NO965054L - Nye lipidestere av nukleosidmonofosfater og deres anvendelse som immunundertrykkende legemidler - Google Patents

Nye lipidestere av nukleosidmonofosfater og deres anvendelse som immunundertrykkende legemidler

Info

Publication number
NO965054L
NO965054L NO965054A NO965054A NO965054L NO 965054 L NO965054 L NO 965054L NO 965054 A NO965054 A NO 965054A NO 965054 A NO965054 A NO 965054A NO 965054 L NO965054 L NO 965054L
Authority
NO
Norway
Prior art keywords
desoxy
chain
immunosuppressants
branched
saturated
Prior art date
Application number
NO965054A
Other languages
English (en)
Other versions
NO308998B1 (no
NO965054D0 (no
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO965054D0 publication Critical patent/NO965054D0/no
Publication of NO965054L publication Critical patent/NO965054L/no
Publication of NO308998B1 publication Critical patent/NO308998B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO965054A 1994-05-28 1996-11-27 Nukleosidmonofosfatderivater og deres anvendelse for fremstilling av legemidler NO308998B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
PCT/EP1995/001951 WO1995032984A1 (en) 1994-05-28 1995-05-23 New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs

Publications (3)

Publication Number Publication Date
NO965054D0 NO965054D0 (no) 1996-11-27
NO965054L true NO965054L (no) 1997-01-28
NO308998B1 NO308998B1 (no) 2000-11-27

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
NO965054A NO308998B1 (no) 1994-05-28 1996-11-27 Nukleosidmonofosfatderivater og deres anvendelse for fremstilling av legemidler

Country Status (27)

Country Link
US (1) US6025343A (no)
EP (2) EP0763049B1 (no)
JP (1) JP3802057B2 (no)
KR (1) KR100279087B1 (no)
CN (1) CN1168735C (no)
AT (2) ATE249472T1 (no)
AU (1) AU688516B2 (no)
BR (1) BR9507785A (no)
CA (1) CA2190983C (no)
CZ (1) CZ291846B6 (no)
DE (3) DE4418690A1 (no)
DK (2) DK0763049T3 (no)
ES (2) ES2206429T3 (no)
FI (1) FI117673B (no)
HU (1) HU220336B (no)
IL (1) IL113865A (no)
MX (1) MX9605809A (no)
NO (1) NO308998B1 (no)
NZ (1) NZ287434A (no)
PL (1) PL185290B1 (no)
PT (2) PT763049E (no)
RU (1) RU2165429C2 (no)
SK (1) SK284207B6 (no)
TW (1) TW420686B (no)
UA (1) UA45339C2 (no)
WO (1) WO1995032984A1 (no)
ZA (1) ZA954374B (no)

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US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
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US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
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US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
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US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
WO2006066074A2 (en) * 2004-12-16 2006-06-22 The Regents Of The University Of California Lung-targeted drugs
CA2594229A1 (en) 2004-12-30 2006-07-06 Medivir Ab 2',3'-dideoxy-3'-c-hyroxymethylcytidine and prodrugs thereof for the treatment of drug escape mutant hiv
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US20080032960A1 (en) 2006-04-04 2008-02-07 Regents Of The University Of California PI3 kinase antagonists
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy
US7378401B2 (en) 2006-07-14 2008-05-27 Heidelberg Pharma Gmbh Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
CN101835374B (zh) 2007-07-09 2014-08-27 东弗吉尼亚医学院 具有抗病毒和抗微生物性质的取代的核苷衍生物
WO2009046448A1 (en) 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
NZ613219A (en) 2008-01-04 2014-11-28 Intellikine Llc Heterocyclic containing entities, compositions and methods
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
JP5547099B2 (ja) 2008-03-14 2014-07-09 インテリカイン， エルエルシー キナーゼ阻害剤および使用方法
CN102124009B (zh) 2008-07-08 2014-07-23 因特利凯公司 激酶抑制剂及其使用方法
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
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AU2009305669A1 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
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US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
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EP2751112B1 (en) 2011-09-02 2019-10-09 The Regents of The University of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
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JP2015532287A (ja) 2012-09-26 2015-11-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア Ｉｒｅ１の調節
BR112015023705A8 (pt) 2013-03-15 2020-03-17 Univ California compostos, composições farmacêuticas, usos de um composto, e método para síntese do composto da fórmula (ia)
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Also Published As

Publication number Publication date
DE69530197D1 (de) 2003-05-08
CN1168735C (zh) 2004-09-29
CA2190983A1 (en) 1995-12-07
EP0763049B1 (en) 2003-04-02
FI964727A (fi) 1996-11-27
HU220336B (hu) 2001-12-28
AU2615495A (en) 1995-12-21
FI964727A0 (fi) 1996-11-27
DK1229040T3 (da) 2003-12-22
FI117673B (fi) 2007-01-15
DE69531749D1 (de) 2003-10-16
JPH10500964A (ja) 1998-01-27
EP1229040B1 (en) 2003-09-10
HU9603269D0 (en) 1997-01-28
RU2165429C2 (ru) 2001-04-20
US6025343A (en) 2000-02-15
EP1229040A2 (en) 2002-08-07
TW420686B (en) 2001-02-01
SK284207B6 (en) 2004-11-03
AU688516B2 (en) 1998-03-12
CN1154111A (zh) 1997-07-09
NO308998B1 (no) 2000-11-27
ES2199250T3 (es) 2004-02-16
PL317380A1 (en) 1997-04-01
EP0763049A1 (en) 1997-03-19
NO965054D0 (no) 1996-11-27
HUT75340A (en) 1997-05-28
DK0763049T3 (da) 2003-07-28
SK151896A3 (en) 1997-06-04
ZA954374B (en) 1996-11-29
UA45339C2 (uk) 2002-04-15
JP3802057B2 (ja) 2006-07-26
KR100279087B1 (ko) 2001-01-15
MX9605809A (es) 1997-12-31
PT763049E (pt) 2003-08-29
DE4418690A1 (de) 1996-01-11
IL113865A (en) 2008-12-29
CA2190983C (en) 2006-08-15
EP1229040A3 (en) 2002-08-21
WO1995032984A1 (en) 1995-12-07
DE69531749T2 (de) 2004-07-29
IL113865A0 (en) 1995-08-31
WO1995032984A8 (en) 2003-01-16
CZ347796A3 (en) 1997-04-16
EP1229040B8 (en) 2003-11-05
PT1229040E (pt) 2003-12-31
CZ291846B6 (cs) 2003-06-18
PL185290B1 (pl) 2003-04-30
ATE236189T1 (de) 2003-04-15
ATE249472T1 (de) 2003-09-15
BR9507785A (pt) 1997-09-23
NZ287434A (en) 1998-01-26
DE69530197T2 (de) 2004-01-29
ES2206429T3 (es) 2004-05-16
KR970703354A (ko) 1997-07-03

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