BR9507785A - Novos ésteres lipidios de monosfosfatos nucleosídeos e seu uso como drogas imunossupressoras - Google Patents

Novos ésteres lipidios de monosfosfatos nucleosídeos e seu uso como drogas imunossupressoras

Info

Publication number
BR9507785A
BR9507785A BR9507785A BR9507785A BR9507785A BR 9507785 A BR9507785 A BR 9507785A BR 9507785 A BR9507785 A BR 9507785A BR 9507785 A BR9507785 A BR 9507785A BR 9507785 A BR9507785 A BR 9507785A
Authority
BR
Brazil
Prior art keywords
desoxy
chain
monosphosphates
nucleoside
immunosuppressive drugs
Prior art date
Application number
BR9507785A
Other languages
English (en)
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of BR9507785A publication Critical patent/BR9507785A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BR9507785A 1994-05-28 1995-05-23 Novos ésteres lipidios de monosfosfatos nucleosídeos e seu uso como drogas imunossupressoras BR9507785A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
PCT/EP1995/001951 WO1995032984A1 (en) 1994-05-28 1995-05-23 New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs

Publications (1)

Publication Number Publication Date
BR9507785A true BR9507785A (pt) 1997-09-23

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9507785A BR9507785A (pt) 1994-05-28 1995-05-23 Novos ésteres lipidios de monosfosfatos nucleosídeos e seu uso como drogas imunossupressoras

Country Status (27)

Country Link
US (1) US6025343A (pt)
EP (2) EP1229040B8 (pt)
JP (1) JP3802057B2 (pt)
KR (1) KR100279087B1 (pt)
CN (1) CN1168735C (pt)
AT (2) ATE236189T1 (pt)
AU (1) AU688516B2 (pt)
BR (1) BR9507785A (pt)
CA (1) CA2190983C (pt)
CZ (1) CZ291846B6 (pt)
DE (3) DE4418690A1 (pt)
DK (2) DK1229040T3 (pt)
ES (2) ES2199250T3 (pt)
FI (1) FI117673B (pt)
HU (1) HU220336B (pt)
IL (1) IL113865A (pt)
MX (1) MX9605809A (pt)
NO (1) NO308998B1 (pt)
NZ (1) NZ287434A (pt)
PL (1) PL185290B1 (pt)
PT (2) PT1229040E (pt)
RU (1) RU2165429C2 (pt)
SK (1) SK284207B6 (pt)
TW (1) TW420686B (pt)
UA (1) UA45339C2 (pt)
WO (1) WO1995032984A1 (pt)
ZA (1) ZA954374B (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
JP3839857B2 (ja) * 1994-09-20 2006-11-01 塩野義製薬株式会社 エーテル型チオリン脂質化合物の製造方法
ES2206522T3 (es) * 1994-12-13 2004-05-16 Taiho Pharmaceutical Co., Ltd. Derivados de nucleosido sustituidos en 3'.
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
CA2348470C (en) 1998-11-05 2007-06-05 Centre National De La Recherche Scientifique Nucleosides with anti-hepatitis b virus activity
DE19855963A1 (de) * 1998-12-04 2000-06-08 Herbert Schott Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung
US7026469B2 (en) 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US6620796B1 (en) 1999-11-08 2003-09-16 Micrologix Biotech Inc. Combinatorial library synthesis and pharmaceutically active compounds produced thereby
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
US6734294B2 (en) * 2001-01-22 2004-05-11 Chad C. Nelson Isotopically enriched nucleic acids and associated methods for the production and purification thereof
WO2002092006A2 (en) 2001-05-16 2002-11-21 Micrologix Biotech, Inc. Nucleic acid-based compounds and methods of use thereof
NZ533094A (en) * 2001-11-21 2006-01-27 Heidelberg Pharma Gmbh Phospholipid derivatives of nucleosides as antitumoral medicaments
WO2006068760A2 (en) 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
EP1831235B1 (en) * 2004-12-16 2013-02-20 The Regents of The University of California Lung-targeted drugs
US7829548B2 (en) 2004-12-30 2010-11-09 Medivir Ab Compounds useful in the treatment of HIV
GB0505781D0 (en) * 2005-03-21 2005-04-27 Univ Cardiff Chemical compounds
ITRM20050391A1 (it) 2005-07-22 2007-01-23 Giuliani Spa Composti analoghi della 6-tioguanosina trifosfato, loro uso in campo medico e procedimento per la loro preparazione.
AU2006271164A1 (en) * 2005-07-22 2007-01-25 Giuliani International Limited Improvements to analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation
PT2004654E (pt) 2006-04-04 2013-08-27 Univ California Derivados de pirazolopirimidina para utilização como antagonistas da quinase
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy
US7378401B2 (en) * 2006-07-14 2008-05-27 Heidelberg Pharma Gmbh Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
MX2010000424A (es) 2007-07-09 2010-08-10 Easter Virginia Medical School Derivados de nucleosidos sustituidos con propiedades antivirales y antimicrobianas.
US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5869222B2 (ja) 2008-01-04 2016-02-24 インテリカイン， エルエルシー 特定の化学的実体、組成物および方法
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
MX2011000216A (es) 2008-07-08 2011-03-29 Intellikine Inc Inhibidores de cinasa y metodos para su uso.
CA2738429C (en) 2008-09-26 2016-10-25 Intellikine, Inc. Heterocyclic kinase inhibitors
WO2010045542A2 (en) 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
CA2760791C (en) 2009-05-07 2017-06-20 Intellikine, Inc. Heterocyclic compounds and uses thereof
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
AU2011255218B2 (en) 2010-05-21 2015-03-12 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
CA2824197C (en) 2011-01-10 2020-02-25 Michael Martin Processes for preparing isoquinolinones and solid forms of isoquinolinones
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン， エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
AR091790A1 (es) 2011-08-29 2015-03-04 Infinity Pharmaceuticals Inc Derivados de isoquinolin-1-ona y sus usos
JP6342805B2 (ja) 2011-09-02 2018-06-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 置換ピラゾロ［３，４−ｄ］ピリミジンおよびその用途
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
CA2886240A1 (en) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
EP3401320B1 (en) 2013-03-15 2020-05-13 The Regents of the University of California Acyclic nucleoside phosphonate diesters for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia
MX2016004340A (es) 2013-10-04 2016-08-08 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PT3119397T (pt) 2014-03-19 2022-04-11 Infinity Pharmaceuticals Inc Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
DE102014112055A1 (de) * 2014-08-22 2016-02-25 Universität Hamburg Di- und Triphosphat-Propharmaka
RS63250B1 (sr) 2014-09-15 2022-06-30 Univ California Nukleotidni analozi
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10160761B2 (en) 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2018016227A (es) 2016-06-24 2019-07-08 Infinity Pharmaceuticals Inc Terapias de combinacion.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2930904A1 (de) * 1979-07-30 1981-02-19 Kailash Kumar Dr Gauri Verwendung von 5-alkyl-pyrimidinnucleosiden bei der bekaempfung von krebs
DE3476770D1 (en) * 1983-04-11 1989-03-23 Meito Sangyo Kk Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique
GB2175588B (en) * 1985-04-15 1988-08-10 Toyo Jozo Kk Nucleoside-phospholipid conjugates
DE3778626D1 (de) * 1986-09-27 1992-06-04 Toyo Jozo Kk Nukleosid-phospholipid-konjugat.
JP2796089B2 (ja) * 1986-10-06 1998-09-10 旭化成工業株式会社 リン脂質誘導体の製造法
DE3730542A1 (de) * 1987-09-11 1989-04-06 Hoechst Ag Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung
US5463092A (en) * 1989-11-22 1995-10-31 Vestar, Inc. Lipid derivatives of phosphonacids for liposomal incorporation and method of use
US5563257A (en) * 1990-08-20 1996-10-08 Boehringer Mannheim Gmbh Phospholipid derivatives of nucleosides
DE4026265A1 (de) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
DE4111730A1 (de) * 1991-04-10 1992-10-15 Knoll Ag Neue cytarabin-derivate, ihre herstellung und verwendung
DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
US5512671A (en) * 1993-02-16 1996-04-30 Wake Forest University Ether lipid-nucleoside covalent conjugates

