US6258360B1
(en)
*
|
1989-05-04 |
2001-07-10 |
Igen International, Inc. |
Prodrugs activated by targeted catalytic proteins
|
US5527782A
(en)
*
|
1990-03-13 |
1996-06-18 |
Acic (Canada) Inc. |
5-halo-2,3'-O-cyclocytidines
|
TW254946B
(no)
*
|
1992-12-18 |
1995-08-21 |
Hoffmann La Roche |
|
AU671491B2
(en)
*
|
1992-12-18 |
1996-08-29 |
F. Hoffmann-La Roche Ag |
N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
|
US5476932A
(en)
*
|
1994-08-26 |
1995-12-19 |
Hoffmann-La Roche Inc. |
Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
|
NZ330360A
(en)
*
|
1997-06-02 |
1999-03-29 |
Hoffmann La Roche |
5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
|
EP0882734B1
(en)
*
|
1997-06-02 |
2009-08-26 |
F. Hoffmann-La Roche Ag |
5'-Deoxy-cytidine derivatives
|
US6005098A
(en)
*
|
1998-02-06 |
1999-12-21 |
Hoffmann-La Roche Inc. |
5'deoxycytidine derivatives
|
US20080113025A1
(en)
*
|
1998-11-02 |
2008-05-15 |
Elan Pharma International Limited |
Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
|
US20010051348A1
(en)
*
|
2000-01-28 |
2001-12-13 |
Lee Chee Wee |
Novel ligands and methods for preparing same
|
SE0102764D0
(sv)
|
2001-08-17 |
2001-08-17 |
Astrazeneca Ab |
Compounds
|
CN1649614A
(zh)
|
2002-02-22 |
2005-08-03 |
新河药品股份有限公司 |
活性剂传递系统和保护及施用活性剂的方法
|
US6774758B2
(en)
*
|
2002-09-11 |
2004-08-10 |
Kalyan P. Gokhale |
Low harmonic rectifier circuit
|
GB0226930D0
(en)
|
2002-11-19 |
2002-12-24 |
Astrazeneca Ab |
Chemical compounds
|
US20080026044A1
(en)
*
|
2003-05-20 |
2008-01-31 |
Jonathan Lewis |
Combination Chemotherapy Comprising Capecitabine and a Liposomal Platinum Complex
|
ATE402185T1
(de)
|
2003-12-22 |
2008-08-15 |
Hoffmann La Roche |
Verfahren für fluorcytidinderivate
|
CA2554686A1
(en)
*
|
2004-02-18 |
2005-09-01 |
Astrazeneca Ab |
Compounds
|
ES2322709T3
(es)
*
|
2004-02-18 |
2009-06-25 |
Astrazeneca Ab |
Derivados de benzamida y su uso como agentes activadores de la glucocinasa.
|
CN100383128C
(zh)
*
|
2004-02-23 |
2008-04-23 |
上海迪赛诺医药发展有限公司 |
N4-氧羰基胞嘧啶衍生物及制备方法与应用
|
TW200600086A
(en)
|
2004-06-05 |
2006-01-01 |
Astrazeneca Ab |
Chemical compound
|
KR101061850B1
(ko)
|
2004-09-08 |
2011-09-02 |
삼성전자주식회사 |
박막 트랜지스터 표시판 및 그 제조방법
|
GB0421294D0
(en)
*
|
2004-09-24 |
2004-10-27 |
Angiogene Pharm Ltd |
Bioreductively-activated prodrugs
|
BRPI0516595A
(pt)
|
2004-10-16 |
2008-09-23 |
Astrazeneca Ab |
processo para fabricar um composto, e, composto
|
GB0423043D0
(en)
*
|
2004-10-16 |
2004-11-17 |
Astrazeneca Ab |
Compounds
|
NZ556673A
(en)
|
2005-02-03 |
2010-03-26 |
Gen Hospital Corp |
Method for treating gefitinib and/or erlotinib resistant cancer with an EGFR inhibitor
|
NO322682B1
(no)
*
|
2005-03-18 |
2006-11-27 |
Clavis Pharma Asa |
Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer
|
WO2006103187A2
(en)
*
|
2005-04-01 |
2006-10-05 |
F. Hoffmann-La Roche Ag |
Method for administration of capecitabine
|
EP1891069A1
(en)
*
|
2005-05-24 |
2008-02-27 |
AstraZeneca AB |
2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators
|
TW200714597A
(en)
|
2005-05-27 |
2007-04-16 |
Astrazeneca Ab |
Chemical compounds
|
US20110053910A1
(en)
*
|
2005-07-09 |
2011-03-03 |
Mckerrecher Darren |
2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
|
EP2027113A1
(en)
*
|
2005-07-09 |
2009-02-25 |
AstraZeneca AB |
Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
|
BRPI0622262A2
(pt)
|
2005-07-09 |
2011-08-09 |
Astrazeneca Ab |
composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
|
CN100569790C
(zh)
*
|
2005-07-15 |
2009-12-16 |
上海奥锐特国际贸易有限公司 |
合成n4-酰基-5'-脱氧-5-氟胞苷衍生物的方法
|
AU2006272343B2
(en)
*
|
2005-07-21 |
2012-09-13 |
Nuvo Research Ag |
Stabilized chlorite solutions in combination with fluoropyrimidines for cancer treatment.
|
US9202182B2
(en)
*
|
2005-08-11 |
2015-12-01 |
International Business Machines Corporation |
Method and system for analyzing business architecture
|
KR101354828B1
(ko)
|
2005-11-04 |
2014-02-18 |
와이어쓰 엘엘씨 |
mTOR 저해자, 헤르셉틴, 및/또는 HKI-272의항신생물성 조합
|
TW200738621A
(en)
|
2005-11-28 |
2007-10-16 |
Astrazeneca Ab |
Chemical process
|
US20080085310A1
(en)
*
|
2006-10-06 |
2008-04-10 |
Maria Oksana Bachynsky |
Capecitabine rapidly disintegrating tablets
|
TW200825063A
(en)
|
2006-10-23 |
2008-06-16 |
Astrazeneca Ab |
Chemical compounds
|
SA07280576B1
(ar)
|
2006-10-26 |
2011-06-22 |
استرازينيكا ايه بي |
مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
|
CN100425617C
(zh)
*
|
2006-10-31 |
2008-10-15 |
浙江海正药业股份有限公司 |
一种含氟嘧啶类化合物烷氧羰酰化的方法
|
KR20090090390A
(ko)
|
2006-12-21 |
2009-08-25 |
아스트라제네카 아베 |
Glk 활성제로서 유용한 신규 결정 화합물
|
ITMI20070435A1
(it)
|
2007-03-05 |
2008-09-06 |
Innovate Biotechnology Srl |
2',3'-di-o-acil-5-fluoronucleosidi
|
EP2137201A2
(en)
*
|
2007-04-20 |
2009-12-30 |
Dr. Reddy's Laboratories Ltd. |
Process for preparing capecitabine
|
WO2008145403A1
(en)
*
|
2007-06-01 |
2008-12-04 |
Synthon B.V. |
Processes related to making capecitabine
|
WO2009042064A2
(en)
|
2007-09-21 |
2009-04-02 |
Nektar Therapeutics Al, Corporation |
Oligomer-nucleoside phosphate conjugates
|
US8022216B2
(en)
|
2007-10-17 |
2011-09-20 |
Wyeth Llc |
Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
|
EP2225566A1
(en)
*
|
2008-01-03 |
2010-09-08 |
Plus Chemicals S.A. |
Process for the preparation of capecitabine
|
EP3730139B1
(en)
|
2008-06-17 |
2023-08-16 |
Wyeth LLC |
Antineoplastic combinations containing hki-272 and vinorelbine
|
KR101434009B1
(ko)
|
2008-08-04 |
2014-08-25 |
와이어쓰 엘엘씨 |
4-아닐리노-3-사이아노퀴놀린과 카페시타빈의 항신생물성 조합물
|
EA201100097A1
(ru)
|
2008-08-04 |
2011-10-31 |
Астразенека Аб |
Производные пиразоло[3,4]пиримидин-4-ила и их применения для лечения диабета и ожирения
|
EP2370414A4
(en)
*
|
2008-12-02 |
2012-11-14 |
Reddys Lab Ltd Dr |
PREPARATION OF CAPECITABINE
|
EP2393472B1
(en)
*
|
2008-12-05 |
2019-06-05 |
NanoMed Holdings Pty Ltd |
Amphiphile prodrugs
|
CN101787066B
(zh)
*
|
2009-01-23 |
2013-07-31 |
高峰 |
阿糖胞苷衍生物及其在抗癌抗肿瘤中的用途
|
GB0902406D0
(en)
|
2009-02-13 |
2009-04-01 |
Astrazeneca Ab |
Crystalline polymorphic form
|
GB0902434D0
(en)
|
2009-02-13 |
2009-04-01 |
Astrazeneca Ab |
Chemical process
|
JP5992325B2
(ja)
|
2009-04-06 |
2016-09-14 |
ワイス・エルエルシー |
乳癌のための、ネラチニブを活用する治療計画
|
WO2010116177A1
(en)
|
2009-04-09 |
2010-10-14 |
Astrazeneca Ab |
A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
|
AR076221A1
(es)
*
|
2009-04-09 |
2011-05-26 |
Astrazeneca Ab |
Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
|
CN101875680B
(zh)
*
|
2009-04-28 |
2012-07-25 |
上海信旗医药科技有限公司 |
一种核苷类化合物及其制备方法和应用
|
CN102858791A
(zh)
*
|
2009-07-23 |
2013-01-02 |
台湾神隆股份有限公司 |
制备氟胞苷衍生物的方法
|
SI2835053T1
(sl)
|
2010-03-12 |
2016-09-30 |
Genzyme Corporation |
Kombinirana terapija za zdravljenje raka dojke
|
AU2013243949A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of biologics and proteins associated with human disease
