HUP0203746A2 - Novel composition and method for stabilizing the same - Google Patents

Novel composition and method for stabilizing the same

Info

Publication number
HUP0203746A2
HUP0203746A2 HU0203746A HUP0203746A HUP0203746A2 HU P0203746 A2 HUP0203746 A2 HU P0203746A2 HU 0203746 A HU0203746 A HU 0203746A HU P0203746 A HUP0203746 A HU P0203746A HU P0203746 A2 HUP0203746 A2 HU P0203746A2
Authority
HU
Hungary
Prior art keywords
group
carbon
atom
represent
lower alkyl
Prior art date
Application number
HU0203746A
Other languages
Hungarian (hu)
Inventor
Tsuyoshi Habe
Ryuji Ueno
Original Assignee
Sucampo Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22573018&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0203746(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sucampo Ag filed Critical Sucampo Ag
Publication of HUP0203746A2 publication Critical patent/HUP0203746A2/en
Publication of HUP0203746A3 publication Critical patent/HUP0203746A3/en
Publication of HU229547B1 publication Critical patent/HU229547B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Abstract

A találmány olyan új kompozícióra vonatkozik, amely egy új biciklusosvegyületet és egy gliceridet tartalmaz. A találmány tárgya továbbáeljárás a biciklusos vegyület stabilizálására, amelynek lényege az,hogy a biciklusos vegyületet egy gliceriddel keverik össze. Atalálmány továbbá az új biciklusos vegyületekre vonatkozik, amelyek(I) általános képletében A jelentése -CH2OH, -COCH2OH vagy -COOHcsoport vagy ezek valamelyikének funkcionális származéka; X1 és X2hidrogénatomot, halogénatomot vagy rövid szénláncú alkilcsoportotjelentenek; V1 és V2 szénatomot vagy oxigénatomot jelentenek; továbbáW1 és W2 (III), (IV) vagy (V) képletű csoportot jelentenek, és az elsőkettőben R4 és R5 egymástól függetlenül hidrogénatomot, halogénatomot,hidroxilcsoportot, rövid szénláncú alkilcsoportot, rövid szénláncúalkoxicsoportot vagy hidroxi(rövid szénláncú)alkilcsoportot jelent,azzal a megkötéssel, hogy R4 és R5 egyidejű jelentésehidroxilcsoporttól vagy rövid szénláncú alkoxicsoporttól eltérő; Zjelentése szén-, oxigén-, kén- vagy nitrogénatom; R1 jelentésetelített vagy telítetlen, kétértékű rövid vagy közepes szénláncúalifás szénhidrogén-maradék, amely adott esetben szubsztituálva van;R2 jelentése telített vagy telítetlen, rövid vagy közepes szénláncúalifás szénhidrogén-maradék, amely adott esetben szubsztituálva van;vagy továbbá R2 jelentése rövid szénláncú cikloalkilcsoport, rövidszénláncú cikloalkoxicsoport, arilcsoport, ariloxicsoport,heterociklusos csoport vagy heterociklusos oxicsoport; és R3 jelentésehidrogénatom, rövid szénláncú alkilcsoport, rövid szénláncúcikloalkilcsoport, arilcsoport vagy heterociklusos csoport. ÓThe invention relates to a new composition comprising a new bicyclic compound and a glyceride. The subject of the invention is also a method for stabilizing the bicyclic compound, the essence of which is that the bicyclic compound is mixed with a glyceride. The invention also relates to new bicyclic compounds, in the general formula (I) of which A is -CH2OH, -COCH2OH or -COOH group or a functional derivative of one of them; X1 and X2 represent a hydrogen atom, a halogen atom or a lower alkyl group; V1 and V2 represent a carbon atom or an oxygen atom; furthermore, W1 and W2 represent a group of the formula (III), (IV) or (V), and in the first two R4 and R5 independently represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkyl group or a hydroxy (lower) alkyl group, with the restriction , that R 4 and R 5 at the same time mean other than a hydroxyl group or a lower alkoxy group; Z means a carbon, oxygen, sulfur or nitrogen atom; R1 is a saturated or unsaturated, divalent, short- or medium-chain aliphatic hydrocarbon residue, which is optionally substituted; R2 is a saturated or unsaturated, short- or medium-carbon chain aliphatic hydrocarbon residue, which is optionally substituted; or, furthermore, R2 is a lower-carbon cycloalkyl group, a lower-carbon cycloalkyl group , aryl group, aryloxy group, heterocyclic group or heterocyclic oxy group; and R 3 is hydrogen, lower alkyl, lower cycloalkyl, aryl or heterocyclic. HE

HU0203746A 1999-10-15 2000-10-13 Novel composition and method for stabilizing the same HU229547B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15954999P 1999-10-15 1999-10-15
PCT/JP2000/007109 WO2001027099A2 (en) 1999-10-15 2000-10-13 Bicyclic compounds composition and method for stabilizing the same

Publications (3)

Publication Number Publication Date
HUP0203746A2 true HUP0203746A2 (en) 2003-03-28
HUP0203746A3 HUP0203746A3 (en) 2005-02-28
HU229547B1 HU229547B1 (en) 2014-01-28

Family

ID=22573018

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1300369A HU230484B1 (en) 1999-10-15 2000-10-13 Novel composition containing a bi-cyclic compound and a glyceride
HU0203746A HU229547B1 (en) 1999-10-15 2000-10-13 Novel composition and method for stabilizing the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU1300369A HU230484B1 (en) 1999-10-15 2000-10-13 Novel composition containing a bi-cyclic compound and a glyceride

Country Status (26)

Country Link
US (5) US6583174B1 (en)
EP (2) EP1426361B2 (en)
JP (2) JP4332316B2 (en)
KR (1) KR100830061B1 (en)
CN (1) CN1268623C (en)
AR (3) AR026046A1 (en)
AT (2) ATE267189T1 (en)
AU (2) AU780342B2 (en)
BR (1) BRPI0014869B8 (en)
CA (1) CA2385732C (en)
CZ (1) CZ303625B6 (en)
DE (2) DE60039727D1 (en)
DK (2) DK1426361T4 (en)
ES (2) ES2309410T5 (en)
HK (2) HK1066792A1 (en)
HU (2) HU230484B1 (en)
IL (2) IL148803A0 (en)
MX (1) MXPA02003756A (en)
NO (1) NO330258B1 (en)
NZ (1) NZ518020A (en)
PT (2) PT1426361E (en)
RU (1) RU2695274C3 (en)
TR (1) TR200201032T2 (en)
TW (1) TWI281918B (en)
WO (1) WO2001027099A2 (en)
ZA (1) ZA200202312B (en)

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KR100830061B1 (en) 2008-05-16
AU2004242503C1 (en) 2005-01-27
WO2001027099A3 (en) 2001-10-25
BR0014869A (en) 2002-06-25
ATE267189T1 (en) 2004-06-15
CZ20021037A3 (en) 2002-09-11
ZA200202312B (en) 2002-12-24
DE60010913T2 (en) 2005-06-09
CA2385732A1 (en) 2001-04-19
EP1220849A2 (en) 2002-07-10
ATE402925T2 (en) 2008-08-15
JP4332316B2 (en) 2009-09-16
US8088934B2 (en) 2012-01-03
WO2001027099A2 (en) 2001-04-19
HK1066792A1 (en) 2005-04-01
EP1220849B1 (en) 2004-05-19
CN1379769A (en) 2002-11-13
CN1268623C (en) 2006-08-09
HUP1300369A2 (en) 2003-03-28
IL148803A (en) 2006-07-05
EP1426361B1 (en) 2008-07-30
TR200201032T2 (en) 2002-08-21
AR026046A1 (en) 2002-12-26
US20080255227A1 (en) 2008-10-16
AR109354A2 (en) 2018-11-21
DK1220849T3 (en) 2004-09-27
KR20020068521A (en) 2002-08-27
CA2385732C (en) 2009-02-10
HU230484B1 (en) 2016-07-28
RU2695274C3 (en) 2020-11-09
EP1426361B2 (en) 2015-02-25
JP2009235079A (en) 2009-10-15
EP1426361A1 (en) 2004-06-09
US20040235885A1 (en) 2004-11-25
DK1426361T4 (en) 2015-03-16
HK1045693A1 (en) 2002-12-06
NO20021736L (en) 2002-04-12
AR089848A2 (en) 2014-09-24
US7417067B2 (en) 2008-08-26
US8097649B1 (en) 2012-01-17
RU2695274C9 (en) 2020-01-22
DE60039727D1 (en) 2008-09-11
AU2004242503A1 (en) 2005-01-27
PT1426361E (en) 2008-10-08
AU7685600A (en) 2001-04-23
HUP0203746A3 (en) 2005-02-28
US6583174B1 (en) 2003-06-24
AU2004242503B2 (en) 2007-06-21
NO330258B1 (en) 2011-03-14
ES2221859T3 (en) 2005-01-16
NZ518020A (en) 2004-02-27
BRPI0014869B8 (en) 2021-05-25
ES2309410T3 (en) 2008-12-16
HK1045693B (en) 2005-01-21
DK1426361T3 (en) 2008-11-17
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IL148803A0 (en) 2002-09-12
AU780342B2 (en) 2005-03-17
PT1220849E (en) 2004-10-29
TWI281918B (en) 2007-06-01
RU2002112984A (en) 2004-01-20
BRPI0014869B1 (en) 2017-06-13
CZ303625B6 (en) 2013-01-16
NO20021736D0 (en) 2002-04-12
JP2003511445A (en) 2003-03-25
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