IT1188654B - Coniugato nucleo side-fosfolipide - Google Patents

Coniugato nucleo side-fosfolipide

Info

Publication number
IT1188654B
IT1188654B IT20090/86A IT2009086A IT1188654B IT 1188654 B IT1188654 B IT 1188654B IT 20090/86 A IT20090/86 A IT 20090/86A IT 2009086 A IT2009086 A IT 2009086A IT 1188654 B IT1188654 B IT 1188654B
Authority
IT
Italy
Prior art keywords
core conjugate
phospholipid core
phospholipid
conjugate
core
Prior art date
Application number
IT20090/86A
Other languages
English (en)
Other versions
IT8620090A1 (it
IT8620090A0 (it
Inventor
Shuto Satoshi
Itoh Hiromichi
Fukukawa Kiyofumi
Sakakibara Hideo
Tsujino Masatoshi
Original Assignee
Toyo Jozo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7828385A external-priority patent/JPS61236793A/ja
Priority claimed from JP23769585A external-priority patent/JPS6299393A/ja
Application filed by Toyo Jozo Kk filed Critical Toyo Jozo Kk
Publication of IT8620090A0 publication Critical patent/IT8620090A0/it
Publication of IT8620090A1 publication Critical patent/IT8620090A1/it
Application granted granted Critical
Publication of IT1188654B publication Critical patent/IT1188654B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
IT20090/86A 1985-04-15 1986-04-15 Coniugato nucleo side-fosfolipide IT1188654B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7828385A JPS61236793A (ja) 1985-04-15 1985-04-15 新規リン脂質・ヌクレオシド誘導体
JP23769585A JPS6299393A (ja) 1985-10-25 1985-10-25 新規アラビノヌクレオシド−リン脂質複合体

Publications (3)

Publication Number Publication Date
IT8620090A0 IT8620090A0 (it) 1986-04-15
IT8620090A1 IT8620090A1 (it) 1987-10-15
IT1188654B true IT1188654B (it) 1988-01-20

Family

ID=26419358

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20090/86A IT1188654B (it) 1985-04-15 1986-04-15 Coniugato nucleo side-fosfolipide

Country Status (5)

Country Link
US (1) US4797479A (it)
DE (1) DE3612636C2 (it)
FR (1) FR2580283B1 (it)
GB (1) GB2175588B (it)
IT (1) IT1188654B (it)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106963A (en) * 1984-12-28 1992-04-21 Miles, Inc., Successor In Interest To Technicon Instruments Corp. Phospholipid conjugates and their preparation
US6448392B1 (en) * 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5187266A (en) * 1986-06-30 1993-02-16 Board Of Regents The University Of Texas System Antitumor aldophosphamide glycoside and dideoxyuridine derivatives
US4737295A (en) * 1986-07-21 1988-04-12 Venture Chemicals, Inc. Organophilic polyphenolic acid adducts
DE3778626D1 (de) * 1986-09-27 1992-06-04 Toyo Jozo Kk Nukleosid-phospholipid-konjugat.
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
JPH0421694A (ja) * 1990-05-16 1992-01-24 Asahi Chem Ind Co Ltd 新規なヌクレオシド―リン脂質複合体
CA2083961A1 (en) * 1990-05-29 1991-11-30 Henk Van Den Bosch Synthesis of glycerol di- and triphosphate derivatives
CA2085354C (en) * 1990-06-15 2002-08-27 Claude Piantadosi Ether lipid-nucleoside covalent conjugates
JPH04364198A (ja) * 1991-04-04 1992-12-16 Asahi Chem Ind Co Ltd ５’−ホスファチジル−５−フルオロウリジン誘導体
US5512671A (en) * 1993-02-16 1996-04-30 Wake Forest University Ether lipid-nucleoside covalent conjugates
WO1994018987A1 (en) * 1993-02-19 1994-09-01 Nippon Shinyaku Co., Ltd. Drug composition containing nucleic acid copolymer
DE69431596D1 (de) * 1993-06-10 2002-11-28 Wake Forest University Winston (phospho)lipide zum bekämpfen einer hepatitis b-infektion
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
ATE395922T1 (de) * 1994-08-29 2008-06-15 Univ Wake Forest Lipid-analoge zur behandlung von viralen infektionen
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
KR20030041130A (ko) * 2001-05-29 2003-05-23 코닌클리케 필립스 일렉트로닉스 엔.브이. 금속-세라믹 접착
CN100469131C (zh) * 2001-08-31 2009-03-11 汤姆森许可公司 实现条件存取系统和传输、接收及处理内容的方法和设备
WO2004012746A2 (en) * 2002-08-02 2004-02-12 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
EP1426053A1 (en) * 2002-12-03 2004-06-09 Fresenius Kabi Deutschland GmbH Use of amphiphilic lipids for reducing tumor metastasis
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
JP5320284B2 (ja) * 2006-05-03 2013-10-23 キメリクス，インコーポレーテッド 抗ウイルス性または抗増殖性のホスホネート、ヌクレオシドホスホネートおよびヌクレオシドホスフェートの代謝安定性アルコキシアルキルエステル

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291024A (en) * 1978-04-10 1981-09-22 Turcotte Joseph G Cytotoxic liponucleotide analogs
US4471113A (en) * 1982-02-03 1984-09-11 The United States Of America As Represented By The Department Of Energy Prodrugs based on phospholipid-nucleoside conjugates
DE3476770D1 (en) * 1983-04-11 1989-03-23 Meito Sangyo Kk Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique

Also Published As

Publication number Publication date
GB8609112D0 (en) 1986-05-21
GB2175588B (en) 1988-08-10
DE3612636C2 (de) 1993-11-18
IT8620090A1 (it) 1987-10-15
FR2580283A1 (fr) 1986-10-17
DE3612636A1 (de) 1986-11-06
GB2175588A (en) 1986-12-03
US4797479A (en) 1989-01-10
FR2580283B1 (fr) 1989-11-24
IT8620090A0 (it) 1986-04-15

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950428