OA07124A - Dipeptides substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant et leur utilisation pour l'inhibition de l'encéphalinase. - Google Patents

Dipeptides substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant et leur utilisation pour l'inhibition de l'encéphalinase.

Info

Publication number
OA07124A
OA07124A OA57714A OA57714A OA07124A OA 07124 A OA07124 A OA 07124A OA 57714 A OA57714 A OA 57714A OA 57714 A OA57714 A OA 57714A OA 07124 A OA07124 A OA 07124A
Authority
OA
OAPI
Prior art keywords
dipipeptides
encephalinase
inhibition
substituted
processes
Prior art date
Application number
OA57714A
Other languages
English (en)
Inventor
Joel G Berger
Jay Weinstein
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority claimed from CA000405374A external-priority patent/CA1304540C/fr
Publication of OA07124A publication Critical patent/OA07124A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
OA57714A 1980-12-18 1982-06-17 Dipeptides substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant et leur utilisation pour l'inhibition de l'encéphalinase. OA07124A (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US21762180A 1980-12-18 1980-12-18
US23354981A 1981-02-12 1981-02-12
US23354881A 1981-02-12 1981-02-12
US25848581A 1981-04-28 1981-04-28
US25848681A 1981-04-28 1981-04-28
US25848781A 1981-04-28 1981-04-28
AU84947/82A AU560004B2 (en) 1980-12-18 1982-06-17 Dipeptide derivatives
CA000405374A CA1304540C (fr) 1981-04-28 1982-06-17 Dipeptides substitues, procedes pour leur preparation et composes pharmaceutiques en contenant, et leur utilisation pour l'inhibition de l'encephalinase

Publications (1)

Publication Number Publication Date
OA07124A true OA07124A (fr) 1984-03-31

Family

ID=36764482

Family Applications (1)

Application Number Title Priority Date Filing Date
OA57714A OA07124A (fr) 1980-12-18 1982-06-17 Dipeptides substitués, procédés pour leur préparation et compositions pharmaceutiques les contenant et leur utilisation pour l'inhibition de l'encéphalinase.

Country Status (4)

Country Link
EP (1) EP0054862B1 (fr)
AU (1) AU560004B2 (fr)
CY (1) CY1406A (fr)
OA (1) OA07124A (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610816A (en) * 1980-12-18 1986-09-09 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
US4906615A (en) * 1980-12-18 1990-03-06 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
GR76792B (fr) * 1981-02-17 1984-09-04 Merck & Co Inc
US4766110A (en) * 1981-08-21 1988-08-23 Ryan James W Novel complex amido and imido derivatives of carboxyalkyl peptides
JPS58188847A (ja) * 1982-04-26 1983-11-04 Takeda Chem Ind Ltd ペプチド誘導体
ZA832844B (en) * 1982-05-18 1984-03-28 Smithkline Beckman Corp Oligopeptide prodrugs
DE3376649D1 (en) * 1982-06-17 1988-06-23 Schering Corp Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
AU1643283A (en) * 1982-07-19 1984-01-26 E.R. Squibb & Sons, Inc. Substituted peptides
EP0109500A1 (fr) * 1982-09-22 1984-05-30 Usv Pharmaceutical Corporation Semi-carbazides substitués à activité thérapeutique
US4866173A (en) * 1982-09-22 1989-09-12 Rorer Pharmaceutical Corporation Therapeutic substituted semicarbazides
US4500713A (en) * 1982-09-23 1985-02-19 Usv Pharmaceutical Corporation Therapeutic dipeptides
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
US4587234A (en) * 1982-11-18 1986-05-06 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
SU1247012A1 (ru) * 1983-07-13 1986-07-30 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Замещенные 3-гидразинопропионаты или их фармацевтически пригодные соли,обладающие антиаритмической активностью
US4798904A (en) * 1983-10-03 1989-01-17 E. R. Squibb & Sons, Inc. Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
US4774256A (en) * 1983-10-03 1988-09-27 E. R. Squibb & Sons, Inc. Use of enkephalinase inhibitors as analgesic agents
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
AU614716B2 (en) * 1985-08-14 1991-09-12 G.D. Searle & Co. Phenyl substituted dipeptide amides
ATE99698T1 (de) * 1985-10-14 1994-01-15 Nippon Zoki Pharmaceutical Co Peptide.
US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
EP0225292A3 (fr) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certains dérivés de butyramide N-substitués
EP0401963A1 (fr) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptides avec activité inhibitrice de collagénase
GB9107368D0 (en) * 1991-04-08 1991-05-22 Smithkline Beecham Plc Novel compounds
WO1992018159A1 (fr) * 1991-04-16 1992-10-29 Schering Corporation Utilisation d'inhibiteurs aux endopeptidases neutres dans le traitement de la nephrotoxicite
US5155100A (en) * 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
US5273990A (en) * 1992-09-03 1993-12-28 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives
US5594106A (en) * 1993-08-23 1997-01-14 Immunex Corporation Inhibitors of TNF-α secretion
DE69515465T2 (de) * 1994-11-04 2000-08-03 Santen Pharmaceutical Co., Ltd Neue hydroxy-substituierte 1,3-dialkyl-harnstoffderivate
WO1996018606A1 (fr) * 1994-12-14 1996-06-20 Santen Pharmaceutical Co., Ltd. Nouveaux derives 1,3-dialkyluree
US5583123A (en) * 1994-12-22 1996-12-10 Ciba-Geigy Corporation Certain tetrazole derivatives
US5550119A (en) * 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors
EP1090625B1 (fr) 1999-10-05 2004-12-22 Kao Corporation Composition topique pour la peau et l'usage de celle-ci

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316896A (en) * 1978-09-07 1982-02-23 Merck & Co., Inc. Aminoacid derivatives as antihypertensives
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0054862B1 (fr) 1985-11-27
EP0054862A1 (fr) 1982-06-30
AU560004B2 (en) 1987-03-26
CY1406A (en) 1988-04-22
AU8494782A (en) 1983-12-22

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