KR900003195A - 2'-메틸리덴피리미딘 뉴클레오시드 화합물, 그의 용도 및 제조방법 - Google Patents

2'-메틸리덴피리미딘 뉴클레오시드 화합물, 그의 용도 및 제조방법 Download PDF

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KR900003195A
KR900003195A KR1019890012101A KR890012101A KR900003195A KR 900003195 A KR900003195 A KR 900003195A KR 1019890012101 A KR1019890012101 A KR 1019890012101A KR 890012101 A KR890012101 A KR 890012101A KR 900003195 A KR900003195 A KR 900003195A
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South Korea
Prior art keywords
carbon atoms
hydroxy group
alkyl
stands
compounds
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KR1019890012101A
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KR0136869B1 (ko
Inventor
도오루 우에다
다쿠마 사사키
아키라 마쓰다
게이지 야마가미
아키히로 후지이
Original Assignee
하기와라 후미오
요시토미 세이야쿠 가부시키가이샤
하마구치 미치오
야마사 쇼유 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

2'-메틸리덴피리미딘 뉴클레오시드 화합물, 그의 용도 및 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅰ)로 표시되는 2'-메틸리덴피리미딘 뉴클레오시드 화합물 또는 그의 염.
    상기식에서, R1은 아미노 또는 히드록시기이고: R2는 할로겐 또는 저급알킬(R1이 아니노인 경우)이거나, 또는 R2는 탄소원자수 2-7의 알킬, 탄소원자수 2-4의 알키닐 또는 할로알킬(R1이 히드록시기인 경우)이며; R3는 수소 또는 인산잔기이다.
  2. 제1항에 있어서, 일반식(Ⅰ)내에서 R1이 히드록시기인 화합물의 토오토머인, 하기식으로 표시되는 화합물.
    상기식에서, R은 할로겐, 탄소원자수 2-4의 알킬, 탄소원자수 2-4의 알카닐 또는 할로알킬이고; R3는 수소 또는 인산잔기이다.
  3. 제1항에 있어서, 2'-데옥시-2'-메틸리덴-5-플루오로시티딘 또는 그의 염인 화합물.
  4. 활성성분으로서 제1항에서 정의한 화합물을 함유하는 것을 특징으로 하는 항암 조성물.
  5. 제4항에 있어서, 활성성분이 2'-데옥시-2'-메틸리덴-5-플루오로시티딘 또는 그의 염인 것을 특징으로 하는 항암 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890012101A 1988-08-25 1989-08-25 2'-메틸리덴피리미딘 뉴클레오시드 화합물, 그의 용도 및 제조방법 KR0136869B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-212061 1988-08-25
JP21206188 1988-08-25

Publications (2)

Publication Number Publication Date
KR900003195A true KR900003195A (ko) 1990-03-26
KR0136869B1 KR0136869B1 (ko) 1998-04-25

Family

ID=16616219

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890012101A KR0136869B1 (ko) 1988-08-25 1989-08-25 2'-메틸리덴피리미딘 뉴클레오시드 화합물, 그의 용도 및 제조방법

Country Status (7)

Country Link
US (1) US5705630A (ko)
EP (2) EP0360018B1 (ko)
KR (1) KR0136869B1 (ko)
AT (2) ATE154359T1 (ko)
CA (1) CA1319685C (ko)
DE (2) DE68928127T2 (ko)
ES (1) ES2057031T3 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100481356B1 (ko) * 2002-10-17 2005-04-07 이수화학 주식회사 2'-ｏ-치환된 뉴클레오시드의 제조 방법

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5665711A (en) * 1995-12-12 1997-09-09 Yoshitomi Pharmaceutical Industries, Ltd. Antitumor composition for oral administration
EP1270008B1 (en) * 2001-05-31 2006-07-12 Yung Shin Pharmaceutical Ind. Co., Ltd. Fused tricyclic analogues of guanosine for treating tumors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310673B1 (en) * 1987-03-19 1995-07-05 Yamasa Shoyu Kabushiki Kaisha 2'-alkylidenepyrimidine nucleoside derivatives, process for their preparation, and their use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100481356B1 (ko) * 2002-10-17 2005-04-07 이수화학 주식회사 2'-ｏ-치환된 뉴클레오시드의 제조 방법

Also Published As

Publication number Publication date
DE68917060D1 (de) 1994-09-01
EP0566162B1 (en) 1997-06-11
EP0566162A1 (en) 1993-10-20
EP0360018B1 (en) 1994-07-27
CA1319685C (en) 1993-06-29
ATE109154T1 (de) 1994-08-15
DE68928127T2 (de) 1997-09-25
DE68928127D1 (de) 1997-07-17
US5705630A (en) 1998-01-06
DE68917060T2 (de) 1994-12-08
ATE154359T1 (de) 1997-06-15
EP0360018A1 (en) 1990-03-28
ES2057031T3 (es) 1994-10-16
KR0136869B1 (ko) 1998-04-25

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