DK713488D0 - Adenosinderivater - Google Patents

Adenosinderivater

Info

Publication number
DK713488D0
DK713488D0 DK713488A DK713488A DK713488D0 DK 713488 D0 DK713488 D0 DK 713488D0 DK 713488 A DK713488 A DK 713488A DK 713488 A DK713488 A DK 713488A DK 713488 D0 DK713488 D0 DK 713488D0
Authority
DK
Denmark
Prior art keywords
adenosine
Prior art date
Application number
DK713488A
Other languages
English (en)
Other versions
DK713488A (da
DK170894B1 (da
Inventor
Brian Evans
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK713488D0 publication Critical patent/DK713488D0/da
Priority to GB898914344A priority Critical patent/GB8914344D0/en
Publication of DK713488A publication Critical patent/DK713488A/da
Application granted granted Critical
Publication of DK170894B1 publication Critical patent/DK170894B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK713488A 1987-12-23 1988-12-21 Adenosinderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende forbindelserne samt anvendelse af forbindelserne DK170894B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB898914344A GB8914344D0 (en) 1988-12-21 1989-06-22 Compounds and compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878729994A GB8729994D0 (en) 1987-12-23 1987-12-23 Chemical compounds
GB8729994 1987-12-23

Publications (3)

Publication Number Publication Date
DK713488D0 true DK713488D0 (da) 1988-12-21
DK713488A DK713488A (da) 1989-06-24
DK170894B1 DK170894B1 (da) 1996-03-04

Family

ID=10628947

Family Applications (1)

Application Number Title Priority Date Filing Date
DK713488A DK170894B1 (da) 1987-12-23 1988-12-21 Adenosinderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende forbindelserne samt anvendelse af forbindelserne

Country Status (36)

Country Link
US (1) US5032583A (da)
EP (1) EP0322242B1 (da)
JP (1) JP2736088B2 (da)
KR (1) KR890009967A (da)
CN (1) CN1024198C (da)
AT (1) ATA315488A (da)
AU (2) AU612747B2 (da)
BE (1) BE1002167A5 (da)
CA (1) CA1320195C (da)
CH (1) CH677495A5 (da)
CZ (1) CZ403991A3 (da)
DE (2) DE3856154T2 (da)
DK (1) DK170894B1 (da)
ES (1) ES2012927A6 (da)
FI (1) FI90429C (da)
FR (1) FR2629715B1 (da)
GB (2) GB8729994D0 (da)
GR (1) GR1000307B (da)
HK (1) HK1009650A1 (da)
HU (1) HU203364B (da)
IE (1) IE61302B1 (da)
IL (1) IL88765A (da)
IT (1) IT1224840B (da)
LU (1) LU87414A1 (da)
MX (1) MX14331A (da)
NL (1) NL8803140A (da)
NO (1) NO171506C (da)
NZ (1) NZ227485A (da)
PH (1) PH25932A (da)
PL (1) PL158800B1 (da)
PT (1) PT89328B (da)
RU (2) RU1826971C (da)
SE (1) SE8804609L (da)
SG (1) SG44701A1 (da)
YU (1) YU234188A (da)
ZA (1) ZA889593B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2226027B (en) * 1988-12-13 1992-05-20 Sandoz Ltd Adenosine derivatives,their production and use
FR2665362B1 (fr) * 1990-08-03 1994-12-09 Cepbepe Substance contenant, comme principe actif, une adenosine substitutee en n6 et son application.
DK0550631T3 (da) * 1990-09-25 1997-01-20 Rhone Poulenc Rorer Int Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
GB9111580D0 (en) * 1991-05-30 1991-07-24 Wellcome Found Nucleoside derivative
DK62692D0 (da) * 1992-05-14 1992-05-14 Novo Nordisk As
US5672588A (en) * 1992-05-20 1997-09-30 Novo Nordisk A/S Purine derivatives
US5443836A (en) * 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
CN1147815A (zh) * 1994-05-10 1997-04-16 山道士有限公司 腺苷衍生物
GB9421133D0 (en) * 1994-10-20 1994-12-07 Glaxo Group Ltd Medicaments
AU2022497A (en) * 1996-03-13 1997-10-01 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
WO1997033591A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
MXPA00011889A (es) 1998-06-02 2003-04-25 Osi Pharm Inc Composiciones de pirrolo (2,3d) piridina y su uso.
US6784165B1 (en) * 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
GB9930077D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
GB9930083D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
GB0106867D0 (en) * 2001-03-20 2001-05-09 Glaxo Group Ltd Process
EP1258247A1 (en) * 2001-05-14 2002-11-20 Aventis Pharma Deutschland GmbH Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
EP1450811B1 (en) 2001-11-30 2009-10-21 OSI Pharmaceuticals, Inc. Compounds specific to adenosine A1 and A3 receptors and uses thereof
CN1620294A (zh) 2001-12-20 2005-05-25 Osi药物公司 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
CN1816551A (zh) 2001-12-20 2006-08-09 Osi药物公司 吡咯并嘧啶A2b选择性拮抗剂化合物,它们的合成及用途
US20050009776A1 (en) * 2003-04-24 2005-01-13 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
TWI494102B (zh) * 2003-05-02 2015-08-01 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
WO2005025545A2 (en) * 2003-09-17 2005-03-24 Aderis Pharmaceuticals, Inc. Pharmaceutical formulation for controlled release of selodenoson
WO2007064795A2 (en) * 2005-11-30 2007-06-07 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
CN101712709A (zh) * 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
AU2010288864A1 (en) 2009-08-31 2012-04-19 Lonza Ltd Process for the preparation of (1S,4R)-2-oxa-3-azabicyclo[2,2.1]hept-5-enes
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130136C (da) * 1966-10-20
NL6717061A (da) * 1966-12-21 1968-06-24
DE2052596A1 (de) * 1970-10-27 1972-05-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten
NL7203984A (da) * 1971-04-10 1972-10-12
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
DE2148838A1 (de) * 1971-09-30 1973-04-05 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2157036A1 (de) * 1971-11-17 1973-05-24 Boehringer Mannheim Gmbh Neue heterocyclisch substituierte nebularin-derivate und verfahren zu deren herstellung
DE2244328A1 (de) * 1972-09-09 1974-03-21 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338705A1 (de) * 1973-07-31 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2338963A1 (de) * 1973-08-01 1975-02-13 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
DE2426682A1 (de) * 1974-06-01 1975-12-11 Boehringer Mannheim Gmbh Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
ZA857998B (en) * 1984-10-26 1986-05-28 Warner Lambert Co N6-substituted adenosines
AU579412B2 (en) * 1984-10-26 1988-11-24 Warner-Lambert Company N` - substituted adenosines

