MX173347B - Procedimiento para producir derivados de 5'-deoxi-5-fluorocitidina y producto obtenido - Google Patents
Procedimiento para producir derivados de 5'-deoxi-5-fluorocitidina y producto obtenidoInfo
- Publication number
- MX173347B MX173347B MX013836A MX1383688A MX173347B MX 173347 B MX173347 B MX 173347B MX 013836 A MX013836 A MX 013836A MX 1383688 A MX1383688 A MX 1383688A MX 173347 B MX173347 B MX 173347B
- Authority
- MX
- Mexico
- Prior art keywords
- radical
- general formula
- protective
- hydrogen atom
- compound represented
- Prior art date
Links
- 150000003254 radicals Chemical class 0.000 abstract 9
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- YSNABXSEHNLERR-ZIYNGMLESA-N 5'-Deoxy-5-fluorocytidine Chemical class O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)N=C(N)C(F)=C1 YSNABXSEHNLERR-ZIYNGMLESA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- -1 aralkyl radical Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000005188 oxoalkyl group Chemical group 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento para producir derivados de 5'-deoxi-5-fluorocitidina representados por la fórmula general (I),en donde R1, R2 y R3 representan, independientemente un átomo de hidróeno o un radical facilmente hidrolizable bajo condiciones fisiológicas, con la salvedad de que, por lo menos uno de los radicales representa por el símbolo R1, R2 o R3 representa un radical facilmente hidrolizable bajo condiciones fisiológicas, asi como hidratos o solvatos de los compuestos de la fórmula general (I), el procedimiento está caracterizado porque comprende hacer reaccionar un compuesto representado por la fórmula general (II), en donde R7 representa un átomo de hidrógeno o un radical amino-protector, R8 y R9 son independientemente un átomo de hidrógeno o un radical hidroxi-protector, o R5 y R9, tomados juntos, pueden formar un radical hidroxi-protector, con un compuesto representado por la fórmula general (III), en donde x representa un radical partiente y R4 representa un átomo de hidrógeno, un radical de alquilo, cicloalquilo, oxoalquilo, alquenilo, aralquilo o arilo, o con un compuesto representado por la fórmula general (IV), en donde Y representa un átomo de halógeno y R10 representa un radical representado por la fórmula en donde R5 y R0 representan un radical de alquilo o aralquilo seguido, de ser necesario, de separación de un radical protector.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP87116926 | 1987-11-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX13836A MX13836A (es) | 1993-10-01 |
| MX173347B true MX173347B (es) | 1994-01-03 |
Family
ID=8197450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX013836A MX173347B (es) | 1987-11-17 | 1988-11-17 | Procedimiento para producir derivados de 5'-deoxi-5-fluorocitidina y producto obtenido |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US4966891A (es) |
| EP (1) | EP0316704B1 (es) |
| JP (1) | JPH0678350B2 (es) |
| KR (1) | KR970000241B1 (es) |
| CN (1) | CN1022688C (es) |
| AR (1) | AR247217A1 (es) |
| AT (1) | ATE124951T1 (es) |
| AU (1) | AU619220B2 (es) |
| CA (1) | CA1327358C (es) |
| CS (1) | CS274486B2 (es) |
| DE (2) | DE10199027I2 (es) |
| DK (1) | DK170893B1 (es) |
| DZ (1) | DZ1270A1 (es) |
| ES (1) | ES2074429T3 (es) |
| FI (1) | FI89804C (es) |
| GR (1) | GR3017686T3 (es) |
| HK (1) | HK1003114A1 (es) |
| HU (1) | HU199866B (es) |
| IE (1) | IE883430L (es) |
| IL (1) | IL88363A0 (es) |
| IS (1) | IS1895B (es) |
| LT (1) | LT2185B (es) |
| LU (1) | LU90769I2 (es) |
| LV (1) | LV5624A3 (es) |
| MC (1) | MC1992A1 (es) |
| MX (1) | MX173347B (es) |
| NL (1) | NL300045I2 (es) |
| NO (2) | NO171167C (es) |
| NZ (1) | NZ226923A (es) |
| PH (1) | PH25641A (es) |
| PT (1) | PT89009B (es) |
| SU (1) | SU1736342A3 (es) |
| UA (1) | UA19333A (es) |
| YU (1) | YU47122B (es) |
| ZA (1) | ZA888428B (es) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258360B1 (en) * | 1989-05-04 | 2001-07-10 | Igen International, Inc. | Prodrugs activated by targeted catalytic proteins |
| US5527782A (en) * | 1990-03-13 | 1996-06-18 | Acic (Canada) Inc. | 5-halo-2,3'-O-cyclocytidines |
| TW254946B (es) * | 1992-12-18 | 1995-08-21 | Hoffmann La Roche | |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| US5476932A (en) * | 1994-08-26 | 1995-12-19 | Hoffmann-La Roche Inc. | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives |
| IT1291983B1 (it) * | 1997-05-23 | 1999-01-25 | Pro Bio Sint Srl | Prodcedimento per la preparazione di un derivato della desossiuridina |
| EP0882734B1 (en) * | 1997-06-02 | 2009-08-26 | F. Hoffmann-La Roche Ag | 5'-Deoxy-cytidine derivatives |
| NZ330360A (en) * | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| US6005098A (en) * | 1998-02-06 | 1999-12-21 | Hoffmann-La Roche Inc. | 5'deoxycytidine derivatives |
| US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
| US20010051348A1 (en) * | 2000-01-28 | 2001-12-13 | Lee Chee Wee | Novel ligands and methods for preparing same |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| EP1490090A4 (en) | 2002-02-22 | 2006-09-20 | New River Pharmaceuticals Inc | SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS |
| US6774758B2 (en) * | 2002-09-11 | 2004-08-10 | Kalyan P. Gokhale | Low harmonic rectifier circuit |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| AU2003233586A1 (en) * | 2003-05-20 | 2005-01-21 | Aronex Pharmaceuticals, Inc. | Combination chemotherapy comprising capecitabine and a liposomal platinum complex |
| ES2310298T3 (es) * | 2003-12-22 | 2009-01-01 | F. Hoffmann-La Roche Ag | Proceso para producir derivados de fluorocitidina. |
| KR20070007104A (ko) * | 2004-02-18 | 2007-01-12 | 아스트라제네카 아베 | 화합물 |
| EP1718624B1 (en) * | 2004-02-18 | 2009-03-25 | AstraZeneca AB | Benzamide derivatives and their use as glucokinase activating agents |
| CN100383128C (zh) * | 2004-02-23 | 2008-04-23 | 上海迪赛诺医药发展有限公司 | N4－氧羰基胞嘧啶衍生物及制备方法与应用 |
| TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| KR101061850B1 (ko) | 2004-09-08 | 2011-09-02 | 삼성전자주식회사 | 박막 트랜지스터 표시판 및 그 제조방법 |
| GB0421294D0 (en) * | 2004-09-24 | 2004-10-27 | Angiogene Pharm Ltd | Bioreductively-activated prodrugs |
| GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| CA2581619A1 (en) | 2004-10-16 | 2006-04-20 | Astrazeneca Ab | Process for making phenoxy benzamide compounds |
| SI1848414T1 (sl) | 2005-02-03 | 2011-08-31 | Gen Hospital Corp | Postopek za zdravljenje raka, odpornega na gefitinib |
| NO322682B1 (no) * | 2005-03-18 | 2006-11-27 | Clavis Pharma Asa | Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer |
| WO2006103187A2 (en) * | 2005-04-01 | 2006-10-05 | F. Hoffmann-La Roche Ag | Method for administration of capecitabine |
| WO2006125958A1 (en) * | 2005-05-24 | 2006-11-30 | Astrazeneca Ab | 2-phenyl substituted imidazol [4 , 5b] pyridine/ pyrazine and purine derivatives as glucokinase modulators |
| TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
| NZ564608A (en) | 2005-07-09 | 2009-09-25 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| JP2009500442A (ja) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | ２型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての２−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
| US20080234273A1 (en) * | 2005-07-09 | 2008-09-25 | Mckerrecher Darren | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes |
| CN100569790C (zh) * | 2005-07-15 | 2009-12-16 | 上海奥锐特国际贸易有限公司 | 合成n4-酰基-5＇-脱氧-5-氟胞苷衍生物的方法 |
| EP1906977B1 (en) * | 2005-07-21 | 2012-02-22 | Nuvo Research AG | Stabilized chlorite solutions in combination with fluoropyrimidines for cancer treatment. |
| US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
| RU2451524C2 (ru) | 2005-11-04 | 2012-05-27 | Вайет | Противоопухолевые комбинации с ингибиторами mtor, герцептином и/или hki-272 |
| TW200738621A (en) | 2005-11-28 | 2007-10-16 | Astrazeneca Ab | Chemical process |
| US20080085310A1 (en) * | 2006-10-06 | 2008-04-10 | Maria Oksana Bachynsky | Capecitabine rapidly disintegrating tablets |
| TW200825063A (en) | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| SA07280576B1 (ar) | 2006-10-26 | 2011-06-22 | استرازينيكا ايه بي | مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز |
| CN100425617C (zh) * | 2006-10-31 | 2008-10-15 | 浙江海正药业股份有限公司 | 一种含氟嘧啶类化合物烷氧羰酰化的方法 |
| JP2010513445A (ja) | 2006-12-21 | 2010-04-30 | アストラゼネカ アクチボラグ | Ｇｌｋアクチベーターとして有用な新規結晶性化合物 |
| ITMI20070435A1 (it) | 2007-03-05 | 2008-09-06 | Innovate Biotechnology Srl | 2',3'-di-o-acil-5-fluoronucleosidi |
| BRPI0810067A2 (pt) * | 2007-04-20 | 2014-10-21 | Reddys Lab Ltd Dr | Processo para a preparação de capecitabina |
| EP2164856A1 (en) * | 2007-06-01 | 2010-03-24 | Synthon B.V. | Processes related to making capecitabine |
| US8741858B2 (en) | 2007-09-21 | 2014-06-03 | Zhongxu Ren | Oligomer-nucleoside phosphate conjugates |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| EP2225566A1 (en) * | 2008-01-03 | 2010-09-08 | Plus Chemicals S.A. | Process for the preparation of capecitabine |
| NZ590009A (en) | 2008-06-17 | 2012-08-31 | Wyeth Llc | Antineoplastic combinations containing hki-272 and vinorelbine |
| JP2011529955A (ja) | 2008-08-04 | 2011-12-15 | アストラゼネカ アクチボラグ | 治療薬４１４ |
| KR101434009B1 (ko) | 2008-08-04 | 2014-08-25 | 와이어쓰 엘엘씨 | 4-아닐리노-3-사이아노퀴놀린과 카페시타빈의 항신생물성 조합물 |
| EP2370414A4 (en) * | 2008-12-02 | 2012-11-14 | Reddys Lab Ltd Dr | PREPARATION OF CAPECITABINE |
| EP2393472B1 (en) * | 2008-12-05 | 2019-06-05 | NanoMed Holdings Pty Ltd | Amphiphile prodrugs |
| CN101787066B (zh) * | 2009-01-23 | 2013-07-31 | 高峰 | 阿糖胞苷衍生物及其在抗癌抗肿瘤中的用途 |
| GB0902434D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
| GB0902406D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
| CN103989681A (zh) | 2009-04-06 | 2014-08-20 | 惠氏有限责任公司 | 用于乳腺癌的利用奈拉替尼的治疗方案 |
| WO2010116176A1 (en) * | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
| WO2010116177A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity |
| CN101875680B (zh) * | 2009-04-28 | 2012-07-25 | 上海信旗医药科技有限公司 | 一种核苷类化合物及其制备方法和应用 |
| EP2456778A4 (en) * | 2009-07-23 | 2013-05-29 | Scinopharm Taiwan Ltd | PROCESS FOR PRODUCING FLUOROCYTIDINE DERIVATIVES |
| HUE027831T2 (en) | 2010-03-12 | 2016-11-28 | Genzyme Corp | Combination therapy for breast cancer |
| CN108949772A (zh) | 2012-04-02 | 2018-12-07 | 现代泰克斯公司 | 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸 |
| EP3520821A1 (en) | 2012-04-02 | 2019-08-07 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| JP6666147B2 (ja) | 2012-09-26 | 2020-03-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 環状エーテルピラゾール−４−イル−ヘテロシクリル−カルボキサミド化合物と使用方法 |
| WO2014074725A1 (en) | 2012-11-07 | 2014-05-15 | Ohio State Innovation Foundation | Substituted gemcitabine aryl amide analogs |
| WO2014152027A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Manufacturing methods for production of rna transcripts |
| EP2968382B1 (en) * | 2013-03-15 | 2018-03-07 | Nucorion Pharmaceuticals, Inc. | Substituted gemcitabine bicyclic amide analogs and treatment methods using same |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| CN103450301B (zh) * | 2013-09-09 | 2015-09-09 | 南通大学 | 法尼基硫代水杨酸-核苷缀合物、其制备方法及其医药用途 |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| RU2770081C2 (ru) * | 2016-06-28 | 2022-04-14 | Селликс Био Прайвет Лимитед | Композиции и способы для лечения рака |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| CA3049435A1 (en) | 2017-01-09 | 2018-07-12 | Scott Grindrod | Selective histone deacetylase inhibitors for the treatment of human disease |
| WO2018200859A1 (en) | 2017-04-26 | 2018-11-01 | Kalman Thomas I | Multitargeted nucleoside derivatives |
| US10435429B2 (en) | 2017-10-03 | 2019-10-08 | Nucorion Pharmaceuticals, Inc. | 5-fluorouridine monophosphate cyclic triester compounds |
| EP3737376B1 (en) | 2018-01-09 | 2024-04-17 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human diseases |
| EP3752511A4 (en) | 2018-01-10 | 2021-12-29 | Nucorion Pharmaceuticals, Inc. | Phosphor(n)amidatacetal and phosph(on)atalcetal compounds |
| US11427550B2 (en) | 2018-01-19 | 2022-08-30 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| WO2019143860A1 (en) * | 2018-01-19 | 2019-07-25 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| SG11202100411TA (en) * | 2018-08-03 | 2021-02-25 | Cellix Bio Private Ltd | Compositions and methods for the treatment of cancer |
| CN109651467A (zh) * | 2019-01-15 | 2019-04-19 | 齐鲁天和惠世制药有限公司 | 一种卡培他滨杂质及其制备方法 |
| EP3999519A4 (en) | 2019-07-17 | 2023-08-16 | Nucorion Pharmaceuticals, Inc. | CYCLIC DEOXYRIBONUCLEOTIDE COMPOUNDS |
| WO2021216427A1 (en) | 2020-04-21 | 2021-10-28 | Ligand Pharmaceuticals, Inc. | Nucleotide prodrug compounds |
| US20230295257A1 (en) | 2020-07-24 | 2023-09-21 | Strand Therapeutics Inc. | Lipid nanoparticle comprising modified nucleotides |
| US20240166707A1 (en) | 2021-01-08 | 2024-05-23 | Strand Therapeutics Inc. | Expression constructs and uses thereof |
| JP2025516226A (ja) | 2022-04-26 | 2025-05-27 | ストランド セラピューティクス インコーポレイテッド | ベネズエラウマ脳炎（ｖｅｅ）レプリコンを含む脂質ナノ粒子及びその使用 |
| WO2025193628A2 (en) | 2024-03-09 | 2025-09-18 | Aadigen, Llc | Compositions for treating cancer with kras mutations and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3404144A (en) * | 1965-12-23 | 1968-10-01 | Research Corp | 1-beta-d-arabinofuranosyl-5-fluorocytosine compounds |
| GB1379410A (en) * | 1971-06-08 | 1975-01-02 | Upjohn Co | 1-beta-d-arabino-furanosyl-n4-alpha-aminoacylcytosines |
| JPS52153977A (en) * | 1976-06-11 | 1977-12-21 | Daikin Ind Ltd | Synthesis of 5-fluorouracil and its derivatives |
| US4071680A (en) * | 1976-12-20 | 1978-01-31 | Hoffmann-La Roche Inc. | 5'-Deoxy-5-fluoropyrimidine nucleosides |
| CH633810A5 (en) * | 1978-01-01 | 1982-12-31 | Hoffmann La Roche | Novel nucleosides and process for their preparation |
| FR2528311B1 (fr) * | 1982-06-14 | 1985-06-14 | Synthelabo | Compositions pharmaceutiques a base de xylosides et lyxosides de bases puriques et pyrimidiques |
| JPS61112093A (ja) * | 1984-11-05 | 1986-05-30 | Wakunaga Seiyaku Kk | ヌクレオチド誘導体 |
-
1988
- 1988-11-02 CA CA000581964A patent/CA1327358C/en not_active Expired - Lifetime
- 1988-11-07 EP EP88118515A patent/EP0316704B1/de not_active Expired - Lifetime
- 1988-11-07 AT AT88118515T patent/ATE124951T1/de active
- 1988-11-07 ES ES88118515T patent/ES2074429T3/es not_active Expired - Lifetime
- 1988-11-07 DE DE2001199027 patent/DE10199027I2/de active Active
- 1988-11-07 DE DE3854148T patent/DE3854148D1/de not_active Expired - Lifetime
- 1988-11-08 US US07/268,437 patent/US4966891A/en not_active Expired - Lifetime
- 1988-11-10 ZA ZA888428A patent/ZA888428B/xx unknown
- 1988-11-10 NZ NZ226923A patent/NZ226923A/xx unknown
- 1988-11-10 YU YU209188A patent/YU47122B/sh unknown
- 1988-11-11 IL IL88363A patent/IL88363A0/xx not_active IP Right Cessation
- 1988-11-14 JP JP63285940A patent/JPH0678350B2/ja not_active Expired - Lifetime
- 1988-11-14 MC MC882015A patent/MC1992A1/fr unknown
- 1988-11-14 HU HU885799A patent/HU199866B/hu unknown
- 1988-11-15 CS CS747588A patent/CS274486B2/cs not_active IP Right Cessation
- 1988-11-15 KR KR1019880014983A patent/KR970000241B1/ko not_active Expired - Lifetime
- 1988-11-16 PT PT89009A patent/PT89009B/pt not_active IP Right Cessation
- 1988-11-16 NO NO885106A patent/NO171167C/no not_active IP Right Cessation
- 1988-11-16 IS IS3412A patent/IS1895B/is unknown
- 1988-11-16 SU SU884356869A patent/SU1736342A3/ru active
- 1988-11-16 PH PH37820A patent/PH25641A/en unknown
- 1988-11-16 AR AR88312471A patent/AR247217A1/es active
- 1988-11-16 CN CN88107886A patent/CN1022688C/zh not_active Expired - Lifetime
- 1988-11-16 IE IE883430A patent/IE883430L/xx not_active IP Right Cessation
- 1988-11-16 DK DK640388A patent/DK170893B1/da not_active IP Right Cessation
- 1988-11-16 AU AU25168/88A patent/AU619220B2/en not_active Expired
- 1988-11-16 DZ DZ880179A patent/DZ1270A1/fr active
- 1988-11-16 UA UA4356869A patent/UA19333A/uk unknown
- 1988-11-17 MX MX013836A patent/MX173347B/es unknown
- 1988-11-17 FI FI885329A patent/FI89804C/fi not_active IP Right Cessation
-
1993
- 1993-06-08 LV LV930507A patent/LV5624A3/xx unknown
- 1993-07-20 LT LTRP802A patent/LT2185B/xx not_active IP Right Cessation
-
1995
- 1995-10-10 GR GR950402791T patent/GR3017686T3/el unknown
-
1998
- 1998-03-17 HK HK98102225A patent/HK1003114A1/xx not_active IP Right Cessation
-
2001
- 2001-05-02 LU LU90769C patent/LU90769I2/fr unknown
- 2001-05-17 NL NL300045C patent/NL300045I2/nl unknown
- 2001-07-17 NO NO2001013C patent/NO2001013I2/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX173347B (es) | Procedimiento para producir derivados de 5'-deoxi-5-fluorocitidina y producto obtenido | |
| UY23697A1 (es) | Procedimiento para la preparacion de 5'-deoxi-5'-fluorcitidinas sustitutas del n-oxicarbonilo | |
| ES482240A1 (es) | Procedimiento de obtencion de un complejo de platinoamina. | |
| GR3004629T3 (es) | ||
| ES8300699A1 (es) | Procedimiento para la preparacion de derivados del indol. | |
| GR861778B (en) | Method for preparing novel dihydro-2,3 benzofurane | |
| ES8101550A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol. | |
| DE69230532D1 (de) | Inositolderivate, sie enthaltende präparate und ihre herstellung | |
| EP0047323A4 (en) | 1,4-NAPHTHOQUINONE DERIVATIVES AND THEIR USE. | |
| ES406551A1 (es) | Procedimiento para la obtencion de derivados de la oxidia- zolona. | |
| HUT35253A (en) | Process for preparing 4-/3-alkynyl-oxy-2-hydroxy-propyl/-piperazin-1-y1-n-phenyl-acetamide derivatives | |
| EP0410953A3 (en) | Piperidine compounds | |
| ES395766A1 (es) | Procedimiento para la obtencion de derivados de la hidan- toina. | |
| FR2487340B1 (es) | ||
| ES481872A1 (es) | Un procedimiento para la preparacion de derivados del 3-azo-biciclo (3.1.0) hexano. | |
| DE3570672D1 (en) | Pentacoordinated silicon complexes, process for their preparation and their use in preparing organosilanes | |
| ES440135A1 (es) | Procedimiento para producir s-inosilcisteina. | |
| ES367168A1 (es) | Un procedimiento de preparacion de nuevos compuestos fosfo-rados. | |
| ZA90231B (en) | Process for separating optical isomers of 1,4-dihydropyridine derivatives | |
| ES8502675A1 (es) | Un metodo para preparar productos intermedios para la obtencion de 4-fenil-1,3-benzodiazepinas | |
| ES468143A1 (es) | Procedimiento para la obtencion de esteres de acido fosfori-co perfluoralquilsustituidos. | |
| SE7503560L (es) | ||
| HUT38090A (en) | Process for production of derivatives of 2,2,5,2-tetraalkyl-cyclohexan-4-on-1-ol | |
| ES474786A1 (es) | Procedimiento para la preparacion de nuevos compuestos hete-rociclicos | |
| GB1067626A (en) | 3-aminoalkyl-4-alkyl-coumarin derivatives and process for the manufacture thereof |