Also Published As

Publication number Publication date
ATE236189T1 (de) 2003-04-15
SK151896A3 (en) 1997-06-04
EP1229040A3 (en) 2002-08-21
SK284207B6 (en) 2004-11-03
DE69530197T2 (de) 2004-01-29
CN1168735C (zh) 2004-09-29
NO965054L (no) 1997-01-28
PL317380A1 (en) 1997-04-01
CA2190983A1 (en) 1995-12-07
DE69531749D1 (de) 2003-10-16
EP0763049A1 (en) 1997-03-19
DK0763049T3 (da) 2003-07-28
DK1229040T3 (da) 2003-12-22
CZ291846B6 (cs) 2003-06-18
KR100279087B1 (ko) 2001-01-15
FI964727A0 (fi) 1996-11-27
AU2615495A (en) 1995-12-21
KR970703354A (ko) 1997-07-03
MX9605809A (es) 1997-12-31
EP1229040A2 (en) 2002-08-07
WO1995032984A1 (en) 1995-12-07
EP0763049B1 (en) 2003-04-02
EP1229040B8 (en) 2003-11-05
ES2199250T3 (es) 2004-02-16
PL185290B1 (pl) 2003-04-30
FI964727A (fi) 1996-11-27
CZ347796A3 (en) 1997-04-16
JPH10500964A (ja) 1998-01-27
HU9603269D0 (en) 1997-01-28
ATE249472T1 (de) 2003-09-15
ES2206429T3 (es) 2004-05-16
DE69530197D1 (de) 2003-05-08
ZA954374B (en) 1996-11-29
HU220336B (hu) 2001-12-28
NZ287434A (en) 1998-01-26
US6025343A (en) 2000-02-15
DE4418690A1 (de) 1996-01-11
NO965054D0 (no) 1996-11-27
CN1154111A (zh) 1997-07-09
IL113865A (en) 2008-12-29
UA45339C2 (uk) 2002-04-15
PT763049E (pt) 2003-08-29
DE69531749T2 (de) 2004-07-29
HUT75340A (en) 1997-05-28
TW420686B (en) 2001-02-01
PT1229040E (pt) 2003-12-31
FI117673B (fi) 2007-01-15
IL113865A0 (en) 1995-08-31
NO308998B1 (no) 2000-11-27
CA2190983C (en) 2006-08-15
AU688516B2 (en) 1998-03-12
JP3802057B2 (ja) 2006-07-26
RU2165429C2 (ru) 2001-04-20
EP1229040B1 (en) 2003-09-10
WO1995032984A8 (en) 2003-01-16

Similar Documents

Publication Publication Date Title
BR9507785A (pt) Novos ésteres lipidios de monosfosfatos nucleosídeos e seu uso como drogas imunossupressoras
FI893750A0 (fi) Menetelmä valmistaa terapeuttisesti aktiivista makrosyklistä johdannaista
KR890011601A (ko) (사이클로알킬아미노)메틸렌비스(포스폰산)및 활성성분으로서 이를 함유한 의약
PT93552A (pt) Processo para a preparacao de derivados de pirrol acriloil-substituidos e de composicoes farmaceuticas que os contem
ES2062443T3 (es) Nuevos derivados peptidicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2014482B3 (es) Nuevas 2-tiazolil imidazo/1,2-a/pirimidinas y sus sales, su procedimiento de preparacion, su aplicacion a titulo de medicamentos y las composiciones que las encierran.
ES2164869T3 (es) Conjugados lipidos especificos de nucleosidos-difosfato y su uso como medicamentos.
ATE198746T1 (de) Pyrimidinderivate und pharmazeutische zusammensetzungen
PT88462A (pt) Process for the preparation of macrolide compounds and of compositions containing them
ES2066181T3 (es) Derivados de glicociamidina.
ES2061864T3 (es) Sustancia antitumoral, procedimiento para su preparacion, y agente anticanceroso que la contiene.

Legal Events

Date Code Title Description
FA Application withdrawn
PC Transfer

Owner name: HEIDELBERG PHARMA HOLDING GMBH (DE)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled