DZ1270A1 - Dérivés de fluorocytidine. - Google Patents

Dérivés de fluorocytidine.

Info

Publication number
DZ1270A1
DZ1270A1 DZ880179A DZ880179A DZ1270A1 DZ 1270 A1 DZ1270 A1 DZ 1270A1 DZ 880179 A DZ880179 A DZ 880179A DZ 880179 A DZ880179 A DZ 880179A DZ 1270 A1 DZ1270 A1 DZ 1270A1
Authority
DZ
Algeria
Prior art keywords
fluorocytidine derivatives
fluorocytidine
derivatives
Prior art date
Application number
DZ880179A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DZ1270A1 publication Critical patent/DZ1270A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DZ880179A 1987-11-17 1988-11-16 Dérivés de fluorocytidine. DZ1270A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87116926 1987-11-17

Publications (1)

Publication Number Publication Date
DZ1270A1 true DZ1270A1 (fr) 2004-09-13

Family

ID=8197450

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ880179A DZ1270A1 (fr) 1987-11-17 1988-11-16 Dérivés de fluorocytidine.

Country Status (35)

Country Link
US (1) US4966891A (fr)
EP (1) EP0316704B1 (fr)
JP (1) JPH0678350B2 (fr)
KR (1) KR970000241B1 (fr)
CN (1) CN1022688C (fr)
AR (1) AR247217A1 (fr)
AT (1) ATE124951T1 (fr)
AU (1) AU619220B2 (fr)
CA (1) CA1327358C (fr)
CS (1) CS274486B2 (fr)
DE (2) DE10199027I2 (fr)
DK (1) DK170893B1 (fr)
DZ (1) DZ1270A1 (fr)
ES (1) ES2074429T3 (fr)
FI (1) FI89804C (fr)
GR (1) GR3017686T3 (fr)
HK (1) HK1003114A1 (fr)
HU (1) HU199866B (fr)
IE (1) IE883430L (fr)
IL (1) IL88363A0 (fr)
IS (1) IS1895B (fr)
LT (1) LT2185B (fr)
LU (1) LU90769I2 (fr)
LV (1) LV5624A3 (fr)
MC (1) MC1992A1 (fr)
MX (1) MX173347B (fr)
NL (1) NL300045I2 (fr)
NO (2) NO171167C (fr)
NZ (1) NZ226923A (fr)
PH (1) PH25641A (fr)
PT (1) PT89009B (fr)
SU (1) SU1736342A3 (fr)
UA (1) UA19333A (fr)
YU (1) YU47122B (fr)
ZA (1) ZA888428B (fr)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258360B1 (en) * 1989-05-04 2001-07-10 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
US5527782A (en) * 1990-03-13 1996-06-18 Acic (Canada) Inc. 5-halo-2,3'-O-cyclocytidines
AU671491B2 (en) 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (fr) * 1992-12-18 1995-08-21 Hoffmann La Roche
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
EP0882734B1 (fr) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag Dérivés de 5'-déoxy-cytidine
US6005098A (en) * 1998-02-06 1999-12-21 Hoffmann-La Roche Inc. 5'deoxycytidine derivatives
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US20010051348A1 (en) * 2000-01-28 2001-12-13 Lee Chee Wee Novel ligands and methods for preparing same
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
EP2266590A3 (fr) 2002-02-22 2011-04-20 Shire LLC Système d'administration de substances actives et méthodes de protection et d'administration de substances actives
US6774758B2 (en) * 2002-09-11 2004-08-10 Kalyan P. Gokhale Low harmonic rectifier circuit
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
AU2003233586A1 (en) * 2003-05-20 2005-01-21 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising capecitabine and a liposomal platinum complex
ATE402185T1 (de) * 2003-12-22 2008-08-15 Hoffmann La Roche Verfahren für fluorcytidinderivate
CA2554686A1 (fr) * 2004-02-18 2005-09-01 Astrazeneca Ab Composes
RU2392275C2 (ru) * 2004-02-18 2010-06-20 Астразенека Аб Бензамидные производные и их применение в качестве активирующих глюкокиназу агентов
CN100383128C (zh) * 2004-02-23 2008-04-23 上海迪赛诺医药发展有限公司 N4－氧羰基胞嘧啶衍生物及制备方法与应用
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
KR101061850B1 (ko) 2004-09-08 2011-09-02 삼성전자주식회사 박막 트랜지스터 표시판 및 그 제조방법
GB0421294D0 (en) * 2004-09-24 2004-10-27 Angiogene Pharm Ltd Bioreductively-activated prodrugs
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1802570A1 (fr) 2004-10-16 2007-07-04 AstraZeneca AB Procede de fabrication de composes de phenoxy benzamide
DE602006021142D1 (de) 2005-02-03 2011-05-19 Gen Hospital Corp Verfahren zur behandlung von gefitinib-resistentem krebs
NO322682B1 (no) * 2005-03-18 2006-11-27 Clavis Pharma Asa Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer
JP2008534548A (ja) * 2005-04-01 2008-08-28 エフ．ホフマン−ラ ロシュ アーゲー カペシタビンの投与のための方法
EP1891069A1 (fr) * 2005-05-24 2008-02-27 AstraZeneca AB Derives d'imidazol[4,5b]pyridine/pyrazine et purine substitues en 2-phenyl en tant que modulateurs de la glucokinase
TW200714597A (en) 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
AU2006268406C1 (en) 2005-07-09 2011-02-24 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
WO2007007040A1 (fr) * 2005-07-09 2007-01-18 Astrazeneca Ab Composés 2-hétérocyclyloxybenzoyl amino hétérocyclyle en tant que modulateurs de glucokinase pour le traitement du diabète de type 2
CN100569790C (zh) * 2005-07-15 2009-12-16 上海奥锐特国际贸易有限公司 合成n4-酰基-5＇-脱氧-5-氟胞苷衍生物的方法
CA2616008A1 (fr) * 2005-07-21 2007-01-25 Stefan Meuer Solutions de chlorite stabilisees associees a des fluoropyrimidines pour traiter des cancers
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
CN103110948A (zh) 2005-11-04 2013-05-22 惠氏公司 mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合
TW200738621A (en) 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
US20080085310A1 (en) * 2006-10-06 2008-04-10 Maria Oksana Bachynsky Capecitabine rapidly disintegrating tablets
TW200825063A (en) 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
SA07280576B1 (ar) 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
CN100425617C (zh) * 2006-10-31 2008-10-15 浙江海正药业股份有限公司 一种含氟嘧啶类化合物烷氧羰酰化的方法
EP2121666A1 (fr) 2006-12-21 2009-11-25 AstraZeneca AB Nouveau composé cristallin utile en tant qu'activateur de glk
ITMI20070435A1 (it) 2007-03-05 2008-09-06 Innovate Biotechnology Srl 2',3'-di-o-acil-5-fluoronucleosidi
US20100130734A1 (en) * 2007-04-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Process for preparing capecitabine
EP2164856A1 (fr) * 2007-06-01 2010-03-24 Synthon B.V. Procédés se rapportant à la fabrication de la capécitabine
WO2009042064A2 (fr) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Conjugués nucléoside phosphate oligomères
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
US20090209754A1 (en) * 2008-01-03 2009-08-20 Macdonald Peter Lindsay Process for the preparation of capecitabine
DK2656844T3 (en) 2008-06-17 2015-03-02 Wyeth Llc ANTINEOPLASTIC COMBINATIONS CONTAINING HKI-272 AND VINORELBINE
CN105963313A (zh) * 2008-08-04 2016-09-28 惠氏有限责任公司 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
PE20110568A1 (es) 2008-08-04 2011-09-07 Astrazeneca Ab Agentes terapeuticos 414
WO2010065586A2 (fr) * 2008-12-02 2010-06-10 Dr. Reddy's Laboratories Ltd. Préparation de capécitabine
US8603999B2 (en) 2008-12-05 2013-12-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
CN101787066B (zh) * 2009-01-23 2013-07-31 高峰 阿糖胞苷衍生物及其在抗癌抗肿瘤中的用途
GB0902434D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AU2010234968B2 (en) 2009-04-06 2015-05-14 Wyeth Llc Treatment regimen utilizing neratinib for breast cancer
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
CN101875680B (zh) * 2009-04-28 2012-07-25 上海信旗医药科技有限公司 一种核苷类化合物及其制备方法和应用
KR20120037932A (ko) * 2009-07-23 2012-04-20 시노팜 타이완 리미티드 플루오로시티딘 유도체를 제조하는 방법
SI2835053T1 (sl) 2010-03-12 2016-09-30 Genzyme Corporation Kombinirana terapija za zdravljenje raka dojke
AU2013243949A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
CA2868398A1 (fr) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Polynucleotides modifies pour la production de proteines et de peptides cosmetiques
PL2900657T3 (pl) 2012-09-26 2020-07-27 F.Hoffmann-La Roche Ag Cykliczne związki eterowe pirazol-4-ilo-heterocyklilo-karboksyamidu i sposoby stosowania
US9447137B2 (en) 2012-11-07 2016-09-20 Nucorion Pharmaceuticals, Inc. Substituted gemcitabine aryl amide analogs
US10000521B2 (en) 2013-03-15 2018-06-19 Nucorion Pharmaceuticals, Inc. Substituted gemcitabine bicyclic amide analogs and treatment methods using same
US10138507B2 (en) 2013-03-15 2018-11-27 Modernatx, Inc. Manufacturing methods for production of RNA transcripts
WO2015034928A1 (fr) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Polynucléotides chimériques
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
CN103450301B (zh) * 2013-09-09 2015-09-09 南通大学 法尼基硫代水杨酸-核苷缀合物、其制备方法及其医药用途
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
KR102306412B1 (ko) * 2016-06-28 2021-09-28 셀릭스 바이오 프라이빗 리미티드 암 치료용 조성물 및 방법
EP3565549B1 (fr) 2017-01-09 2022-03-09 Shuttle Pharmaceuticals, Inc. Inhibiteurs sélectifs d'histone déacétylase pour le traitement d'une maladie humaine
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
CA3061621A1 (fr) 2017-04-26 2018-11-01 Thomas I. Kalman Derives de nucleoside multicibles
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
EP3737376B1 (fr) 2018-01-09 2024-04-17 Shuttle Pharmaceuticals, Inc. Inhibiteurs sélectifs d'histone déacétylase pour le traitement de maladies humaines
WO2019143860A1 (fr) * 2018-01-19 2019-07-25 Nucorion Pharmaceuticals, Inc. Composés de 5-fluorouracile
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
JP2021534085A (ja) * 2018-08-03 2021-12-09 セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited 癌治療のための組成物及び方法
CN109651467A (zh) * 2019-01-15 2019-04-19 齐鲁天和惠世制药有限公司 一种卡培他滨杂质及其制备方法
JP2023523415A (ja) 2020-04-21 2023-06-05 リガンド・ファーマシューティカルズ・インコーポレイテッド ヌクレオチドプロドラッグ化合物
CN116710079A (zh) 2020-07-24 2023-09-05 斯特兰德生物科技公司 包含经修饰的核苷酸的脂质纳米颗粒
JP2024503000A (ja) 2021-01-08 2024-01-24 ストランド セラピューティクス インコーポレイテッド 発現構築物およびその使用
WO2023212618A1 (fr) 2022-04-26 2023-11-02 Strand Therapeutics Inc. Nanoparticules lipidiques comprenant un réplicon d'encéphalite équine du vénézuela (vee) et leurs utilisations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404144A (en) * 1965-12-23 1968-10-01 Research Corp 1-beta-d-arabinofuranosyl-5-fluorocytosine compounds
GB1379410A (en) * 1971-06-08 1975-01-02 Upjohn Co 1-beta-d-arabino-furanosyl-n4-alpha-aminoacylcytosines
JPS52153977A (en) * 1976-06-11 1977-12-21 Daikin Ind Ltd Synthesis of 5-fluorouracil and its derivatives
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
CH633810A5 (en) * 1978-01-01 1982-12-31 Hoffmann La Roche Novel nucleosides and process for their preparation
FR2528311B1 (fr) * 1982-06-14 1985-06-14 Synthelabo Compositions pharmaceutiques a base de xylosides et lyxosides de bases puriques et pyrimidiques
JPS61112093A (ja) * 1984-11-05 1986-05-30 Wakunaga Seiyaku Kk ヌクレオチド誘導体

