ATE116984T1 - Therapeutische nukleoside. - Google Patents

Therapeutische nukleoside.

Info

Publication number
ATE116984T1
ATE116984T1 AT88303158T AT88303158T ATE116984T1 AT E116984 T1 ATE116984 T1 AT E116984T1 AT 88303158 T AT88303158 T AT 88303158T AT 88303158 T AT88303158 T AT 88303158T AT E116984 T1 ATE116984 T1 AT E116984T1
Authority
AT
Austria
Prior art keywords
therapeutic nucleosides
nucleosides
therapeutic
Prior art date
Application number
AT88303158T
Other languages
English (en)
Inventor
George Walter Koszalka
Thomas Anthony Krenitsky
Janet Litster Rideout
Charlene Louise Burns
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878708512A external-priority patent/GB8708512D0/en
Priority claimed from GB878712691A external-priority patent/GB8712691D0/en
Priority claimed from GB878723013A external-priority patent/GB8723013D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE116984T1 publication Critical patent/ATE116984T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
AT88303158T 1987-04-09 1988-04-08 Therapeutische nukleoside. ATE116984T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878708512A GB8708512D0 (en) 1987-04-09 1987-04-09 Therapeutic nucleosides
GB878712691A GB8712691D0 (en) 1987-05-29 1987-05-29 Therapeutic nucleosides
GB878723013A GB8723013D0 (en) 1987-09-30 1987-09-30 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
ATE116984T1 true ATE116984T1 (de) 1995-01-15

Family

ID=27263377

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88303158T ATE116984T1 (de) 1987-04-09 1988-04-08 Therapeutische nukleoside.

Country Status (20)

Country Link
US (1) US5068320A (de)
EP (1) EP0286425B1 (de)
JP (1) JP2763888B2 (de)
KR (1) KR880012630A (de)
AP (1) AP78A (de)
AT (1) ATE116984T1 (de)
AU (1) AU608590B2 (de)
CA (1) CA1326237C (de)
CS (1) CS274461B2 (de)
DE (1) DE3852710T2 (de)
DK (1) DK191688A (de)
FI (1) FI87214C (de)
HU (1) HU201954B (de)
IL (1) IL86007A0 (de)
MC (1) MC1915A1 (de)
NO (1) NO171641C (de)
NZ (1) NZ224189A (de)
PL (1) PL154956B1 (de)
PT (1) PT87191B (de)
RU (1) RU1779256C (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
DE68907013D1 (de) * 1988-10-24 1993-07-15 Wellcome Found Guaninderivate mit antiviraler wirkung und deren pharmazeutisch vertraegliche salze.
WO1990006312A1 (de) * 1988-11-29 1990-06-14 Institut Für Molekularbiologie Und Analytik (Ima) Gmbh 2', 3'-didesoxyribofuranoside und ein verfahren zu ihrer herstellung
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
US5013829A (en) * 1989-04-26 1991-05-07 University Of Iowa Research Foundation Stable congener of 2',3'-dideoxyadenosine
DE4020529A1 (de) * 1989-09-12 1991-03-21 Roxana Vasiloiu Multifunktionelle(s) enzym(e) mit nucleosid-didesoxyribosyltransferase(n) und/oder nucleoside-desoxyribosyltransferasen(n) und/oder kinease- und/oder reduktase- und/oder desaminase- und/oder polymerase-aktivitaet
JPH0637391B2 (ja) * 1989-09-29 1994-05-18 日本製紙株式会社 抗エイズウイルス剤
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
CA2075490A1 (en) * 1990-02-09 1991-08-10 Hiroaki Mitsuya 6-halo-and 2-amino-6-halo-purine 2',3'-dideoxy nucleosides and their use as antiviral agents
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
EA004767B1 (ru) * 1998-12-23 2004-08-26 Шайре Байокем Инк. Аналоги нуклеозида (варианты) и их применение, комбинация и способ лечения вирусных инфекций, фармацевтическая композиция
CN101220071B (zh) * 2008-01-17 2011-04-06 南京长澳医药科技有限公司 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物
CN102234280B (zh) * 2010-04-26 2014-01-08 北京大学 D,l-鸟嘌呤核苷类似物及其制备方法和应用
CA2810928A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
WO2012167053A1 (en) 2011-06-01 2012-12-06 Janus Biotherapeutics, Inc. Novel immune system modulators
CA2860234A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
CN104321333A (zh) 2012-03-21 2015-01-28 沃泰克斯药物股份有限公司 硫代氨基磷酸酯核苷酸前药的固体形式
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
RU2015137298A (ru) * 2013-03-05 2017-04-10 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
DE3608606A1 (de) * 1985-03-16 1986-09-18 The Wellcome Foundation Ltd., London 3'-azido-3'-deoxythymidin oder eine, ein pharmazeutisch vertraegliches derivat davon enthaltende pharmazeutische formulierung, verfahren zu ihrer herstellung und ihre verwendung
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
CA1314875C (en) * 1985-05-15 1993-03-23 George Walter Koszalka Therapeutic nucleosides
WO1987001283A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxycytidine
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
IT1203558B (it) * 1986-05-20 1989-02-15 Firestone Int Dev Spa Metodo per la realizzazione di un pneumatico radiale di prima fase per veicoli
ATE108183T1 (de) * 1987-03-24 1994-07-15 Nycomed Imaging As 2',3'-dideoxyribofuranoxid-derivate.
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
NZ225447A (en) * 1987-07-20 1991-12-23 Merck & Co Inc Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions

Also Published As

Publication number Publication date
FI87214B (fi) 1992-08-31
AU608590B2 (en) 1991-04-11
AU1444488A (en) 1988-10-13
PL154956B1 (en) 1991-10-31
NO881537D0 (no) 1988-04-08
PT87191A (pt) 1988-05-01
RU1779256C (ru) 1992-11-30
FI881651A (fi) 1988-10-10
KR880012630A (ko) 1988-11-28
NZ224189A (en) 1991-09-25
JPS63267796A (ja) 1988-11-04
MC1915A1 (fr) 1989-04-06
EP0286425A2 (de) 1988-10-12
NO171641C (no) 1993-04-14
CS274461B2 (en) 1991-04-11
DE3852710T2 (de) 1995-05-24
US5068320A (en) 1991-11-26
PT87191B (pt) 1993-02-26
FI87214C (fi) 1992-12-10
DK191688A (da) 1988-10-10
CS242188A2 (en) 1990-09-12
NO171641B (no) 1993-01-04
CA1326237C (en) 1994-01-18
PL271722A1 (en) 1989-01-23
IL86007A0 (en) 1988-09-30
DK191688D0 (da) 1988-04-08
HU201954B (en) 1991-01-28
FI881651A0 (fi) 1988-04-08
NO881537L (no) 1988-10-10
EP0286425A3 (en) 1990-12-05
HUT48269A (en) 1989-05-29
JP2763888B2 (ja) 1998-06-11
EP0286425B1 (de) 1995-01-11
DE3852710D1 (de) 1995-02-23
AP78A (en) 1990-03-12
AP8800086A0 (en) 1988-02-01

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties