FR2580283B1 - Nouveau conjugue nucleoside-phospholipide - Google Patents

Nouveau conjugue nucleoside-phospholipide

Info

Publication number
FR2580283B1
FR2580283B1 FR8605371A FR8605371A FR2580283B1 FR 2580283 B1 FR2580283 B1 FR 2580283B1 FR 8605371 A FR8605371 A FR 8605371A FR 8605371 A FR8605371 A FR 8605371A FR 2580283 B1 FR2580283 B1 FR 2580283B1
Authority
FR
France
Prior art keywords
phospholipide
conjugate
new nucleoside
nucleoside
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8605371A
Other languages
English (en)
Other versions
FR2580283A1 (fr
Inventor
Satoshi Shuto
Hiromichi Itoh
Kiyofumi Fukukawa
Hideo Sakakibara
Masatoshi Tsujino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7828385A external-priority patent/JPS61236793A/ja
Priority claimed from JP23769585A external-priority patent/JPS6299393A/ja
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Publication of FR2580283A1 publication Critical patent/FR2580283A1/fr
Application granted granted Critical
Publication of FR2580283B1 publication Critical patent/FR2580283B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR8605371A 1985-04-15 1986-04-15 Nouveau conjugue nucleoside-phospholipide Expired FR2580283B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7828385A JPS61236793A (ja) 1985-04-15 1985-04-15 新規リン脂質・ヌクレオシド誘導体
JP23769585A JPS6299393A (ja) 1985-10-25 1985-10-25 新規アラビノヌクレオシド−リン脂質複合体

Publications (2)

Publication Number Publication Date
FR2580283A1 FR2580283A1 (fr) 1986-10-17
FR2580283B1 true FR2580283B1 (fr) 1989-11-24

Family

ID=26419358

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8605371A Expired FR2580283B1 (fr) 1985-04-15 1986-04-15 Nouveau conjugue nucleoside-phospholipide

Country Status (5)

Country Link
US (1) US4797479A (fr)
DE (1) DE3612636C2 (fr)
FR (1) FR2580283B1 (fr)
GB (1) GB2175588B (fr)
IT (1) IT1188654B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106963A (en) * 1984-12-28 1992-04-21 Miles, Inc., Successor In Interest To Technicon Instruments Corp. Phospholipid conjugates and their preparation
US6448392B1 (en) * 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US5187266A (en) * 1986-06-30 1993-02-16 Board Of Regents The University Of Texas System Antitumor aldophosphamide glycoside and dideoxyuridine derivatives
US4737295A (en) * 1986-07-21 1988-04-12 Venture Chemicals, Inc. Organophilic polyphenolic acid adducts
DE3778626D1 (de) * 1986-09-27 1992-06-04 Toyo Jozo Kk Nukleosid-phospholipid-konjugat.
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
JPH0421694A (ja) * 1990-05-16 1992-01-24 Asahi Chem Ind Co Ltd 新規なヌクレオシド―リン脂質複合体
CA2083961A1 (fr) * 1990-05-29 1991-11-30 Henk Van Den Bosch Synthese de derives de di- et de triphosphate de glycerol
AU660417B2 (en) * 1990-06-15 1995-06-29 University Of North Carolina At Chapel Hill, The Ether lipid-nucleoside covalent conjugates
JPH04364198A (ja) * 1991-04-04 1992-12-16 Asahi Chem Ind Co Ltd ５’−ホスファチジル−５−フルオロウリジン誘導体
US5512671A (en) * 1993-02-16 1996-04-30 Wake Forest University Ether lipid-nucleoside covalent conjugates
EP0685234B1 (fr) * 1993-02-19 2000-05-10 Nippon Shinyaku Company, Limited Composition pharmaceutique contenant un copolymere d'acide nucleique
EP0702556B1 (fr) * 1993-06-10 2002-10-23 Wake Forest University (phospho)lipides contre l'infection a virus de l'hepatite b
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
WO1996006620A2 (fr) * 1994-08-29 1996-03-07 Wake Forest University Analogues de lipides pour le traitement d'infections virales
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
JP2004520175A (ja) * 2001-05-29 2004-07-08 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 金属−セラミック接合
US7551837B2 (en) * 2001-08-31 2009-06-23 Thomson Licensing Sequence counter for an audio visual stream
US20040127435A1 (en) * 2002-08-02 2004-07-01 Regents Of The University Of California Uses for inhibitors of inosine monophosphate dehydrogenase
EP1426053A1 (fr) * 2002-12-03 2004-06-09 Fresenius Kabi Deutschland GmbH Utilisation de lipides amphiphiles pour l'inhibition de métastases
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
US7749983B2 (en) * 2006-05-03 2010-07-06 Chimerix, Inc. Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
AU2020334152A1 (en) 2019-08-22 2022-03-24 Emory University Nucleoside prodrugs and uses related thereto

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291024A (en) * 1978-04-10 1981-09-22 Turcotte Joseph G Cytotoxic liponucleotide analogs
US4471113A (en) * 1982-02-03 1984-09-11 The United States Of America As Represented By The Department Of Energy Prodrugs based on phospholipid-nucleoside conjugates
EP0122151B1 (fr) * 1983-04-11 1989-02-15 Meito Sangyo Kabushiki Kaisha Production de dérivés phospholipidiques d'alcools primaires ou secondaires par la technique enzymatique

Also Published As

Publication number Publication date
FR2580283A1 (fr) 1986-10-17
IT1188654B (it) 1988-01-20
IT8620090A1 (it) 1987-10-15
GB2175588B (en) 1988-08-10
GB2175588A (en) 1986-12-03
DE3612636A1 (de) 1986-11-06
GB8609112D0 (en) 1986-05-21
IT8620090A0 (it) 1986-04-15
DE3612636C2 (de) 1993-11-18
US4797479A (en) 1989-01-10

Similar Documents

Publication Publication Date Title
FR2580283B1 (fr) Nouveau conjugue nucleoside-phospholipide
DK268786A (da) Pyranopyridiner
MX162970B (es) Banda dentada mejorada
DK178687A (da) Antikonvulsivt praeparat
DK109186A (da) Dihydropyridazinonderivater
DK281886A (da) Glycerinderivater
DK552986D0 (da) Faststof-koblingskredslaeb
DK491786A (da) Dichloranilinderivater
BR8606663A (pt) Derivados de triazolil-quinolina
DK556386A (da) Quinilinderivater
DK303886A (da) Secocanthinderivater
NO171144C (no) Benfiskeringssystem
DE3662889D1 (de) Tetrahydrofurancarboxylic-acid derivatives
KR880700821A (ko) 데--데옥시테이코플라닌 유도체
NO171093C (no) Detergensutmatningsapparatur
DK109086D0 (da) 2-aminopyrimidinonderivater
NO170203C (no) Fortoeyningsinnretning
DE3662890D1 (de) Furobenzisoxazole derivatives
FR2579299B1 (fr) Disp
ES290379Y (es) Pesario mejorado
ES290246Y (es) Mondadientes mejorado
KR870002035U (ko) 개량된 스케치북
ES287303Y (es) Caja-cesta plegable
ES286557Y (es) Nueva bolsa-maleta
ES290786Y (es) Expositor mejorado

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse