MC1915A1 - Procédés pour la préparation de 2',3'-didésoxynucléosides et de formulations pharmaceutiques en contenant - Google Patents

Procédés pour la préparation de 2',3'-didésoxynucléosides et de formulations pharmaceutiques en contenant

Info

Publication number
MC1915A1
MC1915A1 MC881970A MC1970A MC1915A1 MC 1915 A1 MC1915 A1 MC 1915A1 MC 881970 A MC881970 A MC 881970A MC 1970 A MC1970 A MC 1970A MC 1915 A1 MC1915 A1 MC 1915A1
Authority
MC
Monaco
Prior art keywords
dideoxynucleosides
processes
preparation
pharmaceutical formulations
formulations containing
Prior art date
Application number
MC881970A
Other languages
English (en)
Inventor
Walter Koskalka George
Anthony Krenitsky Thomas
Litster Rideout Janet
Louise Burns Charlene
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878708512A external-priority patent/GB8708512D0/en
Priority claimed from GB878712691A external-priority patent/GB8712691D0/en
Priority claimed from GB878723013A external-priority patent/GB8723013D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC1915A1 publication Critical patent/MC1915A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
MC881970A 1987-04-09 1988-04-08 Procédés pour la préparation de 2',3'-didésoxynucléosides et de formulations pharmaceutiques en contenant MC1915A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878708512A GB8708512D0 (en) 1987-04-09 1987-04-09 Therapeutic nucleosides
GB878712691A GB8712691D0 (en) 1987-05-29 1987-05-29 Therapeutic nucleosides
GB878723013A GB8723013D0 (en) 1987-09-30 1987-09-30 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
MC1915A1 true MC1915A1 (fr) 1989-04-06

Family

ID=27263377

Family Applications (1)

Application Number Title Priority Date Filing Date
MC881970A MC1915A1 (fr) 1987-04-09 1988-04-08 Procédés pour la préparation de 2',3'-didésoxynucléosides et de formulations pharmaceutiques en contenant

Country Status (20)

Country Link
US (1) US5068320A (fr)
EP (1) EP0286425B1 (fr)
JP (1) JP2763888B2 (fr)
KR (1) KR880012630A (fr)
AP (1) AP78A (fr)
AT (1) ATE116984T1 (fr)
AU (1) AU608590B2 (fr)
CA (1) CA1326237C (fr)
CS (1) CS274461B2 (fr)
DE (1) DE3852710T2 (fr)
DK (1) DK191688A (fr)
FI (1) FI87214C (fr)
HU (1) HU201954B (fr)
IL (1) IL86007A0 (fr)
MC (1) MC1915A1 (fr)
NO (1) NO171641C (fr)
NZ (1) NZ224189A (fr)
PL (1) PL154956B1 (fr)
PT (1) PT87191B (fr)
RU (1) RU1779256C (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185437A (en) * 1987-04-09 1993-02-09 Burroughs Wellcome Co. Therapeutic nucleosides
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
EP0366385B1 (fr) * 1988-10-24 1993-06-09 The Wellcome Foundation Limited Dérivés de guanine ayant une activité anti-virale et leurs sels pharmaceutiquement acceptables
WO1990006312A1 (fr) * 1988-11-29 1990-06-14 Institut Für Molekularbiologie Und Analytik (Ima) Gmbh 2',3'-didesoxyribofuranosides et leur procede de production
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 ２′，３′−ジデオキシプリンヌクレオシド類の製造方法
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
US5013829A (en) * 1989-04-26 1991-05-07 University Of Iowa Research Foundation Stable congener of 2',3'-dideoxyadenosine
DE4020529A1 (de) * 1989-09-12 1991-03-21 Roxana Vasiloiu Multifunktionelle(s) enzym(e) mit nucleosid-didesoxyribosyltransferase(n) und/oder nucleoside-desoxyribosyltransferasen(n) und/oder kinease- und/oder reduktase- und/oder desaminase- und/oder polymerase-aktivitaet
JPH0637391B2 (ja) * 1989-09-29 1994-05-18 日本製紙株式会社 抗エイズウイルス剤
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
WO1991012260A1 (fr) * 1990-02-09 1991-08-22 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce 6-halo- et 2-amino-6-halo-purine 2',3'-didesoxy nucleosides ainsi que leur emploi en tant qu'agents antiviraux
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
JP2002533470A (ja) * 1998-12-23 2002-10-08 シャイアー・バイオケム・インコーポレイテッド 抗ウイルス性ヌクレオシド類似体
CN101220071B (zh) * 2008-01-17 2011-04-06 南京长澳医药科技有限公司 稳定的6-甲氧基-2’,3’-双脱氧鸟嘌呤核苷及其制备方法和包含它的药物组合物
CN102234280B (zh) * 2010-04-26 2014-01-08 北京大学 D,l-鸟嘌呤核苷类似物及其制备方法和应用
NZ607996A (en) 2010-09-22 2014-07-25 Alios Biopharma Inc Substituted nucleotide analogs
ES2583877T3 (es) * 2011-06-01 2016-09-22 Janus Biotherapeutics, Inc. Moduladores novedosos del sistema inmunitario
EP2794630A4 (fr) 2011-12-22 2015-04-01 Alios Biopharma Inc Analogues de nucléotide phosphorothioate substitués
WO2013142124A1 (fr) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Formes solides d'un promédicament nucléotidique thiophosphoramidate
NZ630805A (en) 2012-03-22 2016-01-29 Alios Biopharma Inc Pharmaceutical combinations comprising a thionucleotide analog
KR20150113195A (ko) * 2013-03-05 2015-10-07 에프. 호프만-라 로슈 아게 브루톤 티로신 키나아제의 억제제

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
AP11A (en) * 1985-03-16 1987-12-22 The Wellcome Foundation Ltd Antiviral nucleosides.
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
HU196607B (en) * 1985-05-15 1988-12-28 Wellcome Found Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds
WO1987001283A1 (fr) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition du caractere infectieux et de l'effet cytopathique du htlv-iii/lav in vitro par la 2',3'-dideoxycytidine
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
IT1203558B (it) * 1986-05-20 1989-02-15 Firestone Int Dev Spa Metodo per la realizzazione di un pneumatico radiale di prima fase per veicoli
NZ223990A (en) * 1987-03-24 1990-08-28 Nycomed As Acylated 2',3'-dideoxynucleosides and pharmaceutical compositions
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them
IL87149A (en) * 1987-07-20 1994-05-30 Merck & Co Inc 6-Piperazinyl derivatives of purine and its 3- and 9-deaza isosteres, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US5068320A (en) 1991-11-26
DK191688D0 (da) 1988-04-08
CS242188A2 (en) 1990-09-12
JP2763888B2 (ja) 1998-06-11
DE3852710T2 (de) 1995-05-24
PT87191A (pt) 1988-05-01
FI881651A0 (fi) 1988-04-08
HU201954B (en) 1991-01-28
AP8800086A0 (en) 1988-02-01
NO171641C (no) 1993-04-14
AU608590B2 (en) 1991-04-11
NO171641B (no) 1993-01-04
FI87214B (fi) 1992-08-31
JPS63267796A (ja) 1988-11-04
HUT48269A (en) 1989-05-29
AU1444488A (en) 1988-10-13
FI87214C (fi) 1992-12-10
ATE116984T1 (de) 1995-01-15
PL154956B1 (en) 1991-10-31
DK191688A (da) 1988-10-10
AP78A (en) 1990-03-12
EP0286425A2 (fr) 1988-10-12
PT87191B (pt) 1993-02-26
CS274461B2 (en) 1991-04-11
EP0286425A3 (en) 1990-12-05
DE3852710D1 (de) 1995-02-23
NO881537L (no) 1988-10-10
PL271722A1 (en) 1989-01-23
KR880012630A (ko) 1988-11-28
RU1779256C (ru) 1992-11-30
EP0286425B1 (fr) 1995-01-11
NO881537D0 (no) 1988-04-08
FI881651A (fi) 1988-10-10
NZ224189A (en) 1991-09-25
CA1326237C (fr) 1994-01-18
IL86007A0 (en) 1988-09-30

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