DE3856154D1 - Adenosin-Derivate - Google Patents
Adenosin-DerivateInfo
- Publication number
- DE3856154D1 DE3856154D1 DE3856154T DE3856154T DE3856154D1 DE 3856154 D1 DE3856154 D1 DE 3856154D1 DE 3856154 T DE3856154 T DE 3856154T DE 3856154 T DE3856154 T DE 3856154T DE 3856154 D1 DE3856154 D1 DE 3856154D1
- Authority
- DE
- Germany
- Prior art keywords
- adenosine derivatives
- adenosine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878729994A GB8729994D0 (en) | 1987-12-23 | 1987-12-23 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3856154D1 true DE3856154D1 (de) | 1998-05-07 |
DE3856154T2 DE3856154T2 (de) | 1998-08-27 |
Family
ID=10628947
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3856154T Expired - Lifetime DE3856154T2 (de) | 1987-12-23 | 1988-12-22 | Adenosin-Derivate |
DE3843609A Withdrawn DE3843609A1 (de) | 1987-12-23 | 1988-12-23 | Adenosinderivate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3843609A Withdrawn DE3843609A1 (de) | 1987-12-23 | 1988-12-23 | Adenosinderivate |
Country Status (36)
Country | Link |
---|---|
US (1) | US5032583A (de) |
EP (1) | EP0322242B1 (de) |
JP (1) | JP2736088B2 (de) |
KR (1) | KR890009967A (de) |
CN (1) | CN1024198C (de) |
AT (1) | ATA315488A (de) |
AU (2) | AU612747B2 (de) |
BE (1) | BE1002167A5 (de) |
CA (1) | CA1320195C (de) |
CH (1) | CH677495A5 (de) |
CZ (1) | CZ403991A3 (de) |
DE (2) | DE3856154T2 (de) |
DK (1) | DK170894B1 (de) |
ES (1) | ES2012927A6 (de) |
FI (1) | FI90429C (de) |
FR (1) | FR2629715B1 (de) |
GB (2) | GB8729994D0 (de) |
GR (1) | GR1000307B (de) |
HK (1) | HK1009650A1 (de) |
HU (1) | HU203364B (de) |
IE (1) | IE61302B1 (de) |
IL (1) | IL88765A (de) |
IT (1) | IT1224840B (de) |
LU (1) | LU87414A1 (de) |
MX (1) | MX14331A (de) |
NL (1) | NL8803140A (de) |
NO (1) | NO171506C (de) |
NZ (1) | NZ227485A (de) |
PH (1) | PH25932A (de) |
PL (1) | PL158800B1 (de) |
PT (1) | PT89328B (de) |
RU (2) | RU1826971C (de) |
SE (1) | SE8804609L (de) |
SG (1) | SG44701A1 (de) |
YU (1) | YU234188A (de) |
ZA (1) | ZA889593B (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2226027B (en) * | 1988-12-13 | 1992-05-20 | Sandoz Ltd | Adenosine derivatives,their production and use |
FR2665362B1 (fr) * | 1990-08-03 | 1994-12-09 | Cepbepe | Substance contenant, comme principe actif, une adenosine substitutee en n6 et son application. |
DK0550631T3 (da) * | 1990-09-25 | 1997-01-20 | Rhone Poulenc Rorer Int | Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi |
US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
GB9111580D0 (en) * | 1991-05-30 | 1991-07-24 | Wellcome Found | Nucleoside derivative |
DK62692D0 (de) * | 1992-05-14 | 1992-05-14 | Novo Nordisk As | |
US5672588A (en) * | 1992-05-20 | 1997-09-30 | Novo Nordisk A/S | Purine derivatives |
US5443836A (en) * | 1993-03-15 | 1995-08-22 | Gensia, Inc. | Methods for protecting tissues and organs from ischemic damage |
CN1147815A (zh) * | 1994-05-10 | 1997-04-16 | 山道士有限公司 | 腺苷衍生物 |
GB9421133D0 (en) * | 1994-10-20 | 1994-12-07 | Glaxo Group Ltd | Medicaments |
AU2022497A (en) * | 1996-03-13 | 1997-10-01 | Novo Nordisk A/S | A method of treating disorders related to cytokines in mammals |
WO1997033591A1 (en) * | 1996-03-13 | 1997-09-18 | Novo Nordisk A/S | A method of treating disorders related to cytokines in mammals |
US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
MXPA00011889A (es) | 1998-06-02 | 2003-04-25 | Osi Pharm Inc | Composiciones de pirrolo (2,3d) piridina y su uso. |
US6784165B1 (en) * | 1999-11-23 | 2004-08-31 | Aderis Pharmaceuticals, Inc. | Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines |
US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
US6294522B1 (en) * | 1999-12-03 | 2001-09-25 | Cv Therapeutics, Inc. | N6 heterocyclic 8-modified adenosine derivatives |
GB9930077D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
GB9930083D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
GB0106867D0 (en) * | 2001-03-20 | 2001-05-09 | Glaxo Group Ltd | Process |
EP1258247A1 (de) * | 2001-05-14 | 2002-11-20 | Aventis Pharma Deutschland GmbH | Adenosin-Analoga für die Behandlung Von Insulinresistenz und Diabetes |
EP1450811B1 (de) | 2001-11-30 | 2009-10-21 | OSI Pharmaceuticals, Inc. | Verbindungen, die für Adenosin A1 und A3 Rezeptoren spezifisch sind, und deren Anwendungen |
CN1620294A (zh) | 2001-12-20 | 2005-05-25 | Osi药物公司 | 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途 |
CN1816551A (zh) | 2001-12-20 | 2006-08-09 | Osi药物公司 | 吡咯并嘧啶A2b选择性拮抗剂化合物,它们的合成及用途 |
US20050009776A1 (en) * | 2003-04-24 | 2005-01-13 | Aderis Pharmaceuticals, Inc. | Method of treating atrial fibrillation or atrial flutter |
TWI494102B (zh) * | 2003-05-02 | 2015-08-01 | Japan Tobacco Inc | 包含s-〔2(〔〔1-(2-乙基丁基)環己基〕羰基〕胺基)苯基〕2-甲基丙烷硫酯及hmg輔酶a還原酶抑制劑之組合 |
WO2005025545A2 (en) * | 2003-09-17 | 2005-03-24 | Aderis Pharmaceuticals, Inc. | Pharmaceutical formulation for controlled release of selodenoson |
WO2007064795A2 (en) * | 2005-11-30 | 2007-06-07 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
CN101712709A (zh) * | 2008-10-06 | 2010-05-26 | 中国医学科学院药物研究所 | 三乙酰基-3-羟基苯基腺苷及其调血脂的用途 |
AU2010288864A1 (en) | 2009-08-31 | 2012-04-19 | Lonza Ltd | Process for the preparation of (1S,4R)-2-oxa-3-azabicyclo[2,2.1]hept-5-enes |
TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL130136C (de) * | 1966-10-20 | |||
NL6717061A (de) * | 1966-12-21 | 1968-06-24 | ||
DE2052596A1 (de) * | 1970-10-27 | 1972-05-04 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten |
NL7203984A (de) * | 1971-04-10 | 1972-10-12 | ||
BE788958A (fr) * | 1971-09-18 | 1973-03-19 | Schering Ag | Derives d'adenosine et leur procede de preparation |
DE2148838A1 (de) * | 1971-09-30 | 1973-04-05 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
DE2157036A1 (de) * | 1971-11-17 | 1973-05-24 | Boehringer Mannheim Gmbh | Neue heterocyclisch substituierte nebularin-derivate und verfahren zu deren herstellung |
DE2244328A1 (de) * | 1972-09-09 | 1974-03-21 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
DE2338705A1 (de) * | 1973-07-31 | 1975-02-13 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
DE2338963A1 (de) * | 1973-08-01 | 1975-02-13 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
DE2426682A1 (de) * | 1974-06-01 | 1975-12-11 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
ZA857998B (en) * | 1984-10-26 | 1986-05-28 | Warner Lambert Co | N6-substituted adenosines |
AU579412B2 (en) * | 1984-10-26 | 1988-11-24 | Warner-Lambert Company | N` - substituted adenosines |
-
1987
- 1987-12-23 GB GB878729994A patent/GB8729994D0/en active Pending
-
1988
- 1988-12-21 SE SE8804609A patent/SE8804609L/xx not_active Application Discontinuation
- 1988-12-21 DK DK713488A patent/DK170894B1/da not_active IP Right Cessation
- 1988-12-22 ES ES8803906A patent/ES2012927A6/es not_active Expired - Fee Related
- 1988-12-22 SG SG1996005914A patent/SG44701A1/en unknown
- 1988-12-22 NL NL8803140A patent/NL8803140A/nl not_active Application Discontinuation
- 1988-12-22 FI FI885943A patent/FI90429C/fi not_active IP Right Cessation
- 1988-12-22 CA CA000586787A patent/CA1320195C/en not_active Expired - Lifetime
- 1988-12-22 GR GR880100856A patent/GR1000307B/el unknown
- 1988-12-22 HU HU886569A patent/HU203364B/hu not_active IP Right Cessation
- 1988-12-22 EP EP88312231A patent/EP0322242B1/de not_active Expired - Lifetime
- 1988-12-22 IL IL88765A patent/IL88765A/xx not_active IP Right Cessation
- 1988-12-22 PT PT89328A patent/PT89328B/pt not_active IP Right Cessation
- 1988-12-22 RU SU884613189A patent/RU1826971C/ru active
- 1988-12-22 NO NO885719A patent/NO171506C/no unknown
- 1988-12-22 IE IE384588A patent/IE61302B1/en not_active IP Right Cessation
- 1988-12-22 NZ NZ227485A patent/NZ227485A/en unknown
- 1988-12-22 BE BE8801427A patent/BE1002167A5/fr not_active IP Right Cessation
- 1988-12-22 DE DE3856154T patent/DE3856154T2/de not_active Expired - Lifetime
- 1988-12-22 GB GB8829983A patent/GB2212498B/en not_active Expired - Lifetime
- 1988-12-22 ZA ZA889593A patent/ZA889593B/xx unknown
- 1988-12-23 CN CN88108757A patent/CN1024198C/zh not_active Expired - Fee Related
- 1988-12-23 YU YU02341/88A patent/YU234188A/xx unknown
- 1988-12-23 MX MX1433188A patent/MX14331A/es unknown
- 1988-12-23 AT AT0315488A patent/ATA315488A/de not_active Application Discontinuation
- 1988-12-23 DE DE3843609A patent/DE3843609A1/de not_active Withdrawn
- 1988-12-23 LU LU87414A patent/LU87414A1/fr unknown
- 1988-12-23 JP JP63323836A patent/JP2736088B2/ja not_active Expired - Lifetime
- 1988-12-23 CH CH4777/88A patent/CH677495A5/de not_active IP Right Cessation
- 1988-12-23 PL PL1988276697A patent/PL158800B1/pl unknown
- 1988-12-23 FR FR888817132A patent/FR2629715B1/fr not_active Expired - Lifetime
- 1988-12-23 KR KR1019880017330A patent/KR890009967A/ko not_active Application Discontinuation
- 1988-12-23 IT IT8848714A patent/IT1224840B/it active
- 1988-12-23 AU AU27401/88A patent/AU612747B2/en not_active Expired
- 1988-12-23 PH PH37978A patent/PH25932A/en unknown
-
1989
- 1989-11-03 US US07/431,089 patent/US5032583A/en not_active Expired - Lifetime
-
1991
- 1991-10-16 AU AU85894/91A patent/AU8589491A/en not_active Abandoned
- 1991-12-23 CZ CS914039A patent/CZ403991A3/cs unknown
-
1992
- 1992-02-24 RU SU925010893A patent/RU2060996C1/ru active
-
1998
- 1998-09-01 HK HK98110345A patent/HK1009650A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |