SK284207B6 - New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs - Google Patents

New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs Download PDF

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Publication number
SK284207B6
SK284207B6 SK1518-96A SK151896A SK284207B6 SK 284207 B6 SK284207 B6 SK 284207B6 SK 151896 A SK151896 A SK 151896A SK 284207 B6 SK284207 B6 SK 284207B6
Authority
SK
Slovakia
Prior art keywords
hydrogen
halogen
alkyl
group
carbon atoms
Prior art date
Application number
SK1518-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK151896A3 (en
Inventor
Dieter Herrmann
Hans-Georg Opitz
Harald Zilch
Alfred Mertens
Original Assignee
Heidelberg Pharma Holding Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Holding Gmbh filed Critical Heidelberg Pharma Holding Gmbh
Publication of SK151896A3 publication Critical patent/SK151896A3/sk
Publication of SK284207B6 publication Critical patent/SK284207B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SK1518-96A 1994-05-28 1995-05-23 New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs SK284207B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4418690A DE4418690A1 (de) 1994-05-28 1994-05-28 Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
PCT/EP1995/001951 WO1995032984A1 (en) 1994-05-28 1995-05-23 New lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs

Publications (2)

Publication Number Publication Date
SK151896A3 SK151896A3 (en) 1997-06-04
SK284207B6 true SK284207B6 (en) 2004-11-03

Family

ID=6519215

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1518-96A SK284207B6 (en) 1994-05-28 1995-05-23 New lipid ester of nucleoside monophosphates and their use as immunosupressive drugs

Country Status (27)

Country Link
US (1) US6025343A (es)
EP (2) EP0763049B1 (es)
JP (1) JP3802057B2 (es)
KR (1) KR100279087B1 (es)
CN (1) CN1168735C (es)
AT (2) ATE236189T1 (es)
AU (1) AU688516B2 (es)
BR (1) BR9507785A (es)
CA (1) CA2190983C (es)
CZ (1) CZ291846B6 (es)
DE (3) DE4418690A1 (es)
DK (2) DK0763049T3 (es)
ES (2) ES2206429T3 (es)
FI (1) FI117673B (es)
HU (1) HU220336B (es)
IL (1) IL113865A (es)
MX (1) MX9605809A (es)
NO (1) NO308998B1 (es)
NZ (1) NZ287434A (es)
PL (1) PL185290B1 (es)
PT (2) PT1229040E (es)
RU (1) RU2165429C2 (es)
SK (1) SK284207B6 (es)
TW (1) TW420686B (es)
UA (1) UA45339C2 (es)
WO (1) WO1995032984A1 (es)
ZA (1) ZA954374B (es)

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US20110160232A1 (en) 2007-10-04 2011-06-30 Pingda Ren Certain chemical entities and therapeutic uses thereof
KR101897881B1 (ko) 2008-01-04 2018-09-12 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
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US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
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CA2738429C (en) 2008-09-26 2016-10-25 Intellikine, Inc. Heterocyclic kinase inhibitors
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US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
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TWI592411B (zh) 2011-02-23 2017-07-21 英特爾立秦有限責任公司 激酶抑制劑之組合及其用途
CN103930422A (zh) 2011-07-19 2014-07-16 无限药品股份有限公司 杂环化合物及其用途
TWI565709B (zh) 2011-07-19 2017-01-11 英菲尼提製藥股份有限公司 雜環化合物及其用途
WO2013032591A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
CN104995192A (zh) 2012-09-26 2015-10-21 加利福尼亚大学董事会 Ire1的调节
SI2970346T1 (sl) 2013-03-15 2018-12-31 The Regents Of The University Of California Aciklični diestri nukleozid fosfonata
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
ES2900806T3 (es) 2013-10-04 2022-03-18 Infinity Pharmaceuticals Inc Compuestos heterocíclicos y usos de los mismos
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JP6701088B2 (ja) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物
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Also Published As

Publication number Publication date
EP1229040A2 (en) 2002-08-07
ES2199250T3 (es) 2004-02-16
HUT75340A (en) 1997-05-28
DK1229040T3 (da) 2003-12-22
MX9605809A (es) 1997-12-31
NO965054D0 (no) 1996-11-27
CN1168735C (zh) 2004-09-29
PL185290B1 (pl) 2003-04-30
FI964727A (fi) 1996-11-27
TW420686B (en) 2001-02-01
CN1154111A (zh) 1997-07-09
CA2190983C (en) 2006-08-15
KR100279087B1 (ko) 2001-01-15
NO965054L (no) 1997-01-28
JPH10500964A (ja) 1998-01-27
AU688516B2 (en) 1998-03-12
PT1229040E (pt) 2003-12-31
CA2190983A1 (en) 1995-12-07
DE69530197T2 (de) 2004-01-29
UA45339C2 (uk) 2002-04-15
BR9507785A (pt) 1997-09-23
ATE236189T1 (de) 2003-04-15
ZA954374B (en) 1996-11-29
IL113865A0 (en) 1995-08-31
DE69531749T2 (de) 2004-07-29
DE69530197D1 (de) 2003-05-08
WO1995032984A8 (en) 2003-01-16
HU220336B (hu) 2001-12-28
AU2615495A (en) 1995-12-21
NO308998B1 (no) 2000-11-27
CZ347796A3 (en) 1997-04-16
EP1229040B8 (en) 2003-11-05
DE69531749D1 (de) 2003-10-16
DE4418690A1 (de) 1996-01-11
JP3802057B2 (ja) 2006-07-26
FI117673B (fi) 2007-01-15
US6025343A (en) 2000-02-15
HU9603269D0 (en) 1997-01-28
CZ291846B6 (cs) 2003-06-18
NZ287434A (en) 1998-01-26
EP0763049A1 (en) 1997-03-19
ATE249472T1 (de) 2003-09-15
EP1229040A3 (en) 2002-08-21
PL317380A1 (en) 1997-04-01
KR970703354A (ko) 1997-07-03
EP1229040B1 (en) 2003-09-10
DK0763049T3 (da) 2003-07-28
ES2206429T3 (es) 2004-05-16
PT763049E (pt) 2003-08-29
IL113865A (en) 2008-12-29
WO1995032984A1 (en) 1995-12-07
SK151896A3 (en) 1997-06-04
FI964727A0 (fi) 1996-11-27
RU2165429C2 (ru) 2001-04-20
EP0763049B1 (en) 2003-04-02

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100523