DE60010913D1 - Bizyclische verbindungen zusammenstellung und verfahren zu ihrer stabilisierung - Google Patents
Bizyclische verbindungen zusammenstellung und verfahren zu ihrer stabilisierungInfo
- Publication number
- DE60010913D1 DE60010913D1 DE60010913T DE60010913T DE60010913D1 DE 60010913 D1 DE60010913 D1 DE 60010913D1 DE 60010913 T DE60010913 T DE 60010913T DE 60010913 T DE60010913 T DE 60010913T DE 60010913 D1 DE60010913 D1 DE 60010913D1
- Authority
- DE
- Germany
- Prior art keywords
- bizyclic
- stabilization
- compositions
- bizyclic compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15954999P | 1999-10-15 | 1999-10-15 | |
US159549P | 1999-10-15 | ||
PCT/JP2000/007109 WO2001027099A2 (en) | 1999-10-15 | 2000-10-13 | Bicyclic compounds composition and method for stabilizing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60010913D1 true DE60010913D1 (de) | 2004-06-24 |
DE60010913T2 DE60010913T2 (de) | 2005-06-09 |
Family
ID=22573018
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60010913T Expired - Lifetime DE60010913T2 (de) | 1999-10-15 | 2000-10-13 | Bizyklische Verbindungen, Zusammenstellung und Verfahren zu ihrer Stabilisierung |
DE60039727T Expired - Lifetime DE60039727D1 (de) | 1999-10-15 | 2000-10-13 | Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60039727T Expired - Lifetime DE60039727D1 (de) | 1999-10-15 | 2000-10-13 | Neue Zusammensetzung enthaltend eine bicyclische Verbindung und ein Glycerid |
Country Status (26)
Country | Link |
---|---|
US (5) | US6583174B1 (de) |
EP (2) | EP1426361B2 (de) |
JP (2) | JP4332316B2 (de) |
KR (1) | KR100830061B1 (de) |
CN (1) | CN1268623C (de) |
AR (3) | AR026046A1 (de) |
AT (2) | ATE267189T1 (de) |
AU (2) | AU780342B2 (de) |
BR (1) | BRPI0014869B8 (de) |
CA (1) | CA2385732C (de) |
CZ (1) | CZ303625B6 (de) |
DE (2) | DE60010913T2 (de) |
DK (2) | DK1220849T3 (de) |
ES (2) | ES2221859T3 (de) |
HK (2) | HK1066792A1 (de) |
HU (2) | HU229547B1 (de) |
IL (2) | IL148803A0 (de) |
MX (1) | MXPA02003756A (de) |
NO (1) | NO330258B1 (de) |
NZ (1) | NZ518020A (de) |
PT (2) | PT1426361E (de) |
RU (1) | RU2695274C3 (de) |
TR (1) | TR200201032T2 (de) |
TW (1) | TWI281918B (de) |
WO (1) | WO2001027099A2 (de) |
ZA (1) | ZA200202312B (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4332316B2 (ja) * | 1999-10-15 | 2009-09-16 | スキャンポ・アーゲー | 二環式化合物組成物およびその安定化方法 |
US6414016B1 (en) | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
AR037524A1 (es) | 2001-11-14 | 2004-11-17 | Sucampo Ag | Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion |
FR2842810B1 (fr) * | 2002-07-25 | 2006-01-27 | Inst Nat Sciences Appliq | Nouveaux composes gem difluores, leur procedes de preparation et leurs applications. |
CA2502439C (en) * | 2002-10-23 | 2011-11-22 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
AU2003292556B2 (en) * | 2002-12-27 | 2009-09-10 | Sucampo Ag | Derivatives of prostaglandins for treating abdominal discomfort |
US8337891B2 (en) * | 2003-07-03 | 2012-12-25 | Sucampo Ag | Enteric coated composition comprising prostaglandin analogs as chloride channel opener |
TWI348386B (en) * | 2003-08-12 | 2011-09-11 | R Tech Ueno Ltd | Composition and method for promoting hair growth |
