NL300045I1 - Fluorcytidine-derivaten, de bereiding daarvan en geneesmidddelen die deze derivaten bevatten. - Google Patents

Fluorcytidine-derivaten, de bereiding daarvan en geneesmidddelen die deze derivaten bevatten.

Info

Publication number
NL300045I1
NL300045I1 NL300045C NL300045C NL300045I1 NL 300045 I1 NL300045 I1 NL 300045I1 NL 300045 C NL300045 C NL 300045C NL 300045 C NL300045 C NL 300045C NL 300045 I1 NL300045 I1 NL 300045I1
Authority
NL
Netherlands
Prior art keywords
derivatives
preparation
fluorocytidine
drugs containing
drugs
Prior art date
Application number
NL300045C
Other languages
English (en)
Other versions
NL300045I2 (nl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL300045I1 publication Critical patent/NL300045I1/nl
Publication of NL300045I2 publication Critical patent/NL300045I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NL300045C 1987-11-17 2001-05-17 Fluorcytidine-derivaten, de bereiding daarvan en geneesmiddelen die deze derivaten bevatten. NL300045I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87116926 1987-11-17
EP88118515A EP0316704B1 (de) 1987-11-17 1988-11-07 Fluorcytidinderivate, deren Herstellung und Arzneimittel, die diese Derivate enthalten

Publications (2)

Publication Number Publication Date
NL300045I1 true NL300045I1 (nl) 2001-08-01
NL300045I2 NL300045I2 (nl) 2002-01-02

Family

ID=8197450

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300045C NL300045I2 (nl) 1987-11-17 2001-05-17 Fluorcytidine-derivaten, de bereiding daarvan en geneesmiddelen die deze derivaten bevatten.

Country Status (35)

Country Link
US (1) US4966891A (nl)
EP (1) EP0316704B1 (nl)
JP (1) JPH0678350B2 (nl)
KR (1) KR970000241B1 (nl)
CN (1) CN1022688C (nl)
AR (1) AR247217A1 (nl)
AT (1) ATE124951T1 (nl)
AU (1) AU619220B2 (nl)
CA (1) CA1327358C (nl)
CS (1) CS274486B2 (nl)
DE (2) DE3854148D1 (nl)
DK (1) DK170893B1 (nl)
DZ (1) DZ1270A1 (nl)
ES (1) ES2074429T3 (nl)
FI (1) FI89804C (nl)
GR (1) GR3017686T3 (nl)
HK (1) HK1003114A1 (nl)
HU (1) HU199866B (nl)
IE (1) IE883430L (nl)
IL (1) IL88363A0 (nl)
IS (1) IS1895B (nl)
LT (1) LT2185B (nl)
LU (1) LU90769I2 (nl)
LV (1) LV5624A3 (nl)
MC (1) MC1992A1 (nl)
MX (1) MX173347B (nl)
NL (1) NL300045I2 (nl)
NO (2) NO171167C (nl)
NZ (1) NZ226923A (nl)
PH (1) PH25641A (nl)
PT (1) PT89009B (nl)
SU (1) SU1736342A3 (nl)
UA (1) UA19333A (nl)
YU (1) YU47122B (nl)
ZA (1) ZA888428B (nl)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258360B1 (en) * 1989-05-04 2001-07-10 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
US5527782A (en) * 1990-03-13 1996-06-18 Acic (Canada) Inc. 5-halo-2,3'-O-cyclocytidines
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (nl) * 1992-12-18 1995-08-21 Hoffmann La Roche
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives
US6005098A (en) * 1998-02-06 1999-12-21 Hoffmann-La Roche Inc. 5'deoxycytidine derivatives
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US20010051348A1 (en) * 2000-01-28 2001-12-13 Lee Chee Wee Novel ligands and methods for preparing same
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US6774758B2 (en) * 2002-09-11 2004-08-10 Kalyan P. Gokhale Low harmonic rectifier circuit
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
EP1631278A4 (en) * 2003-05-20 2006-09-20 Aronex Pharmaceuticals Inc COMBINED CHEMOTHERAPY COMPRISING CAPECITABINE AND A COMPLEX BASED ON LIPOSOMIC PLATINUM
ES2310298T3 (es) * 2003-12-22 2009-01-01 F. Hoffmann-La Roche Ag Proceso para producir derivados de fluorocitidina.
KR20070007104A (ko) * 2004-02-18 2007-01-12 아스트라제네카 아베 화합물
EP1718624B1 (en) * 2004-02-18 2009-03-25 AstraZeneca AB Benzamide derivatives and their use as glucokinase activating agents
CN100383128C (zh) * 2004-02-23 2008-04-23 上海迪赛诺医药发展有限公司 N4－氧羰基胞嘧啶衍生物及制备方法与应用
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
KR101061850B1 (ko) 2004-09-08 2011-09-02 삼성전자주식회사 박막 트랜지스터 표시판 및 그 제조방법
GB0421294D0 (en) * 2004-09-24 2004-10-27 Angiogene Pharm Ltd Bioreductively-activated prodrugs
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
KR20070085371A (ko) 2004-10-16 2007-08-27 아스트라제네카 아베 페녹시 벤즈아미드 화합물의 제조 방법
CN113975393A (zh) 2005-02-03 2022-01-28 综合医院公司 治疗吉非替尼耐药性癌症的方法
NO322682B1 (no) * 2005-03-18 2006-11-27 Clavis Pharma Asa Anvendelse av gemcitabinderivater for fremstilling av orale doseringsformer ved kreftbehandling, samt slike orale doseringsformer
WO2006103187A2 (en) * 2005-04-01 2006-10-05 F. Hoffmann-La Roche Ag Method for administration of capecitabine
WO2006125958A1 (en) * 2005-05-24 2006-11-30 Astrazeneca Ab 2-phenyl substituted imidazol [4 , 5b] pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
EP2027113A1 (en) * 2005-07-09 2009-02-25 AstraZeneca AB Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
NZ575512A (en) 2005-07-09 2009-11-27 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
CN100569790C (zh) * 2005-07-15 2009-12-16 上海奥锐特国际贸易有限公司 合成n4-酰基-5＇-脱氧-5-氟胞苷衍生物的方法
US20080292729A1 (en) * 2005-07-21 2008-11-27 Nuvo Research Inc. Stabilized Chlorite Solutions in Combination with Fluoropyrimidines for Cancer Treatment
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
CA2626326C (en) 2005-11-04 2021-02-16 Wyeth Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
TW200738621A (en) 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
US20080085310A1 (en) * 2006-10-06 2008-04-10 Maria Oksana Bachynsky Capecitabine rapidly disintegrating tablets
TW200825063A (en) 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
SA07280576B1 (ar) 2006-10-26 2011-06-22 استرازينيكا ايه بي مركبات بنزويل أمينو سيكليل غير متجانسة بأعتبارها عوامل منشطة للجلوكوكيناز
CN100425617C (zh) * 2006-10-31 2008-10-15 浙江海正药业股份有限公司 一种含氟嘧啶类化合物烷氧羰酰化的方法
CN101595104A (zh) 2006-12-21 2009-12-02 阿斯利康(瑞典)有限公司 作为glk活化剂的新的晶态化合物
ITMI20070435A1 (it) 2007-03-05 2008-09-06 Innovate Biotechnology Srl 2',3'-di-o-acil-5-fluoronucleosidi
MX2009011255A (es) * 2007-04-20 2009-11-23 Reddys Lab Ltd Dr Proceso para preparar capecitabina.
WO2008145403A1 (en) * 2007-06-01 2008-12-04 Synthon B.V. Processes related to making capecitabine
WO2009042064A2 (en) 2007-09-21 2009-04-02 Nektar Therapeutics Al, Corporation Oligomer-nucleoside phosphate conjugates
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
WO2009088989A1 (en) * 2008-01-03 2009-07-16 Plus Chemicals, S.A. Process for the preparation of capecitabine
NZ600982A (en) 2008-06-17 2014-01-31 Wyeth Llc Antineoplastic combinations containing hki-272 and vinorelbine
DK2326329T3 (en) * 2008-08-04 2017-02-20 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
MX2011001333A (es) 2008-08-04 2011-03-15 Astrazeneca Ab Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad.
WO2010065586A2 (en) * 2008-12-02 2010-06-10 Dr. Reddy's Laboratories Ltd. Preparation of capecitabine
WO2010063080A1 (en) * 2008-12-05 2010-06-10 Commonwealth Scientific And Industrial Research Organisation Amphiphile prodrugs
CN101787066B (zh) * 2009-01-23 2013-07-31 高峰 阿糖胞苷衍生物及其在抗癌抗肿瘤中的用途
GB0902434D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
CN105999264A (zh) 2009-04-06 2016-10-12 惠氏有限责任公司 用于乳腺癌的利用奈拉替尼的治疗方案
WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
CN101875680B (zh) * 2009-04-28 2012-07-25 上海信旗医药科技有限公司 一种核苷类化合物及其制备方法和应用
US20110021769A1 (en) * 2009-07-23 2011-01-27 Scinopharm Taiwan Ltd. Process for Producing Fluorocytidine Derivatives
PT2835053T (pt) 2010-03-12 2016-07-14 Genzyme Corp Terapêutica combinada para o tratamento do cancro da mama
CN104411338A (zh) 2012-04-02 2015-03-11 现代治疗公司 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
DE18200782T1 (de) 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
HUE049611T2 (hu) 2012-09-26 2020-09-28 Hoffmann La Roche Ciklikus éter-pirazol-4-il-heterociklil-karboxamid vegyületek és felhasználási módszerek
CN104955458A (zh) 2012-11-07 2015-09-30 Z·索 取代的吉西他滨芳基酰胺类似物和使用所述类似物的治疗方法
EP2968382B1 (en) 2013-03-15 2018-03-07 Nucorion Pharmaceuticals, Inc. Substituted gemcitabine bicyclic amide analogs and treatment methods using same
EP2971033B8 (en) 2013-03-15 2019-07-10 ModernaTX, Inc. Manufacturing methods for production of rna transcripts
CA2923029A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
CN103450301B (zh) * 2013-09-09 2015-09-09 南通大学 法尼基硫代水杨酸-核苷缀合物、其制备方法及其医药用途
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
US10858349B2 (en) * 2016-06-28 2020-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of cancer
ES2914123T3 (es) 2017-01-09 2022-06-07 Shuttle Pharmaceuticals Inc Inhibidores selectivos de la histona desacetilasa para el tratamiento de una enfermedad humana
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
CN110831605A (zh) 2017-04-26 2020-02-21 托马斯·I.·卡尔曼 多靶标的核苷衍生物
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
EP3737376B1 (en) 2018-01-09 2024-04-17 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human diseases
WO2019139920A1 (en) 2018-01-10 2019-07-18 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
WO2019143860A1 (en) * 2018-01-19 2019-07-25 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
EP3817732A4 (en) * 2018-08-03 2022-06-08 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
CN109651467A (zh) * 2019-01-15 2019-04-19 齐鲁天和惠世制药有限公司 一种卡培他滨杂质及其制备方法
US12110311B2 (en) 2019-07-17 2024-10-08 Nucorion Pharmaceuticals, Inc. Cyclic deoxyribonucleotide compounds
WO2021216427A1 (en) 2020-04-21 2021-10-28 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
US20230295257A1 (en) 2020-07-24 2023-09-21 Strand Therapeutics Inc. Lipid nanoparticle comprising modified nucleotides
KR20230129479A (ko) 2021-01-08 2023-09-08 스트랜드 세러퓨틱스 인코포레이티드 발현 구성체 및 이의 용도
AU2023262576A1 (en) 2022-04-26 2024-10-10 Strand Therapeutics Inc. Lipid nanoparticles comprising venezuelan equine encephalitis (vee) replicon and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404144A (en) * 1965-12-23 1968-10-01 Research Corp 1-beta-d-arabinofuranosyl-5-fluorocytosine compounds
GB1379410A (en) * 1971-06-08 1975-01-02 Upjohn Co 1-beta-d-arabino-furanosyl-n4-alpha-aminoacylcytosines
JPS52153977A (en) * 1976-06-11 1977-12-21 Daikin Ind Ltd Synthesis of 5-fluorouracil and its derivatives
US4071680A (en) * 1976-12-20 1978-01-31 Hoffmann-La Roche Inc. 5'-Deoxy-5-fluoropyrimidine nucleosides
CH633810A5 (en) * 1978-01-01 1982-12-31 Hoffmann La Roche Novel nucleosides and process for their preparation
FR2528311B1 (fr) * 1982-06-14 1985-06-14 Synthelabo Compositions pharmaceutiques a base de xylosides et lyxosides de bases puriques et pyrimidiques
JPS61112093A (ja) * 1984-11-05 1986-05-30 Wakunaga Seiyaku Kk ヌクレオチド誘導体

Also Published As

Publication number Publication date
LT2185B (lt) 1993-10-15
KR890008162A (ko) 1989-07-10
HK1003114A1 (en) 1998-10-09
AR247217A1 (es) 1994-11-30
SU1736342A3 (ru) 1992-05-23
GR3017686T3 (en) 1996-01-31
IS1895B (is) 2003-10-20
FI89804C (fi) 1993-11-25
EP0316704B1 (de) 1995-07-12
DK170893B1 (da) 1996-03-04
JPH01153696A (ja) 1989-06-15
ATE124951T1 (de) 1995-07-15
FI885329A0 (fi) 1988-11-17
ZA888428B (en) 1989-06-28
JPH0678350B2 (ja) 1994-10-05
DE3854148D1 (de) 1995-08-17
NZ226923A (en) 1990-10-26
DE10199027I2 (de) 2002-01-31
DK640388D0 (da) 1988-11-16
MX13836A (es) 1993-10-01
NO171167B (no) 1992-10-26
PT89009A (pt) 1988-12-01
US4966891A (en) 1990-10-30
IL88363A0 (en) 1989-06-30
FI89804B (fi) 1993-08-13
CN1033183A (zh) 1989-05-31
NO171167C (no) 1993-02-03
PH25641A (en) 1991-08-21
CN1022688C (zh) 1993-11-10
EP0316704A3 (en) 1990-11-22
UA19333A (uk) 1997-12-25
DE10199027I1 (de) 2001-08-02
EP0316704A2 (de) 1989-05-24
CA1327358C (en) 1994-03-01
AU619220B2 (en) 1992-01-23
KR970000241B1 (ko) 1997-01-08
IE883430L (en) 1989-05-17
NO885106D0 (no) 1988-11-16
NL300045I2 (nl) 2002-01-02
YU47122B (sh) 1994-12-28
DK640388A (da) 1989-05-18
ES2074429T3 (es) 1995-09-16
LU90769I2 (fr) 2001-07-02
NO2001013I2 (no) 2006-05-01
HU199866B (en) 1990-03-28
IS3412A7 (is) 1989-05-18
CS747588A2 (en) 1990-09-12
AU2516888A (en) 1989-05-25
CS274486B2 (en) 1991-04-11
MX173347B (es) 1994-01-03
YU209188A (en) 1990-08-31
LV5624A3 (lv) 1994-05-10
MC1992A1 (fr) 1989-11-30
DZ1270A1 (fr) 2004-09-13
PT89009B (pt) 1993-02-26
HUT48267A (en) 1989-05-29
NO885106L (no) 1989-05-18
FI885329A (fi) 1989-05-18

Similar Documents

Publication Publication Date Title
NL300045I1 (nl) Fluorcytidine-derivaten, de bereiding daarvan en geneesmidddelen die deze derivaten bevatten.
DE68911473D1 (de) Arzneimittelformulierungen.
NL960006I1 (nl) Purine-derivaten en de farmaceutische toepassing daarvan.
FI875326A (fi) Ljusbestraolningsanordning foer medicinal vaord av oera.
NL194239B (nl) Dialkoxyfosfinolmethylbenzamideverbindingen en farmaceutische preparaten, die deze bevatten.
FI893340A0 (fi) Foerfarande foer att erhaolla farmaceutiska sammansaettningar foer att hindra smittbara koenssjukdomar.
IT8821719A0 (it) Piperidine pontate, loro preparazione e loro impiego come medicamenti.
NO873534D0 (no) Stabilt farmasoeytisk gelpreparat.
FI872630A (fi) Farmaceutiska kompositioner foer utvaertes bruk, vilka laett penetrerar huden.
FR2601368B1 (fr) Derives de nitrofuranne, leur preparation et leur application en therapeutique.
PH19739A (en) W-cyano-1,w -diphenyl-azaalkane derivatives,their preparation and drugs containing them
NL8601838A (nl) Distamycinederivaten, werkwijze voor de bereiding ervan, alsmede farmaceutische preparaten, die deze derivaten bevatten.
DK170889A (da) Anvendelse af a1(iii)- eller fe(iii)-chelater til bekaempelse af bloeddyr
NL194431B (nl) Farmaceutische preparaten die ranitidine bevatten.
DE68918215D1 (de) 2'-Halomethyliden, 2'-Ethenyliden und 2'-Ethynyl-Adenosinderivate.
FI905236A0 (fi) Deoxiribonukleosider innehaollande farmaceutiska konsistenser foer laekning av saor.
DE3763519D1 (de) Heilnahrungsmittel.
ZA872739B (en) Benzimidazolesulfonamides and imidazopyridine-sulfonamides,their preparation and their application as drugs
NO882849L (no) 3',4'-dinitrogensubstituerte epipodofyllotoksinglukosidderivater.
FI875616A0 (fi) Farmaceutiska blandningar.
DE58905160D1 (de) Pharmazeutische zubereitung.
DE69012950D1 (de) Antikrebsmittel.
TR25921A (tr) PESTISID ETKINLIGI HAIZ PESTISID ÖZELLIKTE BISIKLOOKTANLAR,BUNLARI IHTIVA EDEN FORMüLASYONLAR VE HAZIRLANMALARINA MAHSUS USULLER.
DE3888800D1 (de) Transdermales Arzneimittelpräparat.
IT8720179A0 (it) 2-sulfinil-acetil-1,3-tiazolidine, loro preparazione e composizioni farmaceutiche.