MX9702886A - Derivados de nucleosidos y proceso para preparalos. - Google Patents

Derivados de nucleosidos y proceso para preparalos.

Info

Publication number
MX9702886A
MX9702886A MX9702886A MX9702886A MX9702886A MX 9702886 A MX9702886 A MX 9702886A MX 9702886 A MX9702886 A MX 9702886A MX 9702886 A MX9702886 A MX 9702886A MX 9702886 A MX9702886 A MX 9702886A
Authority
MX
Mexico
Prior art keywords
compounds
nucleoside derivatives
preparing
compound
formula
Prior art date
Application number
MX9702886A
Other languages
English (en)
Other versions
MXPA97002886A (es
Inventor
Jung Woo Kim
Chong Ryul Lee
Koo Hun Chung
Soon Kil Ahn
Kyung Hoi Cha
Hoe Joo Son
Sung Jo Choi
Byeong Seong Jeong
Kyeong Bok Min
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019940027067A external-priority patent/KR960014116A/ko
Priority claimed from KR1019940027068A external-priority patent/KR960014117A/ko
Priority claimed from KR1019950002124A external-priority patent/KR960031456A/ko
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Publication of MX9702886A publication Critical patent/MX9702886A/es
Publication of MXPA97002886A publication Critical patent/MXPA97002886A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

De conformidad con la presente invencion, se proporcionan derivados de nucleosidos representados por la formula (I), en la cual: R1 es hidrogeno, fosfato o grupo fosfonato, R2 es pirimidina sustituida o insustituida o base purina y Z es S, SO, SO2, O o C; o sales aceptables farmacéuticamente de estos. El compuesto (I) se puede obtener haciendo reaccionar el compuesto de formula (II), en la cual: R7 es hidrogeno o grupo protector hidroxi, L Es acilo aromático, o no aromático, haluro o alcoxi y Z es S, SO, SO2, O o C, con una base. Los compuestos (II), los compuestos intermedios para la síntesis de los compuestos (I), son también compuestos novedosos, y se incluyen dentro del alcance de la presente invencion.
MXPA/A/1997/002886A 1994-10-22 1997-04-21 Derivados de nucleosidos y proceso para preparalos MXPA97002886A (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
KR9427068 1994-10-22
KR1019940027067A KR960014116A (ko) 1994-10-22 1994-10-22 새로운 1,4-디옥산 유도체 및 그 제조방법
KR9427067 1994-10-22
KR1019940027068A KR960014117A (ko) 1994-10-22 1994-10-22 새로운 1,4-옥사티안 유도체 및 그 제조방법
KR952124 1995-02-07
KR1995/2124 1995-02-07
KR1994/27067 1995-02-07
KR1994/27068 1995-02-07
KR1019950002124A KR960031456A (ko) 1995-02-07 1995-02-07 새로운 테트라하이드로피란 유도체 및 그 제조방법
PCT/KR1995/000135 WO1996012716A1 (en) 1994-10-22 1995-10-21 Nucleoside derivatives and process for preparing thereof

Publications (2)

Publication Number Publication Date
MX9702886A true MX9702886A (es) 1998-05-31
MXPA97002886A MXPA97002886A (es) 1998-10-23

Family

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Also Published As

Publication number Publication date
WO1996012716A1 (en) 1996-05-02
JP3047045B2 (ja) 2000-05-29
AU3710395A (en) 1996-05-15
CA2203262A1 (en) 1996-05-02
EP0869953A1 (en) 1998-10-14
JPH10500994A (ja) 1998-01-27
US6034087A (en) 2000-03-07
BR9510327A (pt) 1998-11-10

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