ES2013379A6 - Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales. - Google Patents

Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales.

Info

Publication number
ES2013379A6
ES2013379A6 ES8803792A ES8803792A ES2013379A6 ES 2013379 A6 ES2013379 A6 ES 2013379A6 ES 8803792 A ES8803792 A ES 8803792A ES 8803792 A ES8803792 A ES 8803792A ES 2013379 A6 ES2013379 A6 ES 2013379A6
Authority
ES
Spain
Prior art keywords
purine
sulfinamide
sulfenamide
purines
sulfonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8803792A
Other languages
English (en)
Inventor
Roland Kenith Robins
Ganapathi R Revanker
Naeen Botros Hanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nucleic Acid Research Institute
Original Assignee
Nucleic Acid Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nucleic Acid Research Institute filed Critical Nucleic Acid Research Institute
Publication of ES2013379A6 publication Critical patent/ES2013379A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 6-SULFENAMIDO-, 6-SULFINAMIDO- Y 6-SULFONAMIDO-PURINAS, NUCLEOSIDOS DE PURINAS Y NUCLEOTIDOS DE PURINAS ANTITUMORALES DE ESTRUCTURA DONDE Z ES H O -NH2; X ES -S-NH2, -SO-NH2 O -SO2-NH2; G, T Y Q SON C-H O N; Y ES H O UNA *FORMULA* PENTOFURANOSA O *FORMULA* -PENTOFURANOSA DE FORMULA:DONDE R1 Y R2 SON H, OH, -O-ACILO O O=P-OH-OH-O-, O REPRESENTAN CONJUNTAMENTE O=P-O-OH-O-, Y R3 Y R4 SON H O UNO DE ELLOS ES OH Y EL OTRO ES H; CON LA CONDICION DE QUE CUANDO Y ES H, Z ES -N
ES8803792A 1987-12-14 1988-12-13 Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales. Expired - Lifetime ES2013379A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13314387A 1987-12-14 1987-12-14

Publications (1)

Publication Number Publication Date
ES2013379A6 true ES2013379A6 (es) 1990-05-01

Family

ID=22457208

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8803792A Expired - Lifetime ES2013379A6 (es) 1987-12-14 1988-12-13 Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales.

Country Status (3)

Country Link
CA (1) CA1317291C (es)
ES (1) ES2013379A6 (es)
WO (1) WO1989005817A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908441A (en) * 1988-07-19 1990-03-13 Warner-Lambert Company Deoxyadenosine compounds and methods of making and using the same
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
WO1999008110A1 (en) 1997-08-08 1999-02-18 Newbiotics, Inc. Methods and compositions for overcoming resistance to biologic and chemotherapy
IL137164A0 (en) 1998-01-23 2001-07-24 Newbiotics Inc Enzyme catalyzed therapeutic agents
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
MXPA02000762A (es) 1999-07-22 2002-08-20 Newbiotics Inc Metodos para tratar tumores resistentes a terapia.
US11535645B2 (en) * 2018-10-17 2022-12-27 Xibin Liao 6-mercaptopurine nucleoside analogues

Also Published As

Publication number Publication date
CA1317291C (en) 1993-05-04
WO1989005817A1 (en) 1989-06-29

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-12-13