ATE229527T1 - Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung - Google Patents
Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellungInfo
- Publication number
- ATE229527T1 ATE229527T1 AT97941255T AT97941255T ATE229527T1 AT E229527 T1 ATE229527 T1 AT E229527T1 AT 97941255 T AT97941255 T AT 97941255T AT 97941255 T AT97941255 T AT 97941255T AT E229527 T1 ATE229527 T1 AT E229527T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- lower alkyl
- pyrazolopyridylpyrazinone
- production
- activity
- Prior art date
Links
- BBZZRIPPYOYZOG-UHFFFAOYSA-N N1N=C(C2=C1C=CC=N2)C=2C(NC=CN2)=O Chemical class N1N=C(C2=C1C=CC=N2)C=2C(NC=CN2)=O BBZZRIPPYOYZOG-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- AUSTYKOYMLRNQQ-UHFFFAOYSA-N 5-(1h-pyrazolo[4,3-b]pyridin-3-yl)-1h-pyridazin-6-one Chemical class O=C1NN=CC=C1C1=NNC2=CC=CN=C12 AUSTYKOYMLRNQQ-UHFFFAOYSA-N 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- 230000003182 bronchodilatating effect Effects 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000000168 bronchodilator agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28314896 | 1996-10-04 | ||
| PCT/JP1997/003434 WO1998014448A1 (en) | 1996-10-04 | 1997-09-26 | Pyrazolopyridylpyridazinone derivatives and process for the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229527T1 true ATE229527T1 (de) | 2002-12-15 |
Family
ID=17661845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97941255T ATE229527T1 (de) | 1996-10-04 | 1997-09-26 | Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6265577B1 (de) |
| EP (1) | EP0989129B1 (de) |
| KR (1) | KR100517397B1 (de) |
| CN (1) | CN1083841C (de) |
| AT (1) | ATE229527T1 (de) |
| AU (1) | AU733316B2 (de) |
| CA (1) | CA2267103C (de) |
| DE (1) | DE69717867T2 (de) |
| ES (1) | ES2187814T3 (de) |
| HU (1) | HUP9903018A2 (de) |
| WO (1) | WO1998014448A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
| US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
| US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
| US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
| US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
| US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
| US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
| US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
| US6875575B1 (en) | 1998-11-25 | 2005-04-05 | Osi Pharmaceuticals, Inc. | Diagnostic methods for neoplasia |
| US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
| CZ302882B6 (cs) | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7208516B2 (en) | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| EP1570847B1 (de) * | 2002-12-03 | 2012-04-25 | Kyorin Pharmaceutical Co., Ltd. | Phosphodiesterase 10a-hemmer zur behandlung der parkinson-krankheit, der huntington-krankheit und der schizophrenie |
| US7153824B2 (en) | 2003-04-01 | 2006-12-26 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| JP4890439B2 (ja) * | 2005-03-07 | 2012-03-07 | 杏林製薬株式会社 | ピラゾロピリジン−４−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤 |
| EP2038279A2 (de) * | 2006-06-06 | 2009-03-25 | Avigen, Inc. | Substituierte pyrazolo[1,5-alpha]pyridinverbindungen und verfahren zu ihrer anwendung |
| CA2661850A1 (en) * | 2006-09-01 | 2008-03-06 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same |
| WO2008029829A1 (en) | 2006-09-06 | 2008-03-13 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolopyridine derivative and phosphodiesterase (pde) inhibitor containing the same as active ingredient |
| JP2010013354A (ja) * | 2006-09-07 | 2010-01-21 | Kyorin Pharmaceut Co Ltd | ２−アルキル−６−（ピラゾロピリジン−４−イル）ピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤 |
| WO2008129624A1 (ja) * | 2007-04-10 | 2008-10-30 | Kyorin Pharmaceutical Co., Ltd. | ピラゾロピリジン－４－イルピラゾロン誘導体とその付加塩及びそれを有効成分とするホスホジエステラーゼ阻害剤 |
| WO2010035745A1 (ja) | 2008-09-25 | 2010-04-01 | 杏林製薬株式会社 | ヘテロ環ビアリール誘導体及びそれらを有効成分とするｐｄｅ阻害剤 |
| WO2010041711A1 (ja) | 2008-10-09 | 2010-04-15 | 杏林製薬株式会社 | イソキノリン誘導体及びそれらを有効成分とするｐｄｅ阻害剤 |
| KR101946499B1 (ko) | 2011-04-08 | 2019-02-11 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 치료를 위한 피리미딘 유도체 |
| EP2776439B1 (de) | 2011-11-09 | 2018-07-04 | Janssen Sciences Ireland UC | Purinderivate zur behandlung von virusinfektionen |
| CA2874800C (en) | 2012-07-13 | 2021-04-06 | Janssen R&D Ireland | Macrocyclic purines for the treatment of viral infections |
| NZ705589A (en) | 2012-10-10 | 2019-05-31 | Janssen Sciences Ireland Uc | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
| AU2013346793B2 (en) | 2012-11-16 | 2018-03-08 | Janssen Sciences Ireland Uc | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
| KR102225233B1 (ko) | 2013-02-21 | 2021-03-09 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체 |
| MX366481B (es) | 2013-03-29 | 2019-07-09 | Janssen Sciences Ireland Uc | Deaza-purinonas macrociclicas para el tratamiento de infecciones virales. |
| MY188071A (en) | 2013-05-24 | 2021-11-16 | Janssen Sciences Ireland Uc | Pyridone derivatives for the treatment of viral infections and further diseases |
| CN109369643B (zh) | 2013-06-27 | 2021-05-18 | 爱尔兰詹森科学公司 | 用于治疗病毒感染和其他疾病的吡咯并[3,2-d]嘧啶衍生物 |
| EP3027624B1 (de) | 2013-07-30 | 2018-09-12 | Janssen Sciences Ireland UC | Thieno[3,2-d]pyrimidin-derivate zur behandlung von virusinfektionen |
| JP6687550B2 (ja) | 2014-06-23 | 2020-04-22 | セルジーン コーポレイション | 肝疾患又は肝機能異常を治療するためのアプレミラスト |
| WO2018002319A1 (en) | 2016-07-01 | 2018-01-04 | Janssen Sciences Ireland Uc | Dihydropyranopyrimidines for the treatment of viral infections |
| WO2018060317A1 (en) | 2016-09-29 | 2018-04-05 | Janssen Sciences Ireland Uc | Pyrimidine prodrugs for the treatment of viral infections and further diseases |
| TW202415645A (zh) | 2018-03-01 | 2024-04-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8901423D0 (en) * | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| GB9015764D0 (en) * | 1990-07-18 | 1990-09-05 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
| CA2060138A1 (en) * | 1991-01-29 | 1992-07-30 | Youichi Shiokawa | New use of the adenosine antagonist |
-
1997
- 1997-09-26 ES ES97941255T patent/ES2187814T3/es not_active Expired - Lifetime
- 1997-09-26 DE DE69717867T patent/DE69717867T2/de not_active Expired - Fee Related
- 1997-09-26 CA CA002267103A patent/CA2267103C/en not_active Expired - Fee Related
- 1997-09-26 WO PCT/JP1997/003434 patent/WO1998014448A1/ja not_active Ceased
- 1997-09-26 US US09/269,734 patent/US6265577B1/en not_active Expired - Fee Related
- 1997-09-26 EP EP97941255A patent/EP0989129B1/de not_active Expired - Lifetime
- 1997-09-26 HU HU9903018A patent/HUP9903018A2/hu unknown
- 1997-09-26 KR KR10-1999-7002884A patent/KR100517397B1/ko not_active Expired - Fee Related
- 1997-09-26 AT AT97941255T patent/ATE229527T1/de not_active IP Right Cessation
- 1997-09-26 AU AU43213/97A patent/AU733316B2/en not_active Ceased
- 1997-09-26 CN CN97198468A patent/CN1083841C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100517397B1 (ko) | 2005-09-29 |
| CN1232463A (zh) | 1999-10-20 |
| US6265577B1 (en) | 2001-07-24 |
| CN1083841C (zh) | 2002-05-01 |
| DE69717867D1 (de) | 2003-01-23 |
| EP0989129A1 (de) | 2000-03-29 |
| AU4321397A (en) | 1998-04-24 |
| WO1998014448A1 (en) | 1998-04-09 |
| DE69717867T2 (de) | 2003-10-02 |
| EP0989129A4 (de) | 2001-04-11 |
| ES2187814T3 (es) | 2003-06-16 |
| KR20000048874A (ko) | 2000-07-25 |
| CA2267103C (en) | 2006-05-30 |
| AU733316B2 (en) | 2001-05-10 |
| HUP9903018A2 (hu) | 2000-03-28 |
| EP0989129B1 (de) | 2002-12-11 |
| CA2267103A1 (en) | 1998-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |