KR890006625A - 2,2-디메틸크로멘 유도체, 그의 제조방법 및 그것을 함유하는 약학 조성물 - Google Patents

2,2-디메틸크로멘 유도체, 그의 제조방법 및 그것을 함유하는 약학 조성물 Download PDF

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Publication number
KR890006625A
KR890006625A KR1019880013314A KR880013314A KR890006625A KR 890006625 A KR890006625 A KR 890006625A KR 1019880013314 A KR1019880013314 A KR 1019880013314A KR 880013314 A KR880013314 A KR 880013314A KR 890006625 A KR890006625 A KR 890006625A
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South Korea
Prior art keywords
group
phosphono
cyano
dimethylchromen
pharmaceutical composition
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KR1019880013314A
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English (en)
Inventor
가르씨아 조르쥬
마르따 알랭디
고띠에 빠트릭
Original Assignee
미쉘드아스
소시에떼 아노님 사노피
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Publication of KR890006625A publication Critical patent/KR890006625A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

2,2-디메틸크로멘 유도체, 그의 제조방법 및 그것을 함유하는 약학 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(I)의 2,2-디메틸크로멘 유도체 및 제약학상 허용 가능한 포스포노기의 염 :
    (식중, z는 할로겐원자 또는 시아노, 니트로, 아세틸, 포스포노 또는 디알콕시포스포릴기, 1∼3탄소원자를 함유하는 알콕시기를 나타낸다).
  2. 6-시아노-4-(1,2-디히드로-2-옥속피리드-1-일)-2,2-디메틸크로멘.
  3. 하기 일반식(Ⅱ)의 크로만-3-올을 알칼리 금속 수소화물을 사용하여 탈수 시키고, 원한다면, 디알콕시포스포릴기를 포스포노기로 전환시킨후, 원한다면 생성된 포스폰산을 그의 제약학상 허용가능한 염으로 전환시킴을 특징으로 하는 하기 일반식(I)의 크로멘유도체 및 제약학상 허용 가능한 포스포노기의 염의 제조방법.
    (식중, z, 는 할로겐 원자 또는 시아노, 니트로, 아세틸, 포스포노 또는 디알콕시포스포릴기, 1∼3탄소원자를 함유하는 알콕시기를 나타내고, z'은 할로겐원자 또는 시아노, 니트로, 아세틸 또는 디알콕시포스포릴기를 나타낸다).
  4. 유효성분으로 제1항 또는 제2항의 2,2-디메틸 크로멘 유도체를 함유하는 약학 조성물.
  5. 제4항에 있어서, 약학 부형제와 함께, 투여량 단위당 0.5∼200mg의 유효성분을 함유하는 약학조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880013314A 1987-10-12 1988-10-12 2,2-디메틸크로멘 유도체, 그의 제조방법 및 그것을 함유하는 약학 조성물 KR890006625A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8714067 1987-10-12
FR8714067A FR2621587B1 (fr) 1987-10-12 1987-10-12 Derives du dimethyl-2,2 chromene, procede pour leur preparation et composition pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
KR890006625A true KR890006625A (ko) 1989-06-14

Family

ID=9355735

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880013314A KR890006625A (ko) 1987-10-12 1988-10-12 2,2-디메틸크로멘 유도체, 그의 제조방법 및 그것을 함유하는 약학 조성물

Country Status (18)

Country Link
US (1) US5391751A (ko)
EP (2) EP0312432B1 (ko)
JP (1) JPH02180A (ko)
KR (1) KR890006625A (ko)
AR (1) AR246521A1 (ko)
AT (1) ATE100095T1 (ko)
AU (1) AU619766B2 (ko)
CA (1) CA1329603C (ko)
DE (1) DE3887068D1 (ko)
DK (1) DK567188A (ko)
FI (1) FI90545C (ko)
FR (1) FR2621587B1 (ko)
IE (1) IE940342L (ko)
IL (1) IL88002A (ko)
NO (1) NO171851C (ko)
NZ (1) NZ226516A (ko)
PT (1) PT88718B (ko)
ZA (1) ZA887607B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
JPH03500542A (ja) * 1988-05-09 1991-02-07 ビーチャム　グループ　ピーエルシー 新規な化合物及び治療法
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
ES2071668T3 (es) * 1988-12-13 1995-07-01 Beecham Group Plc Benzopirano y compuestos relacionados.
DE3923839A1 (de) * 1989-07-19 1991-01-31 Beiersdorf Ag Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
DE3924417A1 (de) * 1989-07-24 1991-01-31 Merck Patent Gmbh Chromanderivate
FR2654103B1 (fr) * 1989-11-06 1992-02-21 Sanofi Sa Derives d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques les contenant.
US5185345A (en) * 1989-11-06 1993-02-09 Sanofi 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them
FR2657872B2 (fr) * 1989-11-06 1992-06-12 Sanofi Sa Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant.
US5177616A (en) * 1991-12-02 1993-01-05 Matsushita Avionics Systems Stowable video display assembly
DE102004005179B4 (de) * 2004-02-02 2006-07-13 Wobben, Aloys, Dipl.-Ing. Windenergieanlage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
ES2071668T3 (es) * 1988-12-13 1995-07-01 Beecham Group Plc Benzopirano y compuestos relacionados.

Also Published As

Publication number Publication date
IE940342L (en) 1989-04-12
DK567188D0 (da) 1988-10-11
AR246521A1 (es) 1994-08-31
AU2366088A (en) 1989-04-13
NZ226516A (en) 1990-05-28
NO884533D0 (no) 1988-10-11
JPH02180A (ja) 1990-01-05
ATE100095T1 (de) 1994-01-15
FI90545B (fi) 1993-11-15
DK567188A (da) 1989-04-13
IL88002A0 (en) 1989-06-30
AU619766B2 (en) 1992-02-06
DE3887068D1 (de) 1994-02-24
FI884660A (fi) 1989-04-13
PT88718B (pt) 1992-12-31
ZA887607B (en) 1989-06-28
FR2621587B1 (fr) 1990-02-09
NO171851C (no) 1993-05-12
US5391751A (en) 1995-02-21
NO171851B (no) 1993-02-01
FR2621587A1 (fr) 1989-04-14
CA1329603C (en) 1994-05-17
IL88002A (en) 1994-08-26
EP0556872A1 (fr) 1993-08-25
FI884660A0 (fi) 1988-10-11
NO884533L (no) 1989-04-13
EP0312432A1 (fr) 1989-04-19
EP0312432B1 (fr) 1994-01-12
FI90545C (fi) 1994-02-25

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