Also Published As

Publication number Publication date
FI885943A (fi) 1989-06-24
AU8589491A (en) 1991-12-12
KR890009967A (ko) 1989-08-05
EP0322242A3 (en) 1990-04-18
NO171506C (no) 1993-03-24
AU2740188A (en) 1989-06-29
GB2212498B (en) 1991-07-24
HUT48903A (en) 1989-07-28
IE883845L (en) 1989-06-23
SE8804609D0 (sv) 1988-12-21
DK713488A (da) 1989-06-24
IT1224840B (it) 1990-10-24
NO171506B (no) 1992-12-14
RU2060996C1 (ru) 1996-05-27
FR2629715B1 (fr) 1993-09-03
FR2629715A1 (fr) 1989-10-13
CH677495A5 (da) 1991-05-31
CA1320195C (en) 1993-07-13
IL88765A (en) 1993-04-04
GB8829983D0 (en) 1989-02-15
MX14331A (es) 1993-12-01
NO885719D0 (no) 1988-12-22
US5032583A (en) 1991-07-16
SG44701A1 (en) 1997-12-19
PL276697A1 (en) 1990-02-19
PH25932A (en) 1991-12-19
IT8848714A0 (it) 1988-12-23
CZ403991A3 (en) 1993-04-14
DE3856154D1 (de) 1998-05-07
ZA889593B (en) 1989-09-27
ES2012927A6 (es) 1990-04-16
NL8803140A (nl) 1989-07-17
NO885719L (no) 1989-06-26
PT89328A (pt) 1989-12-29
JP2736088B2 (ja) 1998-04-02
RU1826971C (ru) 1993-07-07
NZ227485A (en) 1991-06-25
CN1035295A (zh) 1989-09-06
JPH01203400A (ja) 1989-08-16
DE3856154T2 (de) 1998-08-27
CN1024198C (zh) 1994-04-13
HK1009650A1 (en) 1999-06-04
DE3843609A1 (de) 1989-07-06
GB8729994D0 (en) 1988-02-03
GB2212498A (en) 1989-07-26
PL158800B1 (en) 1992-10-30
FI90429C (fi) 1994-02-10
AU612747B2 (en) 1991-07-18
DK170894B1 (da) 1996-03-04
LU87414A1 (fr) 1989-07-07
IL88765A0 (en) 1989-07-31
YU234188A (en) 1990-12-31
HU203364B (en) 1991-07-29
EP0322242B1 (en) 1998-04-01
SE8804609L (sv) 1989-06-24
EP0322242A2 (en) 1989-06-28
ATA315488A (de) 1994-02-15
PT89328B (pt) 1993-08-31
BE1002167A5 (fr) 1990-08-28
GR1000307B (el) 1992-05-12
IE61302B1 (en) 1994-10-19
FI90429B (fi) 1993-10-29

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed