KR860001798A - 플라바논 유도체의 제조방법 - Google Patents

플라바논 유도체의 제조방법 Download PDF

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KR860001798A
KR860001798A KR1019850006149A KR850006149A KR860001798A KR 860001798 A KR860001798 A KR 860001798A KR 1019850006149 A KR1019850006149 A KR 1019850006149A KR 850006149 A KR850006149 A KR 850006149A KR 860001798 A KR860001798 A KR 860001798A
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formula
compound
salt
phosphate ester
salts
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KR1019850006149A
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KR930002101B1 (ko
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게리크 롤프 (외 2)
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노우만 헤우만
메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁
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Publication of KR930002101B1 publication Critical patent/KR930002101B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

플라바논 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(Ⅱ)의 플라바논을 일반식(Ⅲ)알데하드와 반응시키거나, 또는 다음 일반식(Ⅳ)의 챨콘을 일반식(Ⅴ)의 알데하드와 반응시키고/시키거나,일반식(Ⅰ)의 하이드록시플라바논을 인산화제로 처리하여 상응하는 인산 에스테르로 전환시키고/시키거나 일반식(Ⅰ)의 화합물을 염기로 처리하여 이의 염들중 하나의 염으로 전환시키는 것을 특징으로 하는 일반식(Ⅰ)의 플라바논 유도체, 이의 인산 에스테르 및 이들 화합물의 염의 제조방법.
  3. 상기 일반식에서 Ar1및 Ar2는 비치환된 페닐 또는 OH·알킬, 알콕시, 아실아미노, 할로겐, COO알킬 및/또는 NO2에 의해 일치한 내지 삼치환된 페닐 및/또는 메틸렌디옥시 그룹에 의해 치한된 페닐이며(여기에서 알킬, 알콕시 및 아실그룹은 탄소수 1내지 7개를 함유함), Ar1및 Ar2의 적어도 하나가 치환된 페닐인 경우, OH그룹은 6-위치에서 존재한다.
  4. 제1항에 있어서, 목적화합물이 언급된 일반식(Ⅰ)의 플라바논 유도체, 이의 인산에스테르 및 이들 화합물의 염인 것을 특징으로 하는 제조방법.
  5. 제1항에 있어서, 염이 일반식(Ⅰ)화합물의 인산 에스테르와 아미노글리코 사이드 항생물질과의 염인 것을 특징으로 하는 제조방법.
  6. 제1항에 있어서, 염이 3-p-메톡시벤질리덴-6-하이드록시-4′메톡시플라바논-6-인산 에스테르의 겐타마이신 염인 것을 특징으로 하는 제조방법.
  7. 일반식(Ⅰ)의 화합물 및/또는 이의 하나의 인산 에스테르및/또는 이들 하나의 화합물의 생리학적으로 허용될 수 있는 염을 적어도 하나의 고체, 액체 또는 반-액체 부형제 또는 보조제와 함께, 필요시, 하나이상의 활성화합물을 추가로 혼합하여 적합한 용량 형태로 제조하는 것을 특징으로 하는 약학적 제형의 제조방법.
  8. 일반식(Ⅰ)의 적어도 하나의 화합물 및/또는 이의 하나의 인산 에스테르 및/또는 이들 하나의 화합물의 생리학으로 허용될 수 있는 염을 함유하는 것을 특징으로 하는 약학적 제제의 제조방법.
  9. 제1항에 있어서, 일반식(Ⅰ)의 화합물, 이들의 인산 에스테르 및/또는 이들 화합물의 생리학적으로 허용될 수 있는 염이 질병퇴치용인 것을 특징으로 하는 제조방법.
  10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850006149A 1984-08-28 1985-08-26 3-p-메톡시벤질리덴-6-하이드록시-4'-메톡시플라바논-6-포스페이트의 겐타마이신염의 제조방법 KR930002101B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3431534.9 1984-08-28
DE19843431534 DE3431534A1 (de) 1984-08-28 1984-08-28 Flavanonderivate
DE3431534 1984-08-28

Publications (2)

Publication Number Publication Date
KR860001798A true KR860001798A (ko) 1986-03-22
KR930002101B1 KR930002101B1 (ko) 1993-03-26

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KR1019850006149A KR930002101B1 (ko) 1984-08-28 1985-08-26 3-p-메톡시벤질리덴-6-하이드록시-4'-메톡시플라바논-6-포스페이트의 겐타마이신염의 제조방법

Country Status (19)

Country Link
US (1) US4937257A (ko)
EP (1) EP0173186B1 (ko)
JP (1) JPH0674259B2 (ko)
KR (1) KR930002101B1 (ko)
AR (1) AR241246A1 (ko)
AT (1) ATE39351T1 (ko)
AU (1) AU586827B2 (ko)
CA (1) CA1270484A (ko)
DD (1) DD236313A5 (ko)
DE (2) DE3431534A1 (ko)
DK (1) DK389985A (ko)
ES (1) ES8609299A1 (ko)
FI (1) FI84061C (ko)
HU (1) HU194901B (ko)
IE (1) IE58202B1 (ko)
IL (1) IL76188A (ko)
NZ (1) NZ213236A (ko)
PT (1) PT81029B (ko)
ZA (1) ZA856521B (ko)

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Publication number Priority date Publication date Assignee Title
JPH0518750U (ja) * 1991-08-23 1993-03-09 新東工業株式会社 鋳造品取り出し装置
DE4314871A1 (de) * 1993-05-05 1994-11-10 Merck Patent Gmbh Lösungsmittel für ein schwerlösliches Gentamicin-Salz
DE19521642C2 (de) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
DE19856668A1 (de) * 1998-12-09 2000-06-15 Aesculap Ag & Co Kg Wirkstoffmatrix in Form eines biologisch resorbierbaren porösen Vlieses, Verfahren zu ihrer Herstellung und Verwendung
EP1957507B1 (en) * 2005-12-02 2018-10-24 Ionis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
KR101504115B1 (ko) 2007-03-12 2015-03-19 삼성전자 주식회사 매크로 명령 동작 장치와 매크로 명령 입력 장치 및 방법
CA2684957A1 (en) * 2007-04-10 2008-10-16 Achaogen Inc. Antibacterial 1,4,5-substituted aminoglycoside analogs
JP5315572B2 (ja) * 2007-08-30 2013-10-16 国立大学法人 千葉大学 フラボノイドの製造方法
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
MX2012004036A (es) 2009-10-09 2012-06-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos.
CN103282370A (zh) 2010-11-17 2013-09-04 尔察祯有限公司 抗菌氨基糖苷类类似物
BR112015022841A8 (pt) * 2013-03-15 2017-10-03 Api Genesis Llc Composições de polifenol/flavonoide e métodos de formular produtos de higiene oral
DE102015214603B4 (de) * 2015-07-31 2019-01-24 Mathys Ag Bettlach Phosphorhaltige Aminoglycosid-Salze
CN115160280B (zh) * 2022-06-07 2023-08-04 贵州农业职业学院 一种黄烷酮类化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3678044A (en) * 1970-10-22 1972-07-18 Chevron Res Substituted flavanones
US4241069A (en) * 1979-09-04 1980-12-23 Miles Laboratories, Inc. 3-Methylene flavanones and 3-methylene chromanones
GB2122987B (en) * 1982-06-01 1985-09-25 Zyma Sa (+)-cyanidan-3-ol derivatives and pharmaceutical preparations thereof
GB8323291D0 (en) * 1983-08-31 1983-10-05 Zyma Sa Flavanone and thioflavanone derivatives

Also Published As

Publication number Publication date
EP0173186A1 (de) 1986-03-05
AU586827B2 (en) 1989-07-27
KR930002101B1 (ko) 1993-03-26
FI853277L (fi) 1986-03-01
JPH0674259B2 (ja) 1994-09-21
ES546493A0 (es) 1986-07-16
HUT40096A (en) 1986-11-28
AU4664885A (en) 1986-03-06
FI84061C (fi) 1991-10-10
AR241246A1 (es) 1992-03-31
NZ213236A (en) 1988-05-30
ZA856521B (en) 1986-04-30
IE58202B1 (en) 1993-07-28
DE3566887D1 (de) 1989-01-26
US4937257A (en) 1990-06-26
CA1270484A (en) 1990-06-19
EP0173186B1 (de) 1988-12-21
HU194901B (en) 1988-03-28
IE852120L (en) 1986-02-28
JPS6160677A (ja) 1986-03-28
DE3431534A1 (de) 1986-03-13
IL76188A0 (en) 1985-12-31
FI84061B (fi) 1991-06-28
PT81029A (en) 1985-09-01
ES8609299A1 (es) 1986-07-16
DD236313A5 (de) 1986-06-04
DK389985A (da) 1986-03-01
FI853277A0 (fi) 1985-08-27
IL76188A (en) 1990-11-29
DK389985D0 (da) 1985-08-27
PT81029B (pt) 1987-12-30
ATE39351T1 (de) 1989-01-15

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