DE69530197T2 (de) 2004-01-29
CN1168735C (zh) 2004-09-29
WO1995032984A8 (en) 2003-01-16
CA2190983C (en) 2006-08-15
SK284207B6 (en) 2004-11-03
PT763049E (pt) 2003-08-29
CA2190983A1 (en) 1995-12-07
KR100279087B1 (ko) 2001-01-15
IL113865A (en) 2008-12-29
ES2206429T3 (es) 2004-05-16
NO965054D0 (no) 1996-11-27
ES2199250T3 (es) 2004-02-16
UA45339C2 (uk) 2002-04-15
NZ287434A (en) 1998-01-26
DK0763049T3 (da) 2003-07-28
EP0763049A1 (de) 1997-03-19
EP0763049B1 (de) 2003-04-02
PL185290B1 (pl) 2003-04-30
PT1229040E (pt) 2003-12-31
MX9605809A (es) 1997-12-31
US6025343A (en) 2000-02-15
HUT75340A (en) 1997-05-28
PL317380A1 (en) 1997-04-01
EP1229040B8 (de) 2003-11-05
DK1229040T3 (da) 2003-12-22
AU2615495A (en) 1995-12-21
KR970703354A (ko) 1997-07-03
WO1995032984A1 (en) 1995-12-07
EP1229040A2 (de) 2002-08-07
ATE249472T1 (de) 2003-09-15
FI117673B (fi) 2007-01-15
EP1229040A3 (de) 2002-08-21
DE69531749D1 (de) 2003-10-16
SK151896A3 (en) 1997-06-04
JP3802057B2 (ja) 2006-07-26
DE4418690A1 (de) 1996-01-11
EP1229040B1 (de) 2003-09-10

Similar Documents

Publication Publication Date Title
DE69530197T2 (de) Nukleosid-monophosphatderivate, verfahren zu deren herstellung sowie deren verwendung als immunsuppresive arzneimittel
ATE25974T1 (de) Acyl-substituierte derivate von 1,2,3,4tetrahydroisochinolin-3-carboxysaeuren, ihre salze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung.
ATE126216T1 (de) Pyrazolderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellung.
KR940019701A (ko) N-헤테로아릴-n'-페닐우레아 유도체, 그의 제조방법 및 용도
ES514267A0 (es) "un procedimiento para la preparacion de derivados de pirrolidina".
DE3677798D1 (de) Aminosaeurederivate und deren verfahren zur herstellung.
OA09454A (fr) Nouveaux dérivés peptidiques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
OA09349A (fr) "Nouveaux dérivés du 3-aminochromane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent".
ATE165822T1 (de) Chinolin-4-carbonylguanidin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
NO178025C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive (benzhydryloksyetylpiperidyl)alifatiske syrederivater
DE3574471D1 (de) 1,6-naphthyridin-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
PT88088A (pt) Processo para a preparacao de derivados de piperidina e de composicoes farmaceuticas que os contem
HUT40793A (en) Process for preparing hexene-carboxylic acid derivatives
ATE198746T1 (de) Pyrimidinderivate und pharmazeutische zusammensetzungen
KR920701232A (ko) 신규 9α-히드록시-3-옥소-4,24(25)-스티그마스타디엔-26-산 유도체, 이의 제조법 및 이를 함유하는 약학 조성물
PT88462A (pt) Process for the preparation of macrolide compounds and of compositions containing them
DE3482324D1 (de) Verbindung mit entzuendungshemmender wirkung, verfahren zu ihrer herstellung und pharmazeutische praeparate die sie enthalten.
DE3884518D1 (de) Naphthothiazepin-derivate und verfahren zu ihrer herstellung.
KR880013900A (ko) 3-아실아미노메틸-5,6,7,8-테트라히드로이미다조[1,2-a]피리딘유도체 그의 제법 및 치료에의 응용
HUT54371A (en) Process for producing macrolide compounds and pharmaceutical compositions containing them as active components
DE69327092D1 (de) Optisch aktives 1-phenylpyrrolidonderivat und dessen herstellung
ATE115132T1 (de) Derivate des 1,2,5,6-tetrahydropyridin-3- caboxaldehydoxims, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
PT86422A (fr) Procede de preparation de derives d:acide dibenzo]be"-oxepine-acetique et de compositions pharmaceutiques les contenant
DE3784883D1 (de) Fluor enthaltende makrolid-verbindungen, pharmazeutische zusammensetzungen, welche diese enthalten und ihre verwendung fuer die herstellung von arzneimitteln.
JO1870B1 (en) CO2 derivatives - pyridinyl benzimidazole innovative

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee