PT87788A - Procede pour l,obtention de derives du dimethyl-2,2 chromannol--3 a activites antihypertensive e antiarythmique - Google Patents
Procede pour l,obtention de derives du dimethyl-2,2 chromannol--3 a activites antihypertensive e antiarythmiqueInfo
- Publication number
- PT87788A PT87788A PT87788A PT8778888A PT87788A PT 87788 A PT87788 A PT 87788A PT 87788 A PT87788 A PT 87788A PT 8778888 A PT8778888 A PT 8778888A PT 87788 A PT87788 A PT 87788A
- Authority
- PT
- Portugal
- Prior art keywords
- antiarythmique
- chromannol
- obtention
- antihypertensive
- derives
- Prior art date
Links
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
- C10L1/00—Liquid carbonaceous fuels
- C10L1/32—Liquid carbonaceous fuels consisting of coal-oil suspensions or aqueous emulsions or oil emulsions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8708830A FR2617165B1 (fr) | 1987-06-23 | 1987-06-23 | Derives du dimethyl-2, 2 chromannol-3 |
FR8800278A FR2625744B1 (fr) | 1988-01-12 | 1988-01-12 | Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant |
FR8803064A FR2628424B1 (fr) | 1988-03-09 | 1988-03-09 | Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
PT87788A true PT87788A (pt) | 1988-07-01 |
PT87788B PT87788B (pt) | 1992-10-30 |
Family
ID=27251476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87788A PT87788B (pt) | 1987-06-23 | 1988-06-22 | Processo para a preparacao de derivados do 2,2-dimetil-3-cromanol que tem actividade anti-hipertensiva e anti-arritmica |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0296975A1 (pt) |
JP (1) | JPS6426578A (pt) |
KR (1) | KR890000470A (pt) |
DK (1) | DK343388A (pt) |
FI (1) | FI90343C (pt) |
IL (1) | IL86798A (pt) |
NO (1) | NO170216C (pt) |
NZ (1) | NZ225117A (pt) |
PT (1) | PT87788B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
US5284838A (en) * | 1987-06-23 | 1994-02-08 | Elf Sanofi | Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma |
US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
US5021432A (en) * | 1988-04-26 | 1991-06-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzopyran compound and its pharmaceutical use |
US5254557A (en) * | 1988-05-09 | 1993-10-19 | Beecham Group P.L.C. | Compound and treatment |
JPH03500542A (ja) * | 1988-05-09 | 1991-02-07 | ビーチャム グループ ピーエルシー | 新規な化合物及び治療法 |
DE3837809A1 (de) * | 1988-11-08 | 1990-05-10 | Merck Patent Gmbh | Tetralinderivate |
DE68921972T2 (de) * | 1988-12-13 | 1995-11-16 | Beecham Group Plc | Benzopyran und verwandte Verbindungen. |
GB8902118D0 (en) * | 1989-02-01 | 1989-03-22 | Beecham Group Plc | Chemical process |
US5239090A (en) * | 1989-02-01 | 1993-08-24 | Beecham Group P.L.C. | Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates |
US5162553A (en) * | 1989-03-03 | 1992-11-10 | Yoshitomi Pharmaceutical Industries, Ltd. | Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor |
US5066816A (en) * | 1989-03-03 | 1991-11-19 | Yoshitomi Pharmaceutical Industries, Ltd. | Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2h-1-benzopyran compounds and intermediates therefor |
FR2645021A1 (fr) * | 1989-03-30 | 1990-10-05 | Sanofi Sa | Utilisation d'un agoniste potassique dans le traitement du glaucome |
DE3923839A1 (de) * | 1989-07-19 | 1991-01-31 | Beiersdorf Ag | Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
GB8916683D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Novel compounds |
DE3924417A1 (de) * | 1989-07-24 | 1991-01-31 | Merck Patent Gmbh | Chromanderivate |
DE3926001A1 (de) * | 1989-08-05 | 1991-02-07 | Merck Patent Gmbh | Chromanderivate |
FR2654103B1 (fr) * | 1989-11-06 | 1992-02-21 | Sanofi Sa | Derives d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques les contenant. |
FR2657872B2 (fr) * | 1989-11-06 | 1992-06-12 | Sanofi Sa | Derive d'amidino-4 chromanne, procede d'obtention et compositions pharmaceutiques le contenant. |
US5185345A (en) * | 1989-11-06 | 1993-02-09 | Sanofi | 4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them |
DE4115465A1 (de) * | 1991-05-11 | 1992-11-12 | Beiersdorf Ag | Neue in 4-stellung durch aryl oder n-heteroaryl substituierte 2h-benzo(b)pyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
HUT70745A (en) * | 1991-12-05 | 1995-10-30 | Smithkline Beecham Plc | Pharmaceutical composition for treatment of disorders of respiratory tract and hypertension containing (3s,4r)-3,4-dihydro-2,2-dimethyl-4-(2-oxo-piperidinyl)-6-pentafluorethyl-2h-1-benzopyranol |
GB9203596D0 (en) * | 1992-02-20 | 1992-04-08 | Smithkline Beecham Plc | Novel process |
GB9207400D0 (en) * | 1992-04-02 | 1992-05-13 | Smithkline Beecham Plc | Novel use |
CA2142471A1 (en) * | 1992-08-17 | 1994-03-03 | Hiroshi Koga | Benzopyran and benzoxazine derivatives |
US6031115A (en) * | 1993-05-14 | 2000-02-29 | Smithkline Beecham Plc | Process for preparing epoxides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0076075B1 (en) * | 1981-09-25 | 1986-11-20 | Beecham Group Plc | Pharmaceutically active benzopyran compounds |
EP0107423B1 (en) * | 1982-10-19 | 1986-07-23 | Beecham Group Plc | Novel chromans and chromenes |
ATE56007T1 (de) * | 1984-06-22 | 1990-09-15 | Beecham Group Plc | Wirksame benzopyranverbindungen. |
DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
-
1988
- 1988-06-20 IL IL86798A patent/IL86798A/xx not_active IP Right Cessation
- 1988-06-20 FI FI882945A patent/FI90343C/fi not_active IP Right Cessation
- 1988-06-21 NZ NZ225117A patent/NZ225117A/xx unknown
- 1988-06-22 DK DK343388A patent/DK343388A/da unknown
- 1988-06-22 PT PT87788A patent/PT87788B/pt not_active IP Right Cessation
- 1988-06-22 NO NO882762A patent/NO170216C/no unknown
- 1988-06-23 JP JP63155989A patent/JPS6426578A/ja active Pending
- 1988-06-23 EP EP88401580A patent/EP0296975A1/fr not_active Withdrawn
- 1988-06-23 KR KR1019880007608A patent/KR890000470A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR890000470A (ko) | 1989-03-14 |
IL86798A0 (en) | 1988-11-30 |
NZ225117A (en) | 1990-02-26 |
FI882945A (fi) | 1988-12-24 |
DK343388A (da) | 1988-12-24 |
EP0296975A1 (fr) | 1988-12-28 |
NO170216C (no) | 1992-09-23 |
NO882762L (no) | 1988-12-27 |
NO882762D0 (no) | 1988-06-22 |
NO170216B (no) | 1992-06-15 |
FI882945A0 (fi) | 1988-06-20 |
IL86798A (en) | 1992-12-01 |
FI90343C (fi) | 1994-01-25 |
DK343388D0 (da) | 1988-06-22 |
JPS6426578A (en) | 1989-01-27 |
FI90343B (fi) | 1993-10-15 |
PT87788B (pt) | 1992-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19920430 |
|
PC3A | Transfer or assignment |
Free format text: 960326 MERCK PATENT GMBH DE |
|
TE3A | Change of address (patent) | ||
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19971031 |