MD1007C2 - 1,3-Oxatiolan,izomeri geometrici şi optici ai lui,amestecurile acestor izomeri, procedeu de obţinere a lor şi compoziţie farmaceutică care manifestă activitate antivirotică - Google Patents
1,3-Oxatiolan,izomeri geometrici şi optici ai lui,amestecurile acestor izomeri, procedeu de obţinere a lor şi compoziţie farmaceutică care manifestă activitate antiviroticăInfo
- Publication number
- MD1007C2 MD1007C2 MD94-0408A MD940408A MD1007C2 MD 1007 C2 MD1007 C2 MD 1007C2 MD 940408 A MD940408 A MD 940408A MD 1007 C2 MD1007 C2 MD 1007C2
- Authority
- MD
- Moldova
- Prior art keywords
- izomers
- mixtures
- preparation
- oxathiolan
- manifesting
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- WJJSZTJGFCFNKI-UHFFFAOYSA-N 1,3-oxathiolane Chemical compound C1CSCO1 WJJSZTJGFCFNKI-UHFFFAOYSA-N 0.000 title 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Sunt revendicaţi compuşii cu formula:în care R1 reprezintă hidrogen;R2 reprezintă bază purinică sau pirimidinică, analogul sau derivatul ei;Z reprezintă S, SO sau SO2 şi derivaţii lor farmaceutic acceptabili.În afară de aceasta, este revendicată utilizarea acestor compuşi în calitate de mijloace antivirotice, sunt revendicate compoziţiile farmaceutice şi procedeul de obţinere a unor astfel de compuşi.obţinere a unor astfel de compuşi.Rezultatul tehnic constă în sinteza compuşilor anti-HIV eficienţi cu o toxicitate joasă.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/308,101 US5047407A (en) | 1989-02-08 | 1989-02-08 | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
Publications (1)
Publication Number | Publication Date |
---|---|
MD1007C2 true MD1007C2 (ro) | 1999-04-30 |
Family
ID=44246162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MD94-0408A MD1007C2 (ro) | 1989-02-08 | 1994-07-14 | 1,3-Oxatiolan,izomeri geometrici şi optici ai lui,amestecurile acestor izomeri, procedeu de obţinere a lor şi compoziţie farmaceutică care manifestă activitate antivirotică |
Country Status (7)
Country | Link |
---|---|
US (1) | US5151426A (ro) |
GE (1) | GEP19991599B (ro) |
HN (1) | HN1999000161A (ro) |
MD (1) | MD1007C2 (ro) |
MY (1) | MY105523A (ro) |
SA (1) | SA90100173B1 (ro) |
UA (1) | UA45942A (ro) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
US5728575A (en) * | 1990-02-01 | 1998-03-17 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US6812233B1 (en) * | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
GB9110874D0 (en) * | 1991-05-20 | 1991-07-10 | Iaf Biochem Int | Medicaments |
US5434163A (en) * | 1993-05-14 | 1995-07-18 | The Medical College Of Pennsylvania | Treatment of Cryptococcus neoformans infection |
US20020120130A1 (en) * | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
IL115156A (en) * | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
EP0831852B1 (en) * | 1995-06-07 | 2006-11-29 | Emory University | Nucleosides with anti-hepatitis b virus activity |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
US6022876A (en) * | 1996-11-15 | 2000-02-08 | Yale University | L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections |
US5792773A (en) * | 1996-11-15 | 1998-08-11 | Yale University | L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection |
US6653318B1 (en) * | 1999-07-21 | 2003-11-25 | Yale University | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use |
US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
KR20090053867A (ko) | 2003-01-14 | 2009-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 복합 항바이러스 치료를 위한 조성물 및 방법 |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000137A (en) * | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
JPS5668674A (en) * | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
DE3529263A1 (de) * | 1985-08-16 | 1987-02-19 | Hoechst Ag | Verfahren zur herstellung von 2-oxo-1,3-dioxolanen |
US4997926A (en) * | 1987-11-18 | 1991-03-05 | Scripps Clinic And Research Foundation | Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy |
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
NZ228645A (en) * | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
DE3827134A1 (de) * | 1988-08-10 | 1990-03-15 | Bayer Ag | Substituierte triazolyl- bzw. imidazolyl-hydroxyalkyldioxolane, verfahren zu ihrer herstellung und ihre verwendung als mikrobizide, oxiranyldioxolane, dioxolanylketone, oxiranylketone und (alpha)-halogenketone als zwischenprodukte und verfahren zu deren herstellung |
NZ233197A (en) * | 1989-04-13 | 1991-11-26 | Richard Thomas Walker | Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions |
IE902574A1 (en) * | 1989-07-17 | 1991-02-27 | Univ Birmingham | Antiviral pyrimidine nucleosides |
-
1990
- 1990-02-07 UA UA4743202A patent/UA45942A/uk unknown
- 1990-02-08 MY MYPI90000206A patent/MY105523A/en unknown
- 1990-04-18 SA SA90100173A patent/SA90100173B1/ar unknown
-
1991
- 1991-06-17 US US07/716,627 patent/US5151426A/en not_active Expired - Lifetime
-
1994
- 1994-06-09 GE GEAP19941986A patent/GEP19991599B/en unknown
- 1994-07-14 MD MD94-0408A patent/MD1007C2/ro unknown
-
1999
- 1999-09-20 HN HN1999000161A patent/HN1999000161A/es unknown
Non-Patent Citations (3)
Title |
---|
"Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/ lymphodenopathy-associated virus (HTLV-III/LAV) by 2(,3(-dideoxynucleosides". Proc. Natl. Acad. Sci. U.S.A., 86, 1986, p. 1911-1915 * |
Baba et al., "Both 2(,3(-dideoxythimidine and its 2(,3(-unsaturated derivative (2(,3(- dideoxythimidinene) are potent and selective inhibitors of human immunodefficiency virus replication in vitro", Biochem. Biophys. Res. Comm., 142, 1987, p. 128-134 * |
Herdewijn et al., "3(-Substituted 2(, 3(-dideoxynucleoside analogues as potential anti- HIV(HTLV-III/ LAV) agents", J. Med. Chem., 30, 1987, p. 1270-1278 * |
Also Published As
Publication number | Publication date |
---|---|
UA45942A (uk) | 2002-05-15 |
GEP19991599B (en) | 1999-04-29 |
MY105523A (en) | 1994-10-31 |
HN1999000161A (es) | 2005-03-18 |
SA90100173B1 (ar) | 2005-10-15 |
US5151426A (en) | 1992-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD1007C2 (ro) | 1,3-Oxatiolan,izomeri geometrici şi optici ai lui,amestecurile acestor izomeri, procedeu de obţinere a lor şi compoziţie farmaceutică care manifestă activitate antivirotică | |
NZ227251A (en) | Macrolide derivatives and pharmaceutical compositions | |
CA2009637A1 (en) | Substituted-1,3-oxathiolanes with antiviral properties | |
AU639514B2 (en) | Bicyclam derivatives | |
PH19940A (en) | Purine derivatives,pharmaceutical compositions containing same and method of use thereof | |
MD1233C2 (ro) | Derivaţi de eritromicină, procedeu de preparare a lor şi compoziţie farmaceutică pe baza acestora | |
HUT41809A (en) | Process for preparing dideoxy-nucleosides and pharmaceutical compositions containing such compounds | |
GR3026218T3 (en) | Antiviral 4-substituted-2-deoxy-2,3-didehydro derivatives of alpha D-neuraminic acid | |
IL93050A0 (en) | Pyrazolopyridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
HUT43843A (en) | Process for production of derivatives of benzimidasole and medical compounds containing thereof | |
IL88755A (en) | (1:, 2, 3:)-3-substituted-2- hydroxycyclo- butanemethanol derivatives and pharmaceutical and veterinary compositions containing the same | |
HU9501825D0 (en) | Process for preparing substituted 1,3-oxathiolanes with antiviral properties | |
AU8864191A (en) | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties | |
IL69095A0 (en) | 9-(2-hydroxyethoxymethyl)guanine derivatives,their preparation and pharmaceutical compositions containing them | |
IL94433A0 (en) | Aminophenol derivatives,their preparation and pharmaceutical compositions containing them | |
MY103801A (en) | Dideoxydidehydrocarbocyclic nucleosides | |
HUT52040A (en) | Process for producing diaryl-derivatives and pharmaceutical compositions containing them | |
IL85945A0 (en) | Pharmaceutical compositions containing 2'-fluoronucleosides and derivatives thereof,certain such novel compounds and their preparation | |
MY105538A (en) | Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them. | |
PT86232A (en) | Process for preparing a pharmaceutical composition containing a9-substituted guanine | |
HUT47096A (en) | Process for producing 1,2-dithiol-3-thion derivatives and pharmaceutical compositions containing them as active components | |
ES2013379A6 (es) | Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales. | |
EP0272596A3 (en) | Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included | |
CA2010982A1 (en) | Osteogenesis promotion with use of vitamin d derivatives | |
IL81752A (en) | Nitrogen containing heterocyclic isohexide derivatives,processes for their preparation and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TC4A | Change of name of proprietor (patent for invention) |
Owner name: SHIRE BIOCHEM INC., CA; 2250, BOUL. ALFRED-NOBEL B Free format text: PREVIOUS NAME OF PROPRIETOR: BIOCHEM PHARMA INC., CA; 275 ARMAND-FRAPPIER BOULEVARD LAVAL, QUEBEC, CANADA H7V 4A7, CANADA |
|
TC4A | Change of name of proprietor (patent for invention) |
Owner name: SHIRE CANADA INC, CA; 2250, BOUL. ALFRED-NOBEL BUR Free format text: PREVIOUS NAME OF PROPRIETOR: SHIRE BIOCHEM INC., CA; 2250, BOUL. ALFRED-NOBEL BUR. 500 VILLE SAINT-LAURENT QUEBEC H4S 2C9 |
|
MK4A | Patent for invention expired |