KR890000470A - 2,2-디메틸크로만-3-올 유도체, 그의 제조방법 및 그를 함유하는 약학 조성물 - Google Patents
2,2-디메틸크로만-3-올 유도체, 그의 제조방법 및 그를 함유하는 약학 조성물 Download PDFInfo
- Publication number
- KR890000470A KR890000470A KR1019880007608A KR880007608A KR890000470A KR 890000470 A KR890000470 A KR 890000470A KR 1019880007608 A KR1019880007608 A KR 1019880007608A KR 880007608 A KR880007608 A KR 880007608A KR 890000470 A KR890000470 A KR 890000470A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- dimethylchroman
- trans
- cyano
- phosphono
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 4
- 238000002360 preparation method Methods 0.000 title claims 2
- HVEQAXBABGOAQI-UHFFFAOYSA-N 2,2-dimethyl-3,4-dihydrochromen-3-ol Chemical class C1=CC=C2CC(O)C(C)(C)OC2=C1 HVEQAXBABGOAQI-UHFFFAOYSA-N 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 claims 6
- 125000001476 phosphono group Chemical class [H]OP(*)(=O)O[H] 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- -1 cyano, acetyl Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 2
- FBQCYDSZESTAFJ-CVEARBPZSA-N (3s,4r)-3-hydroxy-4-(4-hydroxy-2-oxopyridin-1-yl)-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile Chemical compound N1([C@@H]2C3=CC(=CC=C3OC([C@H]2O)(C)C)C#N)C=CC(O)=CC1=O FBQCYDSZESTAFJ-CVEARBPZSA-N 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- 230000003288 anthiarrhythmic effect Effects 0.000 claims 1
- 230000003276 anti-hypertensive effect Effects 0.000 claims 1
- 239000003416 antiarrhythmic agent Substances 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
- C10L1/00—Liquid carbonaceous fuels
- C10L1/32—Liquid carbonaceous fuels consisting of coal-oil suspensions or aqueous emulsions or oil emulsions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 일반식(I)로 표시되는 트랜스-2,2-디메틸 크로만-3-올 유도체 및 그의 포스포노 또는 카르복실기의 약학적으로 수용 가능한 염.[식중 : -N 및 CO사이의 A는 -CH=CH-E=CH-기 또는기를 나타내고; -Z는 할로겐 또는 시아노, 아세틸, 트리플루오로아세틸, 니트로, 알킬티오, 카르복실, 포스포노, 디알콕시포스포릴 또는 알콕시카르보닐기를 나타내며, 이때 알킬티오 및 알콕시기는 1~3개의 탄소원자를 함유하며; -E는 질소원자 또는 C(R4)기를 나타내고; -R1은 수소, 메틸기 또는 히드록실기를 나타내고, R2및 R3는 각각 독립적으로 수소, 또는 메틸기를 나타내며, 이때 치환기 R1, R2, R3중 단 하나만이 메틸기일 수 있으며; -R4는 수소원자, 할로겐원자, 메틸기 또는 히드록실기를 나타낸다.]
- 제1항에 있어서, Z가 시아노기를 나타내는 트랜스 -2,2-디메틸크로만-3-을 유도체.
- 트랜스-6-시아노-4-(1,2-디히드로-2-옥소피리드-1-열)-2,2-디메틸크로만-3-올.
- 트랜스-6-시아노-4-(1,2-디히드로-4-히드록시-2-옥소피리드-1-일)-2,2-디메틸크로만-3-올.
- 트랜스-6-시아노-4-(1,6-디히드로-3-히드록시-6-옥소피리다진-1-일)(-2,2-디메틸크로만-3-올.
- 하기일반식(ii)의 크로만 에폭시드를 하기일반식(III)의 헤테로고리화합물로 처리하고, 적당하다면 알콕시카르보닐기를 카르복실기로, 또는 디알콕시포스포릴기를 포스포노기로 전환시키고, 적당하다면 수득된 카르복시산 또는 포스폰산을 그의 약학적으로 수요가능한 염으로 전환시킴을 특징으로 하는, 제1항~제5항중 어느 한항에 따른 화합물의 제조방법.[식중 Z′은 제1항의 Z에서 정의한 바와 같으나 카르복실기 또는 포스포노기는 아니며, A는 제1항에서 정의한 바와 같다.]