TWI387454B (zh) | 2004-09-02 | 2013-03-01 | Sucampo Ag | 治療胃腸道疾病之方法及組成物 |
EP1871380B1 (de) * | 2005-04-12 | 2011-10-19 | Sucampo AG | Kombinierte verwendung einer prostaglandin-verbindung und eines protonenpumpenhemmers zur behandlung von magen-darm-erkrankungen |
US8026393B2 (en) | 2006-01-24 | 2011-09-27 | Sucampo Ag | Soft-gelatin capsule formulation |
MX2008009652A (es) | 2006-01-24 | 2008-11-06 | R Tech Ueno Ltd | Composicion farmaceutica que comprende un compuesto biciclico y metodo para estabilizar el compuesto biciclico. |
WO2007091697A2 (en) * | 2006-02-07 | 2007-08-16 | R-Tech Ueno, Ltd. | Method for preparing prostaglandin derivative |
US20090012165A1 (en) | 2007-07-03 | 2009-01-08 | Sucampo Ag | Pharmaceutical combination of nsaid and prostaglandin compound |
US20090030072A1 (en) | 2007-07-03 | 2009-01-29 | Sucampo Ag | Pharmaceutical combination of opioid and prostaglandin compound |
MX339727B (es) * | 2007-07-19 | 2016-06-06 | R-Tech Ueno Ltd | Composicion farmaceutica que comprende un compuesto de 11-desoxi-prostaglandina y metodo para estabilizar el compuesto. |
US20090082442A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched lubiprostone |
CN101318948B (zh) | 2008-04-01 | 2011-04-27 | 上海天伟生物制药有限公司 | 鲁比前列酮晶体、其制备方法及用途 |
US8569279B2 (en) * | 2009-05-27 | 2013-10-29 | Sucampo Ag | Method for modulating claudin mediated functions |
US20110034424A1 (en) * | 2009-06-30 | 2011-02-10 | Sucampo Ag | Method for the long term nsaid use |
WO2011013651A1 (ja) | 2009-07-28 | 2011-02-03 | 小野薬品工業株式会社 | 二環式化合物およびその医薬用途 |
NZ598783A (en) * | 2009-09-18 | 2013-07-26 | Adolor Corp | Use of opioid receptor antagonist for gastrointestinal tract disorders |
CA2779736A1 (en) | 2009-11-03 | 2011-05-12 | Bernard Charles Sherman | Stable pharmaceutical formulations comprising lubiprostone |
ES2581852T3 (es) | 2011-01-27 | 2016-09-07 | Ono Pharmaceutical Co., Ltd. | Compuesto bicíclico y uso del mismo para fines médicos |
EP2669279B1 (de) | 2011-01-27 | 2017-01-11 | ONO Pharmaceutical Co., Ltd. | Bizyklische verbindung und ihre verwendung für medizinische zwecke |
WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
EP3277274B1 (de) | 2015-04-01 | 2024-06-12 | Cedars-Sinai Medical Center | Antimethanogene lovastatin-analoga oder -derivate und verwendungen davon |
JP6954282B2 (ja) | 2016-06-30 | 2021-10-27 | 小野薬品工業株式会社 | 二環式化合物の製造方法 |
US11534404B2 (en) | 2016-10-06 | 2022-12-27 | Sucampo Ag | Multilayer beads for pharmaceutical use |
JPWO2019221215A1 (ja) * | 2018-05-18 | 2021-05-27 | ニプロ株式会社 | ルビプロストン含有粒子状医薬組成物 |
JP7518661B2 (ja) | 2020-05-14 | 2024-07-18 | 沢井製薬株式会社 | ルビプロストン含有整粒物、ルビプロストン含有錠剤およびそれらの製造方法 |
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CA2150287C (en) * | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
US5981607A (en) | 1998-01-20 | 1999-11-09 | Allergan | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers |
JP4332316B2 (ja) * | 1999-10-15 | 2009-09-16 | スキャンポ・アーゲー | 二環式化合物組成物およびその安定化方法 |
US6414016B1 (en) | 2000-09-05 | 2002-07-02 | Sucampo, A.G. | Anti-constipation composition |
JP4210631B2 (ja) | 2004-06-24 | 2009-01-21 | 株式会社日立製作所 | ブレーキ制御装置 |
-
2000
- 2000-10-13 JP JP2001530318A patent/JP4332316B2/ja not_active Expired - Lifetime
- 2000-10-13 PT PT04005836T patent/PT1426361E/pt unknown
- 2000-10-13 EP EP04005836.4A patent/EP1426361B2/de not_active Expired - Lifetime
- 2000-10-13 ES ES00966462T patent/ES2221859T3/es not_active Expired - Lifetime
- 2000-10-13 CN CNB008143137A patent/CN1268623C/zh not_active Ceased
- 2000-10-13 HU HU0203746A patent/HU229547B1/hu not_active IP Right Cessation
- 2000-10-13 IL IL14880300A patent/IL148803A0/xx active IP Right Grant
- 2000-10-13 WO PCT/JP2000/007109 patent/WO2001027099A2/en active IP Right Grant
- 2000-10-13 KR KR1020027004709A patent/KR100830061B1/ko active Protection Beyond IP Right Term
- 2000-10-13 DE DE60010913T patent/DE60010913T2/de not_active Expired - Lifetime
- 2000-10-13 RU RU2002112984A patent/RU2695274C3/ru active Protection Beyond IP Right Term
- 2000-10-13 PT PT00966462T patent/PT1220849E/pt unknown
- 2000-10-13 AT AT00966462T patent/ATE267189T1/de active
- 2000-10-13 AR ARP000105407A patent/AR026046A1/es not_active Application Discontinuation
- 2000-10-13 MX MXPA02003756A patent/MXPA02003756A/es active IP Right Grant
- 2000-10-13 TR TR2002/01032T patent/TR200201032T2/xx unknown
- 2000-10-13 NZ NZ518020A patent/NZ518020A/en not_active IP Right Cessation
- 2000-10-13 ES ES04005836.4T patent/ES2309410T5/es not_active Expired - Lifetime
- 2000-10-13 DE DE60039727T patent/DE60039727D1/de not_active Expired - Lifetime
- 2000-10-13 DK DK00966462T patent/DK1220849T3/da active
- 2000-10-13 TW TW089121423A patent/TWI281918B/zh not_active IP Right Cessation
- 2000-10-13 HU HU1300369A patent/HU230484B1/hu not_active IP Right Cessation
- 2000-10-13 EP EP00966462A patent/EP1220849B1/de not_active Expired - Lifetime
- 2000-10-13 CZ CZ20021037A patent/CZ303625B6/cs not_active IP Right Cessation
- 2000-10-13 AT AT04005836T patent/ATE402925T2/de active
- 2000-10-13 CA CA002385732A patent/CA2385732C/en not_active Expired - Lifetime
- 2000-10-13 AU AU76856/00A patent/AU780342B2/en not_active Expired
- 2000-10-13 DK DK04005836T patent/DK1426361T4/en active
- 2000-10-13 BR BRPI0014869A patent/BRPI0014869B8/pt not_active IP Right Cessation
- 2000-10-16 US US09/688,351 patent/US6583174B1/en not_active Expired - Lifetime
-
2002
- 2002-03-21 IL IL148803A patent/IL148803A/en unknown
- 2002-03-22 ZA ZA200202312A patent/ZA200202312B/en unknown
- 2002-04-12 NO NO20021736A patent/NO330258B1/no not_active IP Right Cessation
- 2002-10-07 HK HK04109640.1A patent/HK1066792A1/xx not_active IP Right Cessation
- 2002-10-07 HK HK02107337.5A patent/HK1045693B/zh not_active IP Right Cessation
-
2003
- 2003-03-10 US US10/383,581 patent/US7417067B2/en not_active Expired - Lifetime
-
2004
- 2004-12-24 AU AU2004242503A patent/AU2004242503B2/en not_active Expired
-
2008
- 2008-06-23 US US12/144,000 patent/US8088934B2/en not_active Expired - Lifetime
-
2009
- 2009-05-25 JP JP2009125293A patent/JP2009235079A/ja active Pending
-
2011
- 2011-11-04 US US13/289,386 patent/US8097649B1/en not_active Expired - Lifetime
- 2011-12-27 US US13/337,391 patent/US20120095090A1/en not_active Abandoned
-
2013
- 2013-01-30 AR ARP130100275A patent/AR089848A2/es not_active Application Discontinuation
-
2017
- 2017-08-16 AR ARP170102288A patent/AR109354A2/es unknown
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