ES2164869T3 - Conjugados lipidos especificos de nucleosidos-difosfato y su uso como medicamentos. - Google Patents

Conjugados lipidos especificos de nucleosidos-difosfato y su uso como medicamentos.

Info

Publication number
ES2164869T3
ES2164869T3 ES96904793T ES96904793T ES2164869T3 ES 2164869 T3 ES2164869 T3 ES 2164869T3 ES 96904793 T ES96904793 T ES 96904793T ES 96904793 T ES96904793 T ES 96904793T ES 2164869 T3 ES2164869 T3 ES 2164869T3
Authority
ES
Spain
Prior art keywords
nucleosidos
diffosphate
medicines
chained
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96904793T
Other languages
English (en)
Inventor
Harald Zilch
Dieter Herrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heidelberg Pharma Holding GmbH
Original Assignee
Heidelberg Pharma Holding GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Holding GmbH filed Critical Heidelberg Pharma Holding GmbH
Application granted granted Critical
Publication of ES2164869T3 publication Critical patent/ES2164869T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

EL OBJETO DE LA PRESENTE INVENCION SON NUEVOS DERIVADOS DE FOSFOLIPIDOS DE NUCLEOSIDOS DE FORMULA GENERAL (I), EN LA QUE R{SUP,1} REPRESENTA UN RESTO ALIFATICO SATURADO O INSATURADO DE CADENA LINEAL O RAMIFICADA CON 9 A 14 ATOMOS DE CARBONO, QUE EVENTUALMENTE PUEDE ESTAR MONO O POLISUSTITUIDO; R{SUP,2} ES UN RESTO ALIFATICO SATURADO O INSATURADO DE CADENA LINEAL O RAMIFICADA CON 8 A 12 ATOMOS DE CARBONO, QUE EVENTUALMENTE PUEDE ESTAR MONO O POLISUSTITUIDO; M ES 2 O 3; A ES UN GRUPO METILENO O PUEDE SER OXIGENO; NUC ES UN NUCLEOSIDO O UN RESTO DERIVADO DE UN DERIVADO DE NUCLEOSIDO, Y SUS TAUTOMEROS Y SUS SALES FISIOLOGICAMENTE ACEPTABLES DE ACIDOS INORGANICOS Y ORGANICOS O BASES, ASI COMO LOS MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS.
ES96904793T 1995-02-16 1996-02-15 Conjugados lipidos especificos de nucleosidos-difosfato y su uso como medicamentos. Expired - Lifetime ES2164869T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19505168A DE19505168A1 (de) 1995-02-16 1995-02-16 Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ES2164869T3 true ES2164869T3 (es) 2002-03-01

Family

ID=7754104

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96904793T Expired - Lifetime ES2164869T3 (es) 1995-02-16 1996-02-15 Conjugados lipidos especificos de nucleosidos-difosfato y su uso como medicamentos.

Country Status (8)

Country Link
US (1) US6372725B1 (es)
EP (1) EP0817790B1 (es)
AT (1) ATE208789T1 (es)
AU (1) AU4876596A (es)
CA (1) CA2212877A1 (es)
DE (2) DE19505168A1 (es)
ES (1) ES2164869T3 (es)
WO (1) WO1996025421A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101304748A (zh) 2005-08-22 2008-11-12 加利福尼亚大学董事会 Tlr激动剂
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8846697B2 (en) * 2006-05-31 2014-09-30 The Regents Of The University Of California Purine analogs
CN101790380B (zh) 2007-02-07 2013-07-10 加利福尼亚大学董事会 合成tlr激动剂的缀合物及其应用
BRPI0813269A2 (pt) * 2007-06-29 2014-12-30 Korean Res Inst Of Chemical Technology Inibidores de hiv transcriptase reversa
US8354421B2 (en) * 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
KR20100072230A (ko) * 2007-09-26 2010-06-30 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 아자시티딘 유사체 및 이의 용도
WO2009085797A1 (en) * 2007-12-21 2009-07-09 Gilead Sciences, Inc. Processes for preparing hiv reverse transcriptase inhibitors
JP2011511073A (ja) * 2008-02-07 2011-04-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｔｌｒ７活性化物質による膀胱の疾患の治療
KR20110117705A (ko) * 2009-02-11 2011-10-27 더 리전트 오브 더 유니버시티 오브 캘리포니아 톨-유사 수용체 조정제 및 질병의 치료
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
EP4151646A1 (en) 2021-09-20 2023-03-22 Universität Hamburg 5-fluorouracil derivatives as prodrugs for cancer treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
JPH05507929A (ja) * 1990-06-15 1993-11-11 ウェイク　フォレスト　ユニバーシティー エーテル脂質―ヌクレオシド共有結合体
DE4026265A1 (de) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
US5563257A (en) * 1990-08-20 1996-10-08 Boehringer Mannheim Gmbh Phospholipid derivatives of nucleosides

Also Published As

Publication number Publication date
DE59608201D1 (de) 2001-12-20
WO1996025421A1 (de) 1996-08-22
EP0817790B1 (de) 2001-11-14
DE19505168A1 (de) 1996-08-22
ATE208789T1 (de) 2001-11-15
AU4876596A (en) 1996-09-04
CA2212877A1 (en) 1996-08-22
US6372725B1 (en) 2002-04-16
EP0817790A1 (de) 1998-01-14

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