- 제1항~제5항중 어느 한항에 따른 2,2-디메틸크로만-3-을 유도체를 활성성분으로 함유하는 약학 조성물.
- 제7항에 있어서, 약학 부형제와 혼합된 투여단위당 0.5~200mg의 활성 성분을 함유하는 약학 조성물.
- 하기일반식(I)의 트랜스 -2,2-디메틸크로만을 유도체 및 그의 포스포노 또는 카르복실기의 약학적으로 수용 가능한 염의 항부정맥 및 항고혈압 활성을 갖는 약학 조성물의 제조를 위한 용도.[식중 : -N과 CO사이의 A는 -CH=CH-E=CH-기 또는기를 나타내고; -Z는 할로겐 또는 시아노, 아세틸, 트리플루오로아세틸, 니트로, 알킬티오, 카르복실, 포스포노, 디알콕시포스포릴 또는 알콕시카르보닐기를 나타내며, 이때 알킬티오 및 알콕시기는 1~3개의 탄소원자를 함유하며; -E는 질소원자 또는 C(R4)기를 나타내고; -R1은 수소, 메틸기 또는 히드록실기를 나타내고, R2및 R3는 각각 독립적으로 수소 또는 메틸기를 나타내며, 치환기 R1, R2, R3중 단 하나만이 메틸기일 수 있으며; -R4는 수소원자, 할로겐원자, 메틸기 또는 히드록실기를 나타낸다.]※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8708830 | 1987-06-23 | ||
FR8708830A FR2617165B1 (fr) | 1987-06-23 | 1987-06-23 | Derives du dimethyl-2, 2 chromannol-3 |
FR8800278 | 1988-01-12 | ||
FR8800278A FR2625744B1 (fr) | 1988-01-12 | 1988-01-12 | Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant |
FR8803064 | 1988-03-09 | ||
FR8803064A FR2628424B1 (fr) | 1988-03-09 | 1988-03-09 | Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890000470A true KR890000470A (ko) | 1989-03-14 |
Family
ID=27251476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880007608A KR890000470A (ko) | 1987-06-23 | 1988-06-23 | 2,2-디메틸크로만-3-올 유도체, 그의 제조방법 및 그를 함유하는 약학 조성물 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0296975A1 (ko) |
JP (1) | JPS6426578A (ko) |
KR (1) | KR890000470A (ko) |
DK (1) | DK343388A (ko) |
FI (1) | FI90343C (ko) |
IL (1) | IL86798A (ko) |
NO (1) | NO170216C (ko) |
NZ (1) | NZ225117A (ko) |
PT (1) | PT87788B (ko) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
US5284838A (en) * | 1987-06-23 | 1994-02-08 | Elf Sanofi | Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma |
US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
US5021432A (en) * | 1988-04-26 | 1991-06-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzopyran compound and its pharmaceutical use |
JPH03500542A (ja) * | 1988-05-09 | 1991-02-07 | ビーチャム グループ ピーエルシー | 新規な化合物及び治療法 |
US5254557A (en) * | 1988-05-09 | 1993-10-19 | Beecham Group P.L.C. | Compound and treatment |
DE3837809A1 (de) * | 1988-11-08 | 1990-05-10 | Merck Patent Gmbh | Tetralinderivate |
ATE120459T1 (de) * | 1988-12-13 | 1995-04-15 | Beecham Group Plc | Benzopyran und verwandte verbindungen. |
US5239090A (en) * | 1989-02-01 | 1993-08-24 | Beecham Group P.L.C. | Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates |
GB8902118D0 (en) * | 1989-02-01 | 1989-03-22 | Beecham Group Plc | Chemical process |
US5162553A (en) * | 1989-03-03 | 1992-11-10 | Yoshitomi Pharmaceutical Industries, Ltd. | Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor |
US5066816A (en) * | 1989-03-03 | 1991-11-19 | Yoshitomi Pharmaceutical Industries, Ltd. | Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2h-1-benzopyran compounds and intermediates therefor |
FR2645021A1 (fr) * | 1989-03-30 | 1990-10-05 | Sanofi Sa | Utilisation d'un agoniste potassique dans le traitement du glaucome |
DE3923839A1 (de) * | 1989-07-19 | 1991-01-31 | Beiersdorf Ag | Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
GB8916683D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Novel compounds |
DE3924417A1 (de) * | 1989-07-24 | 1991-01-31 | Merck Patent Gmbh | Chromanderivate |
DE3926001A1 (de) * | 1989-08-05 | 1991-02-07 | Merck Patent Gmbh | Chromanderivate |
US5185345A (en) * | 1989-11-06 | 1993-02-09 | Sanofi | 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them |
FR2657872B2 (fr) * | 1989-11-06 | 1992-06-12 | Sanofi Sa | Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant. |
FR2654103B1 (fr) * | 1989-11-06 | 1992-02-21 | Sanofi Sa | Derives d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques les contenant. |
DE4115465A1 (de) * | 1991-05-11 | 1992-11-12 | Beiersdorf Ag | Neue in 4-stellung durch aryl oder n-heteroaryl substituierte 2h-benzo(b)pyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
RU94030464A (ru) * | 1991-12-05 | 1996-04-27 | Смитклайн Бичам Плс (Gb) | Фармацевтическая композиция, способ ее получения, способ лечения заболеваний дыхательных путей, применение фармацевтической композиции |
GB9203596D0 (en) * | 1992-02-20 | 1992-04-08 | Smithkline Beecham Plc | Novel process |
GB9207400D0 (en) * | 1992-04-02 | 1992-05-13 | Smithkline Beecham Plc | Novel use |
CN1044605C (zh) * | 1992-08-17 | 1999-08-11 | 中外制药株式会社 | 苯并吡喃和苯并嗪衍生物 |
US6031115A (en) * | 1993-05-14 | 2000-02-29 | Smithkline Beecham Plc | Process for preparing epoxides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3274350D1 (en) * | 1981-09-25 | 1987-01-08 | Beecham Group Plc | Pharmaceutically active benzopyran compounds |
EP0107423B1 (en) * | 1982-10-19 | 1986-07-23 | Beecham Group Plc | Novel chromans and chromenes |
EP0172352B1 (en) * | 1984-06-22 | 1990-08-29 | Beecham Group Plc | Active benzopyran compounds |
DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
-
1988
- 1988-06-20 IL IL86798A patent/IL86798A/xx not_active IP Right Cessation
- 1988-06-20 FI FI882945A patent/FI90343C/fi not_active IP Right Cessation
- 1988-06-21 NZ NZ225117A patent/NZ225117A/xx unknown
- 1988-06-22 NO NO882762A patent/NO170216C/no unknown
- 1988-06-22 PT PT87788A patent/PT87788B/pt not_active IP Right Cessation
- 1988-06-22 DK DK343388A patent/DK343388A/da unknown
- 1988-06-23 KR KR1019880007608A patent/KR890000470A/ko not_active Application Discontinuation
- 1988-06-23 EP EP88401580A patent/EP0296975A1/fr not_active Withdrawn
- 1988-06-23 JP JP63155989A patent/JPS6426578A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK343388A (da) | 1988-12-24 |
DK343388D0 (da) | 1988-06-22 |
NO882762D0 (no) | 1988-06-22 |
FI882945A0 (fi) | 1988-06-20 |
FI882945A (fi) | 1988-12-24 |
NO170216B (no) | 1992-06-15 |
NZ225117A (en) | 1990-02-26 |
JPS6426578A (en) | 1989-01-27 |
PT87788B (pt) | 1992-10-30 |
EP0296975A1 (fr) | 1988-12-28 |
FI90343B (fi) | 1993-10-15 |
IL86798A0 (en) | 1988-11-30 |
NO882762L (no) | 1988-12-27 |
FI90343C (fi) | 1994-01-25 |
NO170216C (no) | 1992-09-23 |
PT87788A (pt) | 1988-07-01 |
IL86798A (en) | 1992-12-01 |
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