DE3778626D1 - Nukleosid-phospholipid-konjugat. - Google Patents

Nukleosid-phospholipid-konjugat.

Info

Publication number
DE3778626D1
DE3778626D1 DE8787308497T DE3778626T DE3778626D1 DE 3778626 D1 DE3778626 D1 DE 3778626D1 DE 8787308497 T DE8787308497 T DE 8787308497T DE 3778626 T DE3778626 T DE 3778626T DE 3778626 D1 DE3778626 D1 DE 3778626D1
Authority
DE
Germany
Prior art keywords
phospholipid conjugate
nucleoside
nucleoside phospholipid
conjugate
phospholipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787308497T
Other languages
English (en)
Inventor
Satoshi Shuto
Hiromichi Itoh
Kiyofumi Fukukawa
Masatoshi Tujino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP22920386A external-priority patent/JPS6383093A/ja
Priority claimed from JP22920486A external-priority patent/JPS6383094A/ja
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Application granted granted Critical
Publication of DE3778626D1 publication Critical patent/DE3778626D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
DE8787308497T 1986-09-27 1987-09-25 Nukleosid-phospholipid-konjugat. Expired - Lifetime DE3778626D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22920386A JPS6383093A (ja) 1986-09-27 1986-09-27 ヌクレオシド−リン脂質複合体
JP22920486A JPS6383094A (ja) 1986-09-27 1986-09-27 エ−テル型ヌクレオシド−リン脂質複合体

Publications (1)

Publication Number Publication Date
DE3778626D1 true DE3778626D1 (de) 1992-06-04

Family

ID=26528684

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787308497T Expired - Lifetime DE3778626D1 (de) 1986-09-27 1987-09-25 Nukleosid-phospholipid-konjugat.

Country Status (3)

Country Link
US (2) US4921951A (de)
EP (1) EP0262876B1 (de)
DE (1) DE3778626D1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106963A (en) * 1984-12-28 1992-04-21 Miles, Inc., Successor In Interest To Technicon Instruments Corp. Phospholipid conjugates and their preparation
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
DE3778626D1 (de) * 1986-09-27 1992-06-04 Toyo Jozo Kk Nukleosid-phospholipid-konjugat.
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
CA2004695C (en) * 1988-12-12 1999-08-10 Rosanne Bonjouklian Phospholipid nucleosides
IE980216A1 (en) * 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals
JPH0421694A (ja) * 1990-05-16 1992-01-24 Asahi Chem Ind Co Ltd 新規なヌクレオシド―リン脂質複合体
CA2083961A1 (en) * 1990-05-29 1991-11-30 Henk Van Den Bosch Synthesis of glycerol di- and triphosphate derivatives
EP0533825B1 (de) * 1990-06-15 1996-04-24 Wake Forest University Kovalente-ther lipidnukleosid-konjugate
US5563257A (en) * 1990-08-20 1996-10-08 Boehringer Mannheim Gmbh Phospholipid derivatives of nucleosides
DE4026265A1 (de) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
ES2033193B1 (es) * 1990-10-30 1994-01-16 Ganadera Union Ind Agro Mezcla grasa para nutricion infantil y de adultos.
JPH04364198A (ja) * 1991-04-04 1992-12-16 Asahi Chem Ind Co Ltd ５’−ホスファチジル−５−フルオロウリジン誘導体
SE9101709L (sv) * 1991-06-03 1992-12-04 Karlshamns Lipidteknik Ab Lipidderivat som diagnostikum eller kontrastmedel
US5304325A (en) * 1991-11-13 1994-04-19 Hemagen/Pfc Emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5512671A (en) * 1993-02-16 1996-04-30 Wake Forest University Ether lipid-nucleoside covalent conjugates
EP0690068A4 (de) * 1993-03-18 1996-07-31 Akira Matsuda 2'-methyliden nukleotid-verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
WO1995018533A1 (en) * 1994-01-04 1995-07-13 The Trustees Of The University Of Pennsylvania Methods and compounds affecting adipocyte differentiation and obesity
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
WO1996006620A2 (en) 1994-08-29 1996-03-07 Wake Forest University Lipid analogs for treating viral infections
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
CN1486289A (zh) * 2001-05-29 2004-03-31 皇家菲利浦电子有限公司 金属-陶瓷的结合
EP1423976A1 (de) * 2001-08-31 2004-06-02 Thomson Licensing S.A. Folgezähler für einen audiovisuellen datenstrom
US7045547B2 (en) * 2002-08-20 2006-05-16 University Of Delaware Acyl-CoA dehydrogenase allenic inhibitors
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
PT2970346T (pt) 2013-03-15 2018-11-09 Univ California Diésteres de fosfonato nucleosídico acíclico
EP3194411B1 (de) 2014-09-15 2022-05-04 The Regents of the University of California Nukleotidanaloga
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
WO2022046631A1 (en) 2020-08-24 2022-03-03 Gilead Sciences, Inc. Phospholipid compounds and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291024A (en) * 1978-04-10 1981-09-22 Turcotte Joseph G Cytotoxic liponucleotide analogs
US4471113A (en) * 1982-02-03 1984-09-11 The United States Of America As Represented By The Department Of Energy Prodrugs based on phospholipid-nucleoside conjugates
US4783402A (en) * 1983-04-11 1988-11-08 Meito Sangyo Kabushiki Kaisha Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
JPS59187786A (ja) * 1983-04-11 1984-10-24 Meito Sangyo Kk 酵素法リン脂質二級アルコ−ル誘導体の製法
JPS6188890A (ja) * 1984-10-08 1986-05-07 Meito Sangyo Kk 酵素法リン脂質複素環化合物誘導体の製法
JPS6188887A (ja) * 1984-10-08 1986-05-07 Meito Sangyo Kk 酵素法１−ｏ−アルキル−２−アシルグリセロリン脂質誘導体の製法
JPS61152694A (ja) * 1984-12-27 1986-07-11 Toyama Chem Co Ltd 新規な５−フルオロ−２′−デオキシウリジン−５′−ホスフエ−ト誘導体およびその塩
FR2580283B1 (fr) * 1985-04-15 1989-11-24 Toyo Jozo Kk Nouveau conjugue nucleoside-phospholipide
DE3778626D1 (de) * 1986-09-27 1992-06-04 Toyo Jozo Kk Nukleosid-phospholipid-konjugat.
FI82169C (fi) * 1987-08-21 1991-01-10 Nokia Mobira Oy Rf-skyddad hybridkrets.
JPH01238793A (ja) * 1988-03-18 1989-09-22 Toto Ltd 管の接続構造

Also Published As

Publication number Publication date
US5051499A (en) 1991-09-24
EP0262876B1 (de) 1992-04-29
EP0262876A2 (de) 1988-04-06
EP0262876A3 (en) 1989-11-29
US4921951A (en) 1990-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASAHI KASEI KOGYO K.K., OSAKA, JP

8339 Ceased/non-payment of the annual fee