Also Published As

Publication number Publication date
DE10199027I1 (de) 2001-08-02
EP0316704A3 (en) 1990-11-22
DK170893B1 (da) 1996-03-04
NO171167B (no) 1992-10-26
YU209188A (en) 1990-08-31
DE3854148D1 (de) 1995-08-17
EP0316704A2 (fr) 1989-05-24
DE10199027I2 (de) 2002-01-31
CA1327358C (fr) 1994-03-01
LU90769I2 (fr) 2001-07-02
FI885329A0 (fi) 1988-11-17
FI885329A (fi) 1989-05-18
CS747588A2 (en) 1990-09-12
CN1022688C (zh) 1993-11-10
JPH0678350B2 (ja) 1994-10-05
FI89804C (fi) 1993-11-25
CS274486B2 (en) 1991-04-11
UA19333A (uk) 1997-12-25
NO171167C (no) 1993-02-03
ATE124951T1 (de) 1995-07-15
ZA888428B (en) 1989-06-28
PH25641A (en) 1991-08-21
NO885106L (no) 1989-05-18
GR3017686T3 (en) 1996-01-31
DK640388D0 (da) 1988-11-16
NZ226923A (en) 1990-10-26
NO885106D0 (no) 1988-11-16
HU199866B (en) 1990-03-28
KR970000241B1 (ko) 1997-01-08
AU619220B2 (en) 1992-01-23
PT89009B (pt) 1993-02-26
DK640388A (da) 1989-05-18
IL88363A0 (en) 1989-06-30
CN1033183A (zh) 1989-05-31
US4966891A (en) 1990-10-30
AR247217A1 (es) 1994-11-30
PT89009A (pt) 1988-12-01
NL300045I2 (nl) 2002-01-02
YU47122B (sh) 1994-12-28
JPH01153696A (ja) 1989-06-15
MX173347B (es) 1994-01-03
HK1003114A1 (en) 1998-10-09
FI89804B (fi) 1993-08-13
IS1895B (is) 2003-10-20
IS3412A7 (is) 1989-05-18
IE883430L (en) 1989-05-17
HUT48267A (en) 1989-05-29
SU1736342A3 (ru) 1992-05-23
LT2185B (lt) 1993-10-15
EP0316704B1 (fr) 1995-07-12
MX13836A (es) 1993-10-01
ES2074429T3 (es) 1995-09-16
AU2516888A (en) 1989-05-25
KR890008162A (ko) 1989-07-10
NO2001013I2 (no) 2006-05-01
NL300045I1 (nl) 2001-08-01
LV5624A3 (lv) 1994-05-10
MC1992A1 (fr) 1989-11-30

Similar Documents

Publication Publication Date Title
DZ1270A1 (fr) Dérivés de fluorocytidine.
NO883299L (no) Epipodofyllotoksinglukosid-4'-fosfatderivater.
MX8358A (es) Derivados de sacarosa.
DE3778626D1 (de) Nukleosid-phospholipid-konjugat.
NL990028I2 (nl) Therapeutische nucleosiden.
NL960001I1 (nl) Therapeutische nucleosiden.
OA09358A (fr) Dérivés azoliques.
FI880405A (fi) Adenosin-5'-karboxamidderivat.
DZ1514A1 (fr) Dérivés de benzèneacetamides.
ATE116984T1 (de) Therapeutische nukleoside.
DE68906762T2 (de) Prostaglandin-Polysaccharid-Konjugat.
DE3872153T2 (de) 25-hydroxy-vitamin-d3-derivate.
NO884830L (no) Purin-derivater.
FI883963A (fi) Isoxazol- -karbolinderivat.
DE3887281D1 (de) 1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DE68913565D1 (de) Makrolide Derivate.
DE3888097D1 (de) 1,2,3,4-Tetrahydro-5-nitro-pyrimidin-Derivate.
DE3861208D1 (de) Hydroxyalkyl-triazolyl-derivate.
OA08742A (fr) Dérivés de pyrimidine.
DE3866371D1 (de) Diphenylaethylen-derivate.
DE3874027T2 (de) 1,3-dithiol-2-yliden-derivate.
DE3881146D1 (de) Thiazetidin-derivate.
DE3868364D1 (de) Ucy-1003-derivate.
DE3863447D1 (de) Aminoethylphosphinsaeure-derivate.
DE3884482D1 (de) Thiapentanamid-derivate.