|
EP2833923A4
(en)
|
2012-04-02 |
2016-02-24 |
Moderna Therapeutics Inc |
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS
|
LT2900657T
(lt)
|
2012-09-26 |
2020-05-25 |
F. Hoffmann-La Roche Ag |
Cikliniai eterio pirazol-4-il-heterociklil-karboksamido junginiai ir jų naudojimo būdai
|
US9447137B2
(en)
|
2012-11-07 |
2016-09-20 |
Nucorion Pharmaceuticals, Inc. |
Substituted gemcitabine aryl amide analogs
|
EP2971033B8
(en)
|
2013-03-15 |
2019-07-10 |
ModernaTX, Inc. |
Manufacturing methods for production of rna transcripts
|
EP2968382B1
(en)
*
|
2013-03-15 |
2018-03-07 |
Nucorion Pharmaceuticals, Inc. |
Substituted gemcitabine bicyclic amide analogs and treatment methods using same
|
EP3041934A1
(en)
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
CN103450301B
(zh)
*
|
2013-09-09 |
2015-09-09 |
南通大学 |
法尼基硫代水杨酸-核苷缀合物、其制备方法及其医药用途
|
EP3052521A1
(en)
|
2013-10-03 |
2016-08-10 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
JP6950972B2
(ja)
*
|
2016-06-28 |
2021-10-20 |
セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited |
ガンの処置のための組成物及び方法
|
US11584733B2
(en)
|
2017-01-09 |
2023-02-21 |
Shuttle Pharmaceuticals, Inc. |
Selective histone deacetylase inhibitors for the treatment of human disease
|
EP3565549B1
(en)
|
2017-01-09 |
2022-03-09 |
Shuttle Pharmaceuticals, Inc. |
Selective histone deacetylase inhibitors for the treatment of human disease
|
WO2018200859A1
(en)
|
2017-04-26 |
2018-11-01 |
Kalman Thomas I |
Multitargeted nucleoside derivatives
|
US10435429B2
(en)
|
2017-10-03 |
2019-10-08 |
Nucorion Pharmaceuticals, Inc. |
5-fluorouridine monophosphate cyclic triester compounds
|
CA3087565A1
(en)
|
2018-01-09 |
2019-07-18 |
Shuttle Pharmaceuticals, Inc. |
Selective histone deacetylase inhibitors for the treatment of human disease
|
US12110308B2
(en)
|
2018-01-10 |
2024-10-08 |
Nucorion Pharmaceuticals, Inc. |
Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
|
WO2019143860A1
(en)
*
|
2018-01-19 |
2019-07-25 |
Nucorion Pharmaceuticals, Inc. |
5-fluorouracil compounds
|
US11427550B2
(en)
|
2018-01-19 |
2022-08-30 |
Nucorion Pharmaceuticals, Inc. |
5-fluorouracil compounds
|
EP3817732A4
(en)
*
|
2018-08-03 |
2022-06-08 |
Cellix Bio Private Limited |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
|
CN109651467A
(zh)
*
|
2019-01-15 |
2019-04-19 |
齐鲁天和惠世制药有限公司 |
一种卡培他滨杂质及其制备方法
|
US12110311B2
(en)
|
2019-07-17 |
2024-10-08 |
Nucorion Pharmaceuticals, Inc. |
Cyclic deoxyribonucleotide compounds
|
JP2023523415A
(ja)
|
2020-04-21 |
2023-06-05 |
リガンド・ファーマシューティカルズ・インコーポレイテッド |
ヌクレオチドプロドラッグ化合物
|
WO2022020811A1
(en)
|
2020-07-24 |
2022-01-27 |
Strand Therapeutics, Inc. |
Lipidnanoparticle comprising modified nucleotides
|
AR124599A1
(es)
|
2021-01-08 |
2023-04-12 |
Strand Therapeutics Inc |
Constructos de expresión y usos de estos
|
AU2023262576A1
(en)
|
2022-04-26 |
2024-10-10 |
Strand Therapeutics Inc. |
Lipid nanoparticles comprising venezuelan equine encephalitis (vee) replicon and uses thereof
|