ATE229527T1 - Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung - Google Patents
Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellungInfo
- Publication number
- ATE229527T1 ATE229527T1 AT97941255T AT97941255T ATE229527T1 AT E229527 T1 ATE229527 T1 AT E229527T1 AT 97941255 T AT97941255 T AT 97941255T AT 97941255 T AT97941255 T AT 97941255T AT E229527 T1 ATE229527 T1 AT E229527T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- lower alkyl
- pyrazolopyridylpyrazinone
- production
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28314896 | 1996-10-04 | ||
PCT/JP1997/003434 WO1998014448A1 (fr) | 1996-10-04 | 1997-09-26 | Derives de pyrazolopyridylpyridazinone et procede de preparation des ces derniers |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE229527T1 true ATE229527T1 (de) | 2002-12-15 |
Family
ID=17661845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97941255T ATE229527T1 (de) | 1996-10-04 | 1997-09-26 | Pyrazolopyridylpyrazinon-derivate und ein verfahren zu ihrer herstellung |
Country Status (11)
Country | Link |
---|---|
US (1) | US6265577B1 (de) |
EP (1) | EP0989129B1 (de) |
KR (1) | KR100517397B1 (de) |
CN (1) | CN1083841C (de) |
AT (1) | ATE229527T1 (de) |
AU (1) | AU733316B2 (de) |
CA (1) | CA2267103C (de) |
DE (1) | DE69717867T2 (de) |
ES (1) | ES2187814T3 (de) |
HU (1) | HUP9903018A2 (de) |
WO (1) | WO1998014448A1 (de) |
Families Citing this family (38)
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---|---|---|---|---|
US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
US6875575B1 (en) | 1998-11-25 | 2005-04-05 | Osi Pharmaceuticals, Inc. | Diagnostic methods for neoplasia |
US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
US7208516B2 (en) | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US7276529B2 (en) | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
EP1570847B1 (de) * | 2002-12-03 | 2012-04-25 | Kyorin Pharmaceutical Co., Ltd. | Phosphodiesterase 10a-hemmer zur behandlung der parkinson-krankheit, der huntington-krankheit und der schizophrenie |
WO2006095666A1 (ja) * | 2005-03-07 | 2006-09-14 | Kyorin Pharmaceutical Co., Ltd. | ピラゾロピリジン-4-イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするpde阻害剤 |
JP5352452B2 (ja) * | 2006-06-06 | 2013-11-27 | メディシノバ, インコーポレイテッド | 置換ピラゾロ[1,5−a]ピリジン化合物およびその使用方法 |
US20100056791A1 (en) * | 2006-09-01 | 2010-03-04 | Yasushi Kohno | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same |
CA2661992A1 (en) * | 2006-09-06 | 2008-03-13 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolopyridine derivative and phosphodiesterase (pde) inhibitor containing the same as active ingredient |
JP2010013354A (ja) * | 2006-09-07 | 2010-01-21 | Kyorin Pharmaceut Co Ltd | 2−アルキル−6−(ピラゾロピリジン−4−イル)ピリダジノン誘導体とその付加塩及びそれらを有効成分とするpde阻害剤 |
WO2008129624A1 (ja) * | 2007-04-10 | 2008-10-30 | Kyorin Pharmaceutical Co., Ltd. | ピラゾロピリジン-4-イルピラゾロン誘導体とその付加塩及びそれを有効成分とするホスホジエステラーゼ阻害剤 |
WO2010035745A1 (ja) | 2008-09-25 | 2010-04-01 | 杏林製薬株式会社 | ヘテロ環ビアリール誘導体及びそれらを有効成分とするpde阻害剤 |
EP2351748A4 (de) | 2008-10-09 | 2012-03-21 | Kyorin Seiyaku Kk | Isochinolinderivat und dieses als wirkstoff enthaltender pde-hemmer |
BR122017025423B1 (pt) | 2011-04-08 | 2021-05-11 | Janssen Sciences Ireland Uc | derivados de pirimidina, seu uso no tratamento de infecções virais e composição farmacêutica que os compreende |
BR122019020718B1 (pt) | 2011-11-09 | 2021-07-06 | Janssen Sciences Ireland Uc | Derivados purínicos para o tratamento de infecções virais e composição farmacêutica que os compreende |
NZ702364A (en) | 2012-07-13 | 2016-09-30 | Janssen Sciences Ireland Uc | Macrocyclic purines for the treatment of viral infections |
JP6293765B2 (ja) | 2012-10-10 | 2018-03-14 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染症および他の疾患の処置のためのピロロ[3,2−d]ピリミジン誘導体 |
BR112015011036B1 (pt) | 2012-11-16 | 2022-02-01 | Janssen Sciences Ireland Uc | Derivados de 2-amino-quinazolina substituídos heterocíclicos, composição farmacêutica |
EA035174B1 (ru) | 2013-02-21 | 2020-05-12 | Янссен Сайенсиз Айрлэнд Юси | Производные 2-аминопиримидина в качестве модуляторов толл-подобных рецепторов tlr7 и/или tlr8 |
SG11201508078XA (en) | 2013-03-29 | 2015-11-27 | Janssen Sciences Ireland Uc | Macrocyclic deaza-purinones for the treatment of viral infections |
KR102280559B1 (ko) | 2013-05-24 | 2021-07-22 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가적인 질환의 치료를 위한 피리돈 유도체 |
ES2645950T3 (es) | 2013-06-27 | 2017-12-11 | Janssen Sciences Ireland Uc | Derivados de pirrolo[3,2-d]pirimidina para el tratamiento de infecciones víricas y otras enfermedades |
JP6401788B2 (ja) | 2013-07-30 | 2018-10-10 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染治療用チエノ[3,2−d]ピリミジン誘導体 |
US10300042B2 (en) | 2014-06-23 | 2019-05-28 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
JP7171444B2 (ja) | 2016-07-01 | 2022-11-15 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ウイルス感染治療用のジヒドロピラノピリミジン |
KR102450287B1 (ko) | 2016-09-29 | 2022-09-30 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가적인 질환의 치료를 위한 피리미딘 프로드러그 |
TW201945003A (zh) | 2018-03-01 | 2019-12-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | 2,4-二胺基喹唑啉衍生物及其醫學用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8901423D0 (en) * | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
GB9015764D0 (en) * | 1990-07-18 | 1990-09-05 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
CA2060138A1 (en) * | 1991-01-29 | 1992-07-30 | Youichi Shiokawa | New use of the adenosine antagonist |
-
1997
- 1997-09-26 WO PCT/JP1997/003434 patent/WO1998014448A1/ja active IP Right Grant
- 1997-09-26 DE DE69717867T patent/DE69717867T2/de not_active Expired - Fee Related
- 1997-09-26 CA CA002267103A patent/CA2267103C/en not_active Expired - Fee Related
- 1997-09-26 ES ES97941255T patent/ES2187814T3/es not_active Expired - Lifetime
- 1997-09-26 EP EP97941255A patent/EP0989129B1/de not_active Expired - Lifetime
- 1997-09-26 HU HU9903018A patent/HUP9903018A2/hu unknown
- 1997-09-26 AU AU43213/97A patent/AU733316B2/en not_active Ceased
- 1997-09-26 AT AT97941255T patent/ATE229527T1/de not_active IP Right Cessation
- 1997-09-26 CN CN97198468A patent/CN1083841C/zh not_active Expired - Fee Related
- 1997-09-26 US US09/269,734 patent/US6265577B1/en not_active Expired - Fee Related
- 1997-09-26 KR KR10-1999-7002884A patent/KR100517397B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU4321397A (en) | 1998-04-24 |
CA2267103A1 (en) | 1998-04-09 |
EP0989129B1 (de) | 2002-12-11 |
DE69717867T2 (de) | 2003-10-02 |
HUP9903018A2 (hu) | 2000-03-28 |
EP0989129A1 (de) | 2000-03-29 |
DE69717867D1 (de) | 2003-01-23 |
KR20000048874A (ko) | 2000-07-25 |
CA2267103C (en) | 2006-05-30 |
US6265577B1 (en) | 2001-07-24 |
CN1083841C (zh) | 2002-05-01 |
WO1998014448A1 (fr) | 1998-04-09 |
EP0989129A4 (de) | 2001-04-11 |
AU733316B2 (en) | 2001-05-10 |
CN1232463A (zh) | 1999-10-20 |
ES2187814T3 (es) | 2003-06-16 |
KR100517397B1 (ko) | 